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Turner 2004

Bulge Loops

Example 2

 

 

example structure        

∆G°37 = ∆G°37(Watson-Crick Pairs) + ∆G°37 intermolecular initiation + ∆G°37 AU end penalty + ∆G°37(Bulge Loop)


∆G°37 = ∆G°37(GC followed by AU) +∆G°37 intermolecular initiation + ∆G°37 AU end penalty + ∆G°37 bulge initiation(3)

 

∆G°37 = –2.35 kcal/mol + 4.09 kcal/mol + 0.45 kcal/mol + 3.2 kcal/mol

 

∆G°37 = +5.4 kcal/mol

 

∆H° = ∆H°(Watson-Crick Pairs) + ∆H°intermolecular initiation + ∆H°AU end penalty + ∆H°(Bulge Loop)


∆H° = ∆H°(GC followed by AU) +∆H°intermolecular initiation + ∆H°AU end penalty + ∆H°bulge initiation(3)

 

∆H° = –12.44 kcal/mol + 3.61 kcal/mol + 3.72 kcal/mol + 7.1 kcal/mol

 

∆H° = +2.0 kcal/mol