Data tables for
symetric interior loops of size 4
Free energies at
37 degrees for RNA
Data arrangement:
Y
----------------------------------------------------------------
(X) A
A A A
C C C
C G G G
G U U U U
A
C G U
A C G
U A C
G U A
C G U
----------------------------------------------------------------
5' ------> 3'
A \/ \_/ A
U /\ | U
3' <------ 5'
(AA) .
. . .
. . .
. . .
. . .
. . .
(AC) .
. . .
. . .
. . .
. . .
. . .
(AG) .
. . .
. . . . .
. . .
. . .
.
(AU) .
. . .
. . .
. . .
. . .
. . .
(CA) .
. . .
. . .
. . .
. . .
. . .
(CC) .
. . .
. . .
. . .
. . .
. . .
(CG) . .
. . .
. . .
. . .
. . .
. .
(CU) .
. . .
. . .
. . .
. . .
. . .
(GA) .
. . .
. . .
. . .
. . .
. . .
(GC) .
. . .
. . .
. . .
. . .
. . .
(GG) .
. . .
. . .
. . .
. . .
. . .
(GU) .
. . .
. . .
. . .
. . .
. . .
(UA) .
. . .
. . .
. . .
. . .
. . .
(UC) .
. . . . .
. . .
. . .
. . .
.
(UG) .
. . .
. . .
. . .
. . .
. . .
(UU) .
. . .
. . .
. . .
. . .
. . .
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------>
3'
A \/ \_/ A
U /\ | U
3' <------
5'
14.0
11.2 0.0 11.2
12.7 12.7 12.7
11.4 -3.0 11.2 20.5
11.2 12.7 8.3
12.7 5.7
11.1
8.3 -2.9 8.3 9.8
9.8 9.8 8.5 -5.9
8.3 17.6 8.3
9.8 5.4 9.8
0.4
1.9 -0.8 -12.1 -0.8 0.6
3.0 0.6 1.8 -15.1 -0.8 -4.0 -0.8 0.6 -1.3
0.6 -8.7
11.1
8.3 -2.9 8.3 9.8
9.8 9.8 8.5 -5.9
8.3 17.6 8.3
9.8 5.4 9.8
0.4
10.9
8.1 -3.1 8.1 9.6
9.6 9.6 8.3 -6.1
8.1 17.4 8.1
9.6 5.2 9.6
0.2
11.0
8.2 -0.6 8.2 9.7
9.7 9.7 8.4 -3.6
8.2 17.5 8.2
9.7 5.3 9.7
0.3
10.9
8.1 -3.1 8.1 9.6
9.6 9.6 8.3 -6.1
8.1 17.4 8.1
9.6 5.2 9.6
0.2
11.0
8.2 -0.6 8.2 9.7
9.7 9.7 8.4 -3.6
8.2 17.5 8.2
9.7 5.3 9.7
0.3
0.1 -2.6 -13.9 -2.6 -1.1 1.3 -1.1
0.0 -16.9 -2.6 -5.8 -2.6 -1.1 -3.1 -1.1 -10.5
11.1
8.3 -2.9 8.3 9.8
9.8 9.8 8.5 -5.9
8.3 17.6 8.3
9.8 5.4 9.8
0.4
19.3
16.5 -7.2 16.5 18.0
18.0 18.0 16.7 -10.2
16.5 0.8 16.5
18.0 13.6 18.0 -3.8
11.1
8.3 -2.9 8.3 9.8
9.8 9.8 8.5 -5.9
8.3 17.6 8.3
9.8 5.4 9.8
0.4
10.9
8.1 -3.1 8.1 9.6
9.6 9.6 8.3 -6.1
8.1 17.4 8.1
9.6 5.2 9.6
0.2
11.0
8.2 -0.6 8.2 9.7
9.7 9.7 8.4 -3.6
8.2 17.5 8.2
9.7 5.3 9.7
0.3
10.9
8.1 -3.1 8.1 9.6
9.6 9.6 8.3 -6.1
8.1 17.4 8.1
9.6 5.2 9.6
0.2
3.6 -1.5 -12.8 -1.5 0.0
0.0 0.0 -1.3 -15.8 -1.5 -4.7
-1.5 0.0 -4.4 0.0 -9.4
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G
U U U
U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------>
3'
A \/ \_/ C
U /\ | G
3' <------
5'
6.0
1.5 -5.8 1.5 2.4 -0.6
2.4 -0.6 -1.1 1.5 7.8
1.5 2.4 -3.7 2.4
1.9
3.1 -1.4 -8.8 -1.4 -0.5 -3.6 -0.5 -3.6 -4.0
-1.4 4.9 -1.4 -0.5 -6.7 -0.5 -3.4
-6.0 -10.5 -17.9 -10.5 -9.7 -10.3 -9.7 -10.3
-13.2 -10.5 -16.8 -10.5 -9.7 -13.4 -9.7 -12.6
3.1 -1.4 -8.8 -1.4 -0.5 -3.6 -0.5 -3.6 -4.0
-1.4 4.9 -1.4 -0.5 -6.7 -0.5 -3.4
2.9 -1.5 -8.9 -1.5 -0.7 -3.7 -0.7 -3.7 -4.2 -1.5 4.7 -1.5 -0.7 -6.8 -0.7 -3.6
3.0 -1.4 -6.4 -1.4 -0.6 -3.6 -0.6 -3.6 -1.7
-1.4 4.8 -1.4 -0.6 -6.7 -0.6 -3.5
2.9 -1.5 -8.9 -1.5 -0.7 -3.7 -0.7 -3.7 -4.2
-1.5 4.7 -1.5 -0.7 -6.8 -0.7 -3.6
3.0 -1.4 -6.4 -1.4 -0.6 -3.6 -0.6 -3.6 -1.7
-1.4 4.8 -1.4 -0.6 -6.7 -0.6 -3.5
-7.8 -12.3 -19.7 -12.3 -11.5 -12.1 -11.5 -12.1
-15.0 -12.3 -18.6 -12.3 -11.5 -15.2 -11.5 -14.4
3.1 -1.4 -8.8 -1.4 -0.5 -3.6 -0.5 -3.6 -4.0
-1.4 4.9 -1.4 -0.5 -6.7 -0.5 -3.4
11.4
6.9 -13.0 6.9 7.7
4.7 7.7 4.7 -8.3
6.9 -11.9 6.9 7.7
1.6 7.7 -7.7
3.1 -1.4 -8.8 -1.4 -0.5 -3.6 -0.5 -3.6 -4.0
-1.4 4.9 -1.4 -0.5 -6.7 -0.5 -3.4
2.9 -1.5 -8.9 -1.5 -0.7 -3.7 -0.7 -3.7 -4.2
-1.5 4.7 -1.5 -0.7 -6.8 -0.7 -3.6
3.0 -1.4 -6.4 -1.4 -0.6 -3.6 -0.6 -3.6 -1.7
-1.4 4.8 -1.4 -0.6 -6.7 -0.6 -3.5
2.9 -1.5 -8.9 -1.5 -0.7 -3.7 -0.7 -3.7 -4.2
-1.5 4.7 -1.5 -0.7 -6.8 -0.7 -3.6
-4.3 -11.2 -18.6 -11.2 -10.4 -13.4 -10.4 -13.4
-13.9 -11.2 -17.5 -11.2 -10.4 -16.5 -10.4 -13.3
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------>
3'
A \/ \_/ G
U /\ | C
3' <------
5'
4.4
1.3 2.2 1.3
5.8 5.8 5.8
5.3 -0.6 1.3 7.8
1.3 5.8 6.4
5.8 0.4
1.4 -1.6 -0.7 -1.6 2.9
2.8 2.9 2.3 -3.5 -1.6
4.9 -1.6 2.9 3.4
2.9 -5.0
-7.7 -10.8 -9.8 -10.8 -6.2 -3.9 -6.2 -4.4
-12.7 -10.8 -16.8 -10.8 -6.2 -3.3 -6.2 -14.1
1.4 -1.6 -0.7 -1.6 2.9
2.8 2.9 2.3 -3.5 -1.6
4.9 -1.6 2.9 3.4
2.9 -5.0
1.3 -1.8 -0.8 -1.8 2.7
2.7 2.7 2.2 -3.7 -1.8
4.7 -1.8 2.7 3.3
2.7 -5.1
1.4 -1.7
1.7 -1.7 2.8 2.8
2.8 2.3 -1.2 -1.7 4.8 -1.7
2.8 3.4 2.8 -5.0
1.3 -1.8 -0.8 -1.8 2.7
2.7 2.7 2.2 -3.7 -1.8
4.7 -1.8 2.7 3.3
2.7 -5.1
1.4 -1.7
1.7 -1.7 2.8 2.8
2.8 2.3 -1.2 -1.7 4.8 -1.7
2.8 3.4 2.8 -5.0
-9.5 -12.6 -11.6 -12.6 -8.0 -5.7 -8.0 -6.2
-14.5 -12.6 -18.6 -12.6 -8.0 -5.1 -8.0 -15.9
1.4 -1.6 -0.7 -1.6 2.9
2.8 2.9 2.3 -3.5 -1.6
4.9 -1.6 2.9 3.4
2.9 -5.0
9.7
6.6 -4.9 6.6 11.2
11.1 11.2 10.6 -7.8
6.6 -11.9 6.6 11.2
11.7 11.2 -9.2
1.4 -1.6 -0.7 -1.6 2.9
2.8 2.9 2.3 -3.5 -1.6
4.9 -1.6 2.9 3.4
2.9 -5.0
1.3 -1.8 -0.8 -1.8 2.7
2.7 2.7 2.2 -3.7 -1.8
4.7 -1.8 2.7 3.3
2.7 -5.1
1.4 -1.7
1.7 -1.7 2.8 2.8
2.8 2.3 -1.2 -1.7 4.8 -1.7
2.8 3.4 2.8 -5.0
1.3 -1.8 -0.8 -1.8 2.7
2.7 2.7 2.2 -3.7 -1.8
4.7 -1.8 2.7 3.3
2.7 -5.1
-6.0 -11.5 -10.5 -11.5 -6.9 -7.0 -6.9 -7.5
-13.4 -11.5 -17.5 -11.5 -6.9 -6.4 -6.9 -14.8
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------>
3'
A \/ \_/ G
U /\ | U
3' <------
5'
7.5
2.4 -0.9 2.4 2.4
2.4 2.4 2.4 -2.6
2.4 14.9 2.4
2.4 2.4 2.4
4.8
4.6 -0.5 -3.9 -0.5 -0.5 -0.5 -0.5 -0.5 -5.6
-0.5 12.0 -0.5 -0.5 -0.5 -0.5 -0.5
-4.5 -9.6 -13.0 -9.6 -9.6 -7.2 -9.6 -7.2 -14.7
-9.6 -9.6 -9.6 -9.6 -7.2 -9.6 -9.6
4.6 -0.5 -3.9 -0.5 -0.5 -0.5 -0.5 -0.5 -5.6
-0.5 12.0 -0.5 -0.5 -0.5 -0.5 -0.5
4.4 -0.6 -4.0 -0.6 -0.6 -0.6 -0.6 -0.6 -5.7
-0.6 11.9 -0.6 -0.6 -0.6 -0.6 -0.6
4.5 -0.5 -1.5 -0.5 -0.5 -0.5 -0.5 -0.5 -3.2
-0.5 12.0 -0.5 -0.5 -0.5 -0.5 -0.5
4.4 -0.6 -4.0 -0.6 -0.6 -0.6 -0.6 -0.6 -5.7
-0.6 11.9 -0.6 -0.6 -0.6 -0.6 -0.6
4.5 -0.5 -1.5 -0.5 -0.5 -0.5 -0.5 -0.5 -3.2
-0.5 12.0 -0.5 -0.5 -0.5 -0.5 -0.5
-6.3 -11.4 -14.8 -11.4 -11.4 -9.0 -11.4 -9.0
-16.5 -11.4 -11.4 -11.4 -11.4 -9.0 -11.4 -11.4
4.6 -0.5 -3.9 -0.5 -0.5 -0.5 -0.5 -0.5 -5.6
-0.5 12.0 -0.5 -0.5 -0.5 -0.5 -0.5
12.8
7.8 -8.1 7.8 7.8
7.8 7.8 7.8 -9.8
7.8 -4.7 7.8 7.8 7.8 7.8 -4.7
4.6 -0.5 -3.9 -0.5 -0.5 -0.5 -0.5 -0.5 -5.6
-0.5 12.0 -0.5 -0.5 -0.5 -0.5 -0.5
4.4 -0.6 -4.0 -0.6 -0.6 -0.6 -0.6 -0.6 -5.7
-0.6 11.9 -0.6 -0.6 -0.6 -0.6 -0.6
4.5 -0.5 -1.5 -0.5 -0.5 -0.5 -0.5 -0.5 -3.2
-0.5 12.0 -0.5 -0.5 -0.5 -0.5 -0.5
4.4 -0.6 -4.0 -0.6 -0.6 -0.6 -0.6 -0.6 -5.7
-0.6 11.9 -0.6 -0.6 -0.6 -0.6 -0.6
-2.8 -10.3 -13.7 -10.3 -10.3 -10.3 -10.3 -10.3
-15.4 -10.3 -10.3 -10.3 -10.3 -10.3 -10.3 -10.3
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------>
3'
A \/ \_/ U
U /\ | A
3' <------
5'
13.4
10.3 -0.5 10.3 10.4
10.4 10.4 10.4
1.3 10.3 18.7
10.3 10.4 10.4
10.4 3.0
10.4
7.3 -3.4 7.3 7.5
7.4 7.5 7.4 -1.6
7.3 15.7 7.3
7.5 7.4 7.5 -2.3
1.3 -1.8 -12.6 -1.8 -1.6 0.7 -1.6
0.7 -10.8 -1.8 -5.9 -1.8 -1.6 0.7
-1.6 -11.5
10.4 7.3
-3.4 7.3
7.5 7.4 7.5
7.4 -1.6 7.3 15.7
7.3 7.5 7.4
7.5 -2.3
10.3
7.2 -3.6 7.2 7.3
7.3 7.3 7.3 -1.8
7.2 15.6 7.2
7.3 7.3 7.3 -2.5
10.4
7.3 -1.1 7.3 7.4
7.4 7.4 7.4
0.7 7.3 15.7
7.3 7.4 7.4
7.4 -2.4
10.3
7.2 -3.6 7.2 7.3
7.3 7.3 7.3 -1.8
7.2 15.6 7.2
7.3 7.3 7.3 -2.5
10.4
7.3 -1.1 7.3 7.4
7.4 7.4 7.4
0.7 7.3 15.7
7.3 7.4 7.4
7.4 -2.4
-0.5 -3.6 -14.4 -3.6 -3.4 -1.1 -3.4 -1.1 -12.6
-3.6 -7.7 -3.6 -3.4 -1.1 -3.4 -13.3
10.4
7.3 -3.4 7.3 7.5
7.4 7.5 7.4 -1.6
