# Data tables for 2x2 interior loops
# The Enthalpies for RNA
# Data arrangement:
#
# 5' ------> 3'
# A X1 Y1 A
# U X2 Y2 U
# 3' <------ 5'
#
# Y-->
# ----------------------------------------------------------------------------------------------------------------------------
# (X) A A A A C C C C G G G G U U U U
# | A C G U A C G U A C G U A C G U
# V ----------------------------------------------------------------------------------------------------------------------------
# (AA) 14.0 11.2 0.0 11.2 12.7 12.7 12.7 11.4 -3.0 11.2 20.5 11.2 12.7 8.3 12.7 5.7
# (AC) 11.1 8.3 -2.9 8.3 9.8 9.8 9.8 8.5 -5.9 8.3 17.6 8.3 9.8 5.4 9.8 0.4
# (AG) 1.9 -0.8 -12.1 -0.8 0.6 3.0 0.6 1.8 -15.1 -0.8 -4.0 -0.8 0.6 -1.3 0.6 -8.7
# (AU) 11.1 8.3 -2.9 8.3 9.8 9.8 9.8 8.5 -5.9 8.3 17.6 8.3 9.8 5.4 9.8 0.4
# (CA) 10.9 8.1 -3.1 8.1 9.6 9.6 9.6 8.3 -6.1 8.1 17.4 8.1 9.6 5.2 9.6 0.2
# (CC) 11.0 8.2 -0.6 8.2 9.7 9.7 9.7 8.4 -3.6 8.2 17.5 8.2 9.7 5.3 9.7 0.3
# (CG) 10.9 8.1 -3.1 8.1 9.6 9.6 9.6 8.3 -6.1 8.1 17.4 8.1 9.6 5.2 9.6 0.2
# (CU) 11.0 8.2 -0.6 8.2 9.7 9.7 9.7 8.4 -3.6 8.2 17.5 8.2 9.7 5.3 9.7 0.3
# (GA) 0.1 -2.6 -13.9 -2.6 -1.1 1.3 -1.1 0.0 -16.9 -2.6 -5.8 -2.6 -1.1 -3.1 -1.1 -10.5
# (GC) 11.1 8.3 -2.9 8.3 9.8 9.8 9.8 8.5 -5.9 8.3 17.6 8.3 9.8 5.4 9.8 0.4
# (GG) 19.3 16.5 -7.2 16.5 18.0 18.0 18.0 16.7 -10.2 16.5 0.8 16.5 18.0 13.6 18.0 -3.8
# (GU) 11.1 8.3 -2.9 8.3 9.8 9.8 9.8 8.5 -5.9 8.3 17.6 8.3 9.8 5.4 9.8 0.4
# (UA) 10.9 8.1 -3.1 8.1 9.6 9.6 9.6 8.3 -6.1 8.1 17.4 8.1 9.6 5.2 9.6 0.2
# (UC) 11.0 8.2 -0.6 8.2 9.7 9.7 9.7 8.4 -3.6 8.2 17.5 8.2 9.7 5.3 9.7 0.3
# (UG) 10.9 8.1 -3.1 8.1 9.6 9.6 9.6 8.3 -6.1 8.1 17.4 8.1 9.6 5.2 9.6 0.2
# (UU) 3.6 -1.5 -12.8 -1.5 0.0 0.0 0.0 -1.3 -15.8 -1.5 -4.7 -1.5 0.0 -4.4 0.0 -9.4
# 5' ------> 3'
A X1 Y1 A
U X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 14.0 11.2 0.0 11.2 12.7 12.7 12.7 11.4 -3.0 11.2 20.5 11.2 12.7 8.3 12.7 5.7
AC 11.1 8.3 -2.9 8.3 9.8 9.8 9.8 8.5 -5.9 8.3 17.6 8.3 9.8 5.4 9.8 0.4
AG 1.9 -0.8 -12.1 -0.8 0.6 3.0 0.6 1.8 -15.1 -0.8 -4.0 -0.8 0.6 -1.3 0.6 -8.7
AU 11.1 8.3 -2.9 8.3 9.8 9.8 9.8 8.5 -5.9 8.3 17.6 8.3 9.8 5.4 9.8 0.4
CA 10.9 8.1 -3.1 8.1 9.6 9.6 9.6 8.3 -6.1 8.1 17.4 8.1 9.6 5.2 9.6 0.2
CC 11.0 8.2 -0.6 8.2 9.7 9.7 9.7 8.4 -3.6 8.2 17.5 8.2 9.7 5.3 9.7 0.3
CG 10.9 8.1 -3.1 8.1 9.6 9.6 9.6 8.3 -6.1 8.1 17.4 8.1 9.6 5.2 9.6 0.2
CU 11.0 8.2 -0.6 8.2 9.7 9.7 9.7 8.4 -3.6 8.2 17.5 8.2 9.7 5.3 9.7 0.3
GA 0.1 -2.6 -13.9 -2.6 -1.1 1.3 -1.1 0.0 -16.9 -2.6 -5.8 -2.6 -1.1 -3.1 -1.1 -10.5
GC 11.1 8.3 -2.9 8.3 9.8 9.8 9.8 8.5 -5.9 8.3 17.6 8.3 9.8 5.4 9.8 0.4
GG 19.3 16.5 -7.2 16.5 18.0 18.0 18.0 16.7 -10.2 16.5 0.8 16.5 18.0 13.6 18.0 -3.8
GU 11.1 8.3 -2.9 8.3 9.8 9.8 9.8 8.5 -5.9 8.3 17.6 8.3 9.8 5.4 9.8 0.4
UA 10.9 8.1 -3.1 8.1 9.6 9.6 9.6 8.3 -6.1 8.1 17.4 8.1 9.6 5.2 9.6 0.2
UC 11.0 8.2 -0.6 8.2 9.7 9.7 9.7 8.4 -3.6 8.2 17.5 8.2 9.7 5.3 9.7 0.3
UG 10.9 8.1 -3.1 8.1 9.6 9.6 9.6 8.3 -6.1 8.1 17.4 8.1 9.6 5.2 9.6 0.2
UU 3.6 -1.5 -12.8 -1.5 0.0 0.0 0.0 -1.3 -15.8 -1.5 -4.7 -1.5 0.0 -4.4 0.0 -9.4
# 5' ------> 3'
A X1 Y1 C
U X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 6.0 1.5 -5.8 1.5 2.4 -0.6 2.4 -0.6 -1.1 1.5 7.8 1.5 2.4 -3.7 2.4 1.9
AC 3.1 -1.4 -8.8 -1.4 -0.5 -3.6 -0.5 -3.6 -4.0 -1.4 4.9 -1.4 -0.5 -6.7 -0.5 -3.4
AG -6.0 -10.5 -17.9 -10.5 -9.7 -10.3 -9.7 -10.3 -13.2 -10.5 -16.8 -10.5 -9.7 -13.4 -9.7 -12.6
AU 3.1 -1.4 -8.8 -1.4 -0.5 -3.6 -0.5 -3.6 -4.0 -1.4 4.9 -1.4 -0.5 -6.7 -0.5 -3.4
CA 2.9 -1.5 -8.9 -1.5 -0.7 -3.7 -0.7 -3.7 -4.2 -1.5 4.7 -1.5 -0.7 -6.8 -0.7 -3.6
CC 3.0 -1.4 -6.4 -1.4 -0.6 -3.6 -0.6 -3.6 -1.7 -1.4 4.8 -1.4 -0.6 -6.7 -0.6 -3.5
CG 2.9 -1.5 -8.9 -1.5 -0.7 -3.7 -0.7 -3.7 -4.2 -1.5 4.7 -1.5 -0.7 -6.8 -0.7 -3.6
CU 3.0 -1.4 -6.4 -1.4 -0.6 -3.6 -0.6 -3.6 -1.7 -1.4 4.8 -1.4 -0.6 -6.7 -0.6 -3.5
GA -7.8 -12.3 -19.7 -12.3 -11.5 -12.1 -11.5 -12.1 -15.0 -12.3 -18.6 -12.3 -11.5 -15.2 -11.5 -14.4
GC 3.1 -1.4 -8.8 -1.4 -0.5 -3.6 -0.5 -3.6 -4.0 -1.4 4.9 -1.4 -0.5 -6.7 -0.5 -3.4
GG 11.4 6.9 -13.0 6.9 7.7 4.7 7.7 4.7 -8.3 6.9 -11.9 6.9 7.7 1.6 7.7 -7.7
GU 3.1 -1.4 -8.8 -1.4 -0.5 -3.6 -0.5 -3.6 -4.0 -1.4 4.9 -1.4 -0.5 -6.7 -0.5 -3.4
UA 2.9 -1.5 -8.9 -1.5 -0.7 -3.7 -0.7 -3.7 -4.2 -1.5 4.7 -1.5 -0.7 -6.8 -0.7 -3.6
UC 3.0 -1.4 -6.4 -1.4 -0.6 -3.6 -0.6 -3.6 -1.7 -1.4 4.8 -1.4 -0.6 -6.7 -0.6 -3.5
UG 2.9 -1.5 -8.9 -1.5 -0.7 -3.7 -0.7 -3.7 -4.2 -1.5 4.7 -1.5 -0.7 -6.8 -0.7 -3.6
UU -4.3 -11.2 -18.6 -11.2 -10.4 -13.4 -10.4 -13.4 -13.9 -11.2 -17.5 -11.2 -10.4 -16.5 -10.4 -13.3
# 5' ------> 3'
A X1 Y1 G
U X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 4.4 1.3 2.2 1.3 5.8 5.8 5.8 5.3 -0.6 1.3 7.8 1.3 5.8 6.4 5.8 0.4
AC 1.4 -1.6 -0.7 -1.6 2.9 2.8 2.9 2.3 -3.5 -1.6 4.9 -1.6 2.9 3.4 2.9 -5.0
AG -7.7 -10.8 -9.8 -10.8 -6.2 -3.9 -6.2 -4.4 -12.7 -10.8 -16.8 -10.8 -6.2 -3.3 -6.2 -14.1
AU 1.4 -1.6 -0.7 -1.6 2.9 2.8 2.9 2.3 -3.5 -1.6 4.9 -1.6 2.9 3.4 2.9 -5.0
CA 1.3 -1.8 -0.8 -1.8 2.7 2.7 2.7 2.2 -3.7 -1.8 4.7 -1.8 2.7 3.3 2.7 -5.1
CC 1.4 -1.7 1.7 -1.7 2.8 2.8 2.8 2.3 -1.2 -1.7 4.8 -1.7 2.8 3.4 2.8 -5.0
CG 1.3 -1.8 -0.8 -1.8 2.7 2.7 2.7 2.2 -3.7 -1.8 4.7 -1.8 2.7 3.3 2.7 -5.1
CU 1.4 -1.7 1.7 -1.7 2.8 2.8 2.8 2.3 -1.2 -1.7 4.8 -1.7 2.8 3.4 2.8 -5.0
GA -9.5 -12.6 -11.6 -12.6 -8.0 -5.7 -8.0 -6.2 -14.5 -12.6 -18.6 -12.6 -8.0 -5.1 -8.0 -15.9
GC 1.4 -1.6 -0.7 -1.6 2.9 2.8 2.9 2.3 -3.5 -1.6 4.9 -1.6 2.9 3.4 2.9 -5.0
GG 9.7 6.6 -4.9 6.6 11.2 11.1 11.2 10.6 -7.8 6.6 -11.9 6.6 11.2 11.7 11.2 -9.2
GU 1.4 -1.6 -0.7 -1.6 2.9 2.8 2.9 2.3 -3.5 -1.6 4.9 -1.6 2.9 3.4 2.9 -5.0
UA 1.3 -1.8 -0.8 -1.8 2.7 2.7 2.7 2.2 -3.7 -1.8 4.7 -1.8 2.7 3.3 2.7 -5.1
UC 1.4 -1.7 1.7 -1.7 2.8 2.8 2.8 2.3 -1.2 -1.7 4.8 -1.7 2.8 3.4 2.8 -5.0
UG 1.3 -1.8 -0.8 -1.8 2.7 2.7 2.7 2.2 -3.7 -1.8 4.7 -1.8 2.7 3.3 2.7 -5.1
UU -6.0 -11.5 -10.5 -11.5 -6.9 -7.0 -6.9 -7.5 -13.4 -11.5 -17.5 -11.5 -6.9 -6.4 -6.9 -14.8
# 5' ------> 3'
A X1 Y1 G
U X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 7.5 2.4 -0.9 2.4 2.4 2.4 2.4 2.4 -2.6 2.4 14.9 2.4 2.4 2.4 2.4 4.8
AC 4.6 -0.5 -3.9 -0.5 -0.5 -0.5 -0.5 -0.5 -5.6 -0.5 12.0 -0.5 -0.5 -0.5 -0.5 -0.5
AG -4.5 -9.6 -13.0 -9.6 -9.6 -7.2 -9.6 -7.2 -14.7 -9.6 -9.6 -9.6 -9.6 -7.2 -9.6 -9.6
AU 4.6 -0.5 -3.9 -0.5 -0.5 -0.5 -0.5 -0.5 -5.6 -0.5 12.0 -0.5 -0.5 -0.5 -0.5 -0.5
CA 4.4 -0.6 -4.0 -0.6 -0.6 -0.6 -0.6 -0.6 -5.7 -0.6 11.9 -0.6 -0.6 -0.6 -0.6 -0.6
CC 4.5 -0.5 -1.5 -0.5 -0.5 -0.5 -0.5 -0.5 -3.2 -0.5 12.0 -0.5 -0.5 -0.5 -0.5 -0.5
CG 4.4 -0.6 -4.0 -0.6 -0.6 -0.6 -0.6 -0.6 -5.7 -0.6 11.9 -0.6 -0.6 -0.6 -0.6 -0.6
CU 4.5 -0.5 -1.5 -0.5 -0.5 -0.5 -0.5 -0.5 -3.2 -0.5 12.0 -0.5 -0.5 -0.5 -0.5 -0.5
GA -6.3 -11.4 -14.8 -11.4 -11.4 -9.0 -11.4 -9.0 -16.5 -11.4 -11.4 -11.4 -11.4 -9.0 -11.4 -11.4
GC 4.6 -0.5 -3.9 -0.5 -0.5 -0.5 -0.5 -0.5 -5.6 -0.5 12.0 -0.5 -0.5 -0.5 -0.5 -0.5
GG 12.8 7.8 -8.1 7.8 7.8 7.8 7.8 7.8 -9.8 7.8 -4.7 7.8 7.8 7.8 7.8 -4.7
GU 4.6 -0.5 -3.9 -0.5 -0.5 -0.5 -0.5 -0.5 -5.6 -0.5 12.0 -0.5 -0.5 -0.5 -0.5 -0.5
UA 4.4 -0.6 -4.0 -0.6 -0.6 -0.6 -0.6 -0.6 -5.7 -0.6 11.9 -0.6 -0.6 -0.6 -0.6 -0.6
UC 4.5 -0.5 -1.5 -0.5 -0.5 -0.5 -0.5 -0.5 -3.2 -0.5 12.0 -0.5 -0.5 -0.5 -0.5 -0.5
UG 4.4 -0.6 -4.0 -0.6 -0.6 -0.6 -0.6 -0.6 -5.7 -0.6 11.9 -0.6 -0.6 -0.6 -0.6 -0.6
