Data tables for symetric interior loops of size 4 Free energies at 37 degrees for RNA Data arrangement: Y ---------------------------------------------------------------- (X) A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ---------------------------------------------------------------- 5' ------> 3' A \/ \_/ A U /\ | U 3' <------ 5' (AA) . . . . . . . . . . . . . . . . (AC) . . . . . . . . . . . . . . . . (AG) . . . . . . . . . . . . . . . . (AU) . . . . . . . . . . . . . . . . (CA) . . . . . . . . . . . . . . . . (CC) . . . . . . . . . . . . . . . . (CG) . . . . . . . . . . . . . . . . (CU) . . . . . . . . . . . . . . . . (GA) . . . . . . . . . . . . . . . . (GC) . . . . . . . . . . . . . . . . (GG) . . . . . . . . . . . . . . . . (GU) . . . . . . . . . . . . . . . . (UA) . . . . . . . . . . . . . . . . (UC) . . . . . . . . . . . . . . . . (UG) . . . . . . . . . . . . . . . . (UU) . . . . . . . . . . . . . . . . Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' A \/ \_/ A U /\ | U 3' <------ 5' 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 2.5 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 1.7 2.2 1.1 2.2 2.6 2.3 2.6 1.8 2.2 1.8 1.2 1.8 2.2 2.8 2.2 2.8 1.3 1.8 2.0 1.8 2.2 2.5 2.2 1.4 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 1.7 2.2 1.1 2.2 2.6 2.3 2.6 1.8 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 1.6 2.1 1.0 2.1 2.5 2.2 2.5 1.7 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.2 2.1 1.0 2.1 2.6 2.3 2.6 1.7 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 1.6 2.1 1.0 2.1 2.5 2.2 2.5 1.7 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.2 2.1 1.0 2.1 2.6 2.3 2.6 1.7 1.5 1.1 0.5 1.1 1.5 2.1 1.5 2.1 0.6 1.1 1.3 1.1 1.5 1.8 1.5 0.7 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 1.7 2.2 1.1 2.2 2.6 2.3 2.6 1.8 1.0 0.6 1.3 0.6 1.0 1.0 1.0 1.0 1.4 0.6 2.1 0.6 1.0 0.7 1.0 1.5 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 1.7 2.2 1.1 2.2 2.6 2.3 2.6 1.8 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 1.6 2.1 1.0 2.1 2.5 2.2 2.5 1.7 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.2 2.1 1.0 2.1 2.6 2.3 2.6 1.7 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 1.6 2.1 1.0 2.1 2.5 2.2 2.5 1.7 2.3 1.2 0.6 1.2 1.7 1.7 1.7 1.7 0.7 1.2 1.4 1.2 1.7 1.4 1.7 0.8 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' A \/ \_/ C U /\ | G 3' <------ 5' 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.7 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 0.6 1.7 0.3 1.7 1.7 1.8 1.7 1.0 1.6 1.3 -0.4 1.3 1.3 1.9 1.3 1.9 0.2 1.3 1.2 1.3 1.3 2.0 1.3 0.6 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 0.6 1.7 0.3 1.7 1.7 1.8 1.7 1.0 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 0.5 1.6 0.2 1.6 1.6 1.7 1.6 0.9 1.9 1.7 0.5 1.7 1.6 1.7 1.6 1.7 1.1 1.7 0.3 1.7 1.6 1.7 1.6 0.9 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 0.5 1.6 0.2 1.6 1.6 1.7 1.6 0.9 1.9 1.7 0.5 1.7 1.6 1.7 1.6 1.7 1.1 1.7 0.3 1.7 1.6 1.7 1.6 0.9 0.9 0.6 -1.1 0.6 0.6 1.2 0.6 1.2 -0.5 0.6 0.5 0.6 0.6 1.3 0.6 -0.1 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 0.6 1.7 0.3 1.7 1.7 1.8 1.7 1.0 0.4 0.1 -0.3 0.1 0.1 0.1 0.1 0.1 0.3 0.1 1.3 0.1 0.1 0.2 0.1 0.7 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 0.6 1.7 0.3 1.7 1.7 1.8 1.7 1.0 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 0.5 1.6 0.2 1.6 1.6 1.7 1.6 0.9 1.9 1.7 0.5 1.7 1.6 1.7 1.6 1.7 1.1 1.7 0.3 1.7 1.6 1.7 1.6 0.9 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 0.5 1.6 0.2 1.6 1.6 1.7 1.6 0.9 1.6 0.8 -1.0 0.8 0.7 0.8 0.7 0.8 -0.3 0.8 0.7 0.8 0.7 0.8 0.7 0.0 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' A \/ \_/ G U /\ | C 3' <------ 5' 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.8 1.8 1.8 0.9 1.8 2.2 2.1 2.2 1.9 0.9 1.8 0.3 1.8 2.2 1.9 2.2 1.0 1.4 1.4 0.5 1.4 1.8 2.3 1.8 2.1 0.5 1.4 1.2 1.4 1.8 2.1 1.8 0.6 1.8 1.8 0.9 1.8 2.2 2.1 2.2 1.9 0.9 1.8 0.3 1.8 2.2 1.9 2.2 1.0 1.7 1.7 0.8 1.7 2.1 2.0 2.1 1.8 0.8 1.7 0.2 1.7 2.1 1.8 2.1 0.9 1.8 1.7 1.4 1.7 2.2 2.0 2.2 1.9 1.4 1.7 0.3 1.7 2.2 1.9 2.2 1.0 1.7 1.7 0.8 1.7 2.1 2.0 2.1 1.8 0.8 1.7 0.2 1.7 2.1 1.8 2.1 0.9 1.8 1.7 1.4 1.7 2.2 2.0 2.2 1.9 1.4 1.7 0.3 1.7 2.2 1.9 2.2 1.0 0.7 0.7 -0.2 0.7 1.1 1.6 1.1 1.4 -0.2 0.7 0.5 0.7 1.1 1.4 1.1 0.0 1.8 1.8 0.9 1.8 2.2 2.1 2.2 1.9 0.9 1.8 0.3 1.8 2.2 1.9 2.2 1.0 0.2 0.2 0.6 0.2 0.6 0.5 0.6 0.3 0.6 0.2 1.3 0.2 0.6 0.3 0.6 0.7 1.8 1.8 0.9 1.8 2.2 2.1 2.2 1.9 0.9 1.8 0.3 1.8 2.2 1.9 2.2 1.0 1.7 1.7 0.8 1.7 2.1 2.0 2.1 1.8 0.8 1.7 0.2 1.7 2.1 1.8 2.1 0.9 1.8 1.7 1.4 1.7 2.2 2.0 2.2 1.9 1.4 1.7 0.3 1.7 2.2 1.9 2.2 1.0 1.7 1.7 0.8 1.7 2.1 2.0 2.1 1.8 0.8 1.7 0.2 1.7 2.1 1.8 2.1 0.9 1.5 0.8 0.0 0.8 1.3 1.1 1.3 1.0 0.0 0.8 0.7 0.8 1.3 1.0 1.3 0.1 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' A \/ \_/ G U /\ | U 3' <------ 5' 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 3.4 2.3 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.9 2.6 1.3 2.6 2.6 2.6 2.6 2.6 1.9 2.2 0.9 2.2 2.2 2.8 2.2 2.8 2.5 2.2 2.2 2.2 2.2 2.8 2.2 2.2 2.3 