7.3 15.7 7.3
7.5 7.4 7.5 -2.3
18.7
15.6 -7.7 15.6 15.7
15.7 15.7 15.7 -5.9
15.6 -1.0 15.6 15.7
15.7 15.7 -6.6
10.4
7.3 -3.4 7.3 7.5
7.4 7.5 7.4 -1.6
7.3 15.7 7.3
7.5 7.4 7.5 -2.3
10.3
7.2 -3.6 7.2 7.3
7.3 7.3 7.3 -1.8
7.2 15.6 7.2
7.3 7.3 7.3 -2.5
10.4
7.3 -1.1 7.3 7.4
7.4 7.4 7.4
0.7 7.3 15.7
7.3 7.4 7.4
7.4 -2.4
10.3
7.2 -3.6 7.2 7.3
7.3 7.3 7.3 -1.8
7.2 15.6 7.2
7.3 7.3 7.3 -2.5
3.0 -2.5 -13.3 -2.5 -2.3 -2.4 -2.3 -2.4 -11.5
-2.5 -6.6 -2.5 -2.3 -2.4 -2.3 -12.2
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------>
3'
A \/ \_/ U
U /\ | G
3' <------
5'
-4.9 -3.1 -3.2 -3.1 -3.1 -3.1 -3.1 -3.1 -1.3
-3.1 9.4 -3.1 -3.1 -3.1 -3.1 -0.7
-7.8 -6.0 -6.2 -6.0 -6.0 -6.0 -6.0 -6.0 -4.3
-6.0 6.5 -6.0 -6.0 -6.0 -6.0 -6.0
-17.0 -15.2 -15.3 -15.2 -15.2 -12.8 -15.2
-12.8 -13.4 -15.2 -15.2 -15.2 -15.2 -12.8 -15.2 -15.2
-7.8 -6.0 -6.2 -6.0 -6.0 -6.0 -6.0 -6.0 -4.3
-6.0 6.5 -6.0 -6.0 -6.0 -6.0 -6.0
-8.0 -6.2 -6.3 -6.2 -6.2 -6.2 -6.2 -6.2 -4.4
-6.2 6.3 -6.2 -6.2 -6.2 -6.2 -6.2
-7.9 -6.1 -3.8 -6.1 -6.1 -6.1 -6.1 -6.1 -1.9
-6.1 6.4 -6.1 -6.1 -6.1 -6.1 -6.1
-8.0 -6.2 -6.3 -6.2 -6.2 -6.2 -6.2 -6.2 -4.4
-6.2 6.3 -6.2 -6.2 -6.2 -6.2 -6.2
-7.9 -6.1 -3.8 -6.1 -6.1 -6.1 -6.1 -6.1 -1.9
-6.1 6.4 -6.1 -6.1 -6.1 -6.1 -6.1
-18.8 -17.0 -17.1 -17.0 -17.0 -14.6 -17.0
-14.6 -15.2 -17.0 -17.0 -17.0 -17.0 -14.6 -17.0 -17.0
-7.8 -6.0 -6.2 -6.0 -6.0 -6.0 -6.0 -6.0 -4.3
-6.0 6.5 -6.0 -6.0 -6.0 -6.0 -6.0
0.4
2.2 -10.4 2.2 2.2
2.2 2.2 2.2 -8.5
2.2 -10.3 2.2 2.2
2.2 2.2 -10.3
-7.8 -6.0 -6.2 -6.0 -6.0 -6.0 -6.0 -6.0 -4.3
-6.0 6.5 -6.0 -6.0 -6.0 -6.0 -6.0
-8.0 -6.2 -6.3 -6.2 -6.2 -6.2 -6.2 -6.2 -4.4
-6.2 6.3 -6.2 -6.2 -6.2 -6.2 -6.2
-7.9 -6.1 -3.8 -6.1 -6.1 -6.1 -6.1 -6.1 -1.9
-6.1 6.4 -6.1 -6.1 -6.1 -6.1 -6.1
-8.0 -6.2 -6.3 -6.2 -6.2 -6.2 -6.2 -6.2 -4.4
-6.2 6.3 -6.2 -6.2 -6.2 -6.2 -6.2
-15.3 -15.9 -16.0 -15.9 -15.9 -15.9 -15.9
-15.9 -14.1 -15.9 -15.9 -15.9 -15.9 -15.9 -15.9 -15.9
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------>
3'
C \/ \_/ A
G /\ | U
3' <------
5'
5.0
2.2 -9.0 2.2 3.7
3.7 3.7 2.4 -12.0
2.2 11.6 2.2
3.7 -0.6 3.7 -3.2
6.5
3.7 -7.5 3.7 5.2
5.2 5.2 3.9 -10.5
3.7 13.0 3.7
5.2 0.8 5.2 -4.2
0.0 -2.7 -14.0 -2.7 -1.2 1.2 -1.2 -0.1 -17.0 -2.7 -5.9 -2.7 -1.2 -3.2
-1.2 -10.6
6.5 3.7
-7.5 3.7
5.2 5.2 5.2
3.9 -10.5 3.7 13.0
3.7 5.2 0.8
5.2 -4.2
1.9 -0.8 -12.1 -0.8 0.6
0.6 0.6 -0.6 -15.1 -0.8 8.5 -0.8
0.6 -3.7 0.6 -8.7
6.4
3.6 -5.2 3.6 5.1
5.1 5.1 3.8 -8.2
3.6 12.9 3.6
5.1 0.7 5.1 -4.2
1.9 -0.8 -12.1 -0.8 0.6
0.6 0.6 -0.6 -15.1 -0.8 8.5 -0.8
0.6 -3.7 0.6 -8.7
7.0
4.2 -4.6 4.2 5.7
5.7 5.7 4.4 -7.6
4.2 13.5 4.2
5.7 1.3 5.7 -3.6
2.9
0.1 -11.1 0.1 1.6
4.0 1.6 2.7 -14.1
0.1 -3.1 0.1 1.6 -0.4
1.6 -7.8
6.5
3.7 -7.5 3.7 5.2
5.2 5.2 3.9 -10.5
3.7 13.0 3.7
5.2 0.8 5.2 -4.2
8.5
5.7 -18.1 5.7 7.2
7.2 7.2 5.9 -21.1
5.7 -10.0 5.7 7.2
2.8 7.2 -14.7
6.5
3.7 -7.5 3.7 5.2
5.2 5.2 3.9 -10.5
3.7 13.0 3.7
5.2 0.8 5.2 -4.2
1.9 -0.8 -12.1 -0.8 0.6
0.6 0.6 -0.6 -15.1 -0.8 8.5 -0.8
0.6 -3.7 0.6 -8.7
5.9
3.1 -5.7 3.1 4.6
4.6 4.6 3.3 -8.7
3.1 12.5 3.1
4.6 0.2 4.6 -4.7
1.9 -0.8 -12.1 -0.8 0.6
0.6 0.6 -0.6 -15.1 -0.8 8.5 -0.8
0.6 -3.7 0.6 -8.7
1.0 -4.2 -15.4 -4.2 -2.7 -2.7 -2.7 -4.0 -18.4
-4.2 -7.4 -4.2 -2.7 -7.1 -2.7 -12.1
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------>
3'
C \/ \_/ C
G /\ | G
3' <------
5'
-5.8 -7.4 -20.1 -7.4 -6.6 -9.6 -6.6 -9.6 -13.4
-7.4 1.8 -7.4 -6.6 -12.7 -6.6 -12.4
-2.2 -6.0 -16.5 -6.0 -11.5 -8.2 -5.1 -8.2 -8.6
-6.0 -3.9 -6.0 -5.1 -11.3 -5.1 -0.9
-9.7 -1.0 -19.8 -12.4 0.1
5.4 -11.6 -12.2 -24.5 -12.4 -18.7 -12.4 -11.6 -15.3 -11.6 -8.1
-1.5 -6.0 -13.4 -6.0 -5.1 -8.2 -5.1 -8.2 -8.6
-6.0 0.3 -6.0 -5.1 -11.3 -5.1 -8.0
-6.0 -10.5 -17.9 -10.5 -9.7 -12.7 -9.7 -12.7
-10.7 -10.5 -4.3 -10.5 -9.7 -15.8 -9.7 -8.3
-10.7 -6.0 -6.3 -6.0 -7.5 -8.2 -5.2 -8.2 -5.0
-6.0 0.2 -6.0 -5.2 -11.3 -5.2 -17.1
-6.0 -10.5 -17.9 -10.5 -9.7 -12.7 -9.7 -12.7
-13.2 -10.5 -4.3 -10.5 -9.7 -15.8 -9.7 -12.6
-0.9 -5.4 -10.4 -5.4 -4.6 -7.6 -4.6 -5.5 -5.7
-5.4 1.8 -5.4 -4.6 -10.7 -4.6 -14.6
-16.0 -3.5 -30.7 -9.6 -11.1 -9.4 -8.7 -9.4
-18.8 -9.6 -13.7 -9.6 -8.7 -12.5 -8.7 -13.6
-1.5 -6.0 -13.4 -6.0 -5.1 -8.2 -5.1 -8.2 -8.6
-6.0 0.3 -6.0 -5.1 -11.3 -5.1 -8.0
-2.0 -4.4 -23.9 -4.0 -3.2 -6.2 -3.2 -2.6 -10.8
-4.0 -22.8 -4.0 -3.2 -2.1 -3.2 -15.5
-1.5 -6.0 -13.4 -6.0 -5.1 -8.2 -5.1 -8.2 -8.6
-6.0 0.3 -6.0 -5.1 -11.3 -5.1 -8.0
-6.0 -10.5 -17.9 -10.5 -9.7 -12.7 -9.7 -12.7
-13.2 -10.5 -4.3 -10.5 -9.7 -15.8 -9.7 -12.6
-2.0 -6.5 -11.5 -6.5 -5.7 -8.7 -5.7 -8.7 -17.5
-6.5 -8.8 -6.5 -5.7 -11.8 -5.7 -8.6
-6.0 -10.5 -17.9 -10.5 -9.7 -12.7 -9.7 -12.7
-13.2 -10.5 -4.3 -10.5 -9.7 -15.8 -9.7 -12.6
-14.9 -13.9 -15.2 -13.9 -4.0 -16.1 -13.0 -16.1
-13.0 -13.9 -2.3 -13.9 -13.0 -19.2 -13.0 -23.5
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U
A C G
U
------------------------------------------------------------------------------
5' ------>
3'
C \/ \_/ G
G /\ | C
3' <------ 5'
-4.6 -7.7 -6.7 -7.7 -3.1 -3.2 -3.1 -3.7 -9.6
-7.7 -1.2 -7.7 -3.1 -2.6 -3.1 -8.6
-3.1 -6.2 -5.3 -6.2 -1.7 -1.7 -1.7 -2.2 -8.1
-6.2 0.3 -6.2 -1.7 -1.1 -1.7 -9.6
-9.6 -12.7 -11.7 -12.7 -8.1 -5.8 -8.1 -6.3
-14.6 -12.7 -18.7 -12.7 -8.1 -5.2 -8.1 -16.0
-3.1 -6.2 -5.3 -6.2 -1.7 -1.7 -1.7 -2.2 -8.1
-6.2 0.3 -6.2 -1.7 -1.1 -1.7 -9.6
-7.7 -10.8 -9.8 -10.8 -6.2 -6.3 -6.2 -6.8
-12.7 -10.8 -4.3 -10.8 -6.2 -5.7 -6.2 -14.1
-3.2 -6.3 -2.9 -6.3 -1.7 -1.8 -1.7 -2.3 -5.8
-6.3 0.2 -6.3 -1.7 -1.2 -1.7 -9.6
-7.7 -10.8 -9.8 -10.8 -6.2 -6.3 -6.2 -6.8
-12.7 -10.8 -4.3 -10.8 -6.2 -5.7 -6.2 -14.1
-2.6 -5.7 -2.3 -5.7 -1.1 -1.2 -1.1 -1.7 -5.2
-5.7 0.8 -5.7 -1.1 -0.6 -1.1 -9.0
-6.7 -9.8 -8.9 -9.8 -5.3 -2.9 -5.3 -3.4 -11.7
-9.8 -15.8 -9.8 -5.3 -2.3 -5.3 -13.2
-3.1 -6.2 -5.3 -6.2 -1.7 -1.7 -1.7 -2.2 -8.1
-6.2 0.3 -6.2 -1.7 -1.1 -1.7 -9.6
-1.2 -4.3 -15.8 -4.3 0.3
0.2 0.3 -0.3 -18.7 -4.3 -22.8
-4.3 0.3
0.8 0.3 -20.1
-3.1 -6.2 -5.3 -6.2 -1.7 -1.7 -1.7 -2.2 -8.1
-6.2 0.3 -6.2 -1.7 -1.1 -1.7 -9.6
-7.7 -10.8 -9.8 -10.8 -6.2 -6.3 -6.2 -6.8
-12.7 -10.8 -4.3 -10.8 -6.2 -5.7 -6.2 -14.1
-3.7 -6.8 -3.4 -6.8 -2.2 -2.3 -2.2 -2.8 -6.3
-6.8 -0.3 -6.8 -2.2 -1.7 -2.2 -10.1
-7.7 -10.8 -9.8 -10.8 -6.2 -6.3 -6.2 -6.8
-12.7 -10.8 -4.3 -10.8 -6.2 -5.7 -6.2 -14.1
-8.6 -14.1 -13.2 -14.1 -9.6 -9.6 -9.6 -10.1
-16.0 -14.1 -20.1 -14.1 -9.6 -9.0 -9.6 -17.5
Y
------------------------------------------------------------------------------
A A
A A C
C C C
G G G
G U U
U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------> 3'
C \/ \_/ G
G /\ | U
3' <------
5'
-1.4 -6.5 -9.9 -6.5 -6.5 -6.5 -6.5 -6.5 -11.6
-6.5 6.0 -6.5 -6.5 -6.5 -6.5 -4.1
0.0 -5.1 -8.5 -5.1 -5.1 -5.1 -5.1 -5.1 -10.2
-5.1 7.4 -5.1 -5.1 -5.1 -5.1 -5.1
-6.4 -11.5 -14.9 -11.5 -11.5 -9.1 -11.5 -9.1
-16.6 -11.5 -11.5 -11.5 -11.5 -9.1 -11.5 -11.5
0.0 -5.1 -8.5 -5.1 -5.1 -5.1 -5.1 -5.1 -10.2
-5.1 7.4 -5.1 -5.1 -5.1 -5.1 -5.1
-4.5 -9.6 -13.0 -9.6 -9.6 -9.6 -9.6 -9.6 -14.7
-9.6 2.9 -9.6 -9.6 -9.6 -9.6 -9.6
0.0 -5.1 -6.1 -5.1 -5.1 -5.1 -5.1 -5.1 -7.8
-5.1 7.4 -5.1 -5.1 -5.1 -5.1 -5.1
-4.5 -9.6 -13.0 -9.6 -9.6 -9.6 -9.6 -9.6 -14.7
-9.6 2.9 -9.6 -9.6 -9.6 -9.6 -9.6
0.5 -4.5 -5.5 -4.5 -4.5 -4.5 -4.5 -4.5 -7.2
-4.5 8.0 -4.5 -4.5 -4.5 -4.5 -4.5
-3.6 -8.7 -12.1 -8.7 -8.7 -6.3 -8.7 -6.3 -13.8
-8.7 -8.7 -8.7 -8.7 -6.3 -8.7 -8.7
0.0 -5.1 -8.5 -5.1 -5.1 -5.1 -5.1 -5.1 -10.2