UU -2.8 -10.3 -13.7 -10.3 -10.3 -10.3 -10.3 -10.3 -15.4 -10.3 -10.3 -10.3 -10.3 -10.3 -10.3 -10.3
# 5' ------> 3'
A X1 Y1 U
U X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 13.4 10.3 -0.5 10.3 10.4 10.4 10.4 10.4 1.3 10.3 18.7 10.3 10.4 10.4 10.4 3.0
AC 10.4 7.3 -3.4 7.3 7.5 7.4 7.5 7.4 -1.6 7.3 15.7 7.3 7.5 7.4 7.5 -2.3
AG 1.3 -1.8 -12.6 -1.8 -1.6 0.7 -1.6 0.7 -10.8 -1.8 -5.9 -1.8 -1.6 0.7 -1.6 -11.5
AU 10.4 7.3 -3.4 7.3 7.5 7.4 7.5 7.4 -1.6 7.3 15.7 7.3 7.5 7.4 7.5 -2.3
CA 10.3 7.2 -3.6 7.2 7.3 7.3 7.3 7.3 -1.8 7.2 15.6 7.2 7.3 7.3 7.3 -2.5
CC 10.4 7.3 -1.1 7.3 7.4 7.4 7.4 7.4 0.7 7.3 15.7 7.3 7.4 7.4 7.4 -2.4
CG 10.3 7.2 -3.6 7.2 7.3 7.3 7.3 7.3 -1.8 7.2 15.6 7.2 7.3 7.3 7.3 -2.5
CU 10.4 7.3 -1.1 7.3 7.4 7.4 7.4 7.4 0.7 7.3 15.7 7.3 7.4 7.4 7.4 -2.4
GA -0.5 -3.6 -14.4 -3.6 -3.4 -1.1 -3.4 -1.1 -12.6 -3.6 -7.7 -3.6 -3.4 -1.1 -3.4 -13.3
GC 10.4 7.3 -3.4 7.3 7.5 7.4 7.5 7.4 -1.6 7.3 15.7 7.3 7.5 7.4 7.5 -2.3
GG 18.7 15.6 -7.7 15.6 15.7 15.7 15.7 15.7 -5.9 15.6 -1.0 15.6 15.7 15.7 15.7 -6.6
GU 10.4 7.3 -3.4 7.3 7.5 7.4 7.5 7.4 -1.6 7.3 15.7 7.3 7.5 7.4 7.5 -2.3
UA 10.3 7.2 -3.6 7.2 7.3 7.3 7.3 7.3 -1.8 7.2 15.6 7.2 7.3 7.3 7.3 -2.5
UC 10.4 7.3 -1.1 7.3 7.4 7.4 7.4 7.4 0.7 7.3 15.7 7.3 7.4 7.4 7.4 -2.4
UG 10.3 7.2 -3.6 7.2 7.3 7.3 7.3 7.3 -1.8 7.2 15.6 7.2 7.3 7.3 7.3 -2.5
UU 3.0 -2.5 -13.3 -2.5 -2.3 -2.4 -2.3 -2.4 -11.5 -2.5 -6.6 -2.5 -2.3 -2.4 -2.3 -12.2
# 5' ------> 3'
A X1 Y1 U
U X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA -4.9 -3.1 -3.2 -3.1 -3.1 -3.1 -3.1 -3.1 -1.3 -3.1 9.4 -3.1 -3.1 -3.1 -3.1 -0.7
AC -7.8 -6.0 -6.2 -6.0 -6.0 -6.0 -6.0 -6.0 -4.3 -6.0 6.5 -6.0 -6.0 -6.0 -6.0 -6.0
AG -17.0 -15.2 -15.3 -15.2 -15.2 -12.8 -15.2 -12.8 -13.4 -15.2 -15.2 -15.2 -15.2 -12.8 -15.2 -15.2
AU -7.8 -6.0 -6.2 -6.0 -6.0 -6.0 -6.0 -6.0 -4.3 -6.0 6.5 -6.0 -6.0 -6.0 -6.0 -6.0
CA -8.0 -6.2 -6.3 -6.2 -6.2 -6.2 -6.2 -6.2 -4.4 -6.2 6.3 -6.2 -6.2 -6.2 -6.2 -6.2
CC -7.9 -6.1 -3.8 -6.1 -6.1 -6.1 -6.1 -6.1 -1.9 -6.1 6.4 -6.1 -6.1 -6.1 -6.1 -6.1
CG -8.0 -6.2 -6.3 -6.2 -6.2 -6.2 -6.2 -6.2 -4.4 -6.2 6.3 -6.2 -6.2 -6.2 -6.2 -6.2
CU -7.9 -6.1 -3.8 -6.1 -6.1 -6.1 -6.1 -6.1 -1.9 -6.1 6.4 -6.1 -6.1 -6.1 -6.1 -6.1
GA -18.8 -17.0 -17.1 -17.0 -17.0 -14.6 -17.0 -14.6 -15.2 -17.0 -17.0 -17.0 -17.0 -14.6 -17.0 -17.0
GC -7.8 -6.0 -6.2 -6.0 -6.0 -6.0 -6.0 -6.0 -4.3 -6.0 6.5 -6.0 -6.0 -6.0 -6.0 -6.0
GG 0.4 2.2 -10.4 2.2 2.2 2.2 2.2 2.2 -8.5 2.2 -10.3 2.2 2.2 2.2 2.2 -10.3
GU -7.8 -6.0 -6.2 -6.0 -6.0 -6.0 -6.0 -6.0 -4.3 -6.0 6.5 -6.0 -6.0 -6.0 -6.0 -6.0
UA -8.0 -6.2 -6.3 -6.2 -6.2 -6.2 -6.2 -6.2 -4.4 -6.2 6.3 -6.2 -6.2 -6.2 -6.2 -6.2
UC -7.9 -6.1 -3.8 -6.1 -6.1 -6.1 -6.1 -6.1 -1.9 -6.1 6.4 -6.1 -6.1 -6.1 -6.1 -6.1
UG -8.0 -6.2 -6.3 -6.2 -6.2 -6.2 -6.2 -6.2 -4.4 -6.2 6.3 -6.2 -6.2 -6.2 -6.2 -6.2
UU -15.3 -15.9 -16.0 -15.9 -15.9 -15.9 -15.9 -15.9 -14.1 -15.9 -15.9 -15.9 -15.9 -15.9 -15.9 -15.9
# 5' ------> 3'
C X1 Y1 A
G X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 5.0 2.2 -9.0 2.2 3.7 3.7 3.7 2.4 -12.0 2.2 11.6 2.2 3.7 -0.6 3.7 -3.2
AC 6.5 3.7 -7.5 3.7 5.2 5.2 5.2 3.9 -10.5 3.7 13.0 3.7 5.2 0.8 5.2 -4.2
AG 0.0 -2.7 -14.0 -2.7 -1.2 1.2 -1.2 -0.1 -17.0 -2.7 -5.9 -2.7 -1.2 -3.2 -1.2 -10.6
AU 6.5 3.7 -7.5 3.7 5.2 5.2 5.2 3.9 -10.5 3.7 13.0 3.7 5.2 0.8 5.2 -4.2
CA 1.9 -0.8 -12.1 -0.8 0.6 0.6 0.6 -0.6 -15.1 -0.8 8.5 -0.8 0.6 -3.7 0.6 -8.7
CC 6.4 3.6 -5.2 3.6 5.1 5.1 5.1 3.8 -8.2 3.6 12.9 3.6 5.1 0.7 5.1 -4.2
CG 1.9 -0.8 -12.1 -0.8 0.6 0.6 0.6 -0.6 -15.1 -0.8 8.5 -0.8 0.6 -3.7 0.6 -8.7
CU 7.0 4.2 -4.6 4.2 5.7 5.7 5.7 4.4 -7.6 4.2 13.5 4.2 5.7 1.3 5.7 -3.6
GA 2.9 0.1 -11.1 0.1 1.6 4.0 1.6 2.7 -14.1 0.1 -3.1 0.1 1.6 -0.4 1.6 -7.8
GC 6.5 3.7 -7.5 3.7 5.2 5.2 5.2 3.9 -10.5 3.7 13.0 3.7 5.2 0.8 5.2 -4.2
GG 8.5 5.7 -18.1 5.7 7.2 7.2 7.2 5.9 -21.1 5.7 -10.0 5.7 7.2 2.8 7.2 -14.7
GU 6.5 3.7 -7.5 3.7 5.2 5.2 5.2 3.9 -10.5 3.7 13.0 3.7 5.2 0.8 5.2 -4.2
UA 1.9 -0.8 -12.1 -0.8 0.6 0.6 0.6 -0.6 -15.1 -0.8 8.5 -0.8 0.6 -3.7 0.6 -8.7
UC 5.9 3.1 -5.7 3.1 4.6 4.6 4.6 3.3 -8.7 3.1 12.5 3.1 4.6 0.2 4.6 -4.7
UG 1.9 -0.8 -12.1 -0.8 0.6 0.6 0.6 -0.6 -15.1 -0.8 8.5 -0.8 0.6 -3.7 0.6 -8.7
UU 1.0 -4.2 -15.4 -4.2 -2.7 -2.7 -2.7 -4.0 -18.4 -4.2 -7.4 -4.2 -2.7 -7.1 -2.7 -12.1
# 5' ------> 3'
C X1 Y1 C
G X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA -5.8 -7.4 -20.1 -7.4 -6.6 -9.6 -6.6 -9.6 -13.4 -7.4 1.8 -7.4 -6.6 -12.7 -6.6 -12.4
AC -2.2 -6.0 -16.5 -6.0 -11.5 -8.2 -5.1 -8.2 -8.6 -6.0 -3.9 -6.0 -5.1 -11.3 -5.1 -0.9
AG -9.7 -1.0 -19.8 -12.4 0.1 5.4 -11.6 -12.2 -24.5 -12.4 -18.7 -12.4 -11.6 -15.3 -11.6 -8.1
AU -1.5 -6.0 -13.4 -6.0 -5.1 -8.2 -5.1 -8.2 -8.6 -6.0 0.3 -6.0 -5.1 -11.3 -5.1 -8.0
CA -6.0 -10.5 -17.9 -10.5 -9.7 -12.7 -9.7 -12.7 -10.7 -10.5 -4.3 -10.5 -9.7 -15.8 -9.7 -8.3
CC -10.7 -6.0 -6.3 -6.0 -7.5 -8.2 -5.2 -8.2 -5.0 -6.0 0.2 -6.0 -5.2 -11.3 -5.2 -17.1
CG -6.0 -10.5 -17.9 -10.5 -9.7 -12.7 -9.7 -12.7 -13.2 -10.5 -4.3 -10.5 -9.7 -15.8 -9.7 -12.6
CU -0.9 -5.4 -10.4 -5.4 -4.6 -7.6 -4.6 -5.5 -5.7 -5.4 1.8 -5.4 -4.6 -10.7 -4.6 -14.6
GA -16.0 -3.5 -30.7 -9.6 -11.1 -9.4 -8.7 -9.4 -18.8 -9.6 -13.7 -9.6 -8.7 -12.5 -8.7 -13.6
GC -1.5 -6.0 -13.4 -6.0 -5.1 -8.2 -5.1 -8.2 -8.6 -6.0 0.3 -6.0 -5.1 -11.3 -5.1 -8.0
GG -2.0 -4.4 -23.9 -4.0 -3.2 -6.2 -3.2 -2.6 -10.8 -4.0 -22.8 -4.0 -3.2 -2.1 -3.2 -15.5
GU -1.5 -6.0 -13.4 -6.0 -5.1 -8.2 -5.1 -8.2 -8.6 -6.0 0.3 -6.0 -5.1 -11.3 -5.1 -8.0
UA -6.0 -10.5 -17.9 -10.5 -9.7 -12.7 -9.7 -12.7 -13.2 -10.5 -4.3 -10.5 -9.7 -15.8 -9.7 -12.6
UC -2.0 -6.5 -11.5 -6.5 -5.7 -8.7 -5.7 -8.7 -17.5 -6.5 -8.8 -6.5 -5.7 -11.8 -5.7 -8.6
UG -6.0 -10.5 -17.9 -10.5 -9.7 -12.7 -9.7 -12.7 -13.2 -10.5 -4.3 -10.5 -9.7 -15.8 -9.7 -12.6
UU -14.9 -13.9 -15.2 -13.9 -4.0 -16.1 -13.0 -16.1 -13.0 -13.9 -2.3 -13.9 -13.0 -19.2 -13.0 -23.5
# 5' ------> 3'
C X1 Y1 G
G X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA -4.6 -7.7 -6.7 -7.7 -3.1 -3.2 -3.1 -3.7 -9.6 -7.7 -1.2 -7.7 -3.1 -2.6 -3.1 -8.6
AC -3.1 -6.2 -5.3 -6.2 -1.7 -1.7 -1.7 -2.2 -8.1 -6.2 0.3 -6.2 -1.7 -1.1 -1.7 -9.6
AG -9.6 -12.7 -11.7 -12.7 -8.1 -5.8 -8.1 -6.3 -14.6 -12.7 -18.7 -12.7 -8.1 -5.2 -8.1 -16.0
AU -3.1 -6.2 -5.3 -6.2 -1.7 -1.7 -1.7 -2.2 -8.1 -6.2 0.3 -6.2 -1.7 -1.1 -1.7 -9.6
CA -7.7 -10.8 -9.8 -10.8 -6.2 -6.3 -6.2 -6.8 -12.7 -10.8 -4.3 -10.8 -6.2 -5.7 -6.2 -14.1
CC -3.2 -6.3 -2.9 -6.3 -1.7 -1.8 -1.7 -2.3 -5.8 -6.3 0.2 -6.3 -1.7 -1.2 -1.7 -9.6
CG -7.7 -10.8 -9.8 -10.8 -6.2 -6.3 -6.2 -6.8 -12.7 -10.8 -4.3 -10.8 -6.2 -5.7 -6.2 -14.1
CU -2.6 -5.7 -2.3 -5.7 -1.1 -1.2 -1.1 -1.7 -5.2 -5.7 0.8 -5.7 -1.1 -0.6 -1.1 -9.0
GA -6.7 -9.8 -8.9 -9.8 -5.3 -2.9 -5.3 -3.4 -11.7 -9.8 -15.8 -9.8 -5.3 -2.3 -5.3 -13.2
GC -3.1 -6.2 -5.3 -6.2 -1.7 -1.7 -1.7 -2.2 -8.1 -6.2 0.3 -6.2 -1.7 -1.1 -1.7 -9.6
GG -1.2 -4.3 -15.8 -4.3 0.3 0.2 0.3 -0.3 -18.7 -4.3 -22.8 -4.3 0.3 0.8 0.3 -20.1
GU -3.1 -6.2 -5.3 -6.2 -1.7 -1.7 -1.7 -2.2 -8.1 -6.2 0.3 -6.2 -1.7 -1.1 -1.7 -9.6
UA -7.7 -10.8 -9.8 -10.8 -6.2 -6.3 -6.2 -6.8 -12.7 -10.8 -4.3 -10.8 -6.2 -5.7 -6.2 -14.1
UC -3.7 -6.8 -3.4 -6.8 -2.2 -2.3 -2.2 -2.8 -6.3 -6.8 -0.3 -6.8 -2.2 -1.7 -2.2 -10.1
UG -7.7 -10.8 -9.8 -10.8 -6.2 -6.3 -6.2 -6.8 -12.7 -10.8 -4.3 -10.8 -6.2 -5.7 -6.2 -14.1
