X X X X ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' AX AX AX AX A C G U 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' . . . . . . . . . . . . -0.8 -0.5 -0.8 -0.6 X X X X ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' CX CX CX CX A C G U 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' . . . . . . . . -1.7 -0.8 -1.7 -1.2 . . . . X X X X ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' GX GX GX GX A C G U 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' . . . . -1.1 -0.4 -1.3 -0.6 . . . . -0.8 -0.5 -0.8 -0.6 X X X X ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' UX UX UX UX A C G U 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' -0.7 -0.1 -0.7 -0.1 . . . . -0.7 -0.1 -0.7 -0.1 . . . . X X X X ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' A A A A AX CX GX UX 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' . . . . . . . . . . . . -0.3 -0.1 -0.2 -0.2 X X X X ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' C C C C AX CX GX UX 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' . . . . . . . . -0.2 -0.3 -0.0 -0.0 . . . . X X X X ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' G G G G AX CX GX UX 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' . . . . -0.5 -0.3 -0.2 -0.1 . . . . -0.3 -0.1 -0.2 -0.2 X X X X ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' U U U U AX CX GX UX 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' -0.3 -0.3 -0.4 -0.2 . . . . -0.3 -0.3 -0.4 -0.2 . . . .