-5.1 7.4 -5.1 -5.1 -5.1 -5.1 -5.1
2.0 -3.1 -19.0 -3.1 -3.1 -3.1 -3.1 -3.1 -20.7
-3.1 -15.6 -3.1 -3.1 -3.1 -3.1 -15.6
0.0 -5.1 -8.5 -5.1 -5.1 -5.1 -5.1 -5.1 -10.2
-5.1 7.4 -5.1 -5.1 -5.1 -5.1 -5.1
-4.5 -9.6 -13.0 -9.6 -9.6 -9.6 -9.6 -9.6 -14.7
-9.6 2.9 -9.6 -9.6 -9.6 -9.6 -9.6
-0.5 -5.6 -6.6 -5.6 -5.6 -5.6 -5.6 -5.6 -8.3
-5.6 6.9 -5.6 -5.6 -5.6 -5.6 -5.6
-4.5 -9.6 -13.0 -9.6 -9.6 -9.6 -9.6 -9.6 -14.7
-9.6 2.9 -9.6 -9.6 -9.6 -9.6 -9.6
-5.5 -13.0 -16.4 -13.0 -13.0 -13.0 -13.0 -13.0
-18.1 -13.0 -13.0 -13.0 -13.0 -13.0 -13.0 -13.0
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------>
3'
C \/ \_/ U
G /\ | A
3' <------
5'
4.4
1.3 -9.5 1.3 1.4
1.4 1.4 1.4 -7.7
1.3 9.7 1.3
1.4 1.4 1.4 -6.0
5.8
2.7 -8.0 2.7 2.9
2.8 2.9 2.8 -6.2
2.7 11.2 2.7
2.9 2.8 2.9 -6.9
-0.6 -3.7 -14.5 -3.7 -3.5 -1.2 -3.5 -1.2 -12.7
-3.7 -7.8 -3.7 -3.5 -1.2 -3.5 -13.4
5.8
2.7 -8.0 2.7 2.9
2.8 2.9 2.8 -6.2
2.7 11.2 2.7
2.9 2.8 2.9 -6.9
1.3 -1.8 -12.6 -1.8 -1.6 -1.7 -1.6 -1.7 -10.8
-1.8 6.6 -1.8 -1.6 -1.7 -1.6 -11.5
5.8
2.7 -5.7 2.7 2.8
2.8 2.8 2.8 -3.9
2.7 11.1 2.7
2.8 2.8 2.8 -7.0
1.3 -1.8 -12.6 -1.8 -1.6 -1.7 -1.6 -1.7 -10.8
-1.8 6.6 -1.8 -1.6 -1.7 -1.6 -11.5
6.4
3.3 -5.1 3.3 3.4
3.4 3.4 3.4 -3.3
3.3 11.7 3.3
3.4 3.4 3.4 -6.4
2.2 -0.8 -11.6 -0.8 -0.7 1.7 -0.7
1.7 -9.8 -0.8 -4.9 -0.8 -0.7 1.7
-0.7 -10.5
5.8
2.7 -8.0 2.7 2.9
2.8 2.9 2.8 -6.2
2.7 11.2 2.7
2.9 2.8 2.9 -6.9
7.8
4.7 -18.6 4.7 4.9
4.8 4.9 4.8 -16.8
4.7 -11.9 4.7 4.9
4.8 4.9 -17.5
5.8
2.7 -8.0 2.7 2.9
2.8 2.9 2.8 -6.2
2.7 11.2 2.7
2.9 2.8 2.9 -6.9
1.3 -1.8 -12.6 -1.8 -1.6 -1.7 -1.6 -1.7 -10.8
-1.8 6.6 -1.8 -1.6 -1.7 -1.6 -11.5
5.3
2.2 -6.2 2.2 2.3
2.3 2.3 2.3 -4.4
2.2 10.6 2.2
2.3 2.3 2.3 -7.5
1.3 -1.8 -12.6 -1.8 -1.6 -1.7 -1.6 -1.7 -10.8
-1.8 6.6 -1.8 -1.6 -1.7 -1.6 -11.5
0.4 -5.1 -15.9 -5.1 -5.0 -5.0 -5.0 -5.0 -14.1
-5.1 -9.2 -5.1 -5.0 -5.0 -5.0 -14.8
Y
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A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------> 3'
C \/ \_/ U
G /\ | G
3' <------
5'
-13.7 -12.1 -12.2 -12.1 -12.1 -12.1 -12.1
-12.1 -10.3 -12.1 0.4 -12.1 -12.1 -12.1
-12.1 -9.7
-12.4 -10.6 -10.8 -10.6 -10.6 -10.6 -10.6
-10.6 -8.9 -10.6 1.9 -10.6 -10.6 -10.6
-10.6 -10.6
-18.9 -17.1 -17.2 -17.1 -17.1 -14.7 -17.1
-14.7 -15.3 -17.1 -17.1 -17.1 -17.1 -14.7 -17.1 -17.1
-12.4 -10.6 -10.8 -10.6 -10.6 -10.6 -10.6
-10.6 -8.9 -10.6 1.9 -10.6 -10.6 -10.6
-10.6 -10.6
-17.0 -15.2 -15.3 -15.2 -15.2 -15.2 -15.2
-15.2 -13.4 -15.2 -2.7 -15.2 -15.2 -15.2 -15.2 -15.2
-12.5 -10.7 -8.4 -10.7 -10.7 -10.7 -10.7 -10.7
-6.5 -10.7 1.8 -10.7 -10.7 -10.7 -10.7
-10.7
-17.0 -15.2 -15.3 -15.2 -15.2 -15.2 -15.2
-15.2 -13.4 -15.2 -2.7 -15.2 -15.2 -15.2 -15.2 -15.2
-11.9 -10.1 -7.8 -10.1 -10.1 -10.1 -10.1 -10.1
-5.9 -10.1 2.4 -10.1 -10.1 -10.1 -10.1
-10.1
-16.0 -14.2 -14.4 -14.2 -14.2 -11.8 -14.2
-11.8 -12.5 -14.2 -14.2 -14.2 -14.2 -11.8 -14.2 -14.2
-12.4 -10.6 -10.8 -10.6 -10.6 -10.6 -10.6
-10.6 -8.9 -10.6 1.9 -10.6 -10.6 -10.6
-10.6 -10.6
-10.5 -8.7 -21.3 -8.7 -8.7 -8.7 -8.7 -8.7
-19.4 -8.7 -21.2 -8.7 -8.7 -8.7 -8.7 -21.2
-12.4 -10.6 -10.8 -10.6 -10.6 -10.6 -10.6
-10.6 -8.9 -10.6 1.9 -10.6 -10.6 -10.6
-10.6 -10.6
-17.0 -15.2 -15.3 -15.2 -15.2 -15.2 -15.2
-15.2 -13.4 -15.2 -2.7 -15.2 -15.2 -15.2 -15.2 -15.2
-13.0 -11.2 -8.9 -11.2 -11.2 -11.2 -11.2 -11.2
-7.0 -11.2 1.3 -11.2 -11.2 -11.2 -11.2
-11.2
-17.0 -15.2 -15.3 -15.2 -15.2 -15.2 -15.2
-15.2 -13.4 -15.2 -2.7 -15.2 -15.2 -15.2 -15.2 -15.2
-17.9 -18.5 -18.7 -18.5 -18.5 -18.5 -18.5
-18.5 -16.8 -18.5 -18.5 -18.5 -18.5 -18.5 -18.5 -18.5
Y
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A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------>
3'
G \/ \_/ A
C /\ | U
3' <------
5'
6.7
3.9 -7.3 3.9 5.4
5.4 5.4 4.1 -10.3
3.9 13.2 3.9
5.4 1.0 5.4 -1.6
3.0
0.2 -11.0 0.2 1.7
1.7 1.7 0.4 -14.0
0.2 9.6 0.2
1.7 -2.6 1.7 -7.6
-0.4 -3.2 -14.5 -3.2 -1.7 0.7 -1.7 -0.6 -17.5 -3.2 -6.4 -3.2 -1.7 -3.7
-1.7 -11.1
3.0
0.2 -11.0 0.2 1.7
1.7 1.7 0.4 -14.0
0.2 9.6 0.2
1.7 -2.6 1.7 -7.6
2.2 -0.6 -11.8 -0.6 0.9
0.9 0.9 -0.4 -14.8 -0.6 8.7 -0.6
0.9 -3.5 0.9 -8.5
0.0 -2.8 -11.6 -2.8 -1.3 -1.3 -1.3 -2.6 -14.6
-2.8 6.5 -2.8 -1.3 -5.7 -1.3 -10.7
2.2 -0.6 -11.8 -0.6 0.9
0.9 0.9 -0.4 -14.8 -0.6 8.7 -0.6
0.9 -3.5 0.9 -8.5
-3.1 -5.9 -14.7 -5.9 -4.4 -4.4 -4.4 -5.7 -17.7
-5.9 3.4 -5.9 -4.4 -8.8 -4.4 -13.8
-5.2 -8.0 -19.2 -8.0 -6.5 -4.1 -6.5 -5.4 -22.2
-8.0 -11.2 -8.0 -6.5 -8.5 -6.5 -15.9
3.0
0.2 -11.0 0.2 1.7
1.7 1.7 0.4 -14.0
0.2 9.6 0.2
1.7 -2.6 1.7 -7.6
8.5
5.7 -18.1 5.7 7.2
7.2 7.2 5.9 -21.1
5.7 -10.0 5.7 7.2
2.8 7.2 -14.7
3.0
0.2 -11.0 0.2 1.7
1.7 1.7 0.4 -14.0
0.2 9.6 0.2
1.7 -2.6 1.7 -7.6
2.2 -0.6 -11.8 -0.6 0.9
0.9 0.9 -0.4 -14.8 -0.6 8.7 -0.6
0.9 -3.5 0.9 -8.5
0.0 -2.8 -11.6 -2.8 -1.3 -1.3 -1.3 -2.6 -14.6
-2.8 6.5 -2.8 -1.3 -5.7 -1.3 -10.7
2.2 -0.6 -11.8 -0.6 0.9
0.9 0.9 -0.4 -14.8 -0.6 8.7 -0.6
0.9 -3.5 0.9 -8.5
2.5 -2.6 -13.9 -2.6 -1.1 -1.1 -1.1 -2.4 -16.9
-2.6 -5.8 -2.6 -1.1 -5.5 -1.1 -10.5
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------>
3'
G \/ \_/ C
C /\ | G
3' <------
5'
-1.3 -5.8 -13.2 -5.8 -4.9 -8.0 -4.9 -8.0 -8.4
-5.8 0.5 -5.8 -4.9 -11.1 -4.9 -5.4
-4.9 -9.4 -16.8 -9.4 -8.6 -11.6 -8.6 -11.6
-12.1 -9.4 -3.2 -9.4 -8.6 -14.7 -8.6 -11.5
-8.4 -12.9 -20.3 -12.9 -12.1 -12.7 -12.1 -12.7
-15.6 -12.9 -19.2 -12.9 -12.1 -15.8 -12.1 -15.0
-4.9 -9.4 -16.8 -9.4 -8.6 -11.6 -8.6 -11.6
-12.1 -9.4 -3.2 -9.4 -8.6 -14.7 -8.6 -11.5
-5.8 -10.3 -17.7 -10.3 -9.4 -12.5 -9.4 -12.5
-12.9 -10.3 -4.0 -10.3 -9.4 -15.6 -9.4 -12.3
-8.0 -12.5 -17.5 -12.5 -11.6 -14.7 -11.6 -14.7
-12.7 -12.5 -6.2 -12.5 -11.6 -17.8 -11.6 -14.5
-5.8 -10.3 -17.7 -10.3 -9.4 -12.5 -9.4 -12.5
-12.9 -10.3 -4.0 -10.3 -9.4 -15.6 -9.4 -12.3
-11.1 -15.6 -20.6 -15.6 -14.7 -17.8 -14.7 -17.8
-15.8 -15.6 -9.3 -15.6 -14.7 -20.9 -14.7 -17.6
-13.2 -17.7 -25.1 -17.7 -16.8 -17.5 -16.8
-17.5 -20.3 -17.7 -23.9 -17.7 -16.8 -20.6 -16.8 -19.7
-4.9 -9.4 -16.8 -9.4 -8.6 -11.6 -8.6 -11.6
-12.1 -9.4 -3.2 -9.4 -8.6 -14.7 -8.6 -11.5
0.5 -4.0 -23.9 -4.0 -3.2 -6.2 -3.2 -6.2 -19.2
-4.0 -22.8 -4.0 -3.2 -9.3 -3.2 -18.6
-4.9 -9.4 -16.8 -9.4 -8.6 -11.6 -8.6 -11.6
-12.1 -9.4 -3.2 -9.4 -8.6 -14.7 -8.6 -11.5
-5.8 -10.3 -17.7 -10.3 -9.4 -12.5 -9.4 -12.5
-12.9 -10.3 -4.0 -10.3 -9.4 -15.6 -9.4 -12.3
-8.0 -12.5 -17.5 -12.5 -11.6 -14.7 -11.6 -14.7
-12.7 -12.5 -6.2 -12.5 -11.6 -17.8 -11.6 -14.5
-5.8 -10.3 -17.7 -10.3 -9.4 -12.5 -9.4 -12.5
-12.9 -10.3 -4.0 -10.3 -9.4 -15.6 -9.4 -12.3
-5.4 -12.3 -19.7 -12.3 -11.5 -14.5 -11.5 -14.5
-15.0 -12.3 -18.6 -12.3 -11.5 -17.6 -11.5 -14.4
Y
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A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
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5' ------>
3'
G \/ \_/ G
C /\
| C
3' <------
5'
-5.8 -6.0 -16.0 -6.0 -2.2 -10.7 -1.5 -2.0 -9.7
-6.0 -2.0 -6.0 -1.5 -0.9 -1.5 -14.9
-6.6 -9.7 -11.1 -9.7 -11.5 -7.5 -5.1 -5.7 0.1 -9.7 -3.2 -9.7 -5.1 -4.6 -5.1 -4.0
-13.4 -10.7 -18.8 -13.2 -8.6 -5.0 -8.6 -17.5
-24.5 -13.2 -10.8 -13.2 -8.6 -5.7 -8.6 -13.0
-6.6 -9.7 -8.7 -9.7 -5.1 -5.2 -5.1 -5.7 -11.6
-9.7 -3.2 -9.7 -5.1 -4.6 -5.1 -13.0
-7.4 -10.5 -3.5 -10.5 -6.0 -6.0 -6.0 -6.5 -1.0
-10.5 -4.4 -10.5 -6.0 -5.4 -6.0 -13.9
-9.6 -12.7 -9.4 -12.7 -8.2 -8.2 -8.2 -8.7 5.4 -12.7 -6.2 -12.7 -8.2 -7.6 -8.2 -16.1