UU -8.6 -14.1 -13.2 -14.1 -9.6 -9.6 -9.6 -10.1 -16.0 -14.1 -20.1 -14.1 -9.6 -9.0 -9.6 -17.5
# 5' ------> 3'
C X1 Y1 G
G X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA -1.4 -6.5 -9.9 -6.5 -6.5 -6.5 -6.5 -6.5 -11.6 -6.5 6.0 -6.5 -6.5 -6.5 -6.5 -4.1
AC 0.0 -5.1 -8.5 -5.1 -5.1 -5.1 -5.1 -5.1 -10.2 -5.1 7.4 -5.1 -5.1 -5.1 -5.1 -5.1
AG -6.4 -11.5 -14.9 -11.5 -11.5 -9.1 -11.5 -9.1 -16.6 -11.5 -11.5 -11.5 -11.5 -9.1 -11.5 -11.5
AU 0.0 -5.1 -8.5 -5.1 -5.1 -5.1 -5.1 -5.1 -10.2 -5.1 7.4 -5.1 -5.1 -5.1 -5.1 -5.1
CA -4.5 -9.6 -13.0 -9.6 -9.6 -9.6 -9.6 -9.6 -14.7 -9.6 2.9 -9.6 -9.6 -9.6 -9.6 -9.6
CC 0.0 -5.1 -6.1 -5.1 -5.1 -5.1 -5.1 -5.1 -7.8 -5.1 7.4 -5.1 -5.1 -5.1 -5.1 -5.1
CG -4.5 -9.6 -13.0 -9.6 -9.6 -9.6 -9.6 -9.6 -14.7 -9.6 2.9 -9.6 -9.6 -9.6 -9.6 -9.6
CU 0.5 -4.5 -5.5 -4.5 -4.5 -4.5 -4.5 -4.5 -7.2 -4.5 8.0 -4.5 -4.5 -4.5 -4.5 -4.5
GA -3.6 -8.7 -12.1 -8.7 -8.7 -6.3 -8.7 -6.3 -13.8 -8.7 -8.7 -8.7 -8.7 -6.3 -8.7 -8.7
GC 0.0 -5.1 -8.5 -5.1 -5.1 -5.1 -5.1 -5.1 -10.2 -5.1 7.4 -5.1 -5.1 -5.1 -5.1 -5.1
GG 2.0 -3.1 -19.0 -3.1 -3.1 -3.1 -3.1 -3.1 -20.7 -3.1 -15.6 -3.1 -3.1 -3.1 -3.1 -15.6
GU 0.0 -5.1 -8.5 -5.1 -5.1 -5.1 -5.1 -5.1 -10.2 -5.1 7.4 -5.1 -5.1 -5.1 -5.1 -5.1
UA -4.5 -9.6 -13.0 -9.6 -9.6 -9.6 -9.6 -9.6 -14.7 -9.6 2.9 -9.6 -9.6 -9.6 -9.6 -9.6
UC -0.5 -5.6 -6.6 -5.6 -5.6 -5.6 -5.6 -5.6 -8.3 -5.6 6.9 -5.6 -5.6 -5.6 -5.6 -5.6
UG -4.5 -9.6 -13.0 -9.6 -9.6 -9.6 -9.6 -9.6 -14.7 -9.6 2.9 -9.6 -9.6 -9.6 -9.6 -9.6
UU -5.5 -13.0 -16.4 -13.0 -13.0 -13.0 -13.0 -13.0 -18.1 -13.0 -13.0 -13.0 -13.0 -13.0 -13.0 -13.0
# 5' ------> 3'
C X1 Y1 U
G X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 4.4 1.3 -9.5 1.3 1.4 1.4 1.4 1.4 -7.7 1.3 9.7 1.3 1.4 1.4 1.4 -6.0
AC 5.8 2.7 -8.0 2.7 2.9 2.8 2.9 2.8 -6.2 2.7 11.2 2.7 2.9 2.8 2.9 -6.9
AG -0.6 -3.7 -14.5 -3.7 -3.5 -1.2 -3.5 -1.2 -12.7 -3.7 -7.8 -3.7 -3.5 -1.2 -3.5 -13.4
AU 5.8 2.7 -8.0 2.7 2.9 2.8 2.9 2.8 -6.2 2.7 11.2 2.7 2.9 2.8 2.9 -6.9
CA 1.3 -1.8 -12.6 -1.8 -1.6 -1.7 -1.6 -1.7 -10.8 -1.8 6.6 -1.8 -1.6 -1.7 -1.6 -11.5
CC 5.8 2.7 -5.7 2.7 2.8 2.8 2.8 2.8 -3.9 2.7 11.1 2.7 2.8 2.8 2.8 -7.0
CG 1.3 -1.8 -12.6 -1.8 -1.6 -1.7 -1.6 -1.7 -10.8 -1.8 6.6 -1.8 -1.6 -1.7 -1.6 -11.5
CU 6.4 3.3 -5.1 3.3 3.4 3.4 3.4 3.4 -3.3 3.3 11.7 3.3 3.4 3.4 3.4 -6.4
GA 2.2 -0.8 -11.6 -0.8 -0.7 1.7 -0.7 1.7 -9.8 -0.8 -4.9 -0.8 -0.7 1.7 -0.7 -10.5
GC 5.8 2.7 -8.0 2.7 2.9 2.8 2.9 2.8 -6.2 2.7 11.2 2.7 2.9 2.8 2.9 -6.9
GG 7.8 4.7 -18.6 4.7 4.9 4.8 4.9 4.8 -16.8 4.7 -11.9 4.7 4.9 4.8 4.9 -17.5
GU 5.8 2.7 -8.0 2.7 2.9 2.8 2.9 2.8 -6.2 2.7 11.2 2.7 2.9 2.8 2.9 -6.9
UA 1.3 -1.8 -12.6 -1.8 -1.6 -1.7 -1.6 -1.7 -10.8 -1.8 6.6 -1.8 -1.6 -1.7 -1.6 -11.5
UC 5.3 2.2 -6.2 2.2 2.3 2.3 2.3 2.3 -4.4 2.2 10.6 2.2 2.3 2.3 2.3 -7.5
UG 1.3 -1.8 -12.6 -1.8 -1.6 -1.7 -1.6 -1.7 -10.8 -1.8 6.6 -1.8 -1.6 -1.7 -1.6 -11.5
UU 0.4 -5.1 -15.9 -5.1 -5.0 -5.0 -5.0 -5.0 -14.1 -5.1 -9.2 -5.1 -5.0 -5.0 -5.0 -14.8
# 5' ------> 3'
C X1 Y1 U
G X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA -13.7 -12.1 -12.2 -12.1 -12.1 -12.1 -12.1 -12.1 -10.3 -12.1 0.4 -12.1 -12.1 -12.1 -12.1 -9.7
AC -12.4 -10.6 -10.8 -10.6 -10.6 -10.6 -10.6 -10.6 -8.9 -10.6 1.9 -10.6 -10.6 -10.6 -10.6 -10.6
AG -18.9 -17.1 -17.2 -17.1 -17.1 -14.7 -17.1 -14.7 -15.3 -17.1 -17.1 -17.1 -17.1 -14.7 -17.1 -17.1
AU -12.4 -10.6 -10.8 -10.6 -10.6 -10.6 -10.6 -10.6 -8.9 -10.6 1.9 -10.6 -10.6 -10.6 -10.6 -10.6
CA -17.0 -15.2 -15.3 -15.2 -15.2 -15.2 -15.2 -15.2 -13.4 -15.2 -2.7 -15.2 -15.2 -15.2 -15.2 -15.2
CC -12.5 -10.7 -8.4 -10.7 -10.7 -10.7 -10.7 -10.7 -6.5 -10.7 1.8 -10.7 -10.7 -10.7 -10.7 -10.7
CG -17.0 -15.2 -15.3 -15.2 -15.2 -15.2 -15.2 -15.2 -13.4 -15.2 -2.7 -15.2 -15.2 -15.2 -15.2 -15.2
CU -11.9 -10.1 -7.8 -10.1 -10.1 -10.1 -10.1 -10.1 -5.9 -10.1 2.4 -10.1 -10.1 -10.1 -10.1 -10.1
GA -16.0 -14.2 -14.4 -14.2 -14.2 -11.8 -14.2 -11.8 -12.5 -14.2 -14.2 -14.2 -14.2 -11.8 -14.2 -14.2
GC -12.4 -10.6 -10.8 -10.6 -10.6 -10.6 -10.6 -10.6 -8.9 -10.6 1.9 -10.6 -10.6 -10.6 -10.6 -10.6
GG -10.5 -8.7 -21.3 -8.7 -8.7 -8.7 -8.7 -8.7 -19.4 -8.7 -21.2 -8.7 -8.7 -8.7 -8.7 -21.2
GU -12.4 -10.6 -10.8 -10.6 -10.6 -10.6 -10.6 -10.6 -8.9 -10.6 1.9 -10.6 -10.6 -10.6 -10.6 -10.6
UA -17.0 -15.2 -15.3 -15.2 -15.2 -15.2 -15.2 -15.2 -13.4 -15.2 -2.7 -15.2 -15.2 -15.2 -15.2 -15.2
UC -13.0 -11.2 -8.9 -11.2 -11.2 -11.2 -11.2 -11.2 -7.0 -11.2 1.3 -11.2 -11.2 -11.2 -11.2 -11.2
UG -17.0 -15.2 -15.3 -15.2 -15.2 -15.2 -15.2 -15.2 -13.4 -15.2 -2.7 -15.2 -15.2 -15.2 -15.2 -15.2
UU -17.9 -18.5 -18.7 -18.5 -18.5 -18.5 -18.5 -18.5 -16.8 -18.5 -18.5 -18.5 -18.5 -18.5 -18.5 -18.5
# 5' ------> 3'
G X1 Y1 A
C X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 6.7 3.9 -7.3 3.9 5.4 5.4 5.4 4.1 -10.3 3.9 13.2 3.9 5.4 1.0 5.4 -1.6
AC 3.0 0.2 -11.0 0.2 1.7 1.7 1.7 0.4 -14.0 0.2 9.6 0.2 1.7 -2.6 1.7 -7.6
AG -0.4 -3.2 -14.5 -3.2 -1.7 0.7 -1.7 -0.6 -17.5 -3.2 -6.4 -3.2 -1.7 -3.7 -1.7 -11.1
AU 3.0 0.2 -11.0 0.2 1.7 1.7 1.7 0.4 -14.0 0.2 9.6 0.2 1.7 -2.6 1.7 -7.6
CA 2.2 -0.6 -11.8 -0.6 0.9 0.9 0.9 -0.4 -14.8 -0.6 8.7 -0.6 0.9 -3.5 0.9 -8.5
CC 0.0 -2.8 -11.6 -2.8 -1.3 -1.3 -1.3 -2.6 -14.6 -2.8 6.5 -2.8 -1.3 -5.7 -1.3 -10.7
CG 2.2 -0.6 -11.8 -0.6 0.9 0.9 0.9 -0.4 -14.8 -0.6 8.7 -0.6 0.9 -3.5 0.9 -8.5
CU -3.1 -5.9 -14.7 -5.9 -4.4 -4.4 -4.4 -5.7 -17.7 -5.9 3.4 -5.9 -4.4 -8.8 -4.4 -13.8
GA -5.2 -8.0 -19.2 -8.0 -6.5 -4.1 -6.5 -5.4 -22.2 -8.0 -11.2 -8.0 -6.5 -8.5 -6.5 -15.9
GC 3.0 0.2 -11.0 0.2 1.7 1.7 1.7 0.4 -14.0 0.2 9.6 0.2 1.7 -2.6 1.7 -7.6
GG 8.5 5.7 -18.1 5.7 7.2 7.2 7.2 5.9 -21.1 5.7 -10.0 5.7 7.2 2.8 7.2 -14.7
GU 3.0 0.2 -11.0 0.2 1.7 1.7 1.7 0.4 -14.0 0.2 9.6 0.2 1.7 -2.6 1.7 -7.6
UA 2.2 -0.6 -11.8 -0.6 0.9 0.9 0.9 -0.4 -14.8 -0.6 8.7 -0.6 0.9 -3.5 0.9 -8.5
UC 0.0 -2.8 -11.6 -2.8 -1.3 -1.3 -1.3 -2.6 -14.6 -2.8 6.5 -2.8 -1.3 -5.7 -1.3 -10.7
UG 2.2 -0.6 -11.8 -0.6 0.9 0.9 0.9 -0.4 -14.8 -0.6 8.7 -0.6 0.9 -3.5 0.9 -8.5
UU 2.5 -2.6 -13.9 -2.6 -1.1 -1.1 -1.1 -2.4 -16.9 -2.6 -5.8 -2.6 -1.1 -5.5 -1.1 -10.5
# 5' ------> 3'
G X1 Y1 C
C X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA -1.3 -5.8 -13.2 -5.8 -4.9 -8.0 -4.9 -8.0 -8.4 -5.8 0.5 -5.8 -4.9 -11.1 -4.9 -5.4
AC -4.9 -9.4 -16.8 -9.4 -8.6 -11.6 -8.6 -11.6 -12.1 -9.4 -3.2 -9.4 -8.6 -14.7 -8.6 -11.5
AG -8.4 -12.9 -20.3 -12.9 -12.1 -12.7 -12.1 -12.7 -15.6 -12.9 -19.2 -12.9 -12.1 -15.8 -12.1 -15.0
AU -4.9 -9.4 -16.8 -9.4 -8.6 -11.6 -8.6 -11.6 -12.1 -9.4 -3.2 -9.4 -8.6 -14.7 -8.6 -11.5
CA -5.8 -10.3 -17.7 -10.3 -9.4 -12.5 -9.4 -12.5 -12.9 -10.3 -4.0 -10.3 -9.4 -15.6 -9.4 -12.3
CC -8.0 -12.5 -17.5 -12.5 -11.6 -14.7 -11.6 -14.7 -12.7 -12.5 -6.2 -12.5 -11.6 -17.8 -11.6 -14.5
CG -5.8 -10.3 -17.7 -10.3 -9.4 -12.5 -9.4 -12.5 -12.9 -10.3 -4.0 -10.3 -9.4 -15.6 -9.4 -12.3
CU -11.1 -15.6 -20.6 -15.6 -14.7 -17.8 -14.7 -17.8 -15.8 -15.6 -9.3 -15.6 -14.7 -20.9 -14.7 -17.6
GA -13.2 -17.7 -25.1 -17.7 -16.8 -17.5 -16.8 -17.5 -20.3 -17.7 -23.9 -17.7 -16.8 -20.6 -16.8 -19.7
GC -4.9 -9.4 -16.8 -9.4 -8.6 -11.6 -8.6 -11.6 -12.1 -9.4 -3.2 -9.4 -8.6 -14.7 -8.6 -11.5
GG 0.5 -4.0 -23.9 -4.0 -3.2 -6.2 -3.2 -6.2 -19.2 -4.0 -22.8 -4.0 -3.2 -9.3 -3.2 -18.6
GU -4.9 -9.4 -16.8 -9.4 -8.6 -11.6 -8.6 -11.6 -12.1 -9.4 -3.2 -9.4 -8.6 -14.7 -8.6 -11.5
