# Data tables for 2x2 interior loops # The Enthalpies for RNA # Data arrangement: # # 5' ------> 3' # A X1 Y1 A # U X2 Y2 U # 3' <------ 5' # # Y--> # ---------------------------------------------------------------------------------------------------------------------------- # (X) A A A A C C C C G G G G U U U U # | A C G U A C G U A C G U A C G U # V ---------------------------------------------------------------------------------------------------------------------------- # (AA) 14.0 11.2 0.0 11.2 12.7 12.7 12.7 11.4 -3.0 11.2 20.5 11.2 12.7 8.3 12.7 5.7 # (AC) 11.1 8.3 -2.9 8.3 9.8 9.8 9.8 8.5 -5.9 8.3 17.6 8.3 9.8 5.4 9.8 0.4 # (AG) 1.9 -0.8 -12.1 -0.8 0.6 3.0 0.6 1.8 -15.1 -0.8 -4.0 -0.8 0.6 -1.3 0.6 -8.7 # (AU) 11.1 8.3 -2.9 8.3 9.8 9.8 9.8 8.5 -5.9 8.3 17.6 8.3 9.8 5.4 9.8 0.4 # (CA) 10.9 8.1 -3.1 8.1 9.6 9.6 9.6 8.3 -6.1 8.1 17.4 8.1 9.6 5.2 9.6 0.2 # (CC) 11.0 8.2 -0.6 8.2 9.7 9.7 9.7 8.4 -3.6 8.2 17.5 8.2 9.7 5.3 9.7 0.3 # (CG) 10.9 8.1 -3.1 8.1 9.6 9.6 9.6 8.3 -6.1 8.1 17.4 8.1 9.6 5.2 9.6 0.2 # (CU) 11.0 8.2 -0.6 8.2 9.7 9.7 9.7 8.4 -3.6 8.2 17.5 8.2 9.7 5.3 9.7 0.3 # (GA) 0.1 -2.6 -13.9 -2.6 -1.1 1.3 -1.1 0.0 -16.9 -2.6 -5.8 -2.6 -1.1 -3.1 -1.1 -10.5 # (GC) 11.1 8.3 -2.9 8.3 9.8 9.8 9.8 8.5 -5.9 8.3 17.6 8.3 9.8 5.4 9.8 0.4 # (GG) 19.3 16.5 -7.2 16.5 18.0 18.0 18.0 16.7 -10.2 16.5 0.8 16.5 18.0 13.6 18.0 -3.8 # (GU) 11.1 8.3 -2.9 8.3 9.8 9.8 9.8 8.5 -5.9 8.3 17.6 8.3 9.8 5.4 9.8 0.4 # (UA) 10.9 8.1 -3.1 8.1 9.6 9.6 9.6 8.3 -6.1 8.1 17.4 8.1 9.6 5.2 9.6 0.2 # (UC) 11.0 8.2 -0.6 8.2 9.7 9.7 9.7 8.4 -3.6 8.2 17.5 8.2 9.7 5.3 9.7 0.3 # (UG) 10.9 8.1 -3.1 8.1 9.6 9.6 9.6 8.3 -6.1 8.1 17.4 8.1 9.6 5.2 9.6 0.2 # (UU) 3.6 -1.5 -12.8 -1.5 0.0 0.0 0.0 -1.3 -15.8 -1.5 -4.7 -1.5 0.0 -4.4 0.0 -9.4 # 5' ------> 3' A X1 Y1 A U X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 14.0 11.2 0.0 11.2 12.7 12.7 12.7 11.4 -3.0 11.2 20.5 11.2 12.7 8.3 12.7 5.7 AC 11.1 8.3 -2.9 8.3 9.8 9.8 9.8 8.5 -5.9 8.3 17.6 8.3 9.8 5.4 9.8 0.4 AG 1.9 -0.8 -12.1 -0.8 0.6 3.0 0.6 1.8 -15.1 -0.8 -4.0 -0.8 0.6 -1.3 0.6 -8.7 AU 11.1 8.3 -2.9 8.3 9.8 9.8 9.8 8.5 -5.9 8.3 17.6 8.3 9.8 5.4 9.8 0.4 CA 10.9 8.1 -3.1 8.1 9.6 9.6 9.6 8.3 -6.1 8.1 17.4 8.1 9.6 5.2 9.6 0.2 CC 11.0 8.2 -0.6 8.2 9.7 9.7 9.7 8.4 -3.6 8.2 17.5 8.2 9.7 5.3 9.7 0.3 CG 10.9 8.1 -3.1 8.1 9.6 9.6 9.6 8.3 -6.1 8.1 17.4 8.1 9.6 5.2 9.6 0.2 CU 11.0 8.2 -0.6 8.2 9.7 9.7 9.7 8.4 -3.6 8.2 17.5 8.2 9.7 5.3 9.7 0.3 GA 0.1 -2.6 -13.9 -2.6 -1.1 1.3 -1.1 0.0 -16.9 -2.6 -5.8 -2.6 -1.1 -3.1 -1.1 -10.5 GC 11.1 8.3 -2.9 8.3 9.8 9.8 9.8 8.5 -5.9 8.3 17.6 8.3 9.8 5.4 9.8 0.4 GG 19.3 16.5 -7.2 16.5 18.0 18.0 18.0 16.7 -10.2 16.5 0.8 16.5 18.0 13.6 18.0 -3.8 GU 11.1 8.3 -2.9 8.3 9.8 9.8 9.8 8.5 -5.9 8.3 17.6 8.3 9.8 5.4 9.8 0.4 UA 10.9 8.1 -3.1 8.1 9.6 9.6 9.6 8.3 -6.1 8.1 17.4 8.1 9.6 5.2 9.6 0.2 UC 11.0 8.2 -0.6 8.2 9.7 9.7 9.7 8.4 -3.6 8.2 17.5 8.2 9.7 5.3 9.7 0.3 UG 10.9 8.1 -3.1 8.1 9.6 9.6 9.6 8.3 -6.1 8.1 17.4 8.1 9.6 5.2 9.6 0.2 UU 3.6 -1.5 -12.8 -1.5 0.0 0.0 0.0 -1.3 -15.8 -1.5 -4.7 -1.5 0.0 -4.4 0.0 -9.4 # 5' ------> 3' A X1 Y1 C U X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 6.0 1.5 -5.8 1.5 2.4 -0.6 2.4 -0.6 -1.1 1.5 7.8 1.5 2.4 -3.7 2.4 1.9 AC 3.1 -1.4 -8.8 -1.4 -0.5 -3.6 -0.5 -3.6 -4.0 -1.4 4.9 -1.4 -0.5 -6.7 -0.5 -3.4 AG -6.0 -10.5 -17.9 -10.5 -9.7 -10.3 -9.7 -10.3 -13.2 -10.5 -16.8 -10.5 -9.7 -13.4 -9.7 -12.6 AU 3.1 -1.4 -8.8 -1.4 -0.5 -3.6 -0.5 -3.6 -4.0 -1.4 4.9 -1.4 -0.5 -6.7 -0.5 -3.4 CA 2.9 -1.5 -8.9 -1.5 -0.7 -3.7 -0.7 -3.7 -4.2 -1.5 4.7 -1.5 -0.7 -6.8 -0.7 -3.6 CC 3.0 -1.4 -6.4 -1.4 -0.6 -3.6 -0.6 -3.6 -1.7 -1.4 4.8 -1.4 -0.6 -6.7 -0.6 -3.5 CG 2.9 -1.5 -8.9 -1.5 -0.7 -3.7 -0.7 -3.7 -4.2 -1.5 4.7 -1.5 -0.7 -6.8 -0.7 -3.6 CU 3.0 -1.4 -6.4 -1.4 -0.6 -3.6 -0.6 -3.6 -1.7 -1.4 4.8 -1.4 -0.6 -6.7 -0.6 -3.5 GA -7.8 -12.3 -19.7 -12.3 -11.5 -12.1 -11.5 -12.1 -15.0 -12.3 -18.6 -12.3 -11.5 -15.2 -11.5 -14.4 GC 3.1 -1.4 -8.8 -1.4 -0.5 -3.6 -0.5 -3.6 -4.0 -1.4 4.9 -1.4 -0.5 -6.7 -0.5 -3.4 GG 11.4 6.9 -13.0 6.9 7.7 4.7 7.7 4.7 -8.3 6.9 -11.9 6.9 7.7 1.6 7.7 -7.7 GU 3.1 -1.4 -8.8 -1.4 -0.5 -3.6 -0.5 -3.6 -4.0 -1.4 4.9 -1.4 -0.5 -6.7 -0.5 -3.4 UA 2.9 -1.5 -8.9 -1.5 -0.7 -3.7 -0.7 -3.7 -4.2 -1.5 4.7 -1.5 -0.7 -6.8 -0.7 -3.6 UC 3.0 -1.4 -6.4 -1.4 -0.6 -3.6 -0.6 -3.6 -1.7 -1.4 4.8 -1.4 -0.6 -6.7 -0.6 -3.5 UG 2.9 -1.5 -8.9 -1.5 -0.7 -3.7 -0.7 -3.7 -4.2 -1.5 4.7 -1.5 -0.7 -6.8 -0.7 -3.6 UU -4.3 -11.2 -18.6 -11.2 -10.4 -13.4 -10.4 -13.4 -13.9 -11.2 -17.5 -11.2 -10.4 -16.5 -10.4 -13.3 # 5' ------> 3' A X1 Y1 G U X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 4.4 1.3 2.2 1.3 5.8 5.8 5.8 5.3 -0.6 1.3 7.8 1.3 5.8 6.4 5.8 0.4 AC 1.4 -1.6 -0.7 -1.6 2.9 2.8 2.9 2.3 -3.5 -1.6 4.9 -1.6 2.9 3.4 2.9 -5.0 AG -7.7 -10.8 -9.8 -10.8 -6.2 -3.9 -6.2 -4.4 -12.7 -10.8 -16.8 -10.8 -6.2 -3.3 -6.2 -14.1 AU 1.4 -1.6 -0.7 -1.6 2.9 2.8 2.9 2.3 -3.5 -1.6 4.9 -1.6 2.9 3.4 2.9 -5.0 CA 1.3 -1.8 -0.8 -1.8 2.7 2.7 2.7 2.2 -3.7 -1.8 4.7 -1.8 2.7 3.3 2.7 -5.1 CC 1.4 -1.7 1.7 -1.7 2.8 2.8 2.8 2.3 -1.2 -1.7 4.8 -1.7 2.8 3.4 2.8 -5.0 CG 1.3 -1.8 -0.8 -1.8 2.7 2.7 2.7 2.2 -3.7 -1.8 4.7 -1.8 2.7 3.3 2.7 -5.1 CU 1.4 -1.7 1.7 -1.7 2.8 2.8 2.8 2.3 -1.2 -1.7 4.8 -1.7 2.8 3.4 2.8 -5.0 GA -9.5 -12.6 -11.6 -12.6 -8.0 -5.7 -8.0 -6.2 -14.5 -12.6 -18.6 -12.6 -8.0 -5.1 -8.0 -15.9 GC 1.4 -1.6 -0.7 -1.6 2.9 2.8 2.9 2.3 -3.5 -1.6 4.9 -1.6 2.9 3.4 2.9 -5.0 GG 9.7 6.6 -4.9 6.6 11.2 11.1 11.2 10.6 -7.8 6.6 -11.9 6.6 11.2 11.7 11.2 -9.2 GU 1.4 -1.6 -0.7 -1.6 2.9 2.8 2.9 2.3 -3.5 -1.6 4.9 -1.6 2.9 3.4 2.9 -5.0 UA 1.3 -1.8 -0.8 -1.8 2.7 2.7 2.7 2.2 -3.7 -1.8 4.7 -1.8 2.7 3.3 2.7 -5.1 UC 1.4 -1.7 1.7 -1.7 2.8 2.8 2.8 2.3 -1.2 -1.7 4.8 -1.7 2.8 3.4 2.8 -5.0 UG 1.3 -1.8 -0.8 -1.8 2.7 2.7 2.7 2.2 -3.7 -1.8 4.7 -1.8 2.7 3.3 2.7 -5.1 UU -6.0 -11.5 -10.5 -11.5 -6.9 -7.0 -6.9 -7.5 -13.4 -11.5 -17.5 -11.5 -6.9 -6.4 -6.9 -14.8 # 5' ------> 3' A X1 Y1 G U X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 7.5 2.4 -0.9 2.4 2.4 2.4 2.4 2.4 -2.6 2.4 14.9 2.4 2.4 2.4 2.4 4.8 AC 4.6 -0.5 -3.9 -0.5 -0.5 -0.5 -0.5 -0.5 -5.6 -0.5 12.0 -0.5 -0.5 -0.5 -0.5 -0.5 AG -4.5 -9.6 -13.0 -9.6 -9.6 -7.2 -9.6 -7.2 -14.7 -9.6 -9.6 -9.6 -9.6 -7.2 -9.6 -9.6 AU 4.6 -0.5 -3.9 -0.5 -0.5 -0.5 -0.5 -0.5 -5.6 -0.5 12.0 -0.5 -0.5 -0.5 -0.5 -0.5 CA 4.4 -0.6 -4.0 -0.6 -0.6 -0.6 -0.6 -0.6 -5.7 -0.6 11.9 -0.6 -0.6 -0.6 -0.6 -0.6 CC 4.5 -0.5 -1.5 -0.5 -0.5 -0.5 -0.5 -0.5 -3.2 -0.5 12.0 -0.5 -0.5 -0.5 -0.5 -0.5 CG 4.4 -0.6 -4.0 -0.6 -0.6 -0.6 -0.6 -0.6 -5.7 -0.6 11.9 -0.6 -0.6 -0.6 -0.6 -0.6 CU 4.5 -0.5 -1.5 -0.5 -0.5 -0.5 -0.5 -0.5 -3.2 -0.5 12.0 -0.5 -0.5 -0.5 -0.5 -0.5 GA -6.3 -11.4 -14.8 -11.4 -11.4 -9.0 -11.4 -9.0 -16.5 -11.4 -11.4 -11.4 -11.4 -9.0 -11.4 -11.4 GC 4.6 -0.5 -3.9 -0.5 -0.5 -0.5 -0.5 -0.5 -5.6 -0.5 12.0 -0.5 -0.5 -0.5 -0.5 -0.5 GG 12.8 7.8 -8.1 7.8 7.8 7.8 7.8 7.8 -9.8 7.8 -4.7 7.8 7.8 7.8 7.8 -4.7 GU 4.6 -0.5 -3.9 -0.5 -0.5 -0.5 -0.5 -0.5 -5.6 -0.5 12.0 -0.5 -0.5 -0.5 -0.5 -0.5 UA 4.4 -0.6 -4.0 -0.6 -0.6 -0.6 -0.6 -0.6 -5.7 -0.6 11.9 -0.6 -0.6 -0.6 -0.6 -0.6 UC 4.5 -0.5 -1.5 -0.5 -0.5 -0.5 -0.5 -0.5 -3.2 -0.5 12.0 -0.5 -0.5 -0.5 -0.5 -0.5 UG 4.4 -0.6 -4.0 -0.6 -0.6 -0.6 -0.6 -0.6 -5.7 -0.6 11.9 -0.6 -0.6 -0.6 -0.6 -0.6 UU -2.8 -10.3 -13.7 -10.3 -10.3 -10.3 -10.3 -10.3 -15.4 -10.3 -10.3 -10.3 -10.3 -10.3 -10.3 -10.3 # 5' ------> 3' A X1 Y1 U U X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 13.4 10.3 -0.5 10.3 10.4 10.4 10.4 10.4 1.3 10.3 18.7 10.3 10.4 10.4 10.4 3.0 AC 10.4 7.3 -3.4 7.3 7.5 7.4 7.5 7.4 -1.6 7.3 15.7 7.3 7.5 7.4 7.5 -2.3 AG 1.3 -1.8 -12.6 -1.8 -1.6 0.7 -1.6 0.7 -10.8 -1.8 -5.9 -1.8 -1.6 0.7 -1.6 -11.5 AU 10.4 7.3 -3.4 7.3 7.5 7.4 7.5 7.4 -1.6 7.3 15.7 7.3 7.5 7.4 7.5 -2.3 CA 10.3 7.2 -3.6 7.2 7.3 7.3 7.3 7.3 -1.8 7.2 15.6 7.2 7.3 7.3 7.3 -2.5 CC 10.4 7.3 -1.1 7.3 7.4 7.4 7.4 7.4 0.7 7.3 15.7 7.3 7.4 7.4 7.4 -2.4 CG 10.3 7.2 -3.6 7.2 7.3 7.3 7.3 7.3 -1.8 7.2 15.6 7.2 7.3 7.3 7.3 -2.5 CU 10.4 7.3 -1.1 7.3 7.4 7.4 7.4 7.4 0.7 7.3 15.7 7.3 7.4 7.4 7.4 -2.4 GA -0.5 -3.6 -14.4 -3.6 -3.4 -1.1 -3.4 -1.1 -12.6 -3.6 -7.7 -3.6 -3.4 -1.1 -3.4 -13.3 GC 10.4 7.3 -3.4 7.3 7.5 7.4 7.5 7.4 -1.6 7.3 15.7 7.3 7.5 7.4 7.5 -2.3 GG 18.7 15.6 -7.7 15.6 15.7 15.7 15.7 15.7 -5.9 15.6 -1.0 15.6 15.7 15.7 15.7 -6.6 GU 10.4 7.3 -3.4 7.3 7.5 7.4 7.5 7.4 -1.6 7.3 15.7 7.3 7.5 7.4 7.5 -2.3 UA 10.3 7.2 -3.6 7.2 7.3 7.3 7.3 7.3 -1.8 7.2 15.6 7.2 7.3 7.3 7.3 -2.5 UC 10.4 7.3 -1.1 7.3 7.4 7.4 7.4 7.4 0.7 7.3 15.7 7.3 7.4 7.4 7.4 -2.4 UG 10.3 7.2 -3.6 7.2 7.3 7.3 7.3 7.3 -1.8 7.2 15.6 7.2 7.3 7.3 7.3 -2.5 UU 3.0 -2.5 -13.3 -2.5 -2.3 -2.4 -2.3 -2.4 -11.5 -2.5 -6.6 -2.5 -2.3 -2.4 -2.3 -12.2 # 5' ------> 3' A X1 Y1 U U X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA -4.9 -3.1 -3.2 -3.1 -3.1 -3.1 -3.1 -3.1 -1.3 -3.1 9.4 -3.1 -3.1 -3.1 -3.1 -0.7 AC -7.8 -6.0 -6.2 -6.0 -6.0 -6.0 -6.0 -6.0 -4.3 -6.0 6.5 -6.0 -6.0 -6.0 -6.0 -6.0 AG -17.0 -15.2 -15.3 -15.2 -15.2 -12.8 -15.2 -12.8 -13.4 -15.2 -15.2 -15.2 -15.2 -12.8 -15.2 -15.2 AU -7.8 -6.0 -6.2 -6.0 -6.0 -6.0 -6.0 -6.0 -4.3 -6.0 6.5 -6.0 -6.0 -6.0 -6.0 -6.0 CA -8.0 -6.2 -6.3 -6.2 -6.2 -6.2 -6.2 -6.2 -4.4 -6.2 6.3 -6.2 -6.2 -6.2 -6.2 -6.2 CC -7.9 -6.1 -3.8 -6.1 -6.1 -6.1 -6.1 -6.1 -1.9 -6.1 6.4 -6.1 -6.1 -6.1 -6.1 -6.1 CG -8.0 -6.2 -6.3 -6.2 -6.2 -6.2 -6.2 -6.2 -4.4 -6.2 6.3 -6.2 -6.2 -6.2 -6.2 -6.2 CU -7.9 -6.1 -3.8 -6.1 -6.1 -6.1 -6.1 -6.1 -1.9 -6.1 6.4 -6.1 -6.1 -6.1 -6.1 -6.1 GA -18.8 -17.0 -17.1 -17.0 -17.0 -14.6 -17.0 -14.6 -15.2 -17.0 -17.0 -17.0 -17.0 -14.6 -17.0 -17.0 GC -7.8 -6.0 -6.2 -6.0 -6.0 -6.0 -6.0 -6.0 -4.3 -6.0 6.5 -6.0 -6.0 -6.0 -6.0 -6.0 GG 0.4 2.2 -10.4 2.2 2.2 2.2 2.2 2.2 -8.5 2.2 -10.3 2.2 2.2 2.2 2.2 -10.3 GU -7.8 -6.0 -6.2 -6.0 -6.0 -6.0 -6.0 -6.0 -4.3 -6.0 6.5 -6.0 -6.0 -6.0 -6.0 -6.0 UA -8.0 -6.2 -6.3 -6.2 -6.2 -6.2 -6.2 -6.2 -4.4 -6.2 6.3 -6.2 -6.2 -6.2 -6.2 -6.2 UC -7.9 -6.1 -3.8 -6.1 -6.1 -6.1 -6.1 -6.1 -1.9 -6.1 6.4 -6.1 -6.1 -6.1 -6.1 -6.1 UG -8.0 -6.2 -6.3 -6.2 -6.2 -6.2 -6.2 -6.2 -4.4 -6.2 6.3 -6.2 -6.2 -6.2 -6.2 -6.2 UU -15.3 -15.9 -16.0 -15.9 -15.9 -15.9 -15.9 -15.9 -14.1 -15.9 -15.9 -15.9 -15.9 -15.9 -15.9 -15.9 # 5' ------> 3' C X1 Y1 A G X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 5.0 2.2 -9.0 2.2 3.7 3.7 3.7 2.4 -12.0 2.2 11.6 2.2 3.7 -0.6 3.7 -3.2 AC 6.5 3.7 -7.5 3.7 5.2 5.2 5.2 3.9 -10.5 3.7 13.0 3.7 5.2 0.8 5.2 -4.2 AG 0.0 -2.7 -14.0 -2.7 -1.2 1.2 -1.2 -0.1 -17.0 -2.7 -5.9 -2.7 -1.2 -3.2 -1.2 -10.6 AU 6.5 3.7 -7.5 3.7 5.2 5.2 5.2 3.9 -10.5 3.7 13.0 3.7 5.2 0.8 5.2 -4.2 CA 1.9 -0.8 -12.1 -0.8 0.6 0.6 0.6 -0.6 -15.1 -0.8 8.5 -0.8 0.6 -3.7 0.6 -8.7 CC 6.4 3.6 -5.2 3.6 5.1 5.1 5.1 3.8 -8.2 3.6 12.9 3.6 5.1 0.7 5.1 -4.2 CG 1.9 -0.8 -12.1 -0.8 0.6 0.6 0.6 -0.6 -15.1 -0.8 8.5 -0.8 0.6 -3.7 0.6 -8.7 CU 7.0 4.2 -4.6 4.2 5.7 5.7 5.7 4.4 -7.6 4.2 13.5 4.2 5.7 1.3 5.7 -3.6 GA 2.9 0.1 -11.1 0.1 1.6 4.0 1.6 2.7 -14.1 0.1 -3.1 0.1 1.6 -0.4 1.6 -7.8 GC 6.5 3.7 -7.5 3.7 5.2 5.2 5.2 3.9 -10.5 3.7 13.0 3.7 5.2 0.8 5.2 -4.2 GG 8.5 5.7 -18.1 5.7 7.2 7.2 7.2 5.9 -21.1 5.7 -10.0 5.7 7.2 2.8 7.2 -14.7 GU 6.5 3.7 -7.5 3.7 5.2 5.2 5.2 3.9 -10.5 3.7 13.0 3.7 5.2 0.8 5.2 -4.2 UA 1.9 -0.8 -12.1 -0.8 0.6 0.6 0.6 -0.6 -15.1 -0.8 8.5 -0.8 0.6 -3.7 0.6 -8.7 UC 5.9 3.1 -5.7 3.1 4.6 4.6 4.6 3.3 -8.7 3.1 12.5 3.1 4.6 0.2 4.6 -4.7 UG 1.9 -0.8 -12.1 -0.8 0.6 0.6 0.6 -0.6 -15.1 -0.8 8.5 -0.8 0.6 -3.7 0.6 -8.7 UU 1.0 -4.2 -15.4 -4.2 -2.7 -2.7 -2.7 -4.0 -18.4 -4.2 -7.4 -4.2 -2.7 -7.1 -2.7 -12.1 # 5' ------> 3' C X1 Y1 C G X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA -5.8 -7.4 -20.1 -7.4 -6.6 -9.6 -6.6 -9.6 -13.4 -7.4 1.8 -7.4 -6.6 -12.7 -6.6 -12.4 AC -2.2 -6.0 -16.5 -6.0 -11.5 -8.2 -5.1 -8.2 -8.6 -6.0 -3.9 -6.0 -5.1 -11.3 -5.1 -0.9 AG -9.7 -1.0 -19.8 -12.4 0.1 5.4 -11.6 -12.2 -24.5 -12.4 -18.7 -12.4 -11.6 -15.3 -11.6 -8.1 AU -1.5 -6.0 -13.4 -6.0 -5.1 -8.2 -5.1 -8.2 -8.6 -6.0 0.3 -6.0 -5.1 -11.3 -5.1 -8.0 CA -6.0 -10.5 -17.9 -10.5 -9.7 -12.7 -9.7 -12.7 -10.7 -10.5 -4.3 -10.5 -9.7 -15.8 -9.7 -8.3 CC -10.7 -6.0 -6.3 -6.0 -7.5 -8.2 -5.2 -8.2 -5.0 -6.0 0.2 -6.0 -5.2 -11.3 -5.2 -17.1 CG -6.0 -10.5 -17.9 -10.5 -9.7 -12.7 -9.7 -12.7 -13.2 -10.5 -4.3 -10.5 -9.7 -15.8 -9.7 -12.6 CU -0.9 -5.4 -10.4 -5.4 -4.6 -7.6 -4.6 -5.5 -5.7 -5.4 1.8 -5.4 -4.6 -10.7 -4.6 -14.6 GA -16.0 -3.5 -30.7 -9.6 -11.1 -9.4 -8.7 -9.4 -18.8 -9.6 -13.7 -9.6 -8.7 -12.5 -8.7 -13.6 GC -1.5 -6.0 -13.4 -6.0 -5.1 -8.2 -5.1 -8.2 -8.6 -6.0 0.3 -6.0 -5.1 -11.3 -5.1 -8.0 GG -2.0 -4.4 -23.9 -4.0 -3.2 -6.2 -3.2 -2.6 -10.8 -4.0 -22.8 -4.0 -3.2 -2.1 -3.2 -15.5 GU -1.5 -6.0 -13.4 -6.0 -5.1 -8.2 -5.1 -8.2 -8.6 -6.0 0.3 -6.0 -5.1 -11.3 -5.1 -8.0 UA -6.0 -10.5 -17.9 -10.5 -9.7 -12.7 -9.7 -12.7 -13.2 -10.5 -4.3 -10.5 -9.7 -15.8 -9.7 -12.6 UC -2.0 -6.5 -11.5 -6.5 -5.7 -8.7 -5.7 -8.7 -17.5 -6.5 -8.8 -6.5 -5.7 -11.8 -5.7 -8.6 UG -6.0 -10.5 -17.9 -10.5 -9.7 -12.7 -9.7 -12.7 -13.2 -10.5 -4.3 -10.5 -9.7 -15.8 -9.7 -12.6 UU -14.9 -13.9 -15.2 -13.9 -4.0 -16.1 -13.0 -16.1 -13.0 -13.9 -2.3 -13.9 -13.0 -19.2 -13.0 -23.5 # 5' ------> 3' C X1 Y1 G G X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA -4.6 -7.7 -6.7 -7.7 -3.1 -3.2 -3.1 -3.7 -9.6 -7.7 -1.2 -7.7 -3.1 -2.6 -3.1 -8.6 AC -3.1 -6.2 -5.3 -6.2 -1.7 -1.7 -1.7 -2.2 -8.1 -6.2 0.3 -6.2 -1.7 -1.1 -1.7 -9.6 AG -9.6 -12.7 -11.7 -12.7 -8.1 -5.8 -8.1 -6.3 -14.6 -12.7 -18.7 -12.7 -8.1 -5.2 -8.1 -16.0 AU -3.1 -6.2 -5.3 -6.2 -1.7 -1.7 -1.7 -2.2 -8.1 -6.2 0.3 -6.2 -1.7 -1.1 -1.7 -9.6 CA -7.7 -10.8 -9.8 -10.8 -6.2 -6.3 -6.2 -6.8 -12.7 -10.8 -4.3 -10.8 -6.2 -5.7 -6.2 -14.1 CC -3.2 -6.3 -2.9 -6.3 -1.7 -1.8 -1.7 -2.3 -5.8 -6.3 0.2 -6.3 -1.7 -1.2 -1.7 -9.6 CG -7.7 -10.8 -9.8 -10.8 -6.2 -6.3 -6.2 -6.8 -12.7 -10.8 -4.3 -10.8 -6.2 -5.7 -6.2 -14.1 CU -2.6 -5.7 -2.3 -5.7 -1.1 -1.2 -1.1 -1.7 -5.2 -5.7 0.8 -5.7 -1.1 -0.6 -1.1 -9.0 GA -6.7 -9.8 -8.9 -9.8 -5.3 -2.9 -5.3 -3.4 -11.7 -9.8 -15.8 -9.8 -5.3 -2.3 -5.3 -13.2 GC -3.1 -6.2 -5.3 -6.2 -1.7 -1.7 -1.7 -2.2 -8.1 -6.2 0.3 -6.2 -1.7 -1.1 -1.7 -9.6 GG -1.2 -4.3 -15.8 -4.3 0.3 0.2 0.3 -0.3 -18.7 -4.3 -22.8 -4.3 0.3 0.8 0.3 -20.1 GU -3.1 -6.2 -5.3 -6.2 -1.7 -1.7 -1.7 -2.2 -8.1 -6.2 0.3 -6.2 -1.7 -1.1 -1.7 -9.6 UA -7.7 -10.8 -9.8 -10.8 -6.2 -6.3 -6.2 -6.8 -12.7 -10.8 -4.3 -10.8 -6.2 -5.7 -6.2 -14.1 UC -3.7 -6.8 -3.4 -6.8 -2.2 -2.3 -2.2 -2.8 -6.3 -6.8 -0.3 -6.8 -2.2 -1.7 -2.2 -10.1 UG -7.7 -10.8 -9.8 -10.8 -6.2 -6.3 -6.2 -6.8 -12.7 -10.8 -4.3 -10.8 -6.2 -5.7 -6.2 -14.1 UU -8.6 -14.1 -13.2 -14.1 -9.6 -9.6 -9.6 -10.1 -16.0 -14.1 -20.1 -14.1 -9.6 -9.0 -9.6 -17.5 # 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5' ------> 3' C X1 Y1 U G X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 4.4 1.3 -9.5 1.3 1.4 1.4 1.4 1.4 -7.7 1.3 9.7 1.3 1.4 1.4 1.4 -6.0 AC 5.8 2.7 -8.0 2.7 2.9 2.8 2.9 2.8 -6.2 2.7 11.2 2.7 2.9 2.8 2.9 -6.9 AG -0.6 -3.7 -14.5 -3.7 -3.5 -1.2 -3.5 -1.2 -12.7 -3.7 -7.8 -3.7 -3.5 -1.2 -3.5 -13.4 AU 5.8 2.7 -8.0 2.7 2.9 2.8 2.9 2.8 -6.2 2.7 11.2 2.7 2.9 2.8 2.9 -6.9 CA 1.3 -1.8 -12.6 -1.8 -1.6 -1.7 -1.6 -1.7 -10.8 -1.8 6.6 -1.8 -1.6 -1.7 -1.6 -11.5 CC 5.8 2.7 -5.7 2.7 2.8 2.8 2.8 2.8 -3.9 2.7 11.1 2.7 2.8 2.8 2.8 -7.0 CG 1.3 -1.8 -12.6 -1.8 -1.6 -1.7 -1.6 -1.7 -10.8 -1.8 6.6 -1.8 -1.6 -1.7 -1.6 -11.5 CU 6.4 3.3 -5.1 3.3 3.4 3.4 3.4 3.4 -3.3 3.3 11.7 3.3 3.4 3.4 3.4 -6.4 GA 2.2 -0.8 -11.6 -0.8 -0.7 1.7 -0.7 1.7 -9.8 -0.8 -4.9 -0.8 -0.7 1.7 -0.7 -10.5 GC 5.8 2.7 -8.0 2.7 2.9 2.8 2.9 2.8 -6.2 2.7 11.2 2.7 2.9 2.8 2.9 -6.9 GG 7.8 4.7 -18.6 4.7 4.9 4.8 4.9 4.8 -16.8 4.7 -11.9 4.7 4.9 4.8 4.9 -17.5 GU 5.8 2.7 -8.0 2.7 2.9 2.8 2.9 2.8 -6.2 2.7 11.2 2.7 2.9 2.8 2.9 -6.9 UA 1.3 -1.8 -12.6 -1.8 -1.6 -1.7 -1.6 -1.7 -10.8 -1.8 6.6 -1.8 -1.6 -1.7 -1.6 -11.5 UC 5.3 2.2 -6.2 2.2 2.3 2.3 2.3 2.3 -4.4 2.2 10.6 2.2 2.3 2.3 2.3 -7.5 UG 1.3 -1.8 -12.6 -1.8 -1.6 -1.7 -1.6 -1.7 -10.8 -1.8 6.6 -1.8 -1.6 -1.7 -1.6 -11.5 UU 0.4 -5.1 -15.9 -5.1 -5.0 -5.0 -5.0 -5.0 -14.1 -5.1 -9.2 -5.1 -5.0 -5.0 -5.0 -14.8 # 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5' ------> 3' G X1 Y1 A C X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 6.7 3.9 -7.3 3.9 5.4 5.4 5.4 4.1 -10.3 3.9 13.2 3.9 5.4 1.0 5.4 -1.6 AC 3.0 0.2 -11.0 0.2 1.7 1.7 1.7 0.4 -14.0 0.2 9.6 0.2 1.7 -2.6 1.7 -7.6 AG -0.4 -3.2 -14.5 -3.2 -1.7 0.7 -1.7 -0.6 -17.5 -3.2 -6.4 -3.2 -1.7 -3.7 -1.7 -11.1 AU 3.0 0.2 -11.0 0.2 1.7 1.7 1.7 0.4 -14.0 0.2 9.6 0.2 1.7 -2.6 1.7 -7.6 CA 2.2 -0.6 -11.8 -0.6 0.9 0.9 0.9 -0.4 -14.8 -0.6 8.7 -0.6 0.9 -3.5 0.9 -8.5 CC 0.0 -2.8 -11.6 -2.8 -1.3 -1.3 -1.3 -2.6 -14.6 -2.8 6.5 -2.8 -1.3 -5.7 -1.3 -10.7 CG 2.2 -0.6 -11.8 -0.6 0.9 0.9 0.9 -0.4 -14.8 -0.6 8.7 -0.6 0.9 -3.5 0.9 -8.5 CU -3.1 -5.9 -14.7 -5.9 -4.4 -4.4 -4.4 -5.7 -17.7 -5.9 3.4 -5.9 -4.4 -8.8 -4.4 -13.8 GA -5.2 -8.0 -19.2 -8.0 -6.5 -4.1 -6.5 -5.4 -22.2 -8.0 -11.2 -8.0 -6.5 -8.5 -6.5 -15.9 GC 3.0 0.2 -11.0 0.2 1.7 1.7 1.7 0.4 -14.0 0.2 9.6 0.2 1.7 -2.6 1.7 -7.6 GG 8.5 5.7 -18.1 5.7 7.2 7.2 7.2 5.9 -21.1 5.7 -10.0 5.7 7.2 2.8 7.2 -14.7 GU 3.0 0.2 -11.0 0.2 1.7 1.7 1.7 0.4 -14.0 0.2 9.6 0.2 1.7 -2.6 1.7 -7.6 UA 2.2 -0.6 -11.8 -0.6 0.9 0.9 0.9 -0.4 -14.8 -0.6 8.7 -0.6 0.9 -3.5 0.9 -8.5 UC 0.0 -2.8 -11.6 -2.8 -1.3 -1.3 -1.3 -2.6 -14.6 -2.8 6.5 -2.8 -1.3 -5.7 -1.3 -10.7 UG 2.2 -0.6 -11.8 -0.6 0.9 0.9 0.9 -0.4 -14.8 -0.6 8.7 -0.6 0.9 -3.5 0.9 -8.5 UU 2.5 -2.6 -13.9 -2.6 -1.1 -1.1 -1.1 -2.4 -16.9 -2.6 -5.8 -2.6 -1.1 -5.5 -1.1 -10.5 # 5' ------> 3' G X1 Y1 C C X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA -1.3 -5.8 -13.2 -5.8 -4.9 -8.0 -4.9 -8.0 -8.4 -5.8 0.5 -5.8 -4.9 -11.1 -4.9 -5.4 AC -4.9 -9.4 -16.8 -9.4 -8.6 -11.6 -8.6 -11.6 -12.1 -9.4 -3.2 -9.4 -8.6 -14.7 -8.6 -11.5 AG -8.4 -12.9 -20.3 -12.9 -12.1 -12.7 -12.1 -12.7 -15.6 -12.9 -19.2 -12.9 -12.1 -15.8 -12.1 -15.0 AU -4.9 -9.4 -16.8 -9.4 -8.6 -11.6 -8.6 -11.6 -12.1 -9.4 -3.2 -9.4 -8.6 -14.7 -8.6 -11.5 CA -5.8 -10.3 -17.7 -10.3 -9.4 -12.5 -9.4 -12.5 -12.9 -10.3 -4.0 -10.3 -9.4 -15.6 -9.4 -12.3 CC -8.0 -12.5 -17.5 -12.5 -11.6 -14.7 -11.6 -14.7 -12.7 -12.5 -6.2 -12.5 -11.6 -17.8 -11.6 -14.5 CG -5.8 -10.3 -17.7 -10.3 -9.4 -12.5 -9.4 -12.5 -12.9 -10.3 -4.0 -10.3 -9.4 -15.6 -9.4 -12.3 CU -11.1 -15.6 -20.6 -15.6 -14.7 -17.8 -14.7 -17.8 -15.8 -15.6 -9.3 -15.6 -14.7 -20.9 -14.7 -17.6 GA -13.2 -17.7 -25.1 -17.7 -16.8 -17.5 -16.8 -17.5 -20.3 -17.7 -23.9 -17.7 -16.8 -20.6 -16.8 -19.7 GC -4.9 -9.4 -16.8 -9.4 -8.6 -11.6 -8.6 -11.6 -12.1 -9.4 -3.2 -9.4 -8.6 -14.7 -8.6 -11.5 GG 0.5 -4.0 -23.9 -4.0 -3.2 -6.2 -3.2 -6.2 -19.2 -4.0 -22.8 -4.0 -3.2 -9.3 -3.2 -18.6 GU -4.9 -9.4 -16.8 -9.4 -8.6 -11.6 -8.6 -11.6 -12.1 -9.4 -3.2 -9.4 -8.6 -14.7 -8.6 -11.5 UA -5.8 -10.3 -17.7 -10.3 -9.4 -12.5 -9.4 -12.5 -12.9 -10.3 -4.0 -10.3 -9.4 -15.6 -9.4 -12.3 UC -8.0 -12.5 -17.5 -12.5 -11.6 -14.7 -11.6 -14.7 -12.7 -12.5 -6.2 -12.5 -11.6 -17.8 -11.6 -14.5 UG -5.8 -10.3 -17.7 -10.3 -9.4 -12.5 -9.4 -12.5 -12.9 -10.3 -4.0 -10.3 -9.4 -15.6 -9.4 -12.3 UU -5.4 -12.3 -19.7 -12.3 -11.5 -14.5 -11.5 -14.5 -15.0 -12.3 -18.6 -12.3 -11.5 -17.6 -11.5 -14.4 # 5' ------> 3' G X1 Y1 G C X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA -5.8 -6.0 -16.0 -6.0 -2.2 -10.7 -1.5 -2.0 -9.7 -6.0 -2.0 -6.0 -1.5 -0.9 -1.5 -14.9 AC -6.6 -9.7 -11.1 -9.7 -11.5 -7.5 -5.1 -5.7 0.1 -9.7 -3.2 -9.7 -5.1 -4.6 -5.1 -4.0 AG -13.4 -10.7 -18.8 -13.2 -8.6 -5.0 -8.6 -17.5 -24.5 -13.2 -10.8 -13.2 -8.6 -5.7 -8.6 -13.0 AU -6.6 -9.7 -8.7 -9.7 -5.1 -5.2 -5.1 -5.7 -11.6 -9.7 -3.2 -9.7 -5.1 -4.6 -5.1 -13.0 CA -7.4 -10.5 -3.5 -10.5 -6.0 -6.0 -6.0 -6.5 -1.0 -10.5 -4.4 -10.5 -6.0 -5.4 -6.0 -13.9 CC -9.6 -12.7 -9.4 -12.7 -8.2 -8.2 -8.2 -8.7 5.4 -12.7 -6.2 -12.7 -8.2 -7.6 -8.2 -16.1 CG -7.4 -10.5 -9.6 -10.5 -6.0 -6.0 -6.0 -6.5 -12.4 -10.5 -4.0 -10.5 -6.0 -5.4 -6.0 -13.9 CU -12.7 -15.8 -12.5 -15.8 -11.3 -11.3 -11.3 -11.8 -15.3 -15.8 -2.1 -15.8 -11.3 -10.7 -11.3 -19.2 GA -20.1 -17.9 -30.7 -17.9 -16.5 -6.3 -13.4 -11.5 -19.8 -17.9 -23.9 -17.9 -13.4 -10.4 -13.4 -15.2 GC -6.6 -9.7 -8.7 -9.7 -5.1 -5.2 -5.1 -5.7 -11.6 -9.7 -3.2 -9.7 -5.1 -4.6 -5.1 -13.0 GG 1.8 -4.3 -13.7 -4.3 -3.9 0.2 0.3 -8.8 -18.7 -4.3 -22.8 -4.3 0.3 1.8 0.3 -2.3 GU -6.6 -9.7 -8.7 -9.7 -5.1 -5.2 -5.1 -5.7 -11.6 -9.7 -3.2 -9.7 -5.1 -4.6 -5.1 -13.0 UA -7.4 -10.5 -9.6 -10.5 -6.0 -6.0 -6.0 -6.5 -12.4 -10.5 -4.0 -10.5 -6.0 -5.4 -6.0 -13.9 UC -9.6 -12.7 -9.4 -12.7 -8.2 -8.2 -8.2 -8.7 -12.2 -12.7 -2.6 -12.7 -8.2 -5.5 -8.2 -16.1 UG -7.4 -10.5 -9.6 -10.5 -6.0 -6.0 -6.0 -6.5 -12.4 -10.5 -4.0 -10.5 -6.0 -5.4 -6.0 -13.9 UU -12.4 -8.3 -13.6 -12.6 -0.9 -17.1 -8.0 -8.6 -8.1 -12.6 -15.5 -12.6 -8.0 -14.6 -8.0 -23.5 # 5' ------> 3' G X1 Y1 G C X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA -20.4 -4.9 -8.3 -4.9 -4.9 -4.9 -4.9 -4.9 -10.0 -4.9 7.6 -4.9 -4.9 -4.9 -4.9 -2.5 AC -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5 AG -6.9 -12.0 -15.4 -12.0 -12.0 -9.6 -12.0 -9.6 -17.1 -12.0 -12.0 -12.0 -12.0 -9.6 -12.0 -12.0 AU -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5 CA -4.3 -9.4 -12.8 -9.4 -9.4 -9.4 -9.4 -9.4 -14.5 -9.4 3.1 -9.4 -9.4 -9.4 -9.4 -9.4 CC -6.5 -11.6 -12.6 -11.6 -11.6 -11.6 -11.6 -11.6 -14.3 -11.6 0.9 -11.6 -11.6 -11.6 -11.6 -11.6 CG -4.3 -9.4 -12.8 -9.4 -9.4 -9.4 -9.4 -9.4 -14.5 -9.4 3.1 -9.4 -9.4 -9.4 -9.4 -9.4 CU -9.6 -14.7 -15.7 -14.7 -14.7 -14.7 -14.7 -14.7 -17.4 -14.7 -2.2 -14.7 -14.7 -14.7 -14.7 -14.7 GA -11.7 -16.8 -20.2 -16.8 -16.8 -14.4 -16.8 -14.4 -21.9 -16.8 -16.8 -16.8 -16.8 -14.4 -16.8 -16.8 GC -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5 GG 2.0 -3.1 -19.0 -3.1 -3.1 -3.1 -3.1 -3.1 -20.7 -3.1 -15.6 -3.1 -3.1 -3.1 -3.1 -15.6 GU -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5 UA -4.3 -9.4 -12.8 -9.4 -9.4 -9.4 -9.4 -9.4 -14.5 -9.4 3.1 -9.4 -9.4 -9.4 -9.4 -9.4 UC -6.5 -11.6 -12.6 -11.6 -11.6 -11.6 -11.6 -11.6 -14.3 -11.6 0.9 -11.6 -11.6 -11.6 -11.6 -11.6 UG -4.3 -9.4 -12.8 -9.4 -9.4 -9.4 -9.4 -9.4 -14.5 -9.4 3.1 -9.4 -9.4 -9.4 -9.4 -9.4 UU -3.9 -11.4 -14.8 -11.4 -11.4 -11.4 -11.4 -11.4 -16.5 -11.4 -11.4 -11.4 -11.4 -11.4 -11.4 -11.4 # 5' ------> 3' G X1 Y1 U C X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 6.0 2.9 -7.8 2.9 3.1 3.0 3.1 3.0 -6.0 2.9 11.4 2.9 3.1 3.0 3.1 -4.3 AC 2.4 -0.7 -11.5 -0.7 -0.5 -0.6 -0.5 -0.6 -9.7 -0.7 7.7 -0.7 -0.5 -0.6 -0.5 -10.4 AG -1.1 -4.2 -15.0 -4.2 -4.0 -1.7 -4.0 -1.7 -13.2 -4.2 -8.3 -4.2 -4.0 -1.7 -4.0 -13.9 AU 2.4 -0.7 -11.5 -0.7 -0.5 -0.6 -0.5 -0.6 -9.7 -0.7 7.7 -0.7 -0.5 -0.6 -0.5 -10.4 CA 1.5 -1.5 -12.3 -1.5 -1.4 -1.4 -1.4 -1.4 -10.5 -1.5 6.9 -1.5 -1.4 -1.4 -1.4 -11.2 CC -0.6 -3.7 -12.1 -3.7 -3.6 -3.6 -3.6 -3.6 -10.3 -3.7 4.7 -3.7 -3.6 -3.6 -3.6 -13.4 CG 1.5 -1.5 -12.3 -1.5 -1.4 -1.4 -1.4 -1.4 -10.5 -1.5 6.9 -1.5 -1.4 -1.4 -1.4 -11.2 CU -3.7 -6.8 -15.2 -6.8 -6.7 -6.7 -6.7 -6.7 -13.4 -6.8 1.6 -6.8 -6.7 -6.7 -6.7 -16.5 GA -5.8 -8.9 -19.7 -8.9 -8.8 -6.4 -8.8 -6.4 -17.9 -8.9 -13.0 -8.9 -8.8 -6.4 -8.8 -18.6 GC 2.4 -0.7 -11.5 -0.7 -0.5 -0.6 -0.5 -0.6 -9.7 -0.7 7.7 -0.7 -0.5 -0.6 -0.5 -10.4 GG 7.8 4.7 -18.6 4.7 4.9 4.8 4.9 4.8 -16.8 4.7 -11.9 4.7 4.9 4.8 4.9 -17.5 GU 2.4 -0.7 -11.5 -0.7 -0.5 -0.6 -0.5 -0.6 -9.7 -0.7 7.7 -0.7 -0.5 -0.6 -0.5 -10.4 UA 1.5 -1.5 -12.3 -1.5 -1.4 -1.4 -1.4 -1.4 -10.5 -1.5 6.9 -1.5 -1.4 -1.4 -1.4 -11.2 UC -0.6 -3.7 -12.1 -3.7 -3.6 -3.6 -3.6 -3.6 -10.3 -3.7 4.7 -3.7 -3.6 -3.6 -3.6 -13.4 UG 1.5 -1.5 -12.3 -1.5 -1.4 -1.4 -1.4 -1.4 -10.5 -1.5 6.9 -1.5 -1.4 -1.4 -1.4 -11.2 UU 1.9 -3.6 -14.4 -3.6 -3.4 -3.5 -3.4 -3.5 -12.6 -3.6 -7.7 -3.6 -3.4 -3.5 -3.4 -13.3 # 5' ------> 3' G X1 Y1 U C X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA -12.2 -10.4 -10.6 -10.4 -10.4 -10.4 -10.4 -10.4 -8.7 -10.4 2.1 -10.4 -10.4 -10.4 -10.4 -8.0 AC -15.9 -14.1 -14.2 -14.1 -14.1 -14.1 -14.1 -14.1 -12.3 -14.1 -1.6 -14.1 -14.1 -14.1 -14.1 -14.1 AG -19.4 -17.6 -17.7 -17.6 -17.6 -15.2 -17.6 -15.2 -15.8 -17.6 -17.6 -17.6 -17.6 -15.2 -17.6 -17.6 AU -15.9 -14.1 -14.2 -14.1 -14.1 -14.1 -14.1 -14.1 -12.3 -14.1 -1.6 -14.1 -14.1 -14.1 -14.1 -14.1 CA -16.7 -14.9 -15.1 -14.9 -14.9 -14.9 -14.9 -14.9 -13.2 -14.9 -2.4 -14.9 -14.9 -14.9 -14.9 -14.9 CC -18.9 -17.1 -14.9 -17.1 -17.1 -17.1 -17.1 -17.1 -13.0 -17.1 -4.6 -17.1 -17.1 -17.1 -17.1 -17.1 CG -16.7 -14.9 -15.1 -14.9 -14.9 -14.9 -14.9 -14.9 -13.2 -14.9 -2.4 -14.9 -14.9 -14.9 -14.9 -14.9 CU -22.0 -20.2 -18.0 -20.2 -20.2 -20.2 -20.2 -20.2 -16.1 -20.2 -7.7 -20.2 -20.2 -20.2 -20.2 -20.2 GA -24.1 -22.3 -22.5 -22.3 -22.3 -19.9 -22.3 -19.9 -20.6 -22.3 -22.3 -22.3 -22.3 -19.9 -22.3 -22.3 GC -15.9 -14.1 -14.2 -14.1 -14.1 -14.1 -14.1 -14.1 -12.3 -14.1 -1.6 -14.1 -14.1 -14.1 -14.1 -14.1 GG -10.5 -8.7 -21.3 -8.7 -8.7 -8.7 -8.7 -8.7 -19.4 -8.7 -21.2 -8.7 -8.7 -8.7 -8.7 -21.2 GU -15.9 -14.1 -14.2 -14.1 -14.1 -14.1 -14.1 -14.1 -12.3 -14.1 -1.6 -14.1 -14.1 -14.1 -14.1 -14.1 UA -16.7 -14.9 -15.1 -14.9 -14.9 -14.9 -14.9 -14.9 -13.2 -14.9 -2.4 -14.9 -14.9 -14.9 -14.9 -14.9 UC -18.9 -17.1 -14.9 -17.1 -17.1 -17.1 -17.1 -17.1 -13.0 -17.1 -4.6 -17.1 -17.1 -17.1 -17.1 -17.1 UG -16.7 -14.9 -15.1 -14.9 -14.9 -14.9 -14.9 -14.9 -13.2 -14.9 -2.4 -14.9 -14.9 -14.9 -14.9 -14.9 UU -16.4 -17.0 -17.1 -17.0 -17.0 -17.0 -17.0 -17.0 -15.2 -17.0 -17.0 -17.0 -17.0 -17.0 -17.0 -17.0 # 5' ------> 3' G X1 Y1 A U X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA -4.2 -7.0 -18.3 -7.0 -5.5 -5.5 -5.5 -6.8 -21.3 -7.0 2.3 -7.0 -5.5 -9.9 -5.5 -12.5 AC -2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5 -5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1 AG -0.7 -3.5 -14.7 -3.5 -2.0 0.4 -2.0 -0.9 -17.7 -3.5 -6.7 -3.5 -2.0 -4.0 -2.0 -11.4 AU -2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5 -5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1 CA -2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5 -5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1 CC -2.4 -5.2 -14.1 -5.2 -3.7 -3.7 -3.7 -5.0 -17.1 -5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1 CG -2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5 -5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1 CU -2.4 -5.2 -14.1 -5.2 -3.7 -3.7 -3.7 -5.0 -17.1 -5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1 GA -2.6 -5.4 -16.6 -5.4 -3.9 -1.5 -3.9 -2.8 -19.6 -5.4 -8.6 -5.4 -3.9 -5.9 -3.9 -13.3 GC -2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5 -5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1 GG 10.1 7.3 -16.5 7.3 8.8 8.8 8.8 7.5 -19.5 7.3 -8.4 7.3 8.8 4.4 8.8 -13.1 GU -2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5 -5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1 UA -2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5 -5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1 UC -2.4 -5.2 -14.1 -5.2 -3.7 -3.7 -3.7 -5.0 -17.1 -5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1 UG -2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5 -5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1 UU 0.0 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5 -5.2 -8.4 -5.2 -3.7 -8.1 -3.7 -13.1 # 5' ------> 3' G X1 Y1 C U X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA -12.2 -16.7 -24.1 -16.7 -15.9 -18.9 -15.9 -18.9 -19.4 -16.7 -10.5 -16.7 -15.9 -22.0 -15.9 -16.4 AC -10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1 -17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0 AG -8.7 -13.2 -20.6 -13.2 -12.3 -13.0 -12.3 -13.0 -15.8 -13.2 -19.4 -13.2 -12.3 -16.1 -12.3 -15.2 AU -10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1 -17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0 CA -10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1 -17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0 CC -10.4 -14.9 -19.9 -14.9 -14.1 -17.1 -14.1 -17.1 -15.2 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0 CG -10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1 -17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0 CU -10.4 -14.9 -19.9 -14.9 -14.1 -17.1 -14.1 -17.1 -15.2 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0 GA -10.6 -15.1 -22.5 -15.1 -14.2 -14.9 -14.2 -14.9 -17.7 -15.1 -21.3 -15.1 -14.2 -18.0 -14.2 -17.1 GC -10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1 -17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0 GG 2.1 -2.4 -22.3 -2.4 -1.6 -4.6 -1.6 -4.6 -17.6 -2.4 -21.2 -2.4 -1.6 -7.7 -1.6 -17.0 GU -10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1 -17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0 UA -10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1 -17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0 UC -10.4 -14.9 -19.9 -14.9 -14.1 -17.1 -14.1 -17.1 -15.2 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0 UG -10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1 -17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0 UU -8.0 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1 -17.1 -17.6 -14.9 -21.2 -14.9 -14.1 -20.2 -14.1 -17.0 # 5' ------> 3' G X1 Y1 G U X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA -13.7 -17.0 -16.0 -17.0 -12.4 -12.5 -12.4 -13.0 -18.9 -17.0 -10.5 -17.0 -12.4 -11.9 -12.4 -17.9 AC -12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6 -11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5 AG -10.3 -13.4 -12.5 -13.4 -8.9 -6.5 -8.9 -7.0 -15.3 -13.4 -19.4 -13.4 -8.9 -5.9 -8.9 -16.8 AU -12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6 -11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5 CA -12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6 -11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5 CC -12.1 -15.2 -11.8 -15.2 -10.6 -10.7 -10.6 -11.2 -14.7 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5 CG -12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6 -11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5 CU -12.1 -15.2 -11.8 -15.2 -10.6 -10.7 -10.6 -11.2 -14.7 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5 GA -12.2 -15.3 -14.4 -15.3 -10.8 -8.4 -10.8 -8.9 -17.2 -15.3 -21.3 -15.3 -10.8 -7.8 -10.8 -18.7 GC -12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6 -11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5 GG 0.4 -2.7 -14.2 -2.7 1.9 1.8 1.9 1.3 -17.1 -2.7 -21.2 -2.7 1.9 2.4 1.9 -18.5 GU -12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6 -11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5 UA -12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6 -11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5 UC -12.1 -15.2 -11.8 -15.2 -10.6 -10.7 -10.6 -11.2 -14.7 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5 UG -12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6 -11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5 UU -9.7 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6 -11.2 -17.1 -15.2 -21.2 -15.2 -10.6 -10.1 -10.6 -18.5 # 5' ------> 3' G X1 Y1 G U X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA -0.7 -15.8 -16.0 -15.8 -15.8 -15.8 -15.8 -15.8 -20.9 -15.8 -3.3 -15.8 -15.8 -15.8 -15.8 -13.4 AC -8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0 -19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0 AG -0.3 -12.3 -15.7 -12.3 -12.3 -9.9 -12.3 -9.9 -17.4 -12.3 -12.3 -12.3 -12.3 -9.9 -12.3 -12.3 AU -8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0 -19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0 CA -8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0 -19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0 CC -8.9 -14.0 -15.0 -14.0 -14.0 -14.0 -14.0 -14.0 -16.7 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0 CG -8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0 -19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0 CU -8.9 -14.0 -15.0 -14.0 -14.0 -14.0 -14.0 -14.0 -16.7 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0 GA -9.1 -14.2 -30.4 -14.2 -14.2 -11.8 -14.2 -11.8 -19.3 -14.2 -14.2 -14.2 -14.2 -11.8 -14.2 -14.2 GC -8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0 -19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0 GG 3.6 -1.5 -17.4 -1.5 -1.5 -1.5 -1.5 -1.5 -19.1 -1.5 -14.0 -1.5 -1.5 -1.5 -1.5 -14.0 GU -8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0 -19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0 UA -8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0 -19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0 UC -8.9 -14.0 -15.0 -14.0 -14.0 -14.0 -14.0 -14.0 -16.7 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0 UG -8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0 -19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0 UU -6.5 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0 -19.1 -14.0 -14.0 -14.0 -14.0 -14.0 -14.0 -14.0 # 5' ------> 3' G X1 Y1 U U X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA -4.9 -8.0 -18.8 -8.0 -7.8 -7.9 -7.8 -7.9 -17.0 -8.0 0.4 -8.0 -7.8 -7.9 -7.8 -15.3 AC -3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2 -6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9 AG -1.3 -4.4 -15.2 -4.4 -4.3 -1.9 -4.3 -1.9 -13.4 -4.4 -8.5 -4.4 -4.3 -1.9 -4.3 -14.1 AU -3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2 -6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9 CA -3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2 -6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9 CC -3.1 -6.2 -14.6 -6.2 -6.0 -6.1 -6.0 -6.1 -12.8 -6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9 CG -3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2 -6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9 CU -3.1 -6.2 -14.6 -6.2 -6.0 -6.1 -6.0 -6.1 -12.8 -6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9 GA -3.2 -6.3 -17.1 -6.3 -6.2 -3.8 -6.2 -3.8 -15.3 -6.3 -10.4 -6.3 -6.2 -3.8 -6.2 -16.0 GC -3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2 -6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9 GG 9.4 6.3 -17.0 6.3 6.5 6.4 6.5 6.4 -15.2 6.3 -10.3 6.3 6.5 6.4 6.5 -15.9 GU -3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2 -6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9 UA -3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2 -6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9 UC -3.1 -6.2 -14.6 -6.2 -6.0 -6.1 -6.0 -6.1 -12.8 -6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9 UG -3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2 -6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9 UU -0.7 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2 -6.2 -10.3 -6.2 -6.0 -6.1 -6.0 -15.9 # 5' ------> 3' G X1 Y1 U U X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA -23.2 -21.4 -21.5 -21.4 -21.4 -21.4 -21.4 -21.4 -19.6 -21.4 -8.9 -21.4 -21.4 -21.4 -21.4 -19.0 AC -21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6 -19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6 AG -19.6 -17.8 -18.0 -17.8 -17.8 -15.4 -17.8 -15.4 -16.1 -17.8 -17.8 -17.8 -17.8 -15.4 -17.8 -17.8 AU -21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6 -19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6 CA -21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6 -19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6 CC -21.4 -19.6 -17.3 -19.6 -19.6 -19.6 -19.6 -19.6 -15.4 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6 CG -21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6 -19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6 CU -21.4 -19.6 -17.3 -19.6 -19.6 -19.6 -19.6 -19.6 -15.4 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6 GA -21.5 -19.7 -19.9 -19.7 -19.7 -17.3 -19.7 -17.3 -18.0 -19.7 -19.7 -19.7 -19.7 -17.3 -19.7 -19.7 GC -21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6 -19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6 GG -8.9 -7.1 -19.7 -7.1 -7.1 -7.1 -7.1 -7.1 -17.8 -7.1 -19.6 -7.1 -7.1 -7.1 -7.1 -19.6 GU -21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6 -19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6 UA -21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6 -19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6 UC -21.4 -19.6 -17.3 -19.6 -19.6 -19.6 -19.6 -19.6 -15.4 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6 UG -21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6 -19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6 UU -19.0 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6 -19.6 -17.8 -19.6 -19.6 -19.6 -19.6 -19.6 -19.6 -19.6 # 5' ------> 3' U X1 Y1 A A X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 14.7 11.9 0.6 11.9 13.4 13.4 13.4 12.1 -2.3 11.9 21.2 11.9 13.4 9.0 13.4 6.4 AC 13.4 10.6 -0.6 10.6 12.1 12.1 12.1 10.8 -3.6 10.6 19.9 10.6 12.1 7.7 12.1 2.7 AG -2.3 -5.1 -16.4 -5.1 -3.6 -1.2 -3.6 -2.5 -19.4 -5.1 -8.3 -5.1 -3.6 -5.6 -3.6 -13.0 AU 13.4 10.6 -0.6 10.6 12.1 12.1 12.1 10.8 -3.6 10.6 19.9 10.6 12.1 7.7 12.1 2.7 CA 11.9 9.1 -2.1 9.1 10.6 10.6 10.6 9.3 -5.1 9.1 18.4 9.1 10.6 6.2 10.6 1.2 CC 13.4 10.6 1.8 10.6 12.1 12.1 12.1 10.8 -1.2 10.6 19.9 10.6 12.1 7.7 12.1 2.7 CG 11.9 9.1 -2.1 9.1 10.6 10.6 10.6 9.3 -5.1 9.1 18.4 9.1 10.6 6.2 10.6 1.2 CU 9.0 6.2 -2.6 6.2 7.7 7.7 7.7 6.4 -5.6 6.2 15.5 6.2 7.7 3.3 7.7 -1.7 GA 0.6 -2.1 -13.4 -2.1 -0.6 1.8 -0.6 0.5 -16.4 -2.1 -5.3 -2.1 -0.6 -2.6 -0.6 -10.0 GC 13.4 10.6 -0.6 10.6 12.1 12.1 12.1 10.8 -3.6 10.6 19.9 10.6 12.1 7.7 12.1 2.7 GG 21.2 18.4 -5.3 18.4 19.9 19.9 19.9 18.6 -8.3 18.4 2.7 18.4 19.9 15.5 19.9 -2.0 GU 13.4 10.6 -0.6 10.6 12.1 12.1 12.1 10.8 -3.6 10.6 19.9 10.6 12.1 7.7 12.1 2.7 UA 11.9 9.1 -2.1 9.1 10.6 10.6 10.6 9.3 -5.1 9.1 18.4 9.1 10.6 6.2 10.6 1.2 UC 12.1 9.3 0.5 9.3 10.8 10.8 10.8 9.5 -2.5 9.3 18.6 9.3 10.8 6.4 10.8 1.4 UG 11.9 9.1 -2.1 9.1 10.6 10.6 10.6 9.3 -5.1 9.1 18.4 9.1 10.6 6.2 10.6 1.2 UU 6.4 1.2 -10.0 1.2 2.7 2.7 2.7 1.4 -13.0 1.2 -2.0 1.2 2.7 -1.7 2.7 -6.7 # 5' ------> 3' U X1 Y1 C A X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 6.7 2.2 -5.2 2.2 3.0 0.0 3.0 0.0 -0.4 2.2 8.5 2.2 3.0 -3.1 3.0 2.5 AC 5.4 0.9 -6.5 0.9 1.7 -1.3 1.7 -1.3 -1.7 0.9 7.2 0.9 1.7 -4.4 1.7 -1.1 AG -10.3 -14.8 -22.2 -14.8 -14.0 -14.6 -14.0 -14.6 -17.5 -14.8 -21.1 -14.8 -14.0 -17.7 -14.0 -16.9 AU 5.4 0.9 -6.5 0.9 1.7 -1.3 1.7 -1.3 -1.7 0.9 7.2 0.9 1.7 -4.4 1.7 -1.1 CA 3.9 -0.6 -8.0 -0.6 0.2 -2.8 0.2 -2.8 -3.2 -0.6 5.7 -0.6 0.2 -5.9 0.2 -2.6 CC 5.4 0.9 -4.1 0.9 1.7 -1.3 1.7 -1.3 0.7 0.9 7.2 0.9 1.7 -4.4 1.7 -1.1 CG 3.9 -0.6 -8.0 -0.6 0.2 -2.8 0.2 -2.8 -3.2 -0.6 5.7 -0.6 0.2 -5.9 0.2 -2.6 CU 1.0 -3.5 -8.5 -3.5 -2.6 -5.7 -2.6 -5.7 -3.7 -3.5 2.8 -3.5 -2.6 -8.8 -2.6 -5.5 GA -7.3 -11.8 -19.2 -11.8 -11.0 -11.6 -11.0 -11.6 -14.5 -11.8 -18.1 -11.8 -11.0 -14.7 -11.0 -13.9 GC 5.4 0.9 -6.5 0.9 1.7 -1.3 1.7 -1.3 -1.7 0.9 7.2 0.9 1.7 -4.4 1.7 -1.1 GG 13.2 8.7 -11.2 8.7 9.6 6.5 9.6 6.5 -6.4 8.7 -10.0 8.7 9.6 3.4 9.6 -5.8 GU 5.4 0.9 -6.5 0.9 1.7 -1.3 1.7 -1.3 -1.7 0.9 7.2 0.9 1.7 -4.4 1.7 -1.1 UA 3.9 -0.6 -8.0 -0.6 0.2 -2.8 0.2 -2.8 -3.2 -0.6 5.7 -0.6 0.2 -5.9 0.2 -2.6 UC 4.1 -0.4 -5.4 -0.4 0.4 -2.6 0.4 -2.6 -0.6 -0.4 5.9 -0.4 0.4 -5.7 0.4 -2.4 UG 3.9 -0.6 -8.0 -0.6 0.2 -2.8 0.2 -2.8 -3.2 -0.6 5.7 -0.6 0.2 -5.9 0.2 -2.6 UU -1.6 -8.5 -15.9 -8.5 -7.6 -10.7 -7.6 -10.7 -11.1 -8.5 -14.7 -8.5 -7.6 -13.8 -7.6 -10.5 # 5' ------> 3' U X1 Y1 G A X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 5.0 1.9 2.9 1.9 6.5 6.4 6.5 5.9 0.0 1.9 8.5 1.9 6.5 7.0 6.5 1.0 AC 3.7 0.6 1.6 0.6 5.2 5.1 5.2 4.6 -1.2 0.6 7.2 0.6 5.2 5.7 5.2 -2.7 AG -12.0 -15.1 -14.1 -15.1 -10.5 -8.2 -10.5 -8.7 -17.0 -15.1 -21.1 -15.1 -10.5 -7.6 -10.5 -18.4 AU 3.7 0.6 1.6 0.6 5.2 5.1 5.2 4.6 -1.2 0.6 7.2 0.6 5.2 5.7 5.2 -2.7 CA 2.2 -0.8 0.1 -0.8 3.7 3.6 3.7 3.1 -2.7 -0.8 5.7 -0.8 3.7 4.2 3.7 -4.2 CC 3.7 0.6 4.0 0.6 5.2 5.1 5.2 4.6 1.2 0.6 7.2 0.6 5.2 5.7 5.2 -2.7 CG 2.2 -0.8 0.1 -0.8 3.7 3.6 3.7 3.1 -2.7 -0.8 5.7 -0.8 3.7 4.2 3.7 -4.2 CU -0.6 -3.7 -0.4 -3.7 0.8 0.7 0.8 0.2 -3.2 -3.7 2.8 -3.7 0.8 1.3 0.8 -7.1 GA -9.0 -12.1 -11.1 -12.1 -7.5 -5.2 -7.5 -5.7 -14.0 -12.1 -18.1 -12.1 -7.5 -4.6 -7.5 -15.4 GC 3.7 0.6 1.6 0.6 5.2 5.1 5.2 4.6 -1.2 0.6 7.2 0.6 5.2 5.7 5.2 -2.7 GG 11.6 8.5 -3.1 8.5 13.0 12.9 13.0 12.5 -5.9 8.5 -10.0 8.5 13.0 13.5 13.0 -7.4 GU 3.7 0.6 1.6 0.6 5.2 5.1 5.2 4.6 -1.2 0.6 7.2 0.6 5.2 5.7 5.2 -2.7 UA 2.2 -0.8 0.1 -0.8 3.7 3.6 3.7 3.1 -2.7 -0.8 5.7 -0.8 3.7 4.2 3.7 -4.2 UC 2.4 -0.6 2.7 -0.6 3.9 3.8 3.9 3.3 -0.1 -0.6 5.9 -0.6 3.9 4.4 3.9 -4.0 UG 2.2 -0.8 0.1 -0.8 3.7 3.6 3.7 3.1 -2.7 -0.8 5.7 -0.8 3.7 4.2 3.7 -4.2 UU -3.2 -8.7 -7.8 -8.7 -4.2 -4.2 -4.2 -4.7 -10.6 -8.7 -14.7 -8.7 -4.2 -3.6 -4.2 -12.1 # 5' ------> 3' U X1 Y1 G A X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 8.2 3.1 -0.3 3.1 3.1 3.1 3.1 3.1 -2.0 3.1 15.6 3.1 3.1 3.1 3.1 5.5 AC 6.9 1.8 -1.6 1.8 1.8 1.8 1.8 1.8 -3.3 1.8 14.3 1.8 1.8 1.8 1.8 1.8 AG -8.8 -13.9 -17.3 -13.9 -13.9 -11.5 -13.9 -11.5 -19.0 -13.9 -13.9 -13.9 -13.9 -11.5 -13.9 -13.9 AU 6.9 1.8 -1.6 1.8 1.8 1.8 1.8 1.8 -3.3 1.8 14.3 1.8 1.8 1.8 1.8 1.8 CA 5.4 0.3 -3.1 0.3 0.3 0.3 0.3 0.3 -4.8 0.3 12.8 0.3 0.3 0.3 0.3 0.3 CC 6.9 1.8 0.8 1.8 1.8 