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.9 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.2 2.5 1.2 2.5 2.5 2.5 2.5 2.5 2.8 2.5 1.2 2.5 2.5 2.5 2.5 2.5 2.2 2.6 1.8 2.6 2.6 2.6 2.6 2.6 3.5 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.2 2.5 1.2 2.5 2.5 2.5 2.5 2.5 2.8 2.5 1.2 2.5 2.5 2.5 2.5 2.5 2.2 2.6 1.8 2.6 2.6 2.6 2.6 2.6 3.5 2.6 1.3 2.6 2.6 2.6 2.6 2.6 1.2 1.5 0.2 1.5 1.5 2.1 1.5 2.1 1.8 1.5 1.5 1.5 1.5 2.1 1.5 1.5 2.3 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.9 2.6 1.3 2.6 2.6 2.6 2.6 2.6 0.7 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.6 1.0 2.3 1.0 1.0 1.0 1.0 2.3 2.3 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.9 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.2 2.5 1.2 2.5 2.5 2.5 2.5 2.5 2.8 2.5 1.2 2.5 2.5 2.5 2.5 2.5 2.2 2.6 1.8 2.6 2.6 2.6 2.6 2.6 3.5 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.2 2.5 1.2 2.5 2.5 2.5 2.5 2.5 2.8 2.5 1.2 2.5 2.5 2.5 2.5 2.5 1.9 1.7 0.3 1.7 1.7 1.7 1.7 1.7 2.0 1.7 1.7 1.7 1.7 1.7 1.7 1.7 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' A \/ \_/ U U /\ | A 3' <------ 5' 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.3 2.6 2.4 1.4 2.4 2.5 2.4 2.5 2.4 2.1 2.4 0.9 2.4 2.5 2.4 2.5 1.5 2.2 2.0 1.0 2.0 2.1 2.6 2.1 2.6 1.7 2.0 1.8 2.0 2.1 2.6 2.1 1.1 2.6 2.4 1.4 2.4 2.5 2.4 2.5 2.4 2.1 2.4 0.9 2.4 2.5 2.4 2.5 1.5 2.5 2.3 1.3 2.3 2.4 2.3 2.4 2.3 2.0 2.3 0.8 2.3 2.4 2.3 2.4 1.4 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.6 2.3 0.8 2.3 2.4 2.4 2.4 1.5 2.5 2.3 1.3 2.3 2.4 2.3 2.4 2.3 2.0 2.3 0.8 2.3 2.4 2.3 2.4 1.4 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.6 2.3 0.8 2.3 2.4 2.4 2.4 1.5 1.5 1.3 0.3 1.3 1.4 1.9 1.4 1.9 1.0 1.3 1.1 1.3 1.4 1.9 1.4 0.4 2.6 2.4 1.4 2.4 2.5 2.4 2.5 2.4 2.1 2.4 0.9 2.4 2.5 2.4 2.5 1.5 1.0 0.8 1.1 0.8 0.9 0.8 0.9 0.8 1.8 0.8 1.9 0.8 0.9 0.8 0.9 1.2 2.6 2.4 1.4 2.4 2.5 2.4 2.5 2.4 2.1 2.4 0.9 2.4 2.5 2.4 2.5 1.5 2.5 2.3 1.3 2.3 2.4 2.3 2.4 2.3 2.0 2.3 0.8 2.3 2.4 2.3 2.4 1.4 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.6 2.3 0.8 2.3 2.4 2.4 2.4 1.5 2.5 2.3 1.3 2.3 2.4 2.3 2.4 2.3 2.0 2.3 0.8 2.3 2.4 2.3 2.4 1.4 2.3 1.4 0.4 1.4 1.5 1.5 1.5 1.5 1.1 1.4 1.2 1.4 1.5 1.5 1.5 0.6 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' A \/ \_/ U U /\ | G 3' <------ 5' 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.7 3.3 2.9 2.1 2.9 2.9 2.9 2.9 2.9 2.5 2.9 1.6 2.9 2.9 2.9 2.9 2.9 2.9 2.5 1.7 2.5 2.5 3.1 2.5 3.1 2.1 2.5 2.5 2.5 2.5 3.1 2.5 2.5 3.3 2.9 2.1 2.9 2.9 2.9 2.9 2.9 2.5 2.9 1.6 2.9 2.9 2.9 2.9 2.9 3.2 2.8 2.0 2.8 2.8 2.8 2.8 2.8 2.4 2.8 1.5 2.8 2.8 2.8 2.8 2.8 3.2 2.9 2.7 2.9 2.9 2.9 2.9 2.9 3.1 2.9 1.6 2.9 2.9 2.9 2.9 2.9 3.2 2.8 2.0 2.8 2.8 2.8 2.8 2.8 2.4 2.8 1.5 2.8 2.8 2.8 2.8 2.8 3.2 2.9 2.7 2.9 2.9 2.9 2.9 2.9 3.1 2.9 1.6 2.9 2.9 2.9 2.9 2.9 2.2 1.8 1.0 1.8 1.8 2.4 1.8 2.4 1.4 1.8 1.8 1.8 1.8 2.4 1.8 1.8 3.3 2.9 2.1 2.9 2.9 2.9 2.9 2.9 2.5 2.9 1.6 2.9 2.9 2.9 2.9 2.9 1.7 1.3 1.8 1.3 1.3 1.3 1.3 1.3 2.2 1.3 2.6 1.3 1.3 1.3 1.3 2.6 3.3 2.9 2.1 2.9 2.9 2.9 2.9 2.9 2.5 2.9 1.6 2.9 2.9 2.9 2.9 2.9 3.2 2.8 2.0 2.8 2.8 2.8 2.8 2.8 2.4 2.8 1.5 2.8 2.8 2.8 2.8 2.8 3.2 2.9 2.7 2.9 2.9 2.9 2.9 2.9 3.1 2.9 1.6 2.9 2.9 2.9 2.9 2.9 3.2 2.8 2.0 2.8 2.8 2.8 2.8 2.8 2.4 2.8 1.5 2.8 2.8 2.8 2.8 2.8 2.9 2.0 1.2 2.0 2.0 2.0 2.0 2.0 1.6 2.0 2.0 2.0 2.0 2.0 2.0 2.0 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' C \/ \_/ A G /\ | U 3' <------ 5' 2.0 1.5 0.9 1.5 2.0 2.0 2.0 2.0 1.0 1.5 0.4 1.5 2.0 1.7 2.0 1.7 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 1.4 1.9 0.8 1.9 2.4 2.1 2.4 1.5 1.0 0.6 0.0 0.6 1.0 1.6 1.0 1.6 0.1 0.6 0.8 0.6 1.0 1.3 1.0 0.2 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 1.4 1.9 0.8 1.9 2.4 2.1 2.4 1.5 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.0 1.5 0.4 1.5 1.9 1.6 1.9 1.1 2.2 1.8 1.8 1.8 2.2 2.2 2.2 2.2 1.9 1.8 0.7 1.8 2.2 1.9 2.2 1.4 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.0 1.5 0.4 1.5 1.9 1.6 1.9 1.1 2.1 1.6 1.6 1.6 2.1 2.1 2.1 2.1 1.7 1.6 0.5 1.6 2.1 1.8 2.1 1.2 1.0 0.6 0.0 0.6 1.0 1.6 1.0 1.6 0.1 0.6 0.8 0.6 1.0 1.3 1.0 0.2 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 1.4 1.9 0.8 1.9 2.4 2.1 2.4 1.5 0.5 0.0 0.7 0.0 0.5 0.5 0.5 0.5 0.8 0.0 1.5 0.0 0.5 0.2 0.5 0.9 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 1.4 1.9 0.8 1.9 2.4 2.1 2.4 1.5 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.0 1.5 0.4 1.5 1.9 1.6 1.9 1.1 2.1 1.6 1.6 1.6 2.1 2.1 2.1 2.1 1.7 1.6 0.5 1.6 2.1 1.8 2.1 1.2 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.0 1.5 0.4 1.5 1.9 1.6 1.9 1.1 1.8 0.7 0.1 0.7 1.2 1.2 1.2 1.2 0.2 0.7 0.9 0.7 1.2 0.9 1.2 0.3 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' C \/ \_/ C G /\ | G 3' <------ 5' 1.3 1.1 -0.3 1.1 1.0 1.1 1.0 1.1 0.4 1.1 -0.3 1.1 1.0 1.1 1.0 1.5 0.6 1.5 0.1 1.5 0.5 1.5 1.4 1.5 0.3 1.5 -0.3 1.5 1.4 1.5 1.4 0.0 0.0 -0.7 -1.6 0.1 -1.0 -0.6 0.1 0.7 -0.7 0.1 0.0 0.1 0.1 0.8 0.1 0.9 1.7 1.5 -0.3 1.5 1.4 1.5 1.4 1.5 0.3 1.5 0.1 1.5 1.4 1.5 1.4 0.7 1.3 1.0 -0.7 1.0 1.1 1.0 1.0 1.0 0.7 1.0 -0.4 1.0 1.0 1.1 1.0 -0.2 2.2 1.3 0.7 1.3 1.9 1.3 1.3 1.3 