-7.4 -10.5 -9.6 -10.5 -6.0 -6.0 -6.0 -6.5
-12.4 -10.5 -4.0 -10.5 -6.0 -5.4 -6.0 -13.9
-12.7 -15.8 -12.5 -15.8 -11.3 -11.3 -11.3
-11.8 -15.3 -15.8 -2.1 -15.8 -11.3 -10.7 -11.3 -19.2
-20.1 -17.9 -30.7 -17.9 -16.5 -6.3 -13.4 -11.5
-19.8 -17.9 -23.9 -17.9 -13.4 -10.4 -13.4 -15.2
-6.6 -9.7 -8.7 -9.7 -5.1 -5.2 -5.1 -5.7 -11.6
-9.7 -3.2 -9.7 -5.1 -4.6 -5.1 -13.0
1.8 -4.3 -13.7 -4.3 -3.9 0.2
0.3 -8.8 -18.7 -4.3 -22.8 -4.3 0.3 1.8
0.3 -2.3
-6.6 -9.7 -8.7 -9.7 -5.1 -5.2 -5.1 -5.7 -11.6
-9.7 -3.2 -9.7 -5.1 -4.6 -5.1 -13.0
-7.4 -10.5 -9.6 -10.5 -6.0 -6.0 -6.0 -6.5
-12.4 -10.5 -4.0 -10.5 -6.0 -5.4 -6.0 -13.9
-9.6 -12.7 -9.4 -12.7 -8.2 -8.2 -8.2 -8.7
-12.2 -12.7 -2.6 -12.7 -8.2 -5.5 -8.2 -16.1
-7.4 -10.5 -9.6 -10.5 -6.0 -6.0 -6.0 -6.5
-12.4 -10.5 -4.0 -10.5 -6.0 -5.4 -6.0 -13.9
-12.4 -8.3 -13.6 -12.6 -0.9 -17.1 -8.0 -8.6
-8.1 -12.6 -15.5 -12.6 -8.0 -14.6 -8.0 -23.5
Y
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A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
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5' ------>
3'
G \/ \_/ G
C /\ | U
3' <------
5'
-20.4 -4.9 -8.3 -4.9 -4.9 -4.9 -4.9 -4.9 -10.0
-4.9 7.6 -4.9 -4.9 -4.9 -4.9 -2.5
-3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6
-8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
-6.9 -12.0 -15.4 -12.0 -12.0 -9.6 -12.0 -9.6
-17.1 -12.0 -12.0 -12.0 -12.0 -9.6 -12.0 -12.0
-3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6
-8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
-4.3 -9.4 -12.8 -9.4 -9.4 -9.4 -9.4 -9.4 -14.5
-9.4 3.1 -9.4 -9.4 -9.4 -9.4 -9.4
-6.5 -11.6 -12.6 -11.6 -11.6 -11.6 -11.6 -11.6
-14.3 -11.6 0.9 -11.6 -11.6 -11.6 -11.6
-11.6
-4.3 -9.4 -12.8 -9.4 -9.4 -9.4 -9.4 -9.4 -14.5
-9.4 3.1 -9.4 -9.4 -9.4 -9.4 -9.4
-9.6 -14.7 -15.7 -14.7 -14.7 -14.7 -14.7 -14.7
-17.4 -14.7 -2.2 -14.7 -14.7 -14.7 -14.7 -14.7
-11.7 -16.8 -20.2 -16.8 -16.8 -14.4 -16.8
-14.4 -21.9 -16.8 -16.8 -16.8 -16.8 -14.4 -16.8 -16.8
-3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6
-8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
2.0 -3.1 -19.0 -3.1 -3.1 -3.1 -3.1 -3.1 -20.7
-3.1 -15.6 -3.1 -3.1 -3.1 -3.1 -15.6
-3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6
-8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
-4.3 -9.4 -12.8 -9.4 -9.4 -9.4 -9.4 -9.4 -14.5
-9.4 3.1 -9.4 -9.4 -9.4 -9.4 -9.4
-6.5 -11.6 -12.6 -11.6 -11.6 -11.6 -11.6 -11.6
-14.3 -11.6 0.9 -11.6 -11.6 -11.6 -11.6
-11.6
-4.3 -9.4 -12.8 -9.4 -9.4 -9.4 -9.4 -9.4 -14.5
-9.4 3.1 -9.4 -9.4 -9.4 -9.4 -9.4
-3.9 -11.4 -14.8 -11.4 -11.4 -11.4 -11.4 -11.4
-16.5 -11.4 -11.4 -11.4 -11.4 -11.4 -11.4 -11.4
Y
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A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
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5' ------> 3'
G \/ \_/ U
C /\ | A
3' <------
5'
6.0
2.9 -7.8 2.9 3.1
3.0 3.1 3.0 -6.0
2.9 11.4 2.9
3.1 3.0 3.1 -4.3
2.4 -0.7 -11.5 -0.7 -0.5 -0.6 -0.5 -0.6 -9.7
-0.7 7.7 -0.7 -0.5 -0.6 -0.5 -10.4
-1.1 -4.2 -15.0 -4.2 -4.0 -1.7 -4.0 -1.7 -13.2
-4.2 -8.3 -4.2 -4.0 -1.7 -4.0 -13.9
2.4 -0.7 -11.5 -0.7 -0.5 -0.6 -0.5 -0.6 -9.7
-0.7 7.7 -0.7 -0.5 -0.6 -0.5 -10.4
1.5 -1.5 -12.3 -1.5 -1.4 -1.4 -1.4 -1.4 -10.5
-1.5 6.9 -1.5 -1.4 -1.4 -1.4 -11.2
-0.6 -3.7 -12.1 -3.7 -3.6 -3.6 -3.6 -3.6 -10.3
-3.7 4.7 -3.7 -3.6 -3.6 -3.6 -13.4
1.5 -1.5 -12.3 -1.5 -1.4 -1.4 -1.4 -1.4 -10.5
-1.5 6.9 -1.5 -1.4 -1.4 -1.4 -11.2
-3.7 -6.8 -15.2 -6.8 -6.7 -6.7 -6.7 -6.7 -13.4
-6.8 1.6 -6.8 -6.7 -6.7 -6.7 -16.5
-5.8 -8.9 -19.7 -8.9 -8.8 -6.4 -8.8 -6.4 -17.9
-8.9 -13.0 -8.9 -8.8 -6.4 -8.8 -18.6
2.4 -0.7 -11.5 -0.7 -0.5 -0.6 -0.5 -0.6 -9.7
-0.7 7.7 -0.7 -0.5 -0.6 -0.5 -10.4
7.8
4.7 -18.6 4.7 4.9
4.8 4.9 4.8 -16.8
4.7 -11.9 4.7 4.9
4.8 4.9 -17.5
2.4 -0.7 -11.5 -0.7 -0.5 -0.6 -0.5 -0.6 -9.7
-0.7 7.7 -0.7 -0.5 -0.6 -0.5 -10.4
1.5 -1.5 -12.3 -1.5 -1.4 -1.4 -1.4 -1.4 -10.5
-1.5 6.9 -1.5 -1.4 -1.4 -1.4 -11.2
-0.6 -3.7 -12.1 -3.7 -3.6 -3.6 -3.6 -3.6 -10.3
-3.7 4.7 -3.7 -3.6 -3.6 -3.6 -13.4
1.5 -1.5 -12.3 -1.5 -1.4 -1.4 -1.4 -1.4 -10.5
-1.5 6.9 -1.5 -1.4 -1.4 -1.4 -11.2
1.9 -3.6 -14.4 -3.6 -3.4 -3.5 -3.4 -3.5 -12.6
-3.6 -7.7 -3.6 -3.4 -3.5 -3.4 -13.3
Y
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A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
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5' ------>
3'
G \/ \_/ U
C /\ | G
3' <------
5'
-12.2 -10.4 -10.6 -10.4 -10.4 -10.4 -10.4
-10.4 -8.7 -10.4 2.1 -10.4 -10.4 -10.4
-10.4 -8.0
-15.9 -14.1 -14.2 -14.1 -14.1 -14.1 -14.1
-14.1 -12.3 -14.1 -1.6 -14.1 -14.1 -14.1 -14.1 -14.1
-19.4 -17.6 -17.7 -17.6 -17.6 -15.2 -17.6
-15.2 -15.8 -17.6 -17.6 -17.6 -17.6 -15.2 -17.6 -17.6
-15.9 -14.1 -14.2 -14.1 -14.1 -14.1 -14.1
-14.1 -12.3 -14.1 -1.6 -14.1 -14.1 -14.1 -14.1 -14.1
-16.7 -14.9 -15.1 -14.9 -14.9 -14.9 -14.9
-14.9 -13.2 -14.9 -2.4 -14.9 -14.9 -14.9 -14.9 -14.9
-18.9 -17.1 -14.9 -17.1 -17.1 -17.1 -17.1
-17.1 -13.0 -17.1 -4.6 -17.1 -17.1 -17.1 -17.1 -17.1
-16.7 -14.9 -15.1 -14.9 -14.9 -14.9 -14.9
-14.9 -13.2 -14.9 -2.4 -14.9 -14.9 -14.9 -14.9 -14.9
-22.0 -20.2 -18.0 -20.2 -20.2 -20.2 -20.2
-20.2 -16.1 -20.2 -7.7 -20.2 -20.2 -20.2 -20.2 -20.2
-24.1 -22.3 -22.5 -22.3 -22.3 -19.9 -22.3
-19.9 -20.6 -22.3 -22.3 -22.3 -22.3 -19.9 -22.3 -22.3
-15.9 -14.1 -14.2 -14.1 -14.1 -14.1 -14.1
-14.1 -12.3 -14.1 -1.6 -14.1 -14.1 -14.1 -14.1 -14.1
-10.5 -8.7 -21.3 -8.7 -8.7 -8.7 -8.7 -8.7
-19.4 -8.7 -21.2 -8.7 -8.7 -8.7 -8.7 -21.2
-15.9 -14.1 -14.2 -14.1 -14.1 -14.1 -14.1
-14.1 -12.3 -14.1 -1.6 -14.1 -14.1 -14.1 -14.1 -14.1
-16.7 -14.9 -15.1 -14.9 -14.9 -14.9 -14.9
-14.9 -13.2 -14.9 -2.4 -14.9 -14.9 -14.9 -14.9 -14.9
-18.9 -17.1 -14.9 -17.1 -17.1 -17.1 -17.1
-17.1 -13.0 -17.1 -4.6 -17.1 -17.1 -17.1 -17.1 -17.1
-16.7 -14.9 -15.1 -14.9 -14.9 -14.9 -14.9
-14.9 -13.2 -14.9 -2.4 -14.9 -14.9 -14.9 -14.9 -14.9
-16.4 -17.0 -17.1 -17.0 -17.0 -17.0 -17.0
-17.0 -15.2 -17.0 -17.0 -17.0 -17.0 -17.0 -17.0 -17.0
Y
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A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
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5' ------>
3'
G \/ \_/ A
U /\ | U
3' <------
5'
-4.2 -7.0 -18.3 -7.0 -5.5 -5.5 -5.5 -6.8 -21.3
-7.0 2.3 -7.0 -5.5 -9.9 -5.5 -12.5
-2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5
-5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1
-0.7 -3.5 -14.7 -3.5 -2.0 0.4 -2.0 -0.9 -17.7 -3.5 -6.7 -3.5 -2.0 -4.0
-2.0 -11.4
-2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5
-5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1
-2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5
-5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1
-2.4 -5.2 -14.1 -5.2 -3.7 -3.7 -3.7 -5.0 -17.1
-5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1
-2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5
-5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1
-2.4 -5.2 -14.1 -5.2 -3.7 -3.7 -3.7 -5.0 -17.1
-5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1
-2.6 -5.4 -16.6 -5.4 -3.9 -1.5 -3.9 -2.8 -19.6
-5.4 -8.6 -5.4 -3.9 -5.9 -3.9 -13.3
-2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5
-5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1
