Data tables for
asymmetric interior loops of size 3
Free energies at
37 degrees for RNA
Data arrangement:
Y
------------------
(X) A
C G U
------------------
5' --> 3'
X
A
A
U U
YA
3' <-- 5'
(A) . .
. .
(C) . .
. .
(G) . .
. .
(U) . .
. .
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G U
A C G
U A C
G U A
C G U
A C G
U A C
G U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
A
A A C A G A U A G A U
U
U U G U C
U A U U U G
YA YA YA YA YA YA
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
3.7
3.7 3.7 3.7
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7
3.7
3.7 3.7 3.7
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7
2.6
2.6 2.6 2.6
1.9 3.0 1.9
3.0 1.9 1.9
1.9 1.9 2.6
3.7 2.6 3.7
2.6 2.6 2.6
2.6 2.6 3.7
2.6 3.7
3.7
3.7 3.7 3.0
3.0 3.0 3.0
2.2 3.0 3.0
3.0 2.2 3.7
3.7 3.7 3.0
3.7 3.7 3.7
3.0 3.7 3.7
3.7 3.0
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G U
A C G
U A C
G U A
C G U
A C G
U A C
G U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
A
A A C A G A
U A G A U
U
U U G U C U A U U U G
YC YC YC YC YC YC
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
3.7
3.7 3.7 3.7
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7
3.7
3.7 3.7 3.7
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7
2.6
3.7 2.6 3.7
1.9 3.0 1.9
3.0 1.9 3.0
1.9 3.0 2.6
3.7 2.6 3.7
2.6 3.7 2.6
3.7 2.6 3.7
2.6 3.7
3.7
3.7 3.7 3.0
3.0 3.0 3.0
2.2 3.0 3.0
3.0 2.2 3.7
3.7 3.7 3.0
3.7 3.7 3.7
3.0 3.7 3.7
3.7 3.0
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G U
A C G
U A C
G U A
C G U
A C G
U A C
G U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
A
A A C A G A U A G A U
U
U U G U C U A U
U U G
YG YG YG YG YG YG
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
2.6
2.6 2.6 2.6
1.9 1.9 1.9
1.9 1.9 1.9
1.9 1.9 2.6
2.6 2.6 2.6
2.6 2.6 2.6
2.6 2.6 2.6
2.6 2.6
3.7
3.7 3.7 3.7
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7
2.6
2.6 2.6 2.6
1.9 1.9 1.9
1.9 1.9 1.9
1.9 1.9 2.6
2.6 2.6 2.6
2.6 2.6 2.6
2.6 2.6 2.6
2.6 2.6
3.7
3.7 3.7 3.0
3.0 3.0 3.0
2.2 3.0 3.0
3.0 2.2 3.7
3.7 3.7 3.0
3.7 3.7 3.7
3.0 3.7 3.7
3.7 3.0
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G U
A C G
U A C
G U A
C G U
A C G
U A C
G U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
A
A A C A G A U A G A U
U
U U G U C U A U U U G
YU YU YU YU YU YU
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
3.7
3.7 3.7 3.7
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7
3.7
3.7 3.7 3.7
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7
2.6
3.7 2.6 3.7
1.9 3.0 1.9
3.0 1.9 3.0
1.9 3.0 2.6
3.7 2.6 3.7
2.6 3.7 2.6
3.7 2.6 3.7
2.6 3.7
3.0
3.0 3.0 3.0
2.2 2.2 2.2
2.2 2.2 2.2
2.2 2.2 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G U
A C G
U A C
G U A
C G U
A C G
U A C
G U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
C
A C C C G C U C G C U
G
U G G G C G A G U G G
YA YA YA YA YA YA
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
3.0
3.0 1.9 3.0
2.5 2.3 1.1
2.3 2.3 2.3
1.1 2.3 3.0
3.0 1.9 3.0
3.0 3.0 1.9
3.0 3.0 3.0
1.9 3.0
3.0
3.0 3.0 3.0
2.3 2.3 2.3
2.3 2.3 2.3
2.3 2.3 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0
1.9
1.9 1.9 1.9
1.7 2.3 0.8 2.3 1.1
1.1 1.1 1.1