0.7 1.3 -0.1 1.3 1.3 1.4 1.3 -0.1 1.3 1.0 -0.7 1.0 1.0 1.0 1.0 1.0 -0.1 1.0 -0.4 1.0 1.0 1.1 1.0 0.3 1.4 1.2 0.0 1.2 1.1 1.2 1.1 1.7 0.6 1.2 0.2 1.2 1.1 1.2 1.1 0.2 -0.2 -0.4 -1.7 0.1 0.7 0.7 0.1 0.7 -0.5 0.1 -0.3 0.1 0.1 0.8 0.1 0.9 1.7 1.5 -0.3 1.5 1.4 1.5 1.4 1.5 0.3 1.5 0.1 1.5 1.4 1.5 1.4 0.7 -0.1 -0.4 -0.9 -0.4 -0.5 -0.4 -0.5 0.2 -0.3 -0.4 0.8 -0.4 -0.5 -0.5 -0.5 1.4 1.7 1.5 -0.3 1.5 1.4 1.5 1.4 1.5 0.3 1.5 0.1 1.5 1.4 1.5 1.4 0.7 1.3 1.0 -0.7 1.0 1.0 1.0 1.0 1.0 -0.1 1.0 -0.4 1.0 1.0 1.1 1.0 0.3 1.4 1.2 0.0 1.2 1.1 1.2 1.1 1.2 0.5 1.2 -0.6 1.2 1.1 1.2 1.1 0.4 1.3 1.0 -0.7 1.0 1.0 1.0 1.0 1.0 -0.1 1.0 -0.4 1.0 1.0 1.1 1.0 0.3 1.4 0.3 0.5 0.3 0.3 0.3 0.2 0.3 1.4 0.3 0.7 0.3 0.2 0.3 0.2 -0.6 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' C \/ \_/ G G /\ | C 3' <------ 5' 1.2 1.1 0.2 1.1 1.6 1.4 1.6 1.3 0.2 1.1 -0.3 1.1 1.6 1.3 1.6 1.0 1.6 1.5 0.6 1.5 2.0 1.8 2.0 1.7 0.6 1.5 0.1 1.5 2.0 1.7 2.0 0.8 0.2 0.2 -0.7 0.2 0.6 1.1 0.6 0.9 -0.7 0.2 0.0 0.2 0.6 0.9 0.6 -0.5 1.6 1.5 0.6 1.5 2.0 1.8 2.0 1.7 0.6 1.5 0.1 1.5 2.0 1.7 2.0 0.8 1.1 1.1 0.2 1.1 1.5 1.4 1.5 1.2 0.2 1.1 -0.4 1.1 1.5 1.2 1.5 0.3 1.4 1.4 1.1 1.4 1.8 1.7 1.8 1.5 1.1 1.4 -0.1 1.4 1.8 1.5 1.8 0.6 1.1 1.1 0.2 1.1 1.5 1.4 1.5 1.2 0.2 1.1 -0.4 1.1 1.5 1.2 1.5 0.3 1.3 1.2 0.9 1.2 1.7 1.5 1.7 1.4 0.9 1.2 -0.2 1.2 1.7 1.4 1.7 0.5 0.2 0.2 -0.7 0.2 0.6 1.1 0.6 0.9 -0.7 0.2 0.0 0.2 0.6 0.9 0.6 -0.5 1.6 1.5 0.6 1.5 2.0 1.8 2.0 1.7 0.6 1.5 0.1 1.5 2.0 1.7 2.0 0.8 -0.3 -0.4 0.0 -0.4 0.1 -0.1 0.1 -0.2 0.0 -0.4 0.8 -0.4 0.1 -0.2 0.1 0.2 1.6 1.5 0.6 1.5 2.0 1.8 2.0 1.7 0.6 1.5 0.1 1.5 2.0 1.7 2.0 0.8 1.1 1.1 0.2 1.1 1.5 1.4 1.5 1.2 0.2 1.1 -0.4 1.1 1.5 1.2 1.5 0.3 1.3 1.2 0.9 1.2 1.7 1.5 1.7 1.4 0.9 1.2 -0.2 1.2 1.7 1.4 1.7 0.5 1.1 1.1 0.2 1.1 1.5 1.4 1.5 1.2 0.2 1.1 -0.4 1.1 1.5 1.2 1.5 0.3 1.0 0.3 -0.5 0.3 0.8 0.6 0.8 0.5 -0.5 0.3 0.2 0.3 0.8 0.5 0.8 -0.4 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' C \/ \_/ G G /\ | U 3' <------ 5' 1.6 2.0 0.6 2.0 2.0 2.0 2.0 2.0 2.3 2.0 0.7 2.0 2.0 2.0 2.0 2.6 2.0 2.4 1.0 2.4 2.4 2.4 2.4 2.4 2.7 2.4 1.1 2.4 2.4 2.4 2.4 2.4 0.7 1.0 -0.3 1.0 1.0 1.6 1.0 1.6 1.3 1.0 1.0 1.0 1.0 1.6 1.0 1.0 2.0 2.4 1.0 2.4 2.4 2.4 2.4 2.4 2.7 2.4 1.1 2.4 2.4 2.4 2.4 2.4 1.6 1.9 0.6 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 1.9 2.2 1.5 2.2 2.2 2.2 2.2 2.2 3.1 2.2 0.9 2.2 2.2 2.2 2.2 2.2 1.6 1.9 0.6 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 1.7 2.1 1.3 2.1 2.1 2.1 2.1 2.1 3.0 2.1 0.8 2.1 2.1 2.1 2.1 2.1 0.7 1.0 -0.3 1.0 1.0 1.6 1.0 1.6 1.3 1.0 1.0 1.0 1.0 1.6 1.0 1.0 2.0 2.4 1.0 2.4 2.4 2.4 2.4 2.4 2.7 2.4 1.1 2.4 2.4 2.4 2.4 2.4 0.1 0.5 0.4 0.5 0.5 0.5 0.5 0.5 2.1 0.5 1.8 0.5 0.5 0.5 0.5 1.8 2.0 2.4 1.0 2.4 2.4 2.4 2.4 2.4 2.7 2.4 1.1 2.4 2.4 2.4 2.4 2.4 1.6 1.9 0.6 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 1.7 2.1 1.3 2.1 2.1 2.1 2.1 2.1 3.0 2.1 0.8 2.1 2.1 2.1 2.1 2.1 1.6 1.9 0.6 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 1.4 1.2 -0.1 1.2 1.2 1.2 1.2 1.2 1.5 1.2 1.2 1.2 1.2 1.2 1.2 1.2 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' C \/ \_/ U G /\ | A 3' <------ 5' 2.0 1.7 0.7 1.7 1.8 1.8 1.8 1.8 1.4 1.7 0.2 1.7 1.8 1.8 1.8 1.5 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 1.8 2.1 0.6 2.1 2.2 2.2 2.2 1.3 1.0 0.8 -0.2 0.8 0.9 1.4 0.9 1.4 0.5 0.8 0.6 0.8 0.9 1.4 0.9 0.0 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 1.8 2.1 0.6 2.1 2.2 2.2 2.2 1.3 1.9 1.7 0.7 1.7 1.8 1.7 1.8 1.7 1.4 1.7 0.2 1.7 1.8 1.7 1.8 0.8 2.2 2.0 1.6 2.0 2.1 2.0 2.1 2.0 2.3 2.0 0.5 2.0 2.1 2.0 2.1 1.1 1.9 1.7 0.7 1.7 1.8 1.7 1.8 1.7 1.4 1.7 0.2 1.7 1.8 1.7 1.8 0.8 2.1 1.8 1.4 1.8 1.9 1.9 1.9 1.9 2.1 1.8 0.3 1.8 1.9 1.9 1.9 1.0 1.0 0.8 -0.2 0.8 0.9 1.4 0.9 1.4 0.5 0.8 0.6 0.8 0.9 1.4 0.9 0.0 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 1.8 2.1 0.6 2.1 2.2 2.2 2.2 1.3 0.5 0.2 0.5 0.2 0.3 0.3 0.3 0.3 1.2 0.2 1.3 0.2 0.3 0.3 0.3 0.7 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 1.8 2.1 0.6 2.1 2.2 2.2 2.2 1.3 1.9 1.7 0.7 1.7 1.8 1.7 1.8 1.7 1.4 1.7 0.2 1.7 1.8 1.7 1.8 0.8 2.1 1.8 1.4 1.8 1.9 1.9 1.9 1.9 2.1 1.8 0.3 1.8 1.9 1.9 1.9 1.0 1.9 1.7 0.7 1.7 1.8 1.7 1.8 1.7 1.4 1.7 0.2 1.7 1.8 1.7 1.8 0.8 1.8 0.9 0.0 0.9 1.0 1.0 1.0 1.0 0.6 0.9 0.7 0.9 1.0 1.0 1.0 0.1 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' C \/ \_/ U G /\ | G 3' <------ 5' 2.7 2.3 1.5 2.3 2.3 2.3 2.3 2.3 1.9 2.3 1.0 2.3 2.3 2.3 2.3 2.9 3.0 2.7 1.9 2.7 2.7 2.7 2.7 2.7 2.3 2.7 1.4 2.7 2.7 2.7 2.7 2.7 1.7 1.3 0.5 1.3 1.3 1.9 1.3 1.9 0.9 1.3 1.3 1.3 1.3 1.9 1.3 1.3 3.0 2.7 1.9 2.7 2.7 2.7 2.7 2.7 2.3 2.7 1.4 2.7 2.7 2.7 2.7 2.7 2.6 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2 2.9 2.5 2.3 2.5 2.5 2.5 2.5 2.5 2.7 2.5 1.2 2.5 2.5 2.5 2.5 2.5 2.6 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2 2.7 2.4 2.2 2.4 2.4 2.4 2.4 2.4 2.6 2.4 1.1 2.4 2.4 2.4 2.4 2.4 1.7 1.3 0.5 1.3 1.3 1.9 1.3 1.9 0.9 1.3 1.3 1.3 1.3 1.9 1.3 1.3 3.0 2.7 1.9 2.7 2.7 2.7 2.7 2.7 2.3 2.7 1.4 2.7 2.7 2.7 2.7 2.7 1.1 0.8 1.3 0.8 0.8 0.8 0.8 0.8 1.7 0.8 2.1 0.8 0.8 0.8 0.8 2.1 3.0 2.7 1.9 2.7 2.7 2.7 2.7 2.7 2.3 2.7 1.4 2.7 