10.1
7.3 -16.5 7.3 8.8
8.8 8.8 7.5 -19.5
7.3 -8.4 7.3 8.8
4.4 8.8 -13.1
-2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5
-5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1
-2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5
-5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1
-2.4 -5.2 -14.1 -5.2 -3.7 -3.7 -3.7 -5.0 -17.1
-5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1
-2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5
-5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1
0.0 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5
-5.2 -8.4 -5.2 -3.7 -8.1 -3.7 -13.1
Y
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A
A A A
C C C
C G G
G G U
U U U
A
C G U
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U A C
G U A
C G U
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5' ------>
3'
G \/ \_/ C
U /\ | G
3' <------
5'
-12.2 -16.7 -24.1 -16.7 -15.9 -18.9 -15.9
-18.9 -19.4 -16.7 -10.5 -16.7 -15.9 -22.0 -15.9 -16.4
-10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1
-17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0
-8.7 -13.2 -20.6 -13.2 -12.3 -13.0 -12.3 -13.0
-15.8 -13.2 -19.4 -13.2 -12.3 -16.1 -12.3 -15.2
-10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1
-17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0
-10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1
-17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0
-10.4 -14.9 -19.9 -14.9 -14.1 -17.1 -14.1
-17.1 -15.2 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0
-10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1
-17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0
-10.4 -14.9 -19.9 -14.9 -14.1 -17.1 -14.1
-17.1 -15.2 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0
-10.6 -15.1 -22.5 -15.1 -14.2 -14.9 -14.2
-14.9 -17.7 -15.1 -21.3 -15.1 -14.2 -18.0 -14.2 -17.1
-10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1
-17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0
2.1 -2.4 -22.3 -2.4 -1.6 -4.6 -1.6 -4.6 -17.6
-2.4 -21.2 -2.4 -1.6 -7.7 -1.6 -17.0
-10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1
-17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0
-10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1
-17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0
-10.4 -14.9 -19.9 -14.9 -14.1 -17.1 -14.1
-17.1 -15.2 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0
-10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1
-17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0
-8.0 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1 -17.1
-17.6 -14.9 -21.2 -14.9 -14.1 -20.2 -14.1 -17.0
Y
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A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
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5' ------>
3'
G \/ \_/ G
U /\ | C
3' <------
5'
-13.7 -17.0 -16.0 -17.0 -12.4 -12.5 -12.4
-13.0 -18.9 -17.0 -10.5 -17.0 -12.4 -11.9 -12.4 -17.9
-12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6
-11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5
-10.3 -13.4 -12.5 -13.4 -8.9 -6.5 -8.9 -7.0
-15.3 -13.4 -19.4 -13.4 -8.9 -5.9 -8.9 -16.8
-12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6
-11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5
-12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6
-11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5
-12.1 -15.2 -11.8 -15.2 -10.6 -10.7 -10.6
-11.2 -14.7 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5
-12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6
-11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5
-12.1 -15.2 -11.8 -15.2 -10.6 -10.7 -10.6
-11.2 -14.7 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5
-12.2 -15.3 -14.4 -15.3 -10.8 -8.4 -10.8 -8.9
-17.2 -15.3 -21.3 -15.3 -10.8 -7.8 -10.8 -18.7
-12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6
-11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5
0.4 -2.7 -14.2 -2.7 1.9
1.8 1.9 1.3 -17.1 -2.7 -21.2 -2.7 1.9
2.4 1.9 -18.5
-12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6
-11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5
-12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6
-11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5
-12.1 -15.2 -11.8 -15.2 -10.6 -10.7 -10.6
-11.2 -14.7 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5
-12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6
-11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5
-9.7 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6 -11.2
-17.1 -15.2 -21.2 -15.2 -10.6 -10.1 -10.6 -18.5
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------>
3'
G \/ \_/ G
U /\ | U
3' <------
5'
-0.7 -15.8 -16.0 -15.8 -15.8 -15.8 -15.8 -15.8
-20.9 -15.8 -3.3 -15.8 -15.8 -15.8 -15.8 -13.4
-8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0
-19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
-0.3 -12.3 -15.7 -12.3 -12.3 -9.9 -12.3 -9.9
-17.4 -12.3 -12.3 -12.3 -12.3 -9.9 -12.3 -12.3
-8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0
-19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
-8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0
-19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
-8.9 -14.0 -15.0 -14.0 -14.0 -14.0 -14.0 -14.0
-16.7 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
-8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0
-19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
-8.9 -14.0 -15.0 -14.0 -14.0 -14.0 -14.0 -14.0
-16.7 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
-9.1 -14.2 -30.4 -14.2 -14.2 -11.8 -14.2 -11.8
-19.3 -14.2 -14.2 -14.2 -14.2 -11.8 -14.2 -14.2
-8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0
-19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
3.6 -1.5 -17.4 -1.5 -1.5 -1.5 -1.5 -1.5 -19.1
-1.5 -14.0 -1.5 -1.5 -1.5 -1.5 -14.0
-8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0
-19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
-8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0
-19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
-8.9 -14.0 -15.0 -14.0 -14.0 -14.0 -14.0 -14.0
-16.7 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
-8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0
-19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
-6.5 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0
-19.1 -14.0 -14.0 -14.0 -14.0 -14.0 -14.0 -14.0
Y
------------------------------------------------------------------------------
A
A A A
C C C C
G G G
G U U
U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------>
3'
G \/ \_/ U
U /\ | A
3' <------
5'
-4.9 -8.0 -18.8 -8.0 -7.8 -7.9 -7.8 -7.9 -17.0
-8.0 0.4 -8.0 -7.8 -7.9 -7.8 -15.3
-3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2
-6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9
-1.3 -4.4 -15.2 -4.4 -4.3 -1.9 -4.3 -1.9 -13.4
-4.4 -8.5 -4.4 -4.3 -1.9 -4.3 -14.1
-3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2
-6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9
-3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2
-6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9