UA -5.8 -10.3 -17.7 -10.3 -9.4 -12.5 -9.4 -12.5 -12.9 -10.3 -4.0 -10.3 -9.4 -15.6 -9.4 -12.3
UC -8.0 -12.5 -17.5 -12.5 -11.6 -14.7 -11.6 -14.7 -12.7 -12.5 -6.2 -12.5 -11.6 -17.8 -11.6 -14.5
UG -5.8 -10.3 -17.7 -10.3 -9.4 -12.5 -9.4 -12.5 -12.9 -10.3 -4.0 -10.3 -9.4 -15.6 -9.4 -12.3
UU -5.4 -12.3 -19.7 -12.3 -11.5 -14.5 -11.5 -14.5 -15.0 -12.3 -18.6 -12.3 -11.5 -17.6 -11.5 -14.4
# 5' ------> 3'
G X1 Y1 G
C X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA -5.8 -6.0 -16.0 -6.0 -2.2 -10.7 -1.5 -2.0 -9.7 -6.0 -2.0 -6.0 -1.5 -0.9 -1.5 -14.9
AC -6.6 -9.7 -11.1 -9.7 -11.5 -7.5 -5.1 -5.7 0.1 -9.7 -3.2 -9.7 -5.1 -4.6 -5.1 -4.0
AG -13.4 -10.7 -18.8 -13.2 -8.6 -5.0 -8.6 -17.5 -24.5 -13.2 -10.8 -13.2 -8.6 -5.7 -8.6 -13.0
AU -6.6 -9.7 -8.7 -9.7 -5.1 -5.2 -5.1 -5.7 -11.6 -9.7 -3.2 -9.7 -5.1 -4.6 -5.1 -13.0
CA -7.4 -10.5 -3.5 -10.5 -6.0 -6.0 -6.0 -6.5 -1.0 -10.5 -4.4 -10.5 -6.0 -5.4 -6.0 -13.9
CC -9.6 -12.7 -9.4 -12.7 -8.2 -8.2 -8.2 -8.7 5.4 -12.7 -6.2 -12.7 -8.2 -7.6 -8.2 -16.1
CG -7.4 -10.5 -9.6 -10.5 -6.0 -6.0 -6.0 -6.5 -12.4 -10.5 -4.0 -10.5 -6.0 -5.4 -6.0 -13.9
CU -12.7 -15.8 -12.5 -15.8 -11.3 -11.3 -11.3 -11.8 -15.3 -15.8 -2.1 -15.8 -11.3 -10.7 -11.3 -19.2
GA -20.1 -17.9 -30.7 -17.9 -16.5 -6.3 -13.4 -11.5 -19.8 -17.9 -23.9 -17.9 -13.4 -10.4 -13.4 -15.2
GC -6.6 -9.7 -8.7 -9.7 -5.1 -5.2 -5.1 -5.7 -11.6 -9.7 -3.2 -9.7 -5.1 -4.6 -5.1 -13.0
GG 1.8 -4.3 -13.7 -4.3 -3.9 0.2 0.3 -8.8 -18.7 -4.3 -22.8 -4.3 0.3 1.8 0.3 -2.3
GU -6.6 -9.7 -8.7 -9.7 -5.1 -5.2 -5.1 -5.7 -11.6 -9.7 -3.2 -9.7 -5.1 -4.6 -5.1 -13.0
UA -7.4 -10.5 -9.6 -10.5 -6.0 -6.0 -6.0 -6.5 -12.4 -10.5 -4.0 -10.5 -6.0 -5.4 -6.0 -13.9
UC -9.6 -12.7 -9.4 -12.7 -8.2 -8.2 -8.2 -8.7 -12.2 -12.7 -2.6 -12.7 -8.2 -5.5 -8.2 -16.1
UG -7.4 -10.5 -9.6 -10.5 -6.0 -6.0 -6.0 -6.5 -12.4 -10.5 -4.0 -10.5 -6.0 -5.4 -6.0 -13.9
UU -12.4 -8.3 -13.6 -12.6 -0.9 -17.1 -8.0 -8.6 -8.1 -12.6 -15.5 -12.6 -8.0 -14.6 -8.0 -23.5
# 5' ------> 3'
G X1 Y1 G
C X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA -20.4 -4.9 -8.3 -4.9 -4.9 -4.9 -4.9 -4.9 -10.0 -4.9 7.6 -4.9 -4.9 -4.9 -4.9 -2.5
AC -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
AG -6.9 -12.0 -15.4 -12.0 -12.0 -9.6 -12.0 -9.6 -17.1 -12.0 -12.0 -12.0 -12.0 -9.6 -12.0 -12.0
AU -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
CA -4.3 -9.4 -12.8 -9.4 -9.4 -9.4 -9.4 -9.4 -14.5 -9.4 3.1 -9.4 -9.4 -9.4 -9.4 -9.4
CC -6.5 -11.6 -12.6 -11.6 -11.6 -11.6 -11.6 -11.6 -14.3 -11.6 0.9 -11.6 -11.6 -11.6 -11.6 -11.6
CG -4.3 -9.4 -12.8 -9.4 -9.4 -9.4 -9.4 -9.4 -14.5 -9.4 3.1 -9.4 -9.4 -9.4 -9.4 -9.4
CU -9.6 -14.7 -15.7 -14.7 -14.7 -14.7 -14.7 -14.7 -17.4 -14.7 -2.2 -14.7 -14.7 -14.7 -14.7 -14.7
GA -11.7 -16.8 -20.2 -16.8 -16.8 -14.4 -16.8 -14.4 -21.9 -16.8 -16.8 -16.8 -16.8 -14.4 -16.8 -16.8
GC -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
GG 2.0 -3.1 -19.0 -3.1 -3.1 -3.1 -3.1 -3.1 -20.7 -3.1 -15.6 -3.1 -3.1 -3.1 -3.1 -15.6
GU -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
UA -4.3 -9.4 -12.8 -9.4 -9.4 -9.4 -9.4 -9.4 -14.5 -9.4 3.1 -9.4 -9.4 -9.4 -9.4 -9.4
UC -6.5 -11.6 -12.6 -11.6 -11.6 -11.6 -11.6 -11.6 -14.3 -11.6 0.9 -11.6 -11.6 -11.6 -11.6 -11.6
UG -4.3 -9.4 -12.8 -9.4 -9.4 -9.4 -9.4 -9.4 -14.5 -9.4 3.1 -9.4 -9.4 -9.4 -9.4 -9.4
UU -3.9 -11.4 -14.8 -11.4 -11.4 -11.4 -11.4 -11.4 -16.5 -11.4 -11.4 -11.4 -11.4 -11.4 -11.4 -11.4
# 5' ------> 3'
G X1 Y1 U
C X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 6.0 2.9 -7.8 2.9 3.1 3.0 3.1 3.0 -6.0 2.9 11.4 2.9 3.1 3.0 3.1 -4.3
AC 2.4 -0.7 -11.5 -0.7 -0.5 -0.6 -0.5 -0.6 -9.7 -0.7 7.7 -0.7 -0.5 -0.6 -0.5 -10.4
AG -1.1 -4.2 -15.0 -4.2 -4.0 -1.7 -4.0 -1.7 -13.2 -4.2 -8.3 -4.2 -4.0 -1.7 -4.0 -13.9
AU 2.4 -0.7 -11.5 -0.7 -0.5 -0.6 -0.5 -0.6 -9.7 -0.7 7.7 -0.7 -0.5 -0.6 -0.5 -10.4
CA 1.5 -1.5 -12.3 -1.5 -1.4 -1.4 -1.4 -1.4 -10.5 -1.5 6.9 -1.5 -1.4 -1.4 -1.4 -11.2
CC -0.6 -3.7 -12.1 -3.7 -3.6 -3.6 -3.6 -3.6 -10.3 -3.7 4.7 -3.7 -3.6 -3.6 -3.6 -13.4
CG 1.5 -1.5 -12.3 -1.5 -1.4 -1.4 -1.4 -1.4 -10.5 -1.5 6.9 -1.5 -1.4 -1.4 -1.4 -11.2
CU -3.7 -6.8 -15.2 -6.8 -6.7 -6.7 -6.7 -6.7 -13.4 -6.8 1.6 -6.8 -6.7 -6.7 -6.7 -16.5
GA -5.8 -8.9 -19.7 -8.9 -8.8 -6.4 -8.8 -6.4 -17.9 -8.9 -13.0 -8.9 -8.8 -6.4 -8.8 -18.6
GC 2.4 -0.7 -11.5 -0.7 -0.5 -0.6 -0.5 -0.6 -9.7 -0.7 7.7 -0.7 -0.5 -0.6 -0.5 -10.4
GG 7.8 4.7 -18.6 4.7 4.9 4.8 4.9 4.8 -16.8 4.7 -11.9 4.7 4.9 4.8 4.9 -17.5
GU 2.4 -0.7 -11.5 -0.7 -0.5 -0.6 -0.5 -0.6 -9.7 -0.7 7.7 -0.7 -0.5 -0.6 -0.5 -10.4
UA 1.5 -1.5 -12.3 -1.5 -1.4 -1.4 -1.4 -1.4 -10.5 -1.5 6.9 -1.5 -1.4 -1.4 -1.4 -11.2
UC -0.6 -3.7 -12.1 -3.7 -3.6 -3.6 -3.6 -3.6 -10.3 -3.7 4.7 -3.7 -3.6 -3.6 -3.6 -13.4
UG 1.5 -1.5 -12.3 -1.5 -1.4 -1.4 -1.4 -1.4 -10.5 -1.5 6.9 -1.5 -1.4 -1.4 -1.4 -11.2
UU 1.9 -3.6 -14.4 -3.6 -3.4 -3.5 -3.4 -3.5 -12.6 -3.6 -7.7 -3.6 -3.4 -3.5 -3.4 -13.3
# 5' ------> 3'
G X1 Y1 U
C X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA -12.2 -10.4 -10.6 -10.4 -10.4 -10.4 -10.4 -10.4 -8.7 -10.4 2.1 -10.4 -10.4 -10.4 -10.4 -8.0
AC -15.9 -14.1 -14.2 -14.1 -14.1 -14.1 -14.1 -14.1 -12.3 -14.1 -1.6 -14.1 -14.1 -14.1 -14.1 -14.1
AG -19.4 -17.6 -17.7 -17.6 -17.6 -15.2 -17.6 -15.2 -15.8 -17.6 -17.6 -17.6 -17.6 -15.2 -17.6 -17.6
AU -15.9 -14.1 -14.2 -14.1 -14.1 -14.1 -14.1 -14.1 -12.3 -14.1 -1.6 -14.1 -14.1 -14.1 -14.1 -14.1
CA -16.7 -14.9 -15.1 -14.9 -14.9 -14.9 -14.9 -14.9 -13.2 -14.9 -2.4 -14.9 -14.9 -14.9 -14.9 -14.9
CC -18.9 -17.1 -14.9 -17.1 -17.1 -17.1 -17.1 -17.1 -13.0 -17.1 -4.6 -17.1 -17.1 -17.1 -17.1 -17.1
CG -16.7 -14.9 -15.1 -14.9 -14.9 -14.9 -14.9 -14.9 -13.2 -14.9 -2.4 -14.9 -14.9 -14.9 -14.9 -14.9
CU -22.0 -20.2 -18.0 -20.2 -20.2 -20.2 -20.2 -20.2 -16.1 -20.2 -7.7 -20.2 -20.2 -20.2 -20.2 -20.2
GA -24.1 -22.3 -22.5 -22.3 -22.3 -19.9 -22.3 -19.9 -20.6 -22.3 -22.3 -22.3 -22.3 -19.9 -22.3 -22.3
GC -15.9 -14.1 -14.2 -14.1 -14.1 -14.1 -14.1 -14.1 -12.3 -14.1 -1.6 -14.1 -14.1 -14.1 -14.1 -14.1
GG -10.5 -8.7 -21.3 -8.7 -8.7 -8.7 -8.7 -8.7 -19.4 -8.7 -21.2 -8.7 -8.7 -8.7 -8.7 -21.2
GU -15.9 -14.1 -14.2 -14.1 -14.1 -14.1 -14.1 -14.1 -12.3 -14.1 -1.6 -14.1 -14.1 -14.1 -14.1 -14.1
UA -16.7 -14.9 -15.1 -14.9 -14.9 -14.9 -14.9 -14.9 -13.2 -14.9 -2.4 -14.9 -14.9 -14.9 -14.9 -14.9
UC -18.9 -17.1 -14.9 -17.1 -17.1 -17.1 -17.1 -17.1 -13.0 -17.1 -4.6 -17.1 -17.1 -17.1 -17.1 -17.1
UG -16.7 -14.9 -15.1 -14.9 -14.9 -14.9 -14.9 -14.9 -13.2 -14.9 -2.4 -14.9 -14.9 -14.9 -14.9 -14.9
UU -16.4 -17.0 -17.1 -17.0 -17.0 -17.0 -17.0 -17.0 -15.2 -17.0 -17.0 -17.0 -17.0 -17.0 -17.0 -17.0
# 5' ------> 3'
G X1 Y1 A
U X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA -4.2 -7.0 -18.3 -7.0 -5.5 -5.5 -5.5 -6.8 -21.3 -7.0 2.3 -7.0 -5.5 -9.9 -5.5 -12.5
AC -2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5 -5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1
AG -0.7 -3.5 -14.7 -3.5 -2.0 0.4 -2.0 -0.9 -17.7 -3.5 -6.7 -3.5 -2.0 -4.0 -2.0 -11.4
AU -2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5 -5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1
CA -2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5 -5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1
CC -2.4 -5.2 -14.1 -5.2 -3.7 -3.7 -3.7 -5.0 -17.1 -5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1