1.8 1.8 1.8 -0.9 1.8 14.3 1.8 1.8 1.8 1.8 1.8 CG 5.4 0.3 -3.1 0.3 0.3 0.3 0.3 0.3 -4.8 0.3 12.8 0.3 0.3 0.3 0.3 0.3 CU 2.5 -2.6 -3.6 -2.6 -2.6 -2.6 -2.6 -2.6 -5.3 -2.6 9.9 -2.6 -2.6 -2.6 -2.6 -2.6 GA -5.8 -10.9 -14.3 -10.9 -10.9 -8.5 -10.9 -8.5 -16.0 -10.9 -10.9 -10.9 -10.9 -8.5 -10.9 -10.9 GC 6.9 1.8 -1.6 1.8 1.8 1.8 1.8 1.8 -3.3 1.8 14.3 1.8 1.8 1.8 1.8 1.8 GG 14.7 9.6 -6.3 9.6 9.6 9.6 9.6 9.6 -8.0 9.6 -2.9 9.6 9.6 9.6 9.6 -2.9 GU 6.9 1.8 -1.6 1.8 1.8 1.8 1.8 1.8 -3.3 1.8 14.3 1.8 1.8 1.8 1.8 1.8 UA 5.4 0.3 -3.1 0.3 0.3 0.3 0.3 0.3 -4.8 0.3 12.8 0.3 0.3 0.3 0.3 0.3 UC 5.6 0.5 -0.5 0.5 0.5 0.5 0.5 0.5 -2.2 0.5 13.0 0.5 0.5 0.5 0.5 0.5 UG 5.4 0.3 -3.1 0.3 0.3 0.3 0.3 0.3 -4.8 0.3 12.8 0.3 0.3 0.3 0.3 0.3 UU -0.1 -7.6 -11.0 -7.6 -7.6 -7.6 -7.6 -7.6 -12.7 -7.6 -7.6 -7.6 -7.6 -7.6 -7.6 -7.6 # 5' ------> 3' U X1 Y1 U A X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 14.0 10.9 0.1 10.9 11.1 11.0 11.1 11.0 1.9 10.9 19.3 10.9 11.1 11.0 11.1 3.6 AC 12.7 9.6 -1.1 9.6 9.8 9.7 9.8 9.7 0.6 9.6 18.0 9.6 9.8 9.7 9.8 0.0 AG -3.0 -6.1 -16.9 -6.1 -5.9 -3.6 -5.9 -3.6 -15.1 -6.1 -10.2 -6.1 -5.9 -3.6 -5.9 -15.8 AU 12.7 9.6 -1.1 9.6 9.8 9.7 9.8 9.7 0.6 9.6 18.0 9.6 9.8 9.7 9.8 0.0 CA 11.2 8.1 -2.6 8.1 8.3 8.2 8.3 8.2 -0.8 8.1 16.5 8.1 8.3 8.2 8.3 -1.5 CC 12.7 9.6 1.3 9.6 9.8 9.7 9.8 9.7 3.0 9.6 18.0 9.6 9.8 9.7 9.8 0.0 CG 11.2 8.1 -2.6 8.1 8.3 8.2 8.3 8.2 -0.8 8.1 16.5 8.1 8.3 8.2 8.3 -1.5 CU 8.3 5.2 -3.1 5.2 5.4 5.3 5.4 5.3 -1.3 5.2 13.6 5.2 5.4 5.3 5.4 -4.4 GA 0.0 -3.1 -13.9 -3.1 -2.9 -0.6 -2.9 -0.6 -12.1 -3.1 -7.2 -3.1 -2.9 -0.6 -2.9 -12.8 GC 12.7 9.6 -1.1 9.6 9.8 9.7 9.8 9.7 0.6 9.6 18.0 9.6 9.8 9.7 9.8 0.0 GG 20.5 17.4 -5.8 17.4 17.6 17.5 17.6 17.5 -4.0 17.4 0.8 17.4 17.6 17.5 17.6 -4.7 GU 12.7 9.6 -1.1 9.6 9.8 9.7 9.8 9.7 0.6 9.6 18.0 9.6 9.8 9.7 9.8 0.0 UA 11.2 8.1 -2.6 8.1 8.3 8.2 8.3 8.2 -0.8 8.1 16.5 8.1 8.3 8.2 8.3 -1.5 UC 11.4 8.3 0.0 8.3 8.5 8.4 8.5 8.4 1.8 8.3 16.7 8.3 8.5 8.4 8.5 -1.3 UG 11.2 8.1 -2.6 8.1 8.3 8.2 8.3 8.2 -0.8 8.1 16.5 8.1 8.3 8.2 8.3 -1.5 UU 5.7 0.2 -10.5 0.2 0.4 0.3 0.4 0.3 -8.7 0.2 -3.8 0.2 0.4 0.3 0.4 -9.4 # 5' ------> 3' U X1 Y1 U A X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA -4.2 -2.4 -2.6 -2.4 -2.4 -2.4 -2.4 -2.4 -0.7 -2.4 10.1 -2.4 -2.4 -2.4 -2.4 0.0 AC -5.5 -3.7 -3.9 -3.7 -3.7 -3.7 -3.7 -3.7 -2.0 -3.7 8.8 -3.7 -3.7 -3.7 -3.7 -3.7 AG -21.3 -19.5 -19.6 -19.5 -19.5 -17.1 -19.5 -17.1 -17.7 -19.5 -19.5 -19.5 -19.5 -17.1 -19.5 -19.5 AU -5.5 -3.7 -3.9 -3.7 -3.7 -3.7 -3.7 -3.7 -2.0 -3.7 8.8 -3.7 -3.7 -3.7 -3.7 -3.7 CA -7.0 -5.2 -5.4 -5.2 -5.2 -5.2 -5.2 -5.2 -3.5 -5.2 7.3 -5.2 -5.2 -5.2 -5.2 -5.2 CC -5.5 -3.7 -1.5 -3.7 -3.7 -3.7 -3.7 -3.7 0.4 -3.7 8.8 -3.7 -3.7 -3.7 -3.7 -3.7 CG -7.0 -5.2 -5.4 -5.2 -5.2 -5.2 -5.2 -5.2 -3.5 -5.2 7.3 -5.2 -5.2 -5.2 -5.2 -5.2 CU -9.9 -8.1 -5.9 -8.1 -8.1 -8.1 -8.1 -8.1 -4.0 -8.1 4.4 -8.1 -8.1 -8.1 -8.1 -8.1 GA -18.3 -16.5 -16.6 -16.5 -16.5 -14.1 -16.5 -14.1 -14.7 -16.5 -16.5 -16.5 -16.5 -14.1 -16.5 -16.5 GC -5.5 -3.7 -3.9 -3.7 -3.7 -3.7 -3.7 -3.7 -2.0 -3.7 8.8 -3.7 -3.7 -3.7 -3.7 -3.7 GG 2.3 4.1 -8.6 4.1 4.1 4.1 4.1 4.1 -6.7 4.1 -8.4 4.1 4.1 4.1 4.1 -8.4 GU -5.5 -3.7 -3.9 -3.7 -3.7 -3.7 -3.7 -3.7 -2.0 -3.7 8.8 -3.7 -3.7 -3.7 -3.7 -3.7 UA -7.0 -5.2 -5.4 -5.2 -5.2 -5.2 -5.2 -5.2 -3.5 -5.2 7.3 -5.2 -5.2 -5.2 -5.2 -5.2 UC -6.8 -5.0 -2.8 -5.0 -5.0 -5.0 -5.0 -5.0 -0.9 -5.0 7.5 -5.0 -5.0 -5.0 -5.0 -5.0 UG -7.0 -5.2 -5.4 -5.2 -5.2 -5.2 -5.2 -5.2 -3.5 -5.2 7.3 -5.2 -5.2 -5.2 -5.2 -5.2 UU -12.5 -13.1 -13.3 -13.1 -13.1 -13.1 -13.1 -13.1 -11.4 -13.1 -13.1 -13.1 -13.1 -13.1 -13.1 -13.1 # 5' ------> 3' U X1 Y1 A G X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 8.2 5.4 -5.8 5.4 6.9 6.9 6.9 5.6 -8.8 5.4 14.7 5.4 6.9 2.5 6.9 -0.1 AC 3.1 0.3 -10.9 0.3 1.8 1.8 1.8 0.5 -13.9 0.3 9.6 0.3 1.8 -2.6 1.8 -7.6 AG -2.0 -4.8 -16.0 -4.8 -3.3 -0.9 -3.3 -2.2 -19.0 -4.8 -8.0 -4.8 -3.3 -5.3 -3.3 -12.7 AU 3.1 0.3 -10.9 0.3 1.8 1.8 1.8 0.5 -13.9 0.3 9.6 0.3 1.8 -2.6 1.8 -7.6 CA 3.1 0.3 -10.9 0.3 1.8 1.8 1.8 0.5 -13.9 0.3 9.6 0.3 1.8 -2.6 1.8 -7.6 CC 3.1 0.3 -8.5 0.3 1.8 1.8 1.8 0.5 -11.5 0.3 9.6 0.3 1.8 -2.6 1.8 -7.6 CG 3.1 0.3 -10.9 0.3 1.8 1.8 1.8 0.5 -13.9 0.3 9.6 0.3 1.8 -2.6 1.8 -7.6 CU 3.1 0.3 -8.5 0.3 1.8 1.8 1.8 0.5 -11.5 0.3 9.6 0.3 1.8 -2.6 1.8 -7.6 GA -0.3 -3.1 -14.3 -3.1 -1.6 0.8 -1.6 -0.5 -17.3 -3.1 -6.3 -3.1 -1.6 -3.6 -1.6 -11.0 GC 3.1 0.3 -10.9 0.3 1.8 1.8 1.8 0.5 -13.9 0.3 9.6 0.3 1.8 -2.6 1.8 -7.6 GG 15.6 12.8 -10.9 12.8 14.3 14.3 14.3 13.0 -13.9 12.8 -2.9 12.8 14.3 9.9 14.3 -7.6 GU 3.1 0.3 -10.9 0.3 1.8 1.8 1.8 0.5 -13.9 0.3 9.6 0.3 1.8 -2.6 1.8 -7.6 UA 3.1 0.3 -10.9 0.3 1.8 1.8 1.8 0.5 -13.9 0.3 9.6 0.3 1.8 -2.6 1.8 -7.6 UC 3.1 0.3 -8.5 0.3 1.8 1.8 1.8 0.5 -11.5 0.3 9.6 0.3 1.8 -2.6 1.8 -7.6 UG 3.1 0.3 -10.9 0.3 1.8 1.8 1.8 0.5 -13.9 0.3 9.6 0.3 1.8 -2.6 1.8 -7.6 UU 5.5 0.3 -10.9 0.3 1.8 1.8 1.8 0.5 -13.9 0.3 -2.9 0.3 1.8 -2.6 1.8 -7.6 # 5' ------> 3' U X1 Y1 C G X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA -20.4 -4.3 -11.7 -4.3 -3.4 -6.5 -3.4 -6.5 -6.9 -4.3 2.0 -4.3 -3.4 -9.6 -3.4 -3.9 AC -4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6 -12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4 AG -10.0 -14.5 -21.9 -14.5 -13.6 -14.3 -13.6 -14.3 -17.1 -14.5 -20.7 -14.5 -13.6 -17.4 -13.6 -16.5 AU -4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6 -12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4 CA -4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6 -12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4 CC -4.9 -9.4 -14.4 -9.4 -8.5 -11.6 -8.5 -11.6 -9.6 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4 CG -4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6 -12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4 CU -4.9 -9.4 -14.4 -9.4 -8.5 -11.6 -8.5 -11.6 -9.6 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4 GA -8.3 -12.8 -20.2 -12.8 -11.9 -12.6 -11.9 -12.6 -15.4 -12.8 -19.0 -12.8 -11.9 -15.7 -11.9 -14.8 GC -4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6 -12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4 GG 7.6 3.1 -16.8 3.1 4.0 0.9 4.0 0.9 -12.0 3.1 -15.6 3.1 4.0 -2.2 4.0 -11.4 GU -4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6 -12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4 UA -4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6 -12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4 UC -4.9 -9.4 -14.4 -9.4 -8.5 -11.6 -8.5 -11.6 -9.6 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4 UG -4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6 -12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4 UU -2.5 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6 -12.0 -9.4 -15.6 -9.4 -8.5 -14.7 -8.5 -11.4 # 5' ------> 3' U X1 Y1 G G