-3.1 -6.2 -14.6 -6.2 -6.0 -6.1 -6.0 -6.1 -12.8
-6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9
-3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2
-6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9
-3.1 -6.2 -14.6 -6.2 -6.0 -6.1 -6.0 -6.1 -12.8
-6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9
-3.2 -6.3 -17.1 -6.3 -6.2 -3.8 -6.2 -3.8 -15.3
-6.3 -10.4 -6.3 -6.2 -3.8 -6.2 -16.0
-3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2
-6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9
9.4
6.3 -17.0 6.3 6.5
6.4 6.5 6.4 -15.2
6.3 -10.3 6.3 6.5
6.4 6.5 -15.9
-3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2
-6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9
-3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2
-6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9
-3.1 -6.2 -14.6 -6.2 -6.0 -6.1 -6.0 -6.1 -12.8
-6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9
-3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2
-6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9
-0.7 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2
-6.2 -10.3 -6.2 -6.0 -6.1 -6.0 -15.9
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------>
3'
G \/ \_/ U
U /\ | G
3' <------ 5'
-23.2 -21.4 -21.5 -21.4 -21.4 -21.4 -21.4
-21.4 -19.6 -21.4 -8.9 -21.4 -21.4 -21.4 -21.4 -19.0
-21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6
-19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6
-19.6 -17.8 -18.0 -17.8 -17.8 -15.4 -17.8
-15.4 -16.1 -17.8 -17.8 -17.8 -17.8 -15.4 -17.8 -17.8
-21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6
-19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6
-21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6
-19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6
-21.4 -19.6 -17.3 -19.6 -19.6 -19.6 -19.6
-19.6 -15.4 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6
-21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6
-19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6
-21.4 -19.6 -17.3 -19.6 -19.6 -19.6 -19.6
-19.6 -15.4 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6
-21.5 -19.7 -19.9 -19.7 -19.7 -17.3 -19.7
-17.3 -18.0 -19.7 -19.7 -19.7 -19.7 -17.3 -19.7 -19.7
-21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6
-19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6
-8.9 -7.1 -19.7 -7.1 -7.1 -7.1 -7.1 -7.1 -17.8
-7.1 -19.6 -7.1 -7.1 -7.1 -7.1 -19.6
-21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6
-19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6
-21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6
-19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6
-21.4 -19.6 -17.3 -19.6 -19.6 -19.6 -19.6
-19.6 -15.4 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6
-21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6
-19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6
-19.0 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6
-19.6 -17.8 -19.6 -19.6 -19.6 -19.6 -19.6 -19.6 -19.6
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------>
3'
U \/ \_/ A
A /\ | U
3' <------
5'
14.7
11.9 0.6 11.9
13.4 13.4 13.4
12.1 -2.3 11.9 21.2
11.9 13.4 9.0
13.4 6.4
13.4
10.6 -0.6 10.6 12.1
12.1 12.1 10.8 -3.6
10.6 19.9 10.6
12.1 7.7 12.1
2.7
-2.3 -5.1 -16.4 -5.1 -3.6 -1.2 -3.6 -2.5 -19.4
-5.1 -8.3 -5.1 -3.6 -5.6 -3.6 -13.0
13.4
10.6 -0.6 10.6 12.1
12.1 12.1 10.8 -3.6
10.6 19.9 10.6
12.1 7.7 12.1
2.7
11.9
9.1 -2.1 9.1 10.6
10.6 10.6 9.3 -5.1
9.1 18.4 9.1
10.6 6.2 10.6
1.2
13.4
10.6 1.8 10.6
12.1 12.1 12.1
10.8 -1.2 10.6 19.9
10.6 12.1 7.7
12.1 2.7
11.9
9.1 -2.1 9.1 10.6
10.6 10.6 9.3 -5.1
9.1 18.4 9.1
10.6 6.2 10.6
1.2
9.0
6.2 -2.6 6.2 7.7
7.7 7.7 6.4 -5.6
6.2 15.5 6.2
7.7 3.3 7.7 -1.7
0.6 -2.1 -13.4 -2.1 -0.6 1.8 -0.6
0.5 -16.4 -2.1 -5.3 -2.1 -0.6 -2.6 -0.6 -10.0
13.4
10.6 -0.6 10.6 12.1
12.1 12.1 10.8 -3.6
10.6 19.9 10.6
12.1 7.7 12.1
2.7
21.2
18.4 -5.3 18.4 19.9
19.9 19.9 18.6 -8.3
18.4 2.7 18.4
19.9 15.5 19.9 -2.0
13.4
10.6 -0.6 10.6 12.1
12.1 12.1 10.8 -3.6
10.6 19.9 10.6
12.1 7.7 12.1
2.7
11.9
9.1 -2.1 9.1 10.6
10.6 10.6 9.3 -5.1
9.1 18.4 9.1
10.6 6.2 10.6
1.2
12.1
9.3 0.5 9.3
10.8 10.8 10.8
9.5 -2.5 9.3 18.6
9.3 10.8 6.4
10.8 1.4
11.9
9.1 -2.1 9.1 10.6
10.6 10.6 9.3 -5.1
9.1 18.4 9.1
10.6 6.2 10.6
1.2
6.4
1.2 -10.0 1.2 2.7
2.7 2.7 1.4 -13.0
1.2 -2.0 1.2 2.7 -1.7
2.7 -6.7
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------>
3'
U \/ \_/ C
A /\ | G
3' <------ 5'
6.7
2.2 -5.2 2.2 3.0
0.0 3.0 0.0 -0.4
2.2 8.5 2.2
3.0 -3.1 3.0 2.5
5.4
0.9 -6.5 0.9 1.7 -1.3
1.7 -1.3 -1.7 0.9 7.2
0.9 1.7 -4.4 1.7 -1.1
-10.3 -14.8 -22.2 -14.8 -14.0 -14.6 -14.0
-14.6 -17.5 -14.8 -21.1 -14.8 -14.0 -17.7 -14.0 -16.9
5.4
0.9 -6.5 0.9 1.7 -1.3
1.7 -1.3 -1.7 0.9 7.2
0.9 1.7 -4.4 1.7 -1.1
3.9 -0.6 -8.0 -0.6 0.2 -2.8
0.2 -2.8 -3.2 -0.6 5.7 -0.6 0.2 -5.9
0.2 -2.6
5.4
0.9 -4.1 0.9 1.7 -1.3
1.7 -1.3 0.7 0.9
7.2 0.9 1.7 -4.4
1.7 -1.1
3.9 -0.6 -8.0 -0.6 0.2 -2.8
0.2 -2.8 -3.2 -0.6 5.7 -0.6 0.2 -5.9
0.2 -2.6
1.0 -3.5 -8.5 -3.5 -2.6 -5.7 -2.6 -5.7 -3.7
-3.5 2.8 -3.5 -2.6 -8.8 -2.6 -5.5
-7.3 -11.8 -19.2 -11.8 -11.0 -11.6 -11.0 -11.6
-14.5 -11.8 -18.1 -11.8 -11.0 -14.7 -11.0 -13.9
5.4
0.9 -6.5 0.9 1.7 -1.3
1.7 -1.3 -1.7 0.9 7.2
0.9 1.7 -4.4 1.7 -1.1
13.2
8.7 -11.2 8.7 9.6
6.5 9.6 6.5 -6.4
8.7 -10.0 8.7 9.6
3.4 9.6 -5.8
5.4
0.9 -6.5 0.9 1.7 -1.3
1.7 -1.3 -1.7 0.9 7.2
0.9 1.7 -4.4 1.7 -1.1
3.9 -0.6 -8.0 -0.6 0.2 -2.8
0.2 -2.8 -3.2 -0.6 5.7 -0.6 0.2 -5.9
0.2 -2.6
4.1 -0.4 -5.4 -0.4 0.4 -2.6
0.4 -2.6 -0.6 -0.4 5.9 -0.4 0.4 -5.7
0.4 -2.4
3.9 -0.6 -8.0 -0.6 0.2 -2.8
0.2 -2.8 -3.2 -0.6 5.7 -0.6 0.2 -5.9
0.2 -2.6
-1.6 -8.5 -15.9 -8.5 -7.6 -10.7 -7.6 -10.7
-11.1 -8.5 -14.7 -8.5 -7.6 -13.8 -7.6 -10.5
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------> 3'
U \/ \_/ G
A /\ | C
3' <------
5'
5.0
1.9 2.9 1.9
6.5 6.4 6.5
5.9 0.0 1.9
8.5 1.9 6.5
7.0 6.5 1.0
3.7 0.6 1.6
0.6 5.2 5.1
5.2 4.6 -1.2 0.6
7.2 0.6 5.2
5.7 5.2 -2.7
-12.0 -15.1 -14.1 -15.1 -10.5 -8.2 -10.5 -8.7
-17.0 -15.1 -21.1 -15.1 -10.5 -7.6 -10.5 -18.4
3.7
0.6 1.6 0.6
5.2 5.1 5.2
4.6 -1.2 0.6 7.2
0.6 5.2 5.7
5.2 -2.7
2.2 -0.8
0.1 -0.8 3.7 3.6
3.7 3.1 -2.7 -0.8 5.7 -0.8
3.7 4.2 3.7 -4.2
3.7
0.6 4.0 0.6
5.2 5.1 5.2
4.6 1.2 0.6
7.2 0.6 5.2
5.7 5.2 -2.7
2.2 -0.8
0.1 -0.8 3.7 3.6
3.7 3.1 -2.7 -0.8 5.7 -0.8
3.7 4.2 3.7 -4.2
-0.6 -3.7 -0.4 -3.7 0.8
0.7 0.8 0.2 -3.2 -3.7
2.8 -3.7 0.8 1.3
0.8 -7.1
-9.0 -12.1 -11.1 -12.1 -7.5 -5.2 -7.5 -5.7
-14.0 -12.1 -18.1 -12.1 -7.5 -4.6 -7.5 -15.4
3.7
0.6 1.6 0.6
5.2 5.1 5.2
4.6 -1.2 0.6 7.2
0.6 5.2 5.7
5.2 -2.7
11.6
8.5 -3.1 8.5 13.0
12.9 13.0 12.5 -5.9
8.5 -10.0 8.5 13.0
13.5 13.0 -7.4
3.7
0.6 1.6 0.6
5.2 5.1 5.2
4.6 -1.2 0.6 7.2
0.6 5.2 5.7
5.2 -2.7
2.2 -0.8
0.1 -0.8 3.7 3.6
3.7 3.1 -2.7 -0.8 5.7 -0.8
3.7 4.2 3.7 -4.2
2.4 -0.6
2.7 -0.6 3.9 3.8
3.9 3.3 -0.1 -0.6 5.9 -0.6
3.9 4.4 3.9 -4.0
2.2 -0.8
0.1 -0.8 3.7 3.6
3.7 3.1 -2.7 -0.8 5.7 -0.8
3.7 4.2 3.7 -4.2
-3.2 -8.7 -7.8 -8.7 -4.2 -4.2 -4.2 -4.7 -10.6
-8.7 -14.7 -8.7 -4.2 -3.6 -4.2 -12.1
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G
U
------------------------------------------------------------------------------
5' ------>
3'
U \/ \_/ G
A /\ | U
3' <------ 5'
8.2
3.1 -0.3 3.1 3.1