CG -2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5 -5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1
CU -2.4 -5.2 -14.1 -5.2 -3.7 -3.7 -3.7 -5.0 -17.1 -5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1
GA -2.6 -5.4 -16.6 -5.4 -3.9 -1.5 -3.9 -2.8 -19.6 -5.4 -8.6 -5.4 -3.9 -5.9 -3.9 -13.3
GC -2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5 -5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1
GG 10.1 7.3 -16.5 7.3 8.8 8.8 8.8 7.5 -19.5 7.3 -8.4 7.3 8.8 4.4 8.8 -13.1
GU -2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5 -5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1
UA -2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5 -5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1
UC -2.4 -5.2 -14.1 -5.2 -3.7 -3.7 -3.7 -5.0 -17.1 -5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1
UG -2.4 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5 -5.2 4.1 -5.2 -3.7 -8.1 -3.7 -13.1
UU 0.0 -5.2 -16.5 -5.2 -3.7 -3.7 -3.7 -5.0 -19.5 -5.2 -8.4 -5.2 -3.7 -8.1 -3.7 -13.1
# 5' ------> 3'
G X1 Y1 C
U X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA -12.2 -16.7 -24.1 -16.7 -15.9 -18.9 -15.9 -18.9 -19.4 -16.7 -10.5 -16.7 -15.9 -22.0 -15.9 -16.4
AC -10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1 -17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0
AG -8.7 -13.2 -20.6 -13.2 -12.3 -13.0 -12.3 -13.0 -15.8 -13.2 -19.4 -13.2 -12.3 -16.1 -12.3 -15.2
AU -10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1 -17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0
CA -10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1 -17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0
CC -10.4 -14.9 -19.9 -14.9 -14.1 -17.1 -14.1 -17.1 -15.2 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0
CG -10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1 -17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0
CU -10.4 -14.9 -19.9 -14.9 -14.1 -17.1 -14.1 -17.1 -15.2 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0
GA -10.6 -15.1 -22.5 -15.1 -14.2 -14.9 -14.2 -14.9 -17.7 -15.1 -21.3 -15.1 -14.2 -18.0 -14.2 -17.1
GC -10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1 -17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0
GG 2.1 -2.4 -22.3 -2.4 -1.6 -4.6 -1.6 -4.6 -17.6 -2.4 -21.2 -2.4 -1.6 -7.7 -1.6 -17.0
GU -10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1 -17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0
UA -10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1 -17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0
UC -10.4 -14.9 -19.9 -14.9 -14.1 -17.1 -14.1 -17.1 -15.2 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0
UG -10.4 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1 -17.1 -17.6 -14.9 -8.7 -14.9 -14.1 -20.2 -14.1 -17.0
UU -8.0 -14.9 -22.3 -14.9 -14.1 -17.1 -14.1 -17.1 -17.6 -14.9 -21.2 -14.9 -14.1 -20.2 -14.1 -17.0
# 5' ------> 3'
G X1 Y1 G
U X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA -13.7 -17.0 -16.0 -17.0 -12.4 -12.5 -12.4 -13.0 -18.9 -17.0 -10.5 -17.0 -12.4 -11.9 -12.4 -17.9
AC -12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6 -11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5
AG -10.3 -13.4 -12.5 -13.4 -8.9 -6.5 -8.9 -7.0 -15.3 -13.4 -19.4 -13.4 -8.9 -5.9 -8.9 -16.8
AU -12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6 -11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5
CA -12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6 -11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5
CC -12.1 -15.2 -11.8 -15.2 -10.6 -10.7 -10.6 -11.2 -14.7 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5
CG -12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6 -11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5
CU -12.1 -15.2 -11.8 -15.2 -10.6 -10.7 -10.6 -11.2 -14.7 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5
GA -12.2 -15.3 -14.4 -15.3 -10.8 -8.4 -10.8 -8.9 -17.2 -15.3 -21.3 -15.3 -10.8 -7.8 -10.8 -18.7
GC -12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6 -11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5
GG 0.4 -2.7 -14.2 -2.7 1.9 1.8 1.9 1.3 -17.1 -2.7 -21.2 -2.7 1.9 2.4 1.9 -18.5
GU -12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6 -11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5
UA -12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6 -11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5
UC -12.1 -15.2 -11.8 -15.2 -10.6 -10.7 -10.6 -11.2 -14.7 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5
UG -12.1 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6 -11.2 -17.1 -15.2 -8.7 -15.2 -10.6 -10.1 -10.6 -18.5
UU -9.7 -15.2 -14.2 -15.2 -10.6 -10.7 -10.6 -11.2 -17.1 -15.2 -21.2 -15.2 -10.6 -10.1 -10.6 -18.5
# 5' ------> 3'
G X1 Y1 G
U X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA -0.7 -15.8 -16.0 -15.8 -15.8 -15.8 -15.8 -15.8 -20.9 -15.8 -3.3 -15.8 -15.8 -15.8 -15.8 -13.4
AC -8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0 -19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
AG -0.3 -12.3 -15.7 -12.3 -12.3 -9.9 -12.3 -9.9 -17.4 -12.3 -12.3 -12.3 -12.3 -9.9 -12.3 -12.3
AU -8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0 -19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
CA -8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0 -19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
CC -8.9 -14.0 -15.0 -14.0 -14.0 -14.0 -14.0 -14.0 -16.7 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
CG -8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0 -19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
CU -8.9 -14.0 -15.0 -14.0 -14.0 -14.0 -14.0 -14.0 -16.7 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
GA -9.1 -14.2 -30.4 -14.2 -14.2 -11.8 -14.2 -11.8 -19.3 -14.2 -14.2 -14.2 -14.2 -11.8 -14.2 -14.2
GC -8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0 -19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
GG 3.6 -1.5 -17.4 -1.5 -1.5 -1.5 -1.5 -1.5 -19.1 -1.5 -14.0 -1.5 -1.5 -1.5 -1.5 -14.0
GU -8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0 -19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
UA -8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0 -19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
UC -8.9 -14.0 -15.0 -14.0 -14.0 -14.0 -14.0 -14.0 -16.7 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
UG -8.9 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0 -19.1 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
UU -6.5 -14.0 -17.4 -14.0 -14.0 -14.0 -14.0 -14.0 -19.1 -14.0 -14.0 -14.0 -14.0 -14.0 -14.0 -14.0
# 5' ------> 3'
G X1 Y1 U
U X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA -4.9 -8.0 -18.8 -8.0 -7.8 -7.9 -7.8 -7.9 -17.0 -8.0 0.4 -8.0 -7.8 -7.9 -7.8 -15.3
AC -3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2 -6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9
AG -1.3 -4.4 -15.2 -4.4 -4.3 -1.9 -4.3 -1.9 -13.4 -4.4 -8.5 -4.4 -4.3 -1.9 -4.3 -14.1