2.7 2.7 2.7 2.7 2.6 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2 2.7 2.4 2.2 2.4 2.4 2.4 2.4 2.4 2.6 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.6 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2 2.4 1.5 0.7 1.5 1.5 1.5 1.5 1.5 1.1 1.5 1.5 1.5 1.5 1.5 1.5 1.5 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' G \/ \_/ A C /\ | U 3' <------ 5' 2.1 1.7 1.1 1.7 2.1 2.1 2.1 2.1 1.2 1.7 0.6 1.7 2.1 1.8 2.1 1.9 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 0.9 1.4 0.3 1.4 1.8 1.5 1.8 1.0 0.7 0.3 -0.3 0.3 0.7 1.3 0.7 1.3 -0.2 0.3 0.5 0.3 0.7 1.0 0.7 -0.1 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 0.9 1.4 0.3 1.4 1.8 1.5 1.8 1.0 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 0.9 1.4 0.3 1.4 1.9 1.6 1.9 1.0 1.9 1.4 1.4 1.4 1.9 1.9 1.9 1.9 1.5 1.4 0.3 1.4 1.9 1.6 1.9 1.0 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 0.9 1.4 0.3 1.4 1.9 1.6 1.9 1.0 1.9 1.5 1.5 1.5 1.9 1.9 1.9 1.9 1.6 1.5 0.4 1.5 1.9 1.6 1.9 1.1 0.1 -0.3 -0.9 -0.3 0.1 0.7 0.1 0.7 -0.8 -0.3 -0.1 -0.3 0.1 0.4 0.1 -0.7 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 0.9 1.4 0.3 1.4 1.8 1.5 1.8 1.0 0.5 0.0 0.7 0.0 0.5 0.5 0.5 0.5 0.8 0.0 1.5 0.0 0.5 0.2 0.5 0.9 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 0.9 1.4 0.3 1.4 1.8 1.5 1.8 1.0 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 0.9 1.4 0.3 1.4 1.9 1.6 1.9 1.0 1.9 1.4 1.4 1.4 1.9 1.9 1.9 1.9 1.5 1.4 0.3 1.4 1.9 1.6 1.9 1.0 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 0.9 1.4 0.3 1.4 1.9 1.6 1.9 1.0 1.7 0.7 0.1 0.7 1.1 1.1 1.1 1.1 0.2 0.7 0.9 0.7 1.1 0.8 1.1 0.3 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' G \/ \_/ C C /\ | G 3' <------ 5' 1.5 1.2 -0.5 1.2 1.2 1.2 1.2 1.2 0.1 1.2 -0.2 1.2 1.2 1.3 1.2 1.1 1.2 0.9 -0.8 0.9 0.9 0.9 0.9 0.9 -0.2 0.9 -0.5 0.9 0.9 1.0 0.9 0.2 0.1 -0.1 -1.9 -0.1 -0.2 0.5 -0.2 0.5 -1.3 -0.1 -0.2 -0.1 -0.2 0.5 -0.2 -0.9 1.2 0.9 -0.8 0.9 0.9 0.9 0.9 0.9 -0.2 0.9 -0.5 0.9 0.9 1.0 0.9 0.2 1.2 1.0 -0.8 1.0 0.9 1.0 0.9 1.0 -0.1 1.0 -0.4 1.0 0.9 1.0 0.9 0.2 1.2 1.0 -0.2 1.0 0.9 1.0 0.9 1.0 0.5 1.0 -0.4 1.0 0.9 1.0 0.9 0.2 1.2 1.0 -0.8 1.0 0.9 1.0 0.9 1.0 -0.1 1.0 -0.4 1.0 0.9 1.0 0.9 0.2 1.3 1.0 -0.1 1.0 1.0 1.0 1.0 1.0 0.5 1.0 -0.4 1.0 1.0 1.1 1.0 0.3 -0.5 -0.8 -2.6 -0.8 -0.8 -0.2 -0.8 -0.2 -1.9 -0.8 -0.9 -0.8 -0.8 -0.1 -0.8 -1.5 1.2 0.9 -0.8 0.9 0.9 0.9 0.9 0.9 -0.2 0.9 -0.5 0.9 0.9 1.0 0.9 0.2 -0.2 -0.4 -0.9 -0.4 -0.5 -0.4 -0.5 -0.4 -0.2 -0.4 0.8 -0.4 -0.5 -0.4 -0.5 0.1 1.2 0.9 -0.8 0.9 0.9 0.9 0.9 0.9 -0.2 0.9 -0.5 0.9 0.9 1.0 0.9 0.2 1.2 1.0 -0.8 1.0 0.9 1.0 0.9 1.0 -0.1 1.0 -0.4 1.0 0.9 1.0 0.9 0.2 1.2 1.0 -0.2 1.0 0.9 1.0 0.9 1.0 0.5 1.0 -0.4 1.0 0.9 1.0 0.9 0.2 1.2 1.0 -0.8 1.0 0.9 1.0 0.9 1.0 -0.1 1.0 -0.4 1.0 0.9 1.0 0.9 0.2 1.1 0.2 -1.5 0.2 0.2 0.2 0.2 0.2 -0.9 0.2 0.1 0.2 0.2 0.3 0.2 -0.5 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' G \/ \_/ G C /\ | C 3' <------ 5' 1.3 1.3 -0.2 1.3 0.6 2.2 1.7 1.4 0.0 1.3 -0.1 1.3 1.7 1.4 1.7 1.4 1.0 1.1 0.7 1.0 0.5 1.9 1.4 1.1 -1.0 1.0 -0.5 1.0 1.4 1.1 1.4 0.3 0.4 0.7 -0.5 -0.1 0.3 0.7 0.3 0.5 -0.7 -0.1 -0.3 -0.1 0.3 0.6 0.3 1.4 1.0 1.0 0.1 1.0 1.4 1.3 1.4 1.1 0.1 1.0 -0.5 1.0 1.4 1.1 1.4 0.2 1.1 1.0 -0.4 1.0 1.5 1.3 1.5 1.2 -0.7 1.0 -0.4 1.0 1.5 1.2 1.5 0.3 1.1 1.0 0.7 1.0 1.5 1.3 1.5 1.2 -0.6 1.0 -0.4 1.0 1.5 1.2 1.5 0.3 1.1 1.0 0.1 1.0 1.5 1.3 1.5 1.2 0.1 1.0 -0.4 1.0 1.5 1.2 1.5 0.3 1.1 1.1 0.8 1.1 1.5 1.4 1.5 1.2 0.8 1.1 -0.5 1.1 1.5 1.2 1.5 0.3 -0.3 -0.7 -1.7 -0.7 0.1 0.7 -0.3 0.0 -1.6 -0.7 -0.9 -0.7 -0.3 0.0 -0.3 0.5 1.0 1.0 0.1 1.0 1.4 1.3 1.4 1.1 0.1 1.0 -0.5 1.0 1.4 1.1 1.4 0.2 -0.3 -0.4 -0.3 -0.4 -0.3 -0.1 0.1 -0.6 0.0 -0.4 0.8 -0.4 0.1 0.2 0.1 0.7 1.0 1.0 0.1 1.0 1.4 1.3 1.4 1.1 0.1 1.0 -0.5 1.0 1.4 1.1 1.4 0.2 1.1 1.0 0.1 1.0 1.5 1.3 1.5 1.2 0.1 1.0 -0.4 1.0 1.5 1.2 1.5 0.3 1.1 1.0 0.7 1.0 1.5 1.3 1.5 1.2 0.7 1.0 0.2 1.0 1.5 1.7 1.5 0.3 1.1 1.0 0.1 1.0 1.5 1.3 1.5 1.2 0.1 1.0 -0.4 1.0 1.5 1.2 1.5 0.3 1.5 -0.2 0.9 0.3 0.0 -0.1 0.7 0.4 0.9 0.3 1.4 0.3 0.7 0.2 0.7 -0.6 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' G \/ \_/ G C /\ | U 3' <------ 5' 1.9 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.7 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 0.4 0.7 -0.6 0.7 0.7 1.3 0.7 1.3 1.0 0.7 0.7 0.7 0.7 1.3 0.7 0.7 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.5 1.9 0.5 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 1.5 1.9 1.1 1.9 1.9 1.9 1.9 1.9 2.8 1.9 0.6 1.9 1.9 1.9 1.9 1.9 1.5 1.9 0.5 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 1.6 1.9 1.2 1.9 1.9 1.9 1.9 1.9 2.8 1.9 0.6 1.9 1.9 1.9 1.9 1.9 -0.2 0.1 -1.2 0.1 0.1 0.7 0.1 0.7 0.4 0.1 0.1 0.1 0.1 0.7 0.1 0.1 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 0.1 0.5 0.4 0.5 0.5 0.5 0.5 0.5 2.1 0.5 1.8 0.5 0.5 0.5 0.5 1.8 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.5 1.9 0.5 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 1.5 1.9 1.1 1.9 1.9 1.9 1.9 1.9 2.8 1.9 0.6 1.9 1.9 1.9 1.9 1.9 1.5 1.9 0.5 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 1.4 1.1 -0.2 1.1 1.1 1.1 1.1 1.1 1.4 1.1 1.1 1.1 1.1 