1.9 3.0 1.9
3.0 1.9 1.9
1.9 1.9 1.9
3.0 1.9 3.0
3.0
3.0 3.0 2.2
2.3 2.3 2.3
1.5 2.3 2.3
2.3 1.5 3.0
3.0 3.0 2.2
3.0 3.0 3.0
2.2 3.0 3.0
3.0 2.2
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G U
A C G
U A C
G U A
C G U
A C G
U A C
G U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
C
A C C C G C U
C G C U
G
U G G G C G A G U G G
YC YC YC YC YC YC
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
3.0
3.0 1.9 3.0
2.3 1.7 1.1
2.3 2.3 2.3
1.1 2.3 3.0
3.0 1.9 3.0
3.0 3.0 1.9
3.0 3.0 3.0
1.9 3.0
3.0
3.0 3.0 3.0
2.3 2.5 2.3
2.3 2.3 2.3
2.3 2.3 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0
1.9
3.0 1.9 3.0
1.1 2.3 1.1
2.3 1.1 2.3
1.1 2.3 1.9
3.0 1.9 3.0
1.9 3.0 1.9
3.0 1.9 3.0
1.9 3.0
3.0
3.0 3.0 2.2 2.3 2.2
2.3 1.5 2.3
2.3 2.3 1.5
3.0 3.0 3.0
2.2 3.0 3.0
3.0 2.2 3.0
3.0 3.0 2.2
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G U
A C G
U A C
G U A
C G U
A C G
U A C
G U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
C
A C C C G C U C G C U
G
U G G G C G A G U
G G
YG YG YG YG YG YG
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
1.9
1.9 1.9 1.9
0.8 1.1 1.1
1.1 1.1 1.1
1.1 1.1 1.9
1.9 1.9 1.9
1.9 1.9 1.9
1.9 1.9 1.9
1.9 1.9
3.0
3.0 3.0 3.0
2.3 2.3 2.3
2.3 2.3 2.3
2.3 2.3 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0
1.9
1.9 1.9 1.9
1.2 1.1 1.1
1.1 1.1 1.1
1.1 1.1 1.9
1.9 1.9 1.9
1.9 1.9 1.9
1.9 1.9 1.9
1.9 1.9
3.0
3.0 3.0 2.2
2.3 2.3 2.3
1.5 2.3 2.3
2.3 1.5 3.0
3.0 3.0 2.2
3.0 3.0 3.0
2.2 3.0 3.0
3.0 2.2
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G U
A C G
U A C
G U A
C G U
A C G
U A C
G U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
C
A C C C G C U C G C
U
G
U G G G C G A G U G G
YU YU YU YU YU YU
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
3.0
3.0 1.9 3.0
2.3 2.3 1.1
2.3 2.3 2.3
1.1 2.3 3.0
3.0 1.9 3.0
3.0 3.0 1.9
3.0 3.0 3.0
1.9 3.0
3.0
3.0 3.0 3.0
2.5 2.3 2.3
2.3 2.3 2.3 2.3 2.3
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.0
1.9
3.0 1.9 3.0
1.1 2.3 1.1
2.3 1.1 2.3
1.1 2.3 1.9
3.0 1.9 3.0
1.9 3.0 1.9
3.0 1.9 3.0
1.9 3.0
2.2
2.2 2.2 2.2
1.5 1.7 1.5 1.4 1.5
1.5 1.5 1.5
2.2 2.2 2.2
2.2 2.2 2.2
2.2 2.2 2.2
2.2 2.2 2.2
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G U
A C G
U A C
G U A
C G U
A C G
U A C
G U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
G
A G C G G G U G G G U
C
U C G C C C A C U C G
YA YA YA YA YA YA
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
3.0
3.0 3.0 3.0
2.3 2.3 2.3
2.3 2.5 2.3
2.1 2.3 3.0
3.0 3.0 3.0
2.5 3.0 2.1
3.0 3.0 3.0
3.0 3.0
3.0
3.0 3.0 3.0
2.3 2.3 2.3
2.3 2.3 2.3
2.3 2.3 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0
1.9
1.9 1.9 1.9
1.1 2.3 1.1 2.3 1.1
1.1 1.1 1.1
1.9 3.0 1.9
3.0 1.9 1.9
1.9 1.9 1.9
3.0 1.9 3.0
3.0
3.0 3.0 2.2
2.3 2.3 2.3
1.5 2.3 2.3
2.3 1.5 3.0
3.0 3.0 2.2
3.0 3.0 3.0
2.2 3.0 3.0
3.0 2.2
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G U
A C G
U A C
G U A
C G
U A C
G U A
C G U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
G
A G C G G G U G G G U
C
U C G C C C A C U C G
YC YC YC YC YC YC
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
3.0
3.0 3.0 3.0
2.3 2.3 2.3
2.3 2.3 2.3
2.3 2.3 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0