AU -3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2 -6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9
CA -3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2 -6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9
CC -3.1 -6.2 -14.6 -6.2 -6.0 -6.1 -6.0 -6.1 -12.8 -6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9
CG -3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2 -6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9
CU -3.1 -6.2 -14.6 -6.2 -6.0 -6.1 -6.0 -6.1 -12.8 -6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9
GA -3.2 -6.3 -17.1 -6.3 -6.2 -3.8 -6.2 -3.8 -15.3 -6.3 -10.4 -6.3 -6.2 -3.8 -6.2 -16.0
GC -3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2 -6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9
GG 9.4 6.3 -17.0 6.3 6.5 6.4 6.5 6.4 -15.2 6.3 -10.3 6.3 6.5 6.4 6.5 -15.9
GU -3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2 -6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9
UA -3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2 -6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9
UC -3.1 -6.2 -14.6 -6.2 -6.0 -6.1 -6.0 -6.1 -12.8 -6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9
UG -3.1 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2 -6.2 2.2 -6.2 -6.0 -6.1 -6.0 -15.9
UU -0.7 -6.2 -17.0 -6.2 -6.0 -6.1 -6.0 -6.1 -15.2 -6.2 -10.3 -6.2 -6.0 -6.1 -6.0 -15.9
# 5' ------> 3'
G X1 Y1 U
U X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA -23.2 -21.4 -21.5 -21.4 -21.4 -21.4 -21.4 -21.4 -19.6 -21.4 -8.9 -21.4 -21.4 -21.4 -21.4 -19.0
AC -21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6 -19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6
AG -19.6 -17.8 -18.0 -17.8 -17.8 -15.4 -17.8 -15.4 -16.1 -17.8 -17.8 -17.8 -17.8 -15.4 -17.8 -17.8
AU -21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6 -19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6
CA -21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6 -19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6
CC -21.4 -19.6 -17.3 -19.6 -19.6 -19.6 -19.6 -19.6 -15.4 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6
CG -21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6 -19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6
CU -21.4 -19.6 -17.3 -19.6 -19.6 -19.6 -19.6 -19.6 -15.4 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6
GA -21.5 -19.7 -19.9 -19.7 -19.7 -17.3 -19.7 -17.3 -18.0 -19.7 -19.7 -19.7 -19.7 -17.3 -19.7 -19.7
GC -21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6 -19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6
GG -8.9 -7.1 -19.7 -7.1 -7.1 -7.1 -7.1 -7.1 -17.8 -7.1 -19.6 -7.1 -7.1 -7.1 -7.1 -19.6
GU -21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6 -19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6
UA -21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6 -19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6
UC -21.4 -19.6 -17.3 -19.6 -19.6 -19.6 -19.6 -19.6 -15.4 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6
UG -21.4 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6 -19.6 -17.8 -19.6 -7.1 -19.6 -19.6 -19.6 -19.6 -19.6
UU -19.0 -19.6 -19.7 -19.6 -19.6 -19.6 -19.6 -19.6 -17.8 -19.6 -19.6 -19.6 -19.6 -19.6 -19.6 -19.6
# 5' ------> 3'
U X1 Y1 A
A X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 14.7 11.9 0.6 11.9 13.4 13.4 13.4 12.1 -2.3 11.9 21.2 11.9 13.4 9.0 13.4 6.4
AC 13.4 10.6 -0.6 10.6 12.1 12.1 12.1 10.8 -3.6 10.6 19.9 10.6 12.1 7.7 12.1 2.7
AG -2.3 -5.1 -16.4 -5.1 -3.6 -1.2 -3.6 -2.5 -19.4 -5.1 -8.3 -5.1 -3.6 -5.6 -3.6 -13.0
AU 13.4 10.6 -0.6 10.6 12.1 12.1 12.1 10.8 -3.6 10.6 19.9 10.6 12.1 7.7 12.1 2.7
CA 11.9 9.1 -2.1 9.1 10.6 10.6 10.6 9.3 -5.1 9.1 18.4 9.1 10.6 6.2 10.6 1.2
CC 13.4 10.6 1.8 10.6 12.1 12.1 12.1 10.8 -1.2 10.6 19.9 10.6 12.1 7.7 12.1 2.7
CG 11.9 9.1 -2.1 9.1 10.6 10.6 10.6 9.3 -5.1 9.1 18.4 9.1 10.6 6.2 10.6 1.2
CU 9.0 6.2 -2.6 6.2 7.7 7.7 7.7 6.4 -5.6 6.2 15.5 6.2 7.7 3.3 7.7 -1.7
GA 0.6 -2.1 -13.4 -2.1 -0.6 1.8 -0.6 0.5 -16.4 -2.1 -5.3 -2.1 -0.6 -2.6 -0.6 -10.0
GC 13.4 10.6 -0.6 10.6 12.1 12.1 12.1 10.8 -3.6 10.6 19.9 10.6 12.1 7.7 12.1 2.7
GG 21.2 18.4 -5.3 18.4 19.9 19.9 19.9 18.6 -8.3 18.4 2.7 18.4 19.9 15.5 19.9 -2.0
GU 13.4 10.6 -0.6 10.6 12.1 12.1 12.1 10.8 -3.6 10.6 19.9 10.6 12.1 7.7 12.1 2.7
UA 11.9 9.1 -2.1 9.1 10.6 10.6 10.6 9.3 -5.1 9.1 18.4 9.1 10.6 6.2 10.6 1.2
UC 12.1 9.3 0.5 9.3 10.8 10.8 10.8 9.5 -2.5 9.3 18.6 9.3 10.8 6.4 10.8 1.4
UG 11.9 9.1 -2.1 9.1 10.6 10.6 10.6 9.3 -5.1 9.1 18.4 9.1 10.6 6.2 10.6 1.2
UU 6.4 1.2 -10.0 1.2 2.7 2.7 2.7 1.4 -13.0 1.2 -2.0 1.2 2.7 -1.7 2.7 -6.7
# 5' ------> 3'
U X1 Y1 C
A X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 6.7 2.2 -5.2 2.2 3.0 0.0 3.0 0.0 -0.4 2.2 8.5 2.2 3.0 -3.1 3.0 2.5
AC 5.4 0.9 -6.5 0.9 1.7 -1.3 1.7 -1.3 -1.7 0.9 7.2 0.9 1.7 -4.4 1.7 -1.1
AG -10.3 -14.8 -22.2 -14.8 -14.0 -14.6 -14.0 -14.6 -17.5 -14.8 -21.1 -14.8 -14.0 -17.7 -14.0 -16.9
AU 5.4 0.9 -6.5 0.9 1.7 -1.3 1.7 -1.3 -1.7 0.9 7.2 0.9 1.7 -4.4 1.7 -1.1
CA 3.9 -0.6 -8.0 -0.6 0.2 -2.8 0.2 -2.8 -3.2 -0.6 5.7 -0.6 0.2 -5.9 0.2 -2.6
CC 5.4 0.9 -4.1 0.9 1.7 -1.3 1.7 -1.3 0.7 0.9 7.2 0.9 1.7 -4.4 1.7 -1.1
CG 3.9 -0.6 -8.0 -0.6 0.2 -2.8 0.2 -2.8 -3.2 -0.6 5.7 -0.6 0.2 -5.9 0.2 -2.6
CU 1.0 -3.5 -8.5 -3.5 -2.6 -5.7 -2.6 -5.7 -3.7 -3.5 2.8 -3.5 -2.6 -8.8 -2.6 -5.5
GA -7.3 -11.8 -19.2 -11.8 -11.0 -11.6 -11.0 -11.6 -14.5 -11.8 -18.1 -11.8 -11.0 -14.7 -11.0 -13.9
GC 5.4 0.9 -6.5 0.9 1.7 -1.3 1.7 -1.3 -1.7 0.9 7.2 0.9 1.7 -4.4 1.7 -1.1
GG 13.2 8.7 -11.2 8.7 9.6 6.5 9.6 6.5 -6.4 8.7 -10.0 8.7 9.6 3.4 9.6 -5.8
GU 5.4 0.9 -6.5 0.9 1.7 -1.3 1.7 -1.3 -1.7 0.9 7.2 0.9 1.7 -4.4 1.7 -1.1
UA 3.9 -0.6 -8.0 -0.6 0.2 -2.8 0.2 -2.8 -3.2 -0.6 5.7 -0.6 0.2 -5.9 0.2 -2.6
UC 4.1 -0.4 -5.4 -0.4 0.4 -2.6 0.4 -2.6 -0.6 -0.4 5.9 -0.4 0.4 -5.7 0.4 -2.4
UG 3.9 -0.6 -8.0 -0.6 0.2 -2.8 0.2 -2.8 -3.2 -0.6 5.7 -0.6 0.2 -5.9 0.2 -2.6
UU -1.6 -8.5 -15.9 -8.5 -7.6 -10.7 -7.6 -10.7 -11.1 -8.5 -14.7 -8.5 -7.6 -13.8 -7.6 -10.5
# 5' ------> 3'
U X1 Y1 G
A X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 5.0 1.9 2.9 1.9 6.5 6.4 6.5 5.9 0.0 1.9 8.5 1.9 6.5 7.0 6.5 1.0
AC 3.7 0.6 1.6 0.6 5.2 5.1 5.2 4.6 -1.2 0.6 7.2 0.6 5.2 5.7 5.2 -2.7
AG -12.0 -15.1 -14.1 -15.1 -10.5 -8.2 -10.5 -8.7 -17.0 -15.1 -21.1 -15.1 -10.5 -7.6 -10.5 -18.4
AU 3.7 0.6 1.6 0.6 5.2 5.1 5.2 4.6 -1.2 0.6 7.2 0.6 5.2 5.7 5.2 -2.7
CA 2.2 -0.8 0.1 -0.8 3.7 3.6 3.7 3.1 -2.7 -0.8 5.7 -0.8 3.7 4.2 3.7 -4.2
CC 3.7 0.6 4.0 0.6 5.2 5.1 5.2 4.6 1.2 0.6 7.2 0.6 5.2 5.7 5.2 -2.7
CG 2.2 -0.8 0.1 -0.8 3.7 3.6 3.7 3.1 -2.7 -0.8 5.7 -0.8 3.7 4.2 3.7 -4.2
CU -0.6 -3.7 -0.4 -3.7 0.8 0.7 0.8 0.2 -3.2 -3.7 2.8 -3.7 0.8 1.3 0.8 -7.1
GA -9.0 -12.1 -11.1 -12.1 -7.5 -5.2 -7.5 -5.7 -14.0 -12.1 -18.1 -12.1 -7.5 -4.6 -7.5 -15.4
GC 3.7 0.6 1.6 0.6 5.2 5.1 5.2 4.6 -1.2 0.6 7.2 0.6 5.2 5.7 5.2 -2.7
GG 11.6 8.5 -3.1 8.5 13.0 12.9 13.0 12.5 -5.9 8.5 -10.0 8.5 13.0 13.5 13.0 -7.4
GU 3.7 0.6 1.6 0.6 5.2 5.1 5.2 4.6 -1.2 0.6 7.2 0.6 5.2 5.7 5.2 -2.7
UA 2.2 -0.8 0.1 -0.8 3.7 3.6 3.7 3.1 -2.7 -0.8 5.7 -0.8 3.7 4.2 3.7 -4.2
UC 2.4 -0.6 2.7 -0.6 3.9 3.8 3.9 3.3 -0.1 -0.6 5.9 -0.6 3.9 4.4 3.9 -4.0