1.1 1.1 1.1 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' G \/ \_/ U C /\ | A 3' <------ 5' 2.1 1.9 0.9 1.9 2.0 1.9 2.0 1.9 1.6 1.9 0.4 1.9 2.0 1.9 2.0 1.6 1.8 1.6 0.6 1.6 1.7 1.6 1.7 1.6 1.3 1.6 0.1 1.6 1.7 1.6 1.7 0.7 0.7 0.5 -0.5 0.5 0.6 1.1 0.6 1.1 0.2 0.5 0.3 0.5 0.6 1.1 0.6 -0.3 1.8 1.6 0.6 1.6 1.7 1.6 1.7 1.6 1.3 1.6 0.1 1.6 1.7 1.6 1.7 0.7 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.3 1.6 0.1 1.6 1.7 1.7 1.7 0.8 1.9 1.6 1.2 1.6 1.7 1.7 1.7 1.7 1.9 1.6 0.1 1.6 1.7 1.7 1.7 0.8 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.3 1.6 0.1 1.6 1.7 1.7 1.7 0.8 1.9 1.7 1.3 1.7 1.8 1.7 1.8 1.7 2.0 1.7 0.2 1.7 1.8 1.7 1.8 0.8 0.1 -0.1 -1.1 -0.1 0.0 0.5 0.0 0.5 -0.4 -0.1 -0.3 -0.1 0.0 0.5 0.0 -1.0 1.8 1.6 0.6 1.6 1.7 1.6 1.7 1.6 1.3 1.6 0.1 1.6 1.7 1.6 1.7 0.7 0.5 0.2 0.5 0.2 0.3 0.3 0.3 0.3 1.2 0.2 1.3 0.2 0.3 0.3 0.3 0.7 1.8 1.6 0.6 1.6 1.7 1.6 1.7 1.6 1.3 1.6 0.1 1.6 1.7 1.6 1.7 0.7 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.3 1.6 0.1 1.6 1.7 1.7 1.7 0.8 1.9 1.6 1.2 1.6 1.7 1.7 1.7 1.7 1.9 1.6 0.1 1.6 1.7 1.7 1.7 0.8 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.3 1.6 0.1 1.6 1.7 1.7 1.7 0.8 1.7 0.9 -0.1 0.9 1.0 0.9 1.0 0.9 0.6 0.9 0.7 0.9 1.0 0.9 1.0 0.0 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' G \/ \_/ U C /\ | G 3' <------ 5' 2.8 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.0 2.4 1.1 2.4 2.4 2.4 2.4 3.0 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 1.4 1.0 0.2 1.0 1.0 1.6 1.0 1.6 0.6 1.0 1.0 1.0 1.0 1.6 1.0 1.0 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.5 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2 2.5 2.2 2.0 2.2 2.2 2.2 2.2 2.2 2.4 2.2 0.9 2.2 2.2 2.2 2.2 2.2 2.5 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2 2.6 2.2 2.0 2.2 2.2 2.2 2.2 2.2 2.4 2.2 0.9 2.2 2.2 2.2 2.2 2.2 0.7 0.4 -0.4 0.4 0.4 1.0 0.4 1.0 0.0 0.4 0.4 0.4 0.4 1.0 0.4 0.4 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 1.1 0.8 1.3 0.8 0.8 0.8 0.8 0.8 1.7 0.8 2.1 0.8 0.8 0.8 0.8 2.1 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.5 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2 2.5 2.2 2.0 2.2 2.2 2.2 2.2 2.2 2.4 2.2 0.9 2.2 2.2 2.2 2.2 2.2 2.5 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2 2.4 1.4 0.6 1.4 1.4 1.4 1.4 1.4 1.0 1.4 1.4 1.4 1.4 1.4 1.4 1.4 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' G \/ \_/ A U /\ | U 3' <------ 5' 3.4 3.0 2.4 3.0 3.4 3.4 3.4 3.4 2.5 3.0 1.9 3.0 3.4 3.1 3.4 3.2 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2 2.7 2.2 1.6 2.2 2.7 3.3 2.7 3.3 1.7 2.2 2.4 2.2 2.7 3.0 2.7 1.8 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2 3.1 2.6 2.6 2.6 3.1 3.1 3.1 3.1 2.7 2.6 1.5 2.6 3.1 2.8 3.1 2.2 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2 3.1 2.6 2.6 2.6 3.1 3.1 3.1 3.1 2.7 2.6 1.5 2.6 3.1 2.8 3.1 2.2 2.3 1.8 1.2 1.8 2.3 2.9 2.3 2.9 1.3 1.8 2.0 1.8 2.3 2.6 2.3 1.4 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2 1.8 1.3 2.0 1.3 1.8 1.8 1.8 1.8 2.1 1.3 2.8 1.3 1.8 1.5 1.8 2.2 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2 3.1 2.6 2.6 2.6 3.1 3.1 3.1 3.1 2.7 2.6 1.5 2.6 3.1 2.8 3.1 2.2 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2 3.7 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 2.8 2.6 3.1 2.8 3.1 2.2 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' G \/ \_/ C U /\ | G 3' <------ 5' 2.8 2.5 0.7 2.5 2.5 2.5 2.5 2.5 1.4 2.5 1.1 2.5 2.5 2.6 2.5 2.4 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4 2.0 1.8 0.0 1.8 1.7 2.4 1.7 2.4 0.6 1.8 1.7 1.8 1.7 2.4 1.7 1.0 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4 2.4 2.2 1.0 2.2 2.1 2.2 2.1 2.2 1.6 2.2 0.8 2.2 2.1 2.2 2.1 1.4 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4 2.4 2.2 1.0 2.2 2.1 2.2 2.1 2.2 1.6 2.2 0.8 2.2 2.1 2.2 2.1 1.4 1.6 1.4 -0.4 1.4 1.3 2.0 1.3 2.0 0.2 1.4 1.3 1.4 1.3 2.0 1.3 0.6 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4 1.1 0.9 0.4 0.9 0.8 0.9 0.8 0.9 1.0 0.9 2.1 0.9 0.8 0.9 0.8 1.4 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4 2.4 2.2 1.0 2.2 2.1 2.2 2.1 2.2 1.6 2.2 0.8 2.2 2.1 2.2 2.1 1.4 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4 3.0 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 2.1 2.2 2.1 2.2 2.1 1.4 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' G \/ \_/ G U /\ | C 3' <------ 5' 2.7 2.6 1.7 2.6 3.0 2.9 3.0 2.7 1.7 2.6 1.1 2.6 3.0 2.7 3.0 2.4 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5 1.9 1.8 0.9 1.8 2.3 2.7 2.3 2.6 0.9 1.8 1.7 1.8 2.3 2.6 2.3 1.1 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5 2.3 2.2 1.9 2.2 2.7 2.5 2.7 2.4 1.9 2.2 0.8 2.2 2.7 2.4 2.7 1.5 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5 2.3 2.2 1.9 2.2 2.7 2.5 2.7 2.4 1.9 2.2 0.8 2.2 2.7 2.4 2.7 1.5 1.5 1.4 0.5 1.4 1.9 2.3 1.9 2.2 0.5 1.4 1.3 1.4 1.9 2.2 1.9 0.7 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5 1.0 0.9 1.3 0.9 1.4 1.2 1.4 1.1 1.3 0.9 2.1 0.9 1.4 1.1 1.4 1.5 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5 2.3 2.2 1.9 2.2 2.7 2.5 2.7 2.4 1.9 2.2 0.8 2.2 2.7 2.4 2.7 1.5 