3.0
3.0 3.0 3.0
2.3 2.3 2.3
2.3 2.3 2.3
2.3 2.3 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0
1.9
3.0 1.9 3.0
1.1 2.3 1.1
2.3 1.1 2.3
1.1 2.3 1.9
3.0 1.9 3.0
1.9 3.0 1.9
3.0 1.9 3.0
1.9 3.0
3.0
3.0 3.0 2.2
2.3 2.3 2.3
1.5 2.3 2.3 2.3 1.5
3.0 3.0 3.0
2.2 3.0 3.0
3.0 2.2 3.0
3.0 3.0 2.2
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G U
A C G
U A C
G U A
C G U
A C G
U A C
G U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
G
A G C G G G U G G G U
C
U C G C C C A C U C G
YG
YG YG YG YG YG
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
1.9
1.9 1.9 1.9
1.1 1.1 1.1 1.1 1.2
1.1 1.1 1.1
1.9 1.9 1.9
1.9 1.2 1.9
1.9 1.9 1.9
1.9 1.9 1.9
3.0
3.0 3.0 3.0
2.3 2.3 2.3
2.3 2.3 2.3
2.3 2.3 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0
1.9
1.9 1.9 1.9
1.1 1.1 1.1
1.1 1.1 1.1 1.1
1.1 1.9 1.9
1.9 1.9 1.9
1.9 1.9 1.9
1.9 1.9 1.9
1.9
3.0
3.0 3.0 2.2
2.3 2.3 2.3
1.5 2.3 2.3
2.3 1.5 3.0
3.0 3.0 2.2
3.0 3.0 3.0
2.2 3.0 3.0
3.0 2.2
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G U
A C G
U A C
G U A
C G U A
C G U
A C G
U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
G
A G C G G G U G G G U
C
U C G C C C A C U C G
YU YU YU YU YU YU
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
3.0
3.0 3.0 3.0
2.3 2.3 2.3
2.3 2.3 2.3
2.3 2.3 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0
3.0
3.0 3.0 3.0
2.3 2.3 2.3
2.3 2.3 1.9
2.3 2.3 3.0
3.0 3.0 3.0
3.0 1.9 3.0
3.0 3.0 3.0
3.0 3.0
1.9
3.0 1.9 3.0
1.1 2.3 1.1
2.3 1.1 2.3
1.1 2.3 1.9
3.0 1.9 3.0
1.9 3.0 1.9
3.0 1.9 3.0
1.9 3.0
2.2
2.2 2.2 2.2
1.5 1.5 1.5
1.5 1.5 1.5
1.5 1.5 2.2
2.2 2.2 2.2
2.2 2.2 2.2
2.2 2.2 2.2
2.2 2.2
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G U
A C G
U A C
G U A
C G U
A C G
U A C
G U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
U
A U C U G U U U G U U
A
U A G A C A A A U A G
YA YA YA YA YA YA
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
3.7
3.7 2.6 3.7
3.0 3.0 1.9
3.0 3.0 3.0 1.9
3.0 3.7 3.7
2.6 3.7 3.7
3.7 2.6 3.7
3.7 3.7 2.6
3.7
3.7
3.7 3.7 3.7
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7
2.6
2.6 2.6 2.6
1.9 3.0 1.9
3.0 1.9 1.9
1.9 1.9 2.6
3.7 2.6 3.7
2.6 2.6 2.6
2.6 2.6 3.7
2.6 3.7
3.7
3.7 3.7 3.0
3.0 3.0 3.0
2.2 3.0 3.0
3.0 2.2 3.7
3.7 3.7 3.0
3.7 3.7 3.7
3.0 3.7 3.7
3.7 3.0
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G U
A C G
U A C
G U A
C G U
A C G
U A C
G U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
U
A U C U G U U U G U U
A
U A G A C A A A U A G
YC YC YC YC YC YC
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
3.7
3.7 2.6 3.7
3.0 3.0 1.9
3.0 3.0 3.0
1.9 3.0 3.7
3.7 2.6 3.7
3.7 3.7 2.6
3.7 3.7 3.7
2.6 3.7
3.7
3.7 3.7 3.7
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7
2.6
3.7 2.6 3.7
1.9 3.0 1.9
3.0 1.9 3.0
1.9 3.0 2.6
3.7 2.6 3.7
2.6 3.7 2.6
3.7 2.6 3.7
2.6 3.7
3.7
3.7 3.7 3.0
3.0 3.0 3.0
2.2 3.0 3.0
3.0 2.2 3.7
3.7 3.7 3.0
3.7 3.7 3.7
3.0 3.7 3.7
3.7 3.0
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G U
A C G
U A C
G U A
C G U
A C G
U A C
G U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
U
A U C U G U U U G U U
A
U A G A C A A A U A G
YG YG YG YG YG YG
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
2.6