UG 2.2 -0.8 0.1 -0.8 3.7 3.6 3.7 3.1 -2.7 -0.8 5.7 -0.8 3.7 4.2 3.7 -4.2
UU -3.2 -8.7 -7.8 -8.7 -4.2 -4.2 -4.2 -4.7 -10.6 -8.7 -14.7 -8.7 -4.2 -3.6 -4.2 -12.1
# 5' ------> 3'
U X1 Y1 G
A X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 8.2 3.1 -0.3 3.1 3.1 3.1 3.1 3.1 -2.0 3.1 15.6 3.1 3.1 3.1 3.1 5.5
AC 6.9 1.8 -1.6 1.8 1.8 1.8 1.8 1.8 -3.3 1.8 14.3 1.8 1.8 1.8 1.8 1.8
AG -8.8 -13.9 -17.3 -13.9 -13.9 -11.5 -13.9 -11.5 -19.0 -13.9 -13.9 -13.9 -13.9 -11.5 -13.9 -13.9
AU 6.9 1.8 -1.6 1.8 1.8 1.8 1.8 1.8 -3.3 1.8 14.3 1.8 1.8 1.8 1.8 1.8
CA 5.4 0.3 -3.1 0.3 0.3 0.3 0.3 0.3 -4.8 0.3 12.8 0.3 0.3 0.3 0.3 0.3
CC 6.9 1.8 0.8 1.8 1.8 1.8 1.8 1.8 -0.9 1.8 14.3 1.8 1.8 1.8 1.8 1.8
CG 5.4 0.3 -3.1 0.3 0.3 0.3 0.3 0.3 -4.8 0.3 12.8 0.3 0.3 0.3 0.3 0.3
CU 2.5 -2.6 -3.6 -2.6 -2.6 -2.6 -2.6 -2.6 -5.3 -2.6 9.9 -2.6 -2.6 -2.6 -2.6 -2.6
GA -5.8 -10.9 -14.3 -10.9 -10.9 -8.5 -10.9 -8.5 -16.0 -10.9 -10.9 -10.9 -10.9 -8.5 -10.9 -10.9
GC 6.9 1.8 -1.6 1.8 1.8 1.8 1.8 1.8 -3.3 1.8 14.3 1.8 1.8 1.8 1.8 1.8
GG 14.7 9.6 -6.3 9.6 9.6 9.6 9.6 9.6 -8.0 9.6 -2.9 9.6 9.6 9.6 9.6 -2.9
GU 6.9 1.8 -1.6 1.8 1.8 1.8 1.8 1.8 -3.3 1.8 14.3 1.8 1.8 1.8 1.8 1.8
UA 5.4 0.3 -3.1 0.3 0.3 0.3 0.3 0.3 -4.8 0.3 12.8 0.3 0.3 0.3 0.3 0.3
UC 5.6 0.5 -0.5 0.5 0.5 0.5 0.5 0.5 -2.2 0.5 13.0 0.5 0.5 0.5 0.5 0.5
UG 5.4 0.3 -3.1 0.3 0.3 0.3 0.3 0.3 -4.8 0.3 12.8 0.3 0.3 0.3 0.3 0.3
UU -0.1 -7.6 -11.0 -7.6 -7.6 -7.6 -7.6 -7.6 -12.7 -7.6 -7.6 -7.6 -7.6 -7.6 -7.6 -7.6
# 5' ------> 3'
U X1 Y1 U
A X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 14.0 10.9 0.1 10.9 11.1 11.0 11.1 11.0 1.9 10.9 19.3 10.9 11.1 11.0 11.1 3.6
AC 12.7 9.6 -1.1 9.6 9.8 9.7 9.8 9.7 0.6 9.6 18.0 9.6 9.8 9.7 9.8 0.0
AG -3.0 -6.1 -16.9 -6.1 -5.9 -3.6 -5.9 -3.6 -15.1 -6.1 -10.2 -6.1 -5.9 -3.6 -5.9 -15.8
AU 12.7 9.6 -1.1 9.6 9.8 9.7 9.8 9.7 0.6 9.6 18.0 9.6 9.8 9.7 9.8 0.0
CA 11.2 8.1 -2.6 8.1 8.3 8.2 8.3 8.2 -0.8 8.1 16.5 8.1 8.3 8.2 8.3 -1.5
CC 12.7 9.6 1.3 9.6 9.8 9.7 9.8 9.7 3.0 9.6 18.0 9.6 9.8 9.7 9.8 0.0
CG 11.2 8.1 -2.6 8.1 8.3 8.2 8.3 8.2 -0.8 8.1 16.5 8.1 8.3 8.2 8.3 -1.5
CU 8.3 5.2 -3.1 5.2 5.4 5.3 5.4 5.3 -1.3 5.2 13.6 5.2 5.4 5.3 5.4 -4.4
GA 0.0 -3.1 -13.9 -3.1 -2.9 -0.6 -2.9 -0.6 -12.1 -3.1 -7.2 -3.1 -2.9 -0.6 -2.9 -12.8
GC 12.7 9.6 -1.1 9.6 9.8 9.7 9.8 9.7 0.6 9.6 18.0 9.6 9.8 9.7 9.8 0.0
GG 20.5 17.4 -5.8 17.4 17.6 17.5 17.6 17.5 -4.0 17.4 0.8 17.4 17.6 17.5 17.6 -4.7
GU 12.7 9.6 -1.1 9.6 9.8 9.7 9.8 9.7 0.6 9.6 18.0 9.6 9.8 9.7 9.8 0.0
UA 11.2 8.1 -2.6 8.1 8.3 8.2 8.3 8.2 -0.8 8.1 16.5 8.1 8.3 8.2 8.3 -1.5
UC 11.4 8.3 0.0 8.3 8.5 8.4 8.5 8.4 1.8 8.3 16.7 8.3 8.5 8.4 8.5 -1.3
UG 11.2 8.1 -2.6 8.1 8.3 8.2 8.3 8.2 -0.8 8.1 16.5 8.1 8.3 8.2 8.3 -1.5
UU 5.7 0.2 -10.5 0.2 0.4 0.3 0.4 0.3 -8.7 0.2 -3.8 0.2 0.4 0.3 0.4 -9.4
# 5' ------> 3'
U X1 Y1 U
A X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA -4.2 -2.4 -2.6 -2.4 -2.4 -2.4 -2.4 -2.4 -0.7 -2.4 10.1 -2.4 -2.4 -2.4 -2.4 0.0
AC -5.5 -3.7 -3.9 -3.7 -3.7 -3.7 -3.7 -3.7 -2.0 -3.7 8.8 -3.7 -3.7 -3.7 -3.7 -3.7
AG -21.3 -19.5 -19.6 -19.5 -19.5 -17.1 -19.5 -17.1 -17.7 -19.5 -19.5 -19.5 -19.5 -17.1 -19.5 -19.5
AU -5.5 -3.7 -3.9 -3.7 -3.7 -3.7 -3.7 -3.7 -2.0 -3.7 8.8 -3.7 -3.7 -3.7 -3.7 -3.7
CA -7.0 -5.2 -5.4 -5.2 -5.2 -5.2 -5.2 -5.2 -3.5 -5.2 7.3 -5.2 -5.2 -5.2 -5.2 -5.2
CC -5.5 -3.7 -1.5 -3.7 -3.7 -3.7 -3.7 -3.7 0.4 -3.7 8.8 -3.7 -3.7 -3.7 -3.7 -3.7
CG -7.0 -5.2 -5.4 -5.2 -5.2 -5.2 -5.2 -5.2 -3.5 -5.2 7.3 -5.2 -5.2 -5.2 -5.2 -5.2
CU -9.9 -8.1 -5.9 -8.1 -8.1 -8.1 -8.1 -8.1 -4.0 -8.1 4.4 -8.1 -8.1 -8.1 -8.1 -8.1
GA -18.3 -16.5 -16.6 -16.5 -16.5 -14.1 -16.5 -14.1 -14.7 -16.5 -16.5 -16.5 -16.5 -14.1 -16.5 -16.5
GC -5.5 -3.7 -3.9 -3.7 -3.7 -3.7 -3.7 -3.7 -2.0 -3.7 8.8 -3.7 -3.7 -3.7 -3.7 -3.7
GG 2.3 4.1 -8.6 4.1 4.1 4.1 4.1 4.1 -6.7 4.1 -8.4 4.1 4.1 4.1 4.1 -8.4
GU -5.5 -3.7 -3.9 -3.7 -3.7 -3.7 -3.7 -3.7 -2.0 -3.7 8.8 -3.7 -3.7 -3.7 -3.7 -3.7
UA -7.0 -5.2 -5.4 -5.2 -5.2 -5.2 -5.2 -5.2 -3.5 -5.2 7.3 -5.2 -5.2 -5.2 -5.2 -5.2
UC -6.8 -5.0 -2.8 -5.0 -5.0 -5.0 -5.0 -5.0 -0.9 -5.0 7.5 -5.0 -5.0 -5.0 -5.0 -5.0
UG -7.0 -5.2 -5.4 -5.2 -5.2 -5.2 -5.2 -5.2 -3.5 -5.2 7.3 -5.2 -5.2 -5.2 -5.2 -5.2
UU -12.5 -13.1 -13.3 -13.1 -13.1 -13.1 -13.1 -13.1 -11.4 -13.1 -13.1 -13.1 -13.1 -13.1 -13.1 -13.1
# 5' ------> 3'
U X1 Y1 A
G X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 8.2 5.4 -5.8 5.4 6.9 6.9 6.9 5.6 -8.8 5.4 14.7 5.4 6.9 2.5 6.9 -0.1
AC 3.1 0.3 -10.9 0.3 1.8 1.8 1.8 0.5 -13.9 0.3 9.6 0.3 1.8 -2.6 1.8 -7.6
AG -2.0 -4.8 -16.0 -4.8 -3.3 -0.9 -3.3 -2.2 -19.0 -4.8 -8.0 -4.8 -3.3 -5.3 -3.3 -12.7
AU 3.1 0.3 -10.9 0.3 1.8 1.8 1.8 0.5 -13.9 0.3 9.6 0.3 1.8 -2.6 1.8 -7.6
CA 3.1 0.3 -10.9 0.3 1.8 1.8 1.8 0.5 -13.9 0.3 9.6 0.3 1.8 -2.6 1.8 -7.6
CC 3.1 0.3 -8.5 0.3 1.8 1.8 1.8 0.5 -11.5 0.3 9.6 0.3 1.8 -2.6 1.8 -7.6
CG 3.1 0.3 -10.9 0.3 1.8 1.8 1.8 0.5 -13.9 0.3 9.6 0.3 1.8 -2.6 1.8 -7.6
CU 3.1 0.3 -8.5 0.3 1.8 1.8 1.8 0.5 -11.5 0.3 9.6 0.3 1.8 -2.6 1.8 -7.6
GA -0.3 -3.1 -14.3 -3.1 -1.6 0.8 -1.6 -0.5 -17.3 -3.1 -6.3 -3.1 -1.6 -3.6 -1.6 -11.0
GC 3.1 0.3 -10.9 0.3 1.8 1.8 1.8 0.5 -13.9 0.3 9.6 0.3 1.8 -2.6 1.8 -7.6
GG 15.6 12.8 -10.9 12.8 14.3 14.3 14.3 13.0 -13.9 12.8 -2.9 12.8 14.3 9.9 14.3 -7.6
GU 3.1 0.3 -10.9 0.3 1.8 1.8 1.8 0.5 -13.9 0.3 9.6 0.3 1.8 -2.6 1.8 -7.6
UA 3.1 0.3 -10.9 0.3 1.8 1.8 1.8 0.5 -13.9 0.3 9.6 0.3 1.8 -2.6 1.8 -7.6
UC 3.1 0.3 -8.5 0.3 1.8 1.8 1.8 0.5 -11.5 0.3 9.6 0.3 1.8 -2.6 1.8 -7.6
UG 3.1 0.3 -10.9 0.3 1.8 1.8 1.8 0.5 -13.9 0.3 9.6 0.3 1.8 -2.6 1.8 -7.6
UU 5.5 0.3 -10.9 0.3 1.8 1.8 1.8 0.5 -13.9 0.3 -2.9 0.3 1.8 -2.6 1.8 -7.6
# 5' ------> 3'
U X1 Y1 C
G X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA -20.4 -4.3 -11.7 -4.3 -3.4 -6.5 -3.4 -6.5 -6.9 -4.3 2.0 -4.3 -3.4 -9.6 -3.4 -3.9
AC -4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6 -12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4
AG -10.0 -14.5 -21.9 -14.5 -13.6 -14.3 -13.6 -14.3 -17.1 -14.5 -20.7 -14.5 -13.6 -17.4 -13.6 -16.5
AU -4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6 -12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4
CA -4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6 -12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4
CC -4.9 -9.4 -14.4 -9.4 -8.5 -11.6 -8.5 -11.6 -9.6 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4
CG -4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6 -12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4
CU -4.9 -9.4 -14.4 -9.4 -8.5 -11.6 -8.5 -11.6 -9.6 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4
GA -8.3 -12.8 -20.2 -12.8 -11.9 -12.6 -11.9 -12.6 -15.4 -12.8 -19.0 -12.8 -11.9 -15.7 -11.9 -14.8
GC -4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6 -12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4
GG 7.6 3.1 -16.8 3.1 4.0 0.9 4.0 0.9 -12.0 3.1 -15.6 3.1 4.0 -2.2 4.0 -11.4
GU -4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6 -12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4
UA -4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6 -12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4
UC -4.9 -9.4 -14.4 -9.4 -8.5 -11.6 -8.5 -11.6 -9.6 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4