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5 2.9 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 2.1 2.2 2.7 2.4 2.7 1.5 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' G \/ \_/ G U /\ | U 3' <------ 5' 3.6 3.4 2.2 3.4 3.4 3.4 3.4 3.4 3.7 3.4 2.1 3.4 3.4 3.4 3.4 4.0 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1 3.6 2.7 1.3 2.7 2.7 3.3 2.7 3.3 3.0 2.7 2.7 2.7 2.7 3.3 2.7 2.7 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1 2.7 3.1 2.3 3.1 3.1 3.1 3.1 3.1 4.0 3.1 1.8 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1 2.7 3.1 2.3 3.1 3.1 3.1 3.1 3.1 4.0 3.1 1.8 3.1 3.1 3.1 3.1 3.1 1.9 2.3 0.2 2.3 2.3 2.9 2.3 2.9 2.6 2.3 2.3 2.3 2.3 2.9 2.3 2.3 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1 1.4 1.8 1.7 1.8 1.8 1.8 1.8 1.8 3.4 1.8 3.1 1.8 1.8 1.8 1.8 3.1 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1 2.7 3.1 2.3 3.1 3.1 3.1 3.1 3.1 4.0 3.1 1.8 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1 3.3 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 3.1 3.1 3.1 3.1 3.1 3.1 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' G \/ \_/ U U /\ | A 3' <------ 5' 3.4 3.2 2.2 3.2 3.3 3.2 3.3 3.2 2.9 3.2 1.7 3.2 3.3 3.2 3.3 2.9 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0 2.7 2.4 1.4 2.4 2.5 3.1 2.5 3.1 2.1 2.4 2.2 2.4 2.5 3.1 2.5 1.6 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0 3.1 2.8 2.4 2.8 2.9 2.9 2.9 2.9 3.1 2.8 1.3 2.8 2.9 2.9 2.9 2.0 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0 3.1 2.8 2.4 2.8 2.9 2.9 2.9 2.9 3.1 2.8 1.3 2.8 2.9 2.9 2.9 2.0 2.3 2.0 1.0 2.0 2.1 2.7 2.1 2.7 1.7 2.0 1.8 2.0 2.1 2.7 2.1 1.2 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0 1.8 1.5 1.8 1.5 1.6 1.6 1.6 1.6 2.5 1.5 2.6 1.5 1.6 1.6 1.6 2.0 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0 3.1 2.8 2.4 2.8 2.9 2.9 2.9 2.9 3.1 2.8 1.3 2.8 2.9 2.9 2.9 2.0 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0 3.7 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 2.6 2.8 2.9 2.9 2.9 2.0 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' G \/ \_/ U U /\ | G 3' <------ 5' 4.1 3.7 2.9 3.7 3.7 3.7 3.7 3.7 3.3 3.7 2.4 3.7 3.7 3.7 3.7 4.3 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4 3.3 3.0 2.2 3.0 3.0 3.6 3.0 3.6 2.6 3.0 3.0 3.0 3.0 3.6 3.0 3.0 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4 3.7 3.4 3.2 3.4 3.4 3.4 3.4 3.4 3.6 3.4 2.1 3.4 3.4 3.4 3.4 3.4 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4 3.7 3.4 3.2 3.4 3.4 3.4 3.4 3.4 3.6 3.4 2.1 3.4 3.4 3.4 3.4 3.4 2.9 2.6 1.8 2.6 2.6 3.2 2.6 3.2 2.2 2.6 2.6 2.6 2.6 3.2 2.6 2.6 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4 2.4 2.1 2.6 2.1 2.1 2.1 2.1 2.1 3.0 2.1 3.4 2.1 2.1 2.1 2.1 3.4 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4 3.7 3.4 3.2 3.4 3.4 3.4 3.4 3.4 3.6 3.4 2.1 3.4 3.4 3.4 3.4 3.4 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4 4.3 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 3.4 3.4 3.4 3.4 3.4 3.4 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' U \/ \_/ A A /\ | U 3' <------ 5' 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 2.5 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 1.8 1.4 0.8 1.4 1.8 2.4 1.8 2.4 0.9 1.4 1.6 1.4 1.8 2.1 1.8 1.0 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 1.4 1.9 0.8 1.9 2.3 2.0 2.3 1.5 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.4 2.3 1.2 2.3 2.8 2.5 2.8 1.9 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 1.4 1.9 0.8 1.9 2.3 2.0 2.3 1.5 2.5 2.0 2.0 2.0 2.5 2.5 2.5 2.5 2.1 2.0 0.9 2.0 2.5 2.2 2.5 1.6 1.7 1.3 0.7 1.3 1.7 2.3 1.7 2.3 0.8 1.3 1.5 1.3 1.7 2.0 1.7 0.9 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 1.2 0.8 1.5 0.8 1.2 1.2 1.2 1.2 1.6 0.8 2.3 0.8 1.2 0.9 1.2 1.7 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 1.4 1.9 0.8 1.9 2.3 2.0 2.3 1.5 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.4 2.3 1.2 2.3 2.8 2.5 2.8 1.9 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 1.4 1.9 0.8 1.9 2.3 2.0 2.3 1.5 2.5 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.0 1.5 1.7 1.5 1.9 1.6 1.9 1.1 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' U \/ \_/ C A /\ | G 3' <------ 5' 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.7 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 1.2 0.9 -0.8 0.9 0.9 1.5 0.9 1.5 -0.2 0.9 0.8 0.9 0.9 1.6 0.9 0.2 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 0.3 1.4 0.0 1.4 1.4 1.5 1.4 0.7 2.1 1.9 0.7 1.9 1.8 1.9 1.8 1.9 1.3 1.9 0.5 1.9 1.8 1.9 1.8 1.1 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 0.3 1.4 0.0 1.4 1.4 1.5 1.4 0.7 1.8 1.6 0.4 1.6 1.5 1.6 1.5 1.6 1.0 1.6 0.2 1.6 1.5 1.6 1.5 0.8 1.1 0.8 -0.9 0.8 0.8 1.4 0.8 1.4 -0.3 0.8 0.7 0.8 0.8 1.5 0.8 0.1 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 0.6 0.3 -0.1 0.3 0.3 0.3 0.3 0.3 0.5 0.3 1.5 0.3 0.3 0.4 0.3 0.9 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 0.3 1.4 0.0 1.4 1.4 1.5 1.4 0.7 2.1 1.9 0.7 1.9 1.8 1.9 1.8 1.9 1.3 1.9 0.5 1.9 1.8 1.9 1.8 1.1 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 