3.1 3.1 3.1 -2.0
3.1 15.6 3.1
3.1 3.1 3.1
5.5
6.9
1.8 -1.6 1.8 1.8
1.8 1.8 1.8 -3.3
1.8 14.3 1.8
1.8 1.8 1.8
1.8
-8.8 -13.9 -17.3 -13.9 -13.9 -11.5 -13.9 -11.5
-19.0 -13.9 -13.9 -13.9 -13.9 -11.5 -13.9 -13.9
6.9
1.8 -1.6 1.8 1.8
1.8 1.8 1.8 -3.3
1.8 14.3 1.8
1.8 1.8 1.8
1.8
5.4
0.3 -3.1 0.3 0.3
0.3 0.3 0.3 -4.8
0.3 12.8 0.3
0.3 0.3 0.3
0.3
6.9
1.8 0.8 1.8
1.8 1.8 1.8
1.8 -0.9 1.8 14.3
1.8 1.8 1.8
1.8 1.8
5.4
0.3 -3.1 0.3 0.3
0.3 0.3 0.3 -4.8
0.3 12.8 0.3
0.3 0.3 0.3
0.3
2.5 -2.6 -3.6 -2.6 -2.6 -2.6 -2.6 -2.6 -5.3
-2.6 9.9 -2.6 -2.6 -2.6 -2.6 -2.6
-5.8 -10.9 -14.3 -10.9 -10.9 -8.5 -10.9 -8.5
-16.0 -10.9 -10.9 -10.9 -10.9 -8.5 -10.9 -10.9
6.9
1.8 -1.6 1.8 1.8
1.8 1.8 1.8 -3.3
1.8 14.3 1.8
1.8 1.8 1.8
1.8
14.7
9.6 -6.3 9.6 9.6
9.6 9.6 9.6 -8.0
9.6 -2.9 9.6 9.6
9.6 9.6 -2.9
6.9
1.8 -1.6 1.8 1.8
1.8 1.8 1.8 -3.3
1.8 14.3 1.8
1.8 1.8 1.8
1.8
5.4
0.3 -3.1 0.3 0.3
0.3 0.3 0.3 -4.8
0.3 12.8 0.3
0.3 0.3 0.3
0.3
5.6
0.5 -0.5 0.5 0.5
0.5 0.5 0.5 -2.2
0.5 13.0 0.5
0.5 0.5 0.5
0.5
5.4
0.3 -3.1 0.3 0.3
0.3 0.3 0.3 -4.8
0.3 12.8 0.3
0.3 0.3 0.3
0.3
-0.1 -7.6 -11.0 -7.6 -7.6 -7.6 -7.6 -7.6 -12.7
-7.6 -7.6 -7.6 -7.6 -7.6 -7.6 -7.6
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------>
3'
U \/ \_/ U
A /\ | A
3' <------
5'
14.0
10.9 0.1 10.9
11.1 11.0 11.1
11.0 1.9 10.9
19.3 10.9 11.1
11.0 11.1 3.6
12.7 9.6
-1.1 9.6
9.8 9.7 9.8
9.7 0.6 9.6
18.0 9.6 9.8
9.7 9.8 0.0
-3.0 -6.1 -16.9 -6.1 -5.9 -3.6 -5.9 -3.6 -15.1
-6.1 -10.2 -6.1 -5.9 -3.6 -5.9 -15.8
12.7
9.6 -1.1 9.6 9.8
9.7 9.8 9.7
0.6 9.6 18.0
9.6 9.8 9.7
9.8 0.0
11.2
8.1 -2.6 8.1 8.3
8.2 8.3 8.2 -0.8
8.1 16.5 8.1
8.3 8.2 8.3 -1.5
12.7
9.6 1.3 9.6
9.8 9.7 9.8
9.7 3.0 9.6
18.0 9.6 9.8
9.7 9.8 0.0
11.2
8.1 -2.6 8.1 8.3
8.2 8.3 8.2 -0.8
8.1 16.5 8.1
8.3 8.2 8.3 -1.5
8.3
5.2 -3.1 5.2 5.4
5.3 5.4 5.3 -1.3
5.2 13.6 5.2
5.4 5.3 5.4 -4.4
0.0 -3.1 -13.9 -3.1 -2.9 -0.6 -2.9 -0.6 -12.1
-3.1 -7.2 -3.1 -2.9 -0.6 -2.9 -12.8
12.7
9.6 -1.1 9.6 9.8
9.7 9.8 9.7
0.6 9.6 18.0
9.6 9.8 9.7
9.8 0.0
20.5
17.4 -5.8 17.4 17.6
17.5 17.6 17.5 -4.0
17.4 0.8 17.4
17.6 17.5 17.6 -4.7
12.7
9.6 -1.1 9.6 9.8
9.7 9.8 9.7
0.6 9.6 18.0
9.6 9.8 9.7
9.8 0.0
11.2
8.1 -2.6 8.1 8.3
8.2 8.3 8.2 -0.8
8.1 16.5 8.1
8.3 8.2 8.3 -1.5
11.4
8.3 0.0 8.3
8.5 8.4 8.5 8.4 1.8
8.3 16.7 8.3
8.5 8.4 8.5 -1.3
11.2
8.1 -2.6 8.1 8.3
8.2 8.3 8.2 -0.8
8.1 16.5 8.1
8.3 8.2 8.3 -1.5
5.7
0.2 -10.5 0.2 0.4
0.3 0.4 0.3 -8.7
0.2 -3.8 0.2 0.4
0.3 0.4 -9.4
Y
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A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A C
G U
------------------------------------------------------------------------------
5' ------>
3'
U \/ \_/ U
A /\ | G
3' <------ 5'
-4.2 -2.4 -2.6 -2.4 -2.4 -2.4 -2.4 -2.4 -0.7
-2.4 10.1 -2.4 -2.4 -2.4 -2.4 0.0
-5.5 -3.7 -3.9 -3.7 -3.7 -3.7 -3.7 -3.7 -2.0
-3.7 8.8 -3.7 -3.7 -3.7 -3.7 -3.7
-21.3 -19.5 -19.6 -19.5 -19.5 -17.1 -19.5
-17.1 -17.7 -19.5 -19.5 -19.5 -19.5 -17.1 -19.5 -19.5
-5.5 -3.7 -3.9 -3.7 -3.7 -3.7 -3.7 -3.7 -2.0
-3.7 8.8 -3.7 -3.7 -3.7 -3.7 -3.7
-7.0 -5.2 -5.4 -5.2 -5.2 -5.2 -5.2 -5.2 -3.5
-5.2 7.3 -5.2 -5.2 -5.2 -5.2 -5.2
-5.5 -3.7 -1.5 -3.7 -3.7 -3.7 -3.7 -3.7 0.4 -3.7
8.8 -3.7 -3.7 -3.7 -3.7 -3.7
-7.0 -5.2 -5.4 -5.2 -5.2 -5.2 -5.2 -5.2 -3.5
-5.2 7.3 -5.2 -5.2 -5.2 -5.2 -5.2
-9.9 -8.1 -5.9 -8.1 -8.1 -8.1 -8.1 -8.1 -4.0
-8.1 4.4 -8.1 -8.1 -8.1 -8.1 -8.1
-18.3 -16.5 -16.6 -16.5 -16.5 -14.1 -16.5
-14.1 -14.7 -16.5 -16.5 -16.5 -16.5 -14.1 -16.5 -16.5
-5.5 -3.7 -3.9 -3.7 -3.7 -3.7 -3.7 -3.7 -2.0
-3.7 8.8 -3.7 -3.7 -3.7 -3.7 -3.7
2.3
4.1 -8.6 4.1 4.1
4.1 4.1 4.1 -6.7
4.1 -8.4 4.1 4.1
4.1 4.1 -8.4
-5.5 -3.7 -3.9 -3.7 -3.7 -3.7 -3.7 -3.7 -2.0
-3.7 8.8 -3.7 -3.7 -3.7 -3.7 -3.7
-7.0 -5.2 -5.4 -5.2 -5.2 -5.2 -5.2 -5.2 -3.5
-5.2 7.3 -5.2 -5.2 -5.2 -5.2 -5.2
-6.8 -5.0 -2.8 -5.0 -5.0 -5.0 -5.0 -5.0 -0.9
-5.0 7.5 -5.0 -5.0 -5.0 -5.0 -5.0
-7.0 -5.2 -5.4 -5.2 -5.2 -5.2 -5.2 -5.2 -3.5
-5.2 7.3 -5.2 -5.2 -5.2 -5.2 -5.2
-12.5 -13.1 -13.3 -13.1 -13.1 -13.1 -13.1
-13.1 -11.4 -13.1 -13.1 -13.1 -13.1 -13.1 -13.1 -13.1
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------> 3'
U \/ \_/ A
G /\ | U
3' <------
5'
8.2
5.4 -5.8 5.4 6.9
6.9 6.9 5.6 -8.8
5.4 14.7 5.4
6.9 2.5 6.9 -0.1
3.1
0.3 -10.9 0.3 1.8
1.8 1.8 0.5 -13.9
0.3 9.6 0.3
1.8 -2.6 1.8 -7.6
-2.0 -4.8 -16.0 -4.8 -3.3 -0.9 -3.3 -2.2 -19.0
-4.8 -8.0 -4.8 -3.3 -5.3 -3.3 -12.7
3.1
0.3 -10.9 0.3 1.8
1.8 1.8 0.5 -13.9
0.3 9.6 0.3
1.8 -2.6 1.8 -7.6
3.1 0.3
-10.9 0.3 1.8
1.8 1.8 0.5 -13.9
0.3 9.6 0.3
1.8 -2.6 1.8 -7.6
3.1
0.3 -8.5 0.3 1.8
1.8 1.8 0.5 -11.5
0.3 9.6 0.3
1.8 -2.6 1.8 -7.6
3.1
0.3 -10.9 0.3 1.8
1.8 1.8 0.5 -13.9
0.3 9.6 0.3
1.8 -2.6 1.8 -7.6
3.1
0.3 -8.5 0.3 1.8
1.8 1.8 0.5 -11.5
0.3 9.6 0.3
1.8 -2.6 1.8 -7.6
-0.3 -3.1 -14.3 -3.1 -1.6 0.8 -1.6 -0.5 -17.3 -3.1 -6.3 -3.1 -1.6 -3.6
-1.6 -11.0
3.1
0.3 -10.9 0.3 1.8
1.8 1.8 0.5 -13.9
0.3 9.6 0.3
1.8 -2.6 1.8 -7.6
15.6
12.8 -10.9 12.8 14.3
14.3 14.3 13.0 -13.9
12.8 -2.9 12.8 14.3
9.9 14.3 -7.6
3.1
0.3 -10.9 0.3 1.8
1.8 1.8 0.5 -13.9
0.3 9.6 0.3
1.8 -2.6 1.8 -7.6
3.1
0.3 -10.9 0.3 1.8
1.8 1.8 0.5 -13.9
0.3 9.6 0.3
1.8 -2.6 1.8 -7.6
3.1
0.3 -8.5 0.3 1.8
1.8 1.8 0.5 -11.5
0.3 9.6 0.3
1.8 -2.6 1.8 -7.6
3.1
0.3 -10.9 0.3 1.8
1.8 1.8 0.5 -13.9
0.3 9.6 0.3
1.8 -2.6 1.8 -7.6
5.5
0.3 -10.9 0.3 1.8
1.8 1.8 0.5 -13.9
0.3 -2.9 0.3 1.8 -2.6
1.8 -7.6
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------>
3'
U \/ \_/ C
G /\ | G
3' <------ 5'
-20.4 -4.3 -11.7 -4.3 -3.4 -6.5 -3.4 -6.5 -6.9
-4.3 2.0 -4.3 -3.4 -9.6 -3.4 -3.9
-4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6
-12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4
-10.0 -14.5 -21.9 -14.5 -13.6 -14.3 -13.6 -14.3
-17.1 -14.5 -20.7 -14.5 -13.6 -17.4 -13.6 -16.5
-4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6
-12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4
-4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6
-12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4
-4.9 -9.4 -14.4 -9.4 -8.5 -11.6 -8.5 -11.6
-9.6 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4
-4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6
-12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4
-4.9 -9.4 -14.4 -9.4 -8.5 -11.6 -8.5 -11.6
-9.6 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4
-8.3 -12.8 -20.2 -12.8 -11.9 -12.6 -11.9 -12.6
-15.4 -12.8 -19.0 -12.8 -11.9 -15.7 -11.9 -14.8
-4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6
-12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4
7.6
3.1 -16.8 3.1 4.0
0.9 4.0 0.9 -12.0
3.1 -15.6 3.1 4.0 -2.2
4.0 -11.4
-4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6
-12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4
-4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6
-12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4
-4.9 -9.4 -14.4 -9.4 -8.5 -11.6 -8.5 -11.6
-9.6 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4
-4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6
-12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4
-2.5 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6
-12.0 -9.4 -15.6 -9.4 -8.5 -14.7 -8.5 -11.4
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------>
3'
U \/ \_/ G
G /\ | C
3' <------
5'