2.6 2.6 2.6
1.9 1.9 1.9
1.9 1.9 1.9
1.9 1.9 2.6
2.6 2.6 2.6
2.6 2.6 2.6
2.6 2.6 2.6
2.6 2.6
3.7
3.7 3.7 3.7
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7
2.6
2.6 2.6 2.6
1.9 1.9 1.9
1.9 1.9 1.9
1.9 1.9 2.6
2.6 2.6 2.6
2.6 2.6 2.6
2.6 2.6 2.6
2.6 2.6
3.7
3.7 3.7 3.0
3.0 3.0 3.0
2.2 3.0 3.0
3.0 2.2 3.7
3.7 3.7 3.0
3.7 3.7 3.7
3.0 3.7 3.7
3.7 3.0
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G U
A C G
U A C
G U A
C G U
A C G
U A C
G U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
U
A U C U G U U U G U U
A
U A G A C A A A U A G
YU YU YU YU YU YU
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
3.7
3.7 2.6 3.7
3.0 3.0 1.9
3.0 3.0 3.0
1.9 3.0 3.7
3.7 2.6 3.7
3.7 3.7 2.6
3.7 3.7 3.7
2.6 3.7
3.7
3.7 3.7 3.7
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7
2.6
3.7 2.6 3.7
1.9 3.0 1.9
3.0 1.9 3.0
1.9 3.0 2.6
3.7 2.6 3.7
2.6 3.7 2.6
3.7 2.6 3.7
2.6 3.7
3.0
3.0 3.0 3.0
2.2 2.2 2.2
2.2 2.2 2.2
2.2 2.2 3.0
3.0 3.0 3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.0
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G U
A C G
U A C
G U A
C G U
A C G
U A C
G U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
G
A G C G G G U G G G U
U
U U G U C U A U U U G
YA YA YA YA YA YA
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
3.7
3.7 3.7 3.7
3.0 3.0 3.0
3.0 2.5 3.0
2.1 3.0 3.7
3.7 3.7 3.7
2.5 3.7 2.1 3.7 3.7
3.7 3.7 3.7
3.7
3.7 3.7 3.7
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7
2.6
2.6 2.6 2.6
1.9 3.0 1.9
3.0 1.9 1.9
1.9 1.9 2.6
3.7 2.6 3.7 2.6 2.6
2.6 2.6 2.6
3.7 2.6 3.7
3.7
3.7 3.7 3.0
3.0 3.0 3.0
2.2 3.0 3.0
3.0 2.2 3.7
3.7 3.7 3.0
3.7 3.7 3.7
3.0 3.7 3.7
3.7 3.0
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G U
A C G
U A C
G U A
C G U
A C G
U A C
G U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
G
A G C G G G U G G G U
U
U U G U
C U A U U U G
YC YC YC YC YC YC
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
3.7
3.7 3.7 3.7
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7
3.7
3.7 3.7 3.7
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.7
3.7 3.7 3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7 3.7
2.6
3.7 2.6 3.7
1.9 3.0 1.9
3.0 1.9 3.0
1.9 3.0 2.6
3.7 2.6 3.7
2.6 3.7 2.6
3.7 2.6 3.7
2.6 3.7
3.7
3.7 3.7 3.0
3.0 3.0 3.0
2.2 3.0 3.0
3.0 2.2 3.7
3.7 3.7 3.0
3.7 3.7 3.7
3.0 3.7 3.7
3.7 3.0
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G U
A C G
U A C
G U A
C G U
A C G
U A C
G U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5'
--> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
G
A G C G G G U G G G U
U
U U G U C U A U U U G
YG YG YG YG YG YG
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
2.6
2.6 2.6 2.6
1.9 1.9 1.9
1.9 1.2 1.9
1.9 1.9 2.6
2.6 2.6 2.6 1.2
2.6 2.6 2.6
2.6 2.6 2.6
2.6
3.7
3.7 3.7 3.7
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7
2.6
2.6 2.6 2.6
1.9 1.9 1.9
1.9 1.9 1.9
1.9 1.9 2.6
2.6 2.6 2.6
2.6 2.6 2.6
2.6 2.6 2.6
2.6 2.6
3.7
3.7 3.7 3.0
3.0 3.0 3.0
2.2 3.0 3.0
3.0 2.2 3.7
3.7 3.7 3.0
3.7 3.7 3.7
3.0 3.7 3.7
3.7 3.0
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G U
A C G
U A C
G U A
C G U
A C G
U A C
G U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
G