0.3 1.4 0.0 1.4 1.4 1.5 1.4 0.7 1.9 1.0 -0.7 1.0 1.0 1.0 1.0 1.0 -0.1 1.0 0.9 1.0 1.0 1.1 1.0 0.3 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' U \/ \_/ G A /\ | C 3' <------ 5' 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.8 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 1.0 1.0 0.1 1.0 1.4 1.9 1.4 1.7 0.1 1.0 0.8 1.0 1.4 1.7 1.4 0.2 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 1.5 1.5 0.6 1.5 1.9 1.8 1.9 1.6 0.6 1.5 0.0 1.5 1.9 1.6 1.9 0.7 2.0 1.9 1.6 1.9 2.4 2.2 2.4 2.1 1.6 1.9 0.5 1.9 2.4 2.1 2.4 1.2 1.5 1.5 0.6 1.5 1.9 1.8 1.9 1.6 0.6 1.5 0.0 1.5 1.9 1.6 1.9 0.7 1.7 1.6 1.3 1.6 2.1 1.9 2.1 1.8 1.3 1.6 0.2 1.6 2.1 1.8 2.1 0.9 0.9 0.9 0.0 0.9 1.3 1.8 1.3 1.6 0.0 0.9 0.7 0.9 1.3 1.6 1.3 0.1 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 0.4 0.4 0.8 0.4 0.8 0.7 0.8 0.5 0.8 0.4 1.5 0.4 0.8 0.5 0.8 0.9 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 1.5 1.5 0.6 1.5 1.9 1.8 1.9 1.6 0.6 1.5 0.0 1.5 1.9 1.6 1.9 0.7 2.0 1.9 1.6 1.9 2.4 2.2 2.4 2.1 1.6 1.9 0.5 1.9 2.4 2.1 2.4 1.2 1.5 1.5 0.6 1.5 1.9 1.8 1.9 1.6 0.6 1.5 0.0 1.5 1.9 1.6 1.9 0.7 1.7 1.1 0.2 1.1 1.5 1.4 1.5 1.2 0.2 1.1 0.9 1.1 1.5 1.2 1.5 0.3 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' U \/ \_/ G A /\ | U 3' <------ 5' 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 3.4 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 1.5 1.8 0.5 1.8 1.8 2.4 1.8 2.4 2.1 1.8 1.8 1.8 1.8 2.4 1.8 1.8 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 2.0 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.4 2.8 2.0 2.8 2.8 2.8 2.8 2.8 3.7 2.8 1.5 2.8 2.8 2.8 2.8 2.8 2.0 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.1 2.5 1.7 2.5 2.5 2.5 2.5 2.5 3.4 2.5 1.2 2.5 2.5 2.5 2.5 2.5 1.4 1.7 0.4 1.7 1.7 2.3 1.7 2.3 2.0 1.7 1.7 1.7 1.7 2.3 1.7 1.7 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 0.9 1.2 1.2 1.2 1.2 1.2 1.2 1.2 2.8 1.2 2.5 1.2 1.2 1.2 1.2 2.5 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 2.0 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.4 2.8 2.0 2.8 2.8 2.8 2.8 2.8 3.7 2.8 1.5 2.8 2.8 2.8 2.8 2.8 2.0 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 2.2 1.9 1.9 1.9 1.9 1.9 1.9 1.9 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' U \/ \_/ U A /\ | A 3' <------ 5' 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.3 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 1.8 1.6 0.6 1.6 1.7 2.2 1.7 2.2 1.3 1.6 1.4 1.6 1.7 2.2 1.7 0.7 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 2.3 2.1 1.1 2.1 2.2 2.1 2.2 2.1 1.8 2.1 0.6 2.1 2.2 2.1 2.2 1.2 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.8 2.5 1.0 2.5 2.6 2.6 2.6 1.7 2.3 2.1 1.1 2.1 2.2 2.1 2.2 2.1 1.8 2.1 0.6 2.1 2.2 2.1 2.2 1.2 2.5 2.2 1.8 2.2 2.3 2.3 2.3 2.3 2.5 2.2 0.7 2.2 2.3 2.3 2.3 1.4 1.7 1.5 0.5 1.5 1.6 2.1 1.6 2.1 1.2 1.5 1.3 1.5 1.6 2.1 1.6 0.6 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 1.2 1.0 1.3 1.0 1.1 1.0 1.1 1.0 2.0 1.0 2.1 1.0 1.1 1.0 1.1 1.4 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 2.3 2.1 1.1 2.1 2.2 2.1 2.2 2.1 1.8 2.1 0.6 2.1 2.2 2.1 2.2 1.2 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.8 2.5 1.0 2.5 2.6 2.6 2.6 1.7 2.3 2.1 1.1 2.1 2.2 2.1 2.2 2.1 1.8 2.1 0.6 2.1 2.2 2.1 2.2 1.2 2.5 1.7 0.7 1.7 1.8 1.7 1.8 1.7 1.4 1.7 1.5 1.7 1.8 1.7 1.8 0.8 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' U \/ \_/ U A /\ | G 3' <------ 5' 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.7 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 2.5 2.1 1.3 2.1 2.1 2.7 2.1 2.7 1.7 2.1 2.1 2.1 2.1 2.7 2.1 2.1 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 3.0 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 3.4 3.1 2.9 3.1 3.1 3.1 3.1 3.1 3.3 3.1 1.8 3.1 3.1 3.1 3.1 3.1 3.0 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 3.1 2.8 2.6 2.8 2.8 2.8 2.8 2.8 3.0 2.8 1.5 2.8 2.8 2.8 2.8 2.8 2.4 2.0 1.2 2.0 2.0 2.6 2.0 2.6 1.6 2.0 2.0 2.0 2.0 2.6 2.0 2.0 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 1.9 1.5 2.0 1.5 1.5 1.5 1.5 1.5 2.4 1.5 2.8 1.5 1.5 1.5 1.5 2.8 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 3.0 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 3.4 3.1 2.9 3.1 3.1 3.1 3.1 3.1 3.3 3.1 1.8 3.1 3.1 3.1 3.1 3.1 3.0 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 3.2 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 2.2 2.2 2.2 2.2 2.2 2.2 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' U \/ \_/ A G /\ | U 3' <------ 5' 2.4 2.0 1.4 2.0 2.4 2.4 2.4 2.4 1.5 2.0 0.9 2.0 2.4 2.1 2.4 2.2 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 3.1 2.6 2.0 2.6 3.1 3.7 3.1 3.7 2.1 2.6 2.8 2.6 3.1 3.4 3.1 2.2 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.4 2.3 1.2 2.3 2.8 2.5 2.8 1.9 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.4 2.3 1.2 2.3 2.8 2.5 2.8 1.9 1.4 1.0 0.4 1.0 1.4 2.0 1.4 2.0 0.5 1.0 1.2 1.0 1.4 1.7 1.4 0.6 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 1.5 1.0 1.7 1.0 1.5 1.5 1.5 1.5 1.8 1.0 2.5 1.0 1.5 1.2 1.5 1.9 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.4 