Turner 1999
GU Basepair Example

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Turner 1999

GU Pairs

Example

 

 

        

∆G°₃₇ = ∆G°_{37 intermolecular initiation} + ∆G°_{37 GU end penalty} + ∆G°₃₇(GC followed by GU, followed by UG, followed by GC) + ∆G°₃₇(CG followed by GU) + ∆G°₃₇(GU followed by UG) + ∆G°₃₇(UG followed by GC) + ∆G°₃₇(GC followed by UG)

 

∆G°₃₇ = 4.09 kcal/mol + 0.45 kcal/mol – 4.12 kcal/mol –1.41 kcal/mol + 1.29 kcal/mol – 1.41 kcal/mol – 2.51 kcal/mol

 

∆G°₃₇ = –3.62 kcal/mol

 

 

 

 

Note that this example shows the stack of GU followed by UG in two different contexts, including the stabilizing context and the destabilizing context. In the stabilizing context, a single parameter is used for three consecutive basepair stacks.

 

Page Revised 8/14/09