A G C G G G U G G G U
U
U U G U
C U A U U U G
YU YU YU YU YU YU
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
3.7
3.7 3.7 3.7
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7
3.7
3.7 3.7 3.7
3.0 3.0 3.0
3.0 3.0 1.9
3.0 3.0 3.7
3.7 3.7 3.7
3.7 1.9 3.7
3.7 3.7 3.7
3.7 3.7
2.6
3.7 2.6 3.7
1.9 3.0 1.9
3.0 1.9 3.0
1.9 3.0 2.6
3.7 2.6 3.7
2.6 3.7 2.6
3.7 2.6 3.7
2.6 3.7
3.0
3.0 3.0 3.0
2.2 2.2 2.2
2.2 2.2 2.2
2.2 2.2 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A C
G U A
C G U
A C G
U A C
G U A
C G U
A C G
U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
U
A U C U
G U U U G U U
G
U G G G C G A G U G G
YA YA YA YA YA YA
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
3.7
3.7 2.6 3.7
3.0 3.0 1.9
3.0 3.0 3.0
1.9 3.0 3.7
3.7 2.6 3.7
3.7 3.7 2.6
3.7 3.7 3.7
2.6 3.7
3.7
3.7 3.7 3.7
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7
2.6
2.6 2.6 2.6
1.9 3.0 1.9
3.0 1.9 1.9
1.9 1.9 2.6
3.7 2.6 3.7
2.6 2.6 2.6
2.6 2.6 3.7
2.6 3.7
3.7
3.7 3.7 3.0
3.0 3.0 3.0
2.2 3.0 3.0
3.0 2.2 3.7
3.7 3.7 3.0
3.7 3.7 3.7
3.0 3.7 3.7
3.7 3.0
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G U
A C G
U A C
G U A
C G U
A C G
U A C
G U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
U
A U C U G U U U G U U
G
U G G G C G
A G U G G
YC YC YC YC YC YC
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
3.7
3.7 2.6 3.7
3.0 3.0 1.9
3.0 3.0 3.0
1.9 3.0 3.7
3.7 2.6 3.7
3.7 3.7 2.6
3.7 3.7 3.7
2.6 3.7
3.7
3.7 3.7 3.7
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7
2.6
3.7 2.6 3.7
1.9 3.0 1.9
3.0 1.9 3.0
1.9 3.0 2.6
3.7 2.6 3.7
2.6 3.7 2.6
3.7 2.6 3.7
2.6 3.7
3.7
3.7 3.7 3.0
3.0 3.0 3.0
2.2 3.0 3.0
3.0 2.2 3.7
3.7 3.7 3.0
3.7 3.7 3.7
3.0 3.7 3.7 3.7 3.0
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G
U A C
G U A
C G U
A C G
U A C
G U A
C G U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
U
A U C U G U U U G U U
G
U G G G C G A G U G G
YG YG YG YG YG YG
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
2.6
2.6 2.6 2.6
1.9 1.9 1.9
1.9 1.9 1.9
1.9 1.9 2.6
2.6 2.6 2.6
2.6 2.6 2.6
2.6 2.6 2.6
2.6 2.6
3.7
3.7 3.7 3.7
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7
2.6
2.6 2.6 2.6
1.9 1.9 1.9
1.9 1.9 1.9
1.9 1.9 2.6
2.6 2.6 2.6
2.6 2.6 2.6
2.6 2.6 2.6 2.6 2.6
3.7
3.7 3.7 3.0
3.0 3.0 3.0
2.2 3.0 3.0
3.0 2.2 3.7
3.7 3.7 3.0
3.7 3.7 3.7
3.0 3.7 3.7
3.7 3.0
Y Y Y Y Y Y
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
A
C G U
A C G
U A C
G U A
C G U
A C G
U A C
G U
------------------ ------------------ ------------------ ------------------ ------------------ ------------------
5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3'
X X X X X X
U
A U C U G U U U G U U
G
U G G G C G
A G U G G
YU YU YU YU YU YU
3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5'
3.7
3.7 2.6 3.7
3.0 3.0 1.9
3.0 3.0 3.0
1.9 3.0 3.7
3.7 2.6 3.7
3.7 3.7 2.6
3.7 3.7 3.7
2.6 3.7
3.7
3.7 3.7 3.7
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.7
3.7 3.7 3.7
3.7 3.7 3.7
3.7 3.7 3.7 3.7 3.7
2.6
3.7 2.6 3.7
1.9 3.0 1.9
3.0 1.9 3.0
1.9 3.0 2.6
3.7 2.6 3.7
2.6 3.7 2.6
3.7 2.6 3.7
2.6 3.7
3.0
3.0 3.0 3.0
2.2 2.2 2.2
2.2 2.2 2.2
2.2 2.2 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0 3.0
3.0 3.0