-1.4 -4.5 -3.6 -4.5 0.0 0.0 0.0 -0.5 -6.4 -4.5 2.0 -4.5
0.0 0.5 0.0 -5.5
-6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5
-9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0
-11.6 -14.7 -13.8 -14.7 -10.2 -7.8 -10.2 -8.3
-16.6 -14.7 -20.7 -14.7 -10.2 -7.2 -10.2 -18.1
-6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5
-9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0
-6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5
-9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0
-6.5 -9.6 -6.3 -9.6 -5.1 -5.1 -5.1 -5.6 -9.1
-9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0
-6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5
-9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0
-6.5 -9.6 -6.3 -9.6 -5.1 -5.1 -5.1 -5.6 -9.1
-9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0
-9.9 -13.0 -12.1 -13.0 -8.5 -6.1 -8.5 -6.6
-14.9 -13.0 -19.0 -13.0 -8.5 -5.5 -8.5 -16.4
-6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5
-9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0
6.0
2.9 -8.7 2.9 7.4
7.4 7.4 6.9 -11.5
2.9 -15.6 2.9 7.4
8.0 7.4 -13.0
-6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5
-9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0
-6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5
-9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0
-6.5 -9.6 -6.3 -9.6 -5.1 -5.1 -5.1 -5.6 -9.1
-9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0
-6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5
-9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0
-4.1 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5
-9.6 -15.6 -9.6 -5.1 -4.5 -5.1 -13.0
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------>
3'
U \/ \_/ G
G /\ | U
3' <------
5'
1.7 -3.4 -6.8 -3.4 -3.4 -3.4 -3.4 -3.4 -8.5
-3.4 9.1 -3.4 -3.4 -3.4 -3.4 -1.0
-3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6
-8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
-8.5 -13.6 -17.0 -13.6 -13.6 -11.2 -13.6 -11.2
-18.7 -13.6 -13.6 -13.6 -13.6 -11.2 -13.6 -13.6
-3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6
-8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
-3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6
-8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
-3.4 -8.5 -9.5 -8.5 -8.5 -8.5 -8.5 -8.5 -11.2
-8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
-3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6
-8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
-3.4 -8.5 -9.5 -8.5 -8.5 -8.5 -8.5 -8.5 -11.2
-8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
-6.8 -11.9 -15.3 -11.9 -11.9 -9.5 -11.9 -9.5
-17.0 -11.9 -11.9 -11.9 -11.9 -9.5 -11.9 -11.9
-3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6
-8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
9.1
4.0 -11.9 4.0 4.0
4.0 4.0 4.0 -13.6
4.0 -8.5 4.0 4.0
4.0 4.0 -8.5
-3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6
-8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
-3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6
-8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
-3.4 -8.5 -9.5 -8.5 -8.5 -8.5 -8.5 -8.5 -11.2
-8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
-3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6
-8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
-1.0 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6
-8.5 -8.5 -8.5 -8.5 -8.5 -8.5 -8.5
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------>
3'
U \/ \_/ U
G /\ | A
3' <------
5'
7.5
4.4 -6.3 4.4 4.6
4.5 4.6 4.5 -4.5
4.4 12.8 4.4
4.6 4.5 4.6 -2.8
2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6
-0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3
-2.6 -5.7 -16.5 -5.7 -5.6 -3.2 -5.6 -3.2 -14.7
-5.7 -9.8 -5.7 -5.6 -3.2 -5.6 -15.4
2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6
-0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3
2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6
-0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3
2.4 -0.6 -9.0 -0.6 -0.5 -0.5 -0.5 -0.5 -7.2
-0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3
2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6
-0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3
2.4 -0.6 -9.0 -0.6 -0.5 -0.5 -0.5 -0.5 -7.2
-0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3
-0.9 -4.0 -14.8 -4.0 -3.9 -1.5 -3.9 -1.5 -13.0
-4.0 -8.1 -4.0 -3.9 -1.5 -3.9 -13.7
2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6
-0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3
14.9
11.9 -11.4 11.9 12.0
12.0 12.0 12.0 -9.6
11.9 -4.7 11.9 12.0
12.0 12.0 -10.3
2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6
-0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3
2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6
-0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3
2.4 -0.6 -9.0 -0.6 -0.5 -0.5 -0.5 -0.5 -7.2
-0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3
2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6
-0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3
4.8 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6
-0.6 -4.7 -0.6 -0.5 -0.5 -0.5 -10.3
Y
------------------------------------------------------------------------------
A
A A A
C C C
C G G
G G U
U U U
A
C G U
A C G
U A C
G U A
C G U
------------------------------------------------------------------------------
5' ------>
3'
U \/ \_/ U
G /\ | G
3' <------
5'
-0.7 -8.9 -9.1 -8.9 -8.9 -8.9 -8.9 -8.9 -0.3
-8.9 3.6 -8.9 -8.9 -8.9 -8.9 -6.5
-15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0
-14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
-20.9 -19.1 -19.3 -19.1 -19.1 -16.7 -19.1
-16.7 -17.4 -19.1 -19.1 -19.1 -19.1 -16.7 -19.1 -19.1
-15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0
-14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
-15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0
-14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
-15.8 -14.0 -11.8 -14.0 -14.0 -14.0 -14.0
-14.0 -9.9 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
-15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0
-14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
-15.8 -14.0 -11.8 -14.0 -14.0 -14.0 -14.0
-14.0 -9.9 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
-16.0 -17.4 -30.4 -17.4 -17.4 -15.0 -17.4
-15.0 -15.7 -17.4 -17.4 -17.4 -17.4 -15.0 -17.4 -17.4
-15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0
-14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
-3.3 -1.5 -14.2 -1.5 -1.5 -1.5 -1.5 -1.5 -12.3
-1.5 -14.0 -1.5 -1.5 -1.5 -1.5 -14.0
-15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0
-14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
-15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0
-14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
-15.8 -14.0 -11.8 -14.0 -14.0 -14.0 -14.0
-14.0 -9.9 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
-15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0
-14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
-13.4 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0
-14.0 -12.3 -14.0 -14.0 -14.0 -14.0 -14.0 -14.0 -14.0