2.3 1.2 2.3 2.8 2.5 2.8 1.9 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 3.4 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 2.5 2.3 2.8 2.5 2.8 1.9 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' U \/ \_/ C G /\ | G 3' <------ 5' 1.9 1.5 -0.2 1.5 1.5 1.5 1.5 1.5 0.4 1.5 0.1 1.5 1.5 1.6 1.5 1.4 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 2.4 2.2 0.4 2.2 2.1 2.8 2.1 2.8 1.0 2.2 2.1 2.2 2.1 2.8 2.1 1.4 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 2.1 1.9 0.7 1.9 1.8 1.9 1.8 1.9 1.3 1.9 0.5 1.9 1.8 1.9 1.8 1.1 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 2.1 1.9 0.7 1.9 1.8 1.9 1.8 1.9 1.3 1.9 0.5 1.9 1.8 1.9 1.8 1.1 0.8 0.5 -1.2 0.5 0.5 1.1 0.5 1.1 -0.6 0.5 0.4 0.5 0.5 1.2 0.5 -0.2 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 0.8 0.6 0.1 0.6 0.5 0.6 0.5 0.6 0.7 0.6 1.8 0.6 0.5 0.6 0.5 1.1 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 2.1 1.9 0.7 1.9 1.8 1.9 1.8 1.9 1.3 1.9 0.5 1.9 1.8 1.9 1.8 1.1 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 2.7 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 1.8 1.9 1.8 1.9 1.8 1.1 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' U \/ \_/ G G /\ | C 3' <------ 5' 1.6 1.6 0.7 1.6 2.0 1.9 2.0 1.7 0.7 1.6 0.1 1.6 2.0 1.7 2.0 1.4 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 2.3 2.2 1.3 2.2 2.7 3.1 2.7 3.0 1.3 2.2 2.1 2.2 2.7 3.0 2.7 1.5 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 2.0 1.9 1.6 1.9 2.4 2.2 2.4 2.1 1.6 1.9 0.5 1.9 2.4 2.1 2.4 1.2 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 2.0 1.9 1.6 1.9 2.4 2.2 2.4 2.1 1.6 1.9 0.5 1.9 2.4 2.1 2.4 1.2 0.6 0.6 -0.3 0.6 1.0 1.5 1.0 1.3 -0.3 0.6 0.4 0.6 1.0 1.3 1.0 -0.1 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 0.7 0.6 1.0 0.6 1.1 0.9 1.1 0.8 1.0 0.6 1.8 0.6 1.1 0.8 1.1 1.2 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 2.0 1.9 1.6 1.9 2.4 2.2 2.4 2.1 1.6 1.9 0.5 1.9 2.4 2.1 2.4 1.2 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 2.6 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 1.8 1.9 2.4 2.1 2.4 1.2 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' U \/ \_/ G G /\ | U 3' <------ 5' 2.1 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.7 2.4 1.1 2.4 2.4 2.4 2.4 3.0 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 2.7 3.1 1.7 3.1 3.1 3.7 3.1 3.7 3.4 3.1 3.1 3.1 3.1 3.7 3.1 3.1 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 2.4 2.8 2.0 2.8 2.8 2.8 2.8 2.8 3.7 2.8 1.5 2.8 2.8 2.8 2.8 2.8 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 2.4 2.8 2.0 2.8 2.8 2.8 2.8 2.8 3.7 2.8 1.5 2.8 2.8 2.8 2.8 2.8 1.1 1.4 0.1 1.4 1.4 2.0 1.4 2.0 1.7 1.4 1.4 1.4 1.4 2.0 1.4 1.4 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 1.1 1.5 1.4 1.5 1.5 1.5 1.5 1.5 3.1 1.5 2.8 1.5 1.5 1.5 1.5 2.8 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 2.4 2.8 2.0 2.8 2.8 2.8 2.8 2.8 3.7 2.8 1.5 2.8 2.8 2.8 2.8 2.8 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 3.0 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 2.8 2.8 2.8 2.8 2.8 2.8 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' U \/ \_/ U G /\ | A 3' <------ 5' 2.4 2.2 1.2 2.2 2.3 2.2 2.3 2.2 1.9 2.2 0.7 2.2 2.3 2.2 2.3 1.9 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 3.1 2.8 1.8 2.8 2.9 3.5 2.9 3.5 2.5 2.8 2.6 2.8 2.9 3.5 2.9 2.0 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.8 2.5 1.0 2.5 2.6 2.6 2.6 1.7 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.8 2.5 1.0 2.5 2.6 2.6 2.6 1.7 1.4 1.2 0.2 1.2 1.3 1.8 1.3 1.8 0.9 1.2 1.0 1.2 1.3 1.8 1.3 0.3 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 1.5 1.2 1.5 1.2 1.3 1.3 1.3 1.3 2.2 1.2 2.3 1.2 1.3 1.3 1.3 1.7 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.8 2.5 1.0 2.5 2.6 2.6 2.6 1.7 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 3.4 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 2.3 2.5 2.6 2.6 2.6 1.7 Y ------------------------------------------------------------------------------ A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U ------------------------------------------------------------------------------ 5' ------> 3' U \/ \_/ U G /\ | G 3' <------ 5' 3.6 2.7 1.9 2.7 2.7 2.7 2.7 2.7 3.6 2.7 1.4 2.7 2.7 2.7 2.7 3.3 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 3.7 3.4 2.6 3.4 3.4 4.0 3.4 4.0 3.0 3.4 3.4 3.4 3.4 4.0 3.4 3.4 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 3.4 3.1 2.9 3.1 3.1 3.1 3.1 3.1 3.3 3.1 1.8 3.1 3.1 3.1 3.1 3.1 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 3.4 3.1 2.9 3.1 3.1 3.1 3.1 3.1 3.3 3.1 1.8 3.1 3.1 3.1 3.1 3.1 2.2 1.7 0.2 1.7 1.7 2.3 1.7 2.3 1.3 1.7 1.7 1.7 1.7 2.3 1.7 1.7 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 2.1 1.8 2.3 1.8 1.8 1.8 1.8 1.8 2.7 1.8 3.1 1.8 1.8 1.8 1.8 3.1 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 3.4 3.1 2.9 3.1 3.1 3.1 3.1 3.1 3.3 3.1 1.8 3.1 3.1 3.1 3.1 3.1 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 4.0 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 3.1 3.1 3.1 3.1 3.1 3.1