Data table for symmetric interior loops of size 2 The Enthalpies at 37 degrees for RNA Data Arrangement: Y ------------------ (X) A C G U ------------------ 5' --> 3' X A A U U Y 3' <-- 5' (A) . . . . (C) . . . . (G) . . . . (U) . . . . Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X A A A C A G A U A G A U U U U G U C U A U U U G Y Y Y Y Y Y 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' -0.5 -0.5 -0.5 -0.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -8.3 -0.5 -5.5 -5.5 -13.4 -5.5 -5.5 -5.5 -13.4 -5.5 -0.5 -0.5 -8.3 -0.5 -0.5 -0.5 -8.3 -0.5 -0.5 -0.5 -8.3 -0.5 -0.5 -0.5 -0.5 -3.9 -5.5 -5.5 -5.5 -12.3 -5.5 -5.5 -5.5 -8.9 -0.5 -0.5 -0.5 -7.3 -0.5 -0.5 -0.5 -3.9 -0.5 -0.5 -0.5 -7.3 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X C A C C C G C U C G C U G U G G G C G A G U G G Y Y Y Y Y Y 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' -5.5 -5.5 -5.5 -5.5 -10.5 -10.5 -10.5 -10.5 -10.5 -10.5 -10.5 -10.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -10.5 -10.5 -10.5 -10.5 -10.5 -10.5 -10.5 -10.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -13.4 -5.5 -10.5 -10.5 -18.4 -10.5 -10.5 -10.5 -18.4 -10.5 -5.5 -5.5 -13.4 -5.5 -5.5 -5.5 -13.4 -5.5 -5.5 -5.5 -13.4 -5.5 -5.5 -5.5 -5.5 -5.5 -10.5 -10.5 -10.5 -13.9 -10.5 -10.5 -10.5 -10.5 -5.5 -5.5 -5.5 -8.9 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -8.9 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X G A G C G G G U G G G U C U C G C C C A C U C G Y Y Y Y Y Y 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' -5.5 -5.5 -5.5 -5.5 -10.5 -10.5 -10.5 -10.5 -10.5 -10.5 -10.5 -10.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -10.5 -10.5 -10.5 -10.5 -10.5 -10.5 -10.5 -10.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -13.4 -5.5 -10.5 -10.5 -18.4 -10.5 -10.5 -10.5 -18.4 -10.5 -5.5 -5.5 -13.4 -5.5 -5.5 -5.5 -13.4 -5.5 -5.5 -5.5 -13.4 -5.5 -5.5 -5.5 -5.5 -8.9 -10.5 -10.5 -10.5 -17.3 -10.5 -10.5 -10.5 -13.9 -5.5 -5.5 -5.5 -12.3 -5.5 -5.5 -5.5 -8.9 -5.5 -5.5 -5.5 -12.3 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X U A U C U G U U U G U U A U A G A C A A A U A G Y Y Y Y Y Y 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' -0.5 -0.5 -0.5 -0.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -8.3 -0.5 -5.5 -5.5 -13.4 -5.5 -5.5 -5.5 -13.4 -5.5 -0.5 -0.5 -8.3 -0.5 -0.5 -0.5 -8.3 -0.5 -0.5 -0.5 -8.3 -0.5 -0.5 -0.5 -0.5 -0.5 -5.5 -5.5 -5.5 -8.9 -5.5 -5.5 -5.5 -5.5 -0.5 -0.5 -0.5 -3.9 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -3.9 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X G A G C G G G U G G G U U U U G U C U A U U U G Y Y Y Y Y Y 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' -0.5 -0.5 -0.5 -0.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -8.3 -0.5 -5.5 -5.5 -13.4 -5.5 -5.5 -5.5 -13.4 -5.5 -0.5 -0.5 -8.3 -0.5 -0.5 -0.5 -8.3 -0.5 -0.5 -0.5 -8.3 -0.5 -0.5 -0.5 -0.5 -3.9 -5.5 -5.5 -5.5 -12.3 -5.5 -5.5 -5.5 -8.9 -0.5 -0.5 -0.5 -7.3 -0.5 -0.5 -0.5 -3.9 -0.5 -0.5 -0.5 -7.3 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X U A U C U G U U U G U U G U G G G C G A G U G G Y Y Y Y Y Y 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' -0.5 -0.5 -0.5 -0.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -5.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -8.3 -0.5 -5.5 -5.5 -13.4 -5.5 -5.5 -5.5 -13.4 -5.5 -0.5 -0.5 -8.3 -0.5 -0.5 -0.5 -8.3 -0.5 -0.5 -0.5 -8.3 -0.5 -0.5 -0.5 -0.5 -0.5 -5.5 -5.5 -5.5 -8.9 -5.5 -5.5 -5.5 -5.5 -0.5 -0.5 -0.5 -3.9 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -0.5 -3.9