UG -4.9 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6 -12.0 -9.4 -3.1 -9.4 -8.5 -14.7 -8.5 -11.4
UU -2.5 -9.4 -16.8 -9.4 -8.5 -11.6 -8.5 -11.6 -12.0 -9.4 -15.6 -9.4 -8.5 -14.7 -8.5 -11.4
# 5' ------> 3'
U X1 Y1 G
G X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA -1.4 -4.5 -3.6 -4.5 0.0 0.0 0.0 -0.5 -6.4 -4.5 2.0 -4.5 0.0 0.5 0.0 -5.5
AC -6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5 -9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0
AG -11.6 -14.7 -13.8 -14.7 -10.2 -7.8 -10.2 -8.3 -16.6 -14.7 -20.7 -14.7 -10.2 -7.2 -10.2 -18.1
AU -6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5 -9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0
CA -6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5 -9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0
CC -6.5 -9.6 -6.3 -9.6 -5.1 -5.1 -5.1 -5.6 -9.1 -9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0
CG -6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5 -9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0
CU -6.5 -9.6 -6.3 -9.6 -5.1 -5.1 -5.1 -5.6 -9.1 -9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0
GA -9.9 -13.0 -12.1 -13.0 -8.5 -6.1 -8.5 -6.6 -14.9 -13.0 -19.0 -13.0 -8.5 -5.5 -8.5 -16.4
GC -6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5 -9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0
GG 6.0 2.9 -8.7 2.9 7.4 7.4 7.4 6.9 -11.5 2.9 -15.6 2.9 7.4 8.0 7.4 -13.0
GU -6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5 -9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0
UA -6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5 -9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0
UC -6.5 -9.6 -6.3 -9.6 -5.1 -5.1 -5.1 -5.6 -9.1 -9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0
UG -6.5 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5 -9.6 -3.1 -9.6 -5.1 -4.5 -5.1 -13.0
UU -4.1 -9.6 -8.7 -9.6 -5.1 -5.1 -5.1 -5.6 -11.5 -9.6 -15.6 -9.6 -5.1 -4.5 -5.1 -13.0
# 5' ------> 3'
U X1 Y1 G
G X2 Y2 U
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.7 -3.4 -6.8 -3.4 -3.4 -3.4 -3.4 -3.4 -8.5 -3.4 9.1 -3.4 -3.4 -3.4 -3.4 -1.0
AC -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
AG -8.5 -13.6 -17.0 -13.6 -13.6 -11.2 -13.6 -11.2 -18.7 -13.6 -13.6 -13.6 -13.6 -11.2 -13.6 -13.6
AU -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
CA -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
CC -3.4 -8.5 -9.5 -8.5 -8.5 -8.5 -8.5 -8.5 -11.2 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
CG -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
CU -3.4 -8.5 -9.5 -8.5 -8.5 -8.5 -8.5 -8.5 -11.2 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
GA -6.8 -11.9 -15.3 -11.9 -11.9 -9.5 -11.9 -9.5 -17.0 -11.9 -11.9 -11.9 -11.9 -9.5 -11.9 -11.9
GC -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
GG 9.1 4.0 -11.9 4.0 4.0 4.0 4.0 4.0 -13.6 4.0 -8.5 4.0 4.0 4.0 4.0 -8.5
GU -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
UA -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
UC -3.4 -8.5 -9.5 -8.5 -8.5 -8.5 -8.5 -8.5 -11.2 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
UG -3.4 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 4.0 -8.5 -8.5 -8.5 -8.5 -8.5
UU -1.0 -8.5 -11.9 -8.5 -8.5 -8.5 -8.5 -8.5 -13.6 -8.5 -8.5 -8.5 -8.5 -8.5 -8.5 -8.5
# 5' ------> 3'
U X1 Y1 U
G X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA 7.5 4.4 -6.3 4.4 4.6 4.5 4.6 4.5 -4.5 4.4 12.8 4.4 4.6 4.5 4.6 -2.8
AC 2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6 -0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3
AG -2.6 -5.7 -16.5 -5.7 -5.6 -3.2 -5.6 -3.2 -14.7 -5.7 -9.8 -5.7 -5.6 -3.2 -5.6 -15.4
AU 2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6 -0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3
CA 2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6 -0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3
CC 2.4 -0.6 -9.0 -0.6 -0.5 -0.5 -0.5 -0.5 -7.2 -0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3
CG 2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6 -0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3
CU 2.4 -0.6 -9.0 -0.6 -0.5 -0.5 -0.5 -0.5 -7.2 -0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3
GA -0.9 -4.0 -14.8 -4.0 -3.9 -1.5 -3.9 -1.5 -13.0 -4.0 -8.1 -4.0 -3.9 -1.5 -3.9 -13.7
GC 2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6 -0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3
GG 14.9 11.9 -11.4 11.9 12.0 12.0 12.0 12.0 -9.6 11.9 -4.7 11.9 12.0 12.0 12.0 -10.3
GU 2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6 -0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3
UA 2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6 -0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3
UC 2.4 -0.6 -9.0 -0.6 -0.5 -0.5 -0.5 -0.5 -7.2 -0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3
UG 2.4 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6 -0.6 7.8 -0.6 -0.5 -0.5 -0.5 -10.3
UU 4.8 -0.6 -11.4 -0.6 -0.5 -0.5 -0.5 -0.5 -9.6 -0.6 -4.7 -0.6 -0.5 -0.5 -0.5 -10.3
# 5' ------> 3'
U X1 Y1 U
G X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G U U U U
A C G U A C G U A C G U A C G U
#----------------------------------------------------------------------------------------------------------------------------------
AA -0.7 -8.9 -9.1 -8.9 -8.9 -8.9 -8.9 -8.9 -0.3 -8.9 3.6 -8.9 -8.9 -8.9 -8.9 -6.5
AC -15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0 -14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
AG -20.9 -19.1 -19.3 -19.1 -19.1 -16.7 -19.1 -16.7 -17.4 -19.1 -19.1 -19.1 -19.1 -16.7 -19.1 -19.1
AU -15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0 -14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
CA -15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0 -14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
CC -15.8 -14.0 -11.8 -14.0 -14.0 -14.0 -14.0 -14.0 -9.9 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
CG -15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0 -14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
CU -15.8 -14.0 -11.8 -14.0 -14.0 -14.0 -14.0 -14.0 -9.9 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
GA -16.0 -17.4 -30.4 -17.4 -17.4 -15.0 -17.4 -15.0 -15.7 -17.4 -17.4 -17.4 -17.4 -15.0 -17.4 -17.4
GC -15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0 -14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
GG -3.3 -1.5 -14.2 -1.5 -1.5 -1.5 -1.5 -1.5 -12.3 -1.5 -14.0 -1.5 -1.5 -1.5 -1.5 -14.0
GU -15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0 -14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
UA -15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0 -14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
UC -15.8 -14.0 -11.8 -14.0 -14.0 -14.0 -14.0 -14.0 -9.9 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
UG -15.8 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0 -14.0 -12.3 -14.0 -1.5 -14.0 -14.0 -14.0 -14.0 -14.0
UU -13.4 -14.0 -14.2 -14.0 -14.0 -14.0 -14.0 -14.0 -12.3 -14.0 -14.0 -14.0 -14.0 -14.0 -14.0 -14.0