X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA -1.4 -4.5 -3.6 -4.5 0.0 0.0 0.0 -0.5 -6.4 -4.5 2.0 -4.5 0.0 0.5 0.0 -5.5 AC -6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5 -9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0 AG -11.6 -14.7 -13.8 -14.7 -10.2 -7.8 -10.2 -8.3 -16.6 -14.7 -20.7 -14.7 -10.2 -7.2 -10.2 -18.1 AU -6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5 -9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0 CA -6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5 -9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0 CC -6.5 -9.6 -6.3 -9.6 -5.1 -5.1 -5.1 -5.6 -9.1 -9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0 CG -6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5 -9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0 CU -6.5 -9.6 -6.3 -9.6 -5.1 -5.1 -5.1 -5.6 -9.1 -9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0 GA -9.9 -13.0 -12.1 -13.0 -8.5 -6.1 -8.5 -6.6 -14.9 -13.0 -19.0 -13.0 -8.5 -5.5 -8.5 -16.4 GC -6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5 -9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0 GG 6.0 2.9 -8.7 2.9 7.4 7.4 7.4 6.9 -11.5 2.9 -15.6 2.9 7.4 8.0 7.4 -13.0 GU -6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5 -9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0 UA -6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5 -9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0 UC -6.5 -9.6 -6.3 -9.6 -5.1 -5.1 -5.1 -5.6 -9.1 -9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0 UG -6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5 -9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0 UU -4.1 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5 -9.6 -15.6 -9.6 -5.1 -4.5 -5.1 -13.0 # 5' ------> 3' U X1 Y1 G G X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 1.7 -3.4 -6.8 -3.4 -3.4 -3.4 -3.4 -3.4 -8.5 -3.4 9.1 -3.4 -3.4 -3.4 -3.4 -1.0 AC -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5 AG -8.5 -13.6 -17.0 -13.6 -13.6 -11.2 -13.6 -11.2 -18.7 -13.6 -13.6 -13.6 -13.6 -11.2 -13.6 -13.6 AU -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5 CA -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5 CC -3.4 -8.5 -9.5 -8.5 -8.5 -8.5 -8.5 -8.5 -11.2 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5 CG -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5 CU -3.4 -8.5 -9.5 -8.5 -8.5 -8.5 -8.5 -8.5 -11.2 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5 GA -6.8 -11.9 -15.3 -11.9 -11.9 -9.5 -11.9 -9.5 -17.0 -11.9 -11.9 -11.9 -11.9 -9.5 -11.9 -11.9 GC -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5 GG 9.1 4.0 -11.9 4.0 4.0 4.0 4.0 4.0 -13.6 4.0 -8.5 4.0 4.0 4.0 4.0 -8.5 GU -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5 UA -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5 UC -3.4 -8.5 -9.5 -8.5 -8.5 -8.5 -8.5 -8.5 -11.2 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5 UG -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5 UU -1.0 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 -8.5 -8.5 -8.5 -8.5 -8.5 -8.5 # 5' ------> 3' U X1 Y1 U G X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 7.5 4.4 -6.3 4.4 4.6 4.5 4.6 4.5 -4.5 4.4 12.8 4.4 4.6 4.5 4.6 -2.8 AC 2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6 -0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3 AG -2.6 -5.7 -16.5 -5.7 -5.6 -3.2 -5.6 -3.2 -14.7 -5.7 -9.8 -5.7 -5.6 -3.2 -5.6 -15.4 AU 2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6 -0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3 CA 2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6 -0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3 CC 2.4 -0.6 -9.0 -0.6 -0.5 -0.5 -0.5 -0.5 -7.2 -0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3 CG 2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6 -0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3 CU 2.4 -0.6 -9.0 -0.6 -0.5 -0.5 -0.5 -0.5 -7.2 -0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3 GA -0.9 -4.0 -14.8 -4.0 -3.9 -1.5 -3.9 -1.5 -13.0 -4.0 -8.1 -4.0 -3.9 -1.5 -3.9 -13.7 GC 2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6 -0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3 GG 14.9 11.9 -11.4 11.9 12.0 12.0 12.0 12.0 -9.6 11.9 -4.7 11.9 12.0 12.0 12.0 -10.3 GU 2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6 -0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3 UA 2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6 -0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3 UC 2.4 -0.6 -9.0 -0.6 -0.5 -0.5 -0.5 -0.5 -7.2 -0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3 UG 2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6 -0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3 UU 4.8 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6 -0.6 -4.7 -0.6 -0.5 -0.5 -0.5 -10.3 # 5' ------> 3' U X1 Y1 U G X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA -0.7 -8.9 -9.1 -8.9 -8.9 -8.9 -8.9 -8.9 -0.3 -8.9 3.6 -8.9 -8.9 -8.9 -8.9 -6.5 AC -15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0 -14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0 AG -20.9 -19.1 -19.3 -19.1 -19.1 -16.7 -19.1 -16.7 -17.4 -19.1 -19.1 -19.1 -19.1 -16.7 -19.1 -19.1 AU -15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0 -14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0 CA -15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0 -14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0 CC -15.8 -14.0 -11.8 -14.0 -14.0 -14.0 -14.0 -14.0 -9.9 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0 CG -15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0 -14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0 CU -15.8 -14.0 -11.8 -14.0 -14.0 -14.0 -14.0 -14.0 -9.9 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0 GA -16.0 -17.4 -30.4 -17.4 -17.4 -15.0 -17.4 -15.0 -15.7 -17.4 -17.4 -17.4 -17.4 -15.0 -17.4 -17.4 GC -15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0 -14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0 GG -3.3 -1.5 -14.2 -1.5 -1.5 -1.5 -1.5 -1.5 -12.3 -1.5 -14.0 -1.5 -1.5 -1.5 -1.5 -14.0 GU -15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0 -14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0 UA -15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0 -14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0 UC -15.8 -14.0 -11.8 -14.0 -14.0 -14.0 -14.0 -14.0 -9.9 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0 UG -15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0 -14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0 UU -13.4 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0 -14.0 -12.3 -14.0 -14.0 -14.0 -14.0 -14.0 -14.0 -14.0