# Data tables for 2x2 interior loops # Free energies at 37 degrees for RNA # Data arrangement: # # 5' ------> 3' # A X1 Y1 A # U X2 Y2 U # 3' <------ 5' # # Y--> # ---------------------------------------------------------------------------------------------------------------------------- # (X) A A A A C C C C G G G G U U U U # | A C G U A C G U A C G U A C G U # V ---------------------------------------------------------------------------------------------------------------------------- # (AA) 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 2.5 # (AC) 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 1.7 2.2 1.1 2.2 2.6 2.3 2.6 1.8 # (AG) 2.2 1.8 1.2 1.8 2.2 2.8 2.2 2.8 1.3 1.8 2.0 1.8 2.2 2.5 2.2 1.4 # (AU) 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 1.7 2.2 1.1 2.2 2.6 2.3 2.6 1.8 # (CA) 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 1.6 2.1 1.0 2.1 2.5 2.2 2.5 1.7 # (CC) 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.2 2.1 1.0 2.1 2.6 2.3 2.6 1.7 # (CG) 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 1.6 2.1 1.0 2.1 2.5 2.2 2.5 1.7 # (CU) 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.2 2.1 1.0 2.1 2.6 2.3 2.6 1.7 # (GA) 1.5 1.1 0.5 1.1 1.5 2.1 1.5 2.1 0.6 1.1 1.3 1.1 1.5 1.8 1.5 0.7 # (GC) 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 1.7 2.2 1.1 2.2 2.6 2.3 2.6 1.8 # (GG) 1.0 0.6 1.3 0.6 1.0 1.0 1.0 1.0 1.4 0.6 2.1 0.6 1.0 0.7 1.0 1.5 # (GU) 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 1.7 2.2 1.1 2.2 2.6 2.3 2.6 1.8 # (UA) 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 1.6 2.1 1.0 2.1 2.5 2.2 2.5 1.7 # (UC) 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.2 2.1 1.0 2.1 2.6 2.3 2.6 1.7 # (UG) 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 1.6 2.1 1.0 2.1 2.5 2.2 2.5 1.7 # (UU) 2.3 1.2 0.6 1.2 1.7 1.7 1.7 1.7 0.7 1.2 1.4 1.2 1.7 1.4 1.7 0.8 # 5' ------> 3' A X1 Y1 A U X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 2.5 AC 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 1.7 2.2 1.1 2.2 2.6 2.3 2.6 1.8 AG 2.2 1.8 1.2 1.8 2.2 2.8 2.2 2.8 1.3 1.8 2.0 1.8 2.2 2.5 2.2 1.4 AU 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 1.7 2.2 1.1 2.2 2.6 2.3 2.6 1.8 CA 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 1.6 2.1 1.0 2.1 2.5 2.2 2.5 1.7 CC 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.2 2.1 1.0 2.1 2.6 2.3 2.6 1.7 CG 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 1.6 2.1 1.0 2.1 2.5 2.2 2.5 1.7 CU 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.2 2.1 1.0 2.1 2.6 2.3 2.6 1.7 GA 1.5 1.1 0.5 1.1 1.5 2.1 1.5 2.1 0.6 1.1 1.3 1.1 1.5 1.8 1.5 0.7 GC 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 1.7 2.2 1.1 2.2 2.6 2.3 2.6 1.8 GG 1.0 0.6 1.3 0.6 1.0 1.0 1.0 1.0 1.4 0.6 2.1 0.6 1.0 0.7 1.0 1.5 GU 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 1.7 2.2 1.1 2.2 2.6 2.3 2.6 1.8 UA 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 1.6 2.1 1.0 2.1 2.5 2.2 2.5 1.7 UC 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.2 2.1 1.0 2.1 2.6 2.3 2.6 1.7 UG 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 1.6 2.1 1.0 2.1 2.5 2.2 2.5 1.7 UU 2.3 1.2 0.6 1.2 1.7 1.7 1.7 1.7 0.7 1.2 1.4 1.2 1.7 1.4 1.7 0.8 # 5' ------> 3' A X1 Y1 C U X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.7 AC 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 0.6 1.7 0.3 1.7 1.7 1.8 1.7 1.0 AG 1.6 1.3 -0.4 1.3 1.3 1.9 1.3 1.9 0.2 1.3 1.2 1.3 1.3 2.0 1.3 0.6 AU 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 0.6 1.7 0.3 1.7 1.7 1.8 1.7 1.0 CA 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 0.5 1.6 0.2 1.6 1.6 1.7 1.6 0.9 CC 1.9 1.7 0.5 1.7 1.6 1.7 1.6 1.7 1.1 1.7 0.3 1.7 1.6 1.7 1.6 0.9 CG 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 0.5 1.6 0.2 1.6 1.6 1.7 1.6 0.9 CU 1.9 1.7 0.5 1.7 1.6 1.7 1.6 1.7 1.1 1.7 0.3 1.7 1.6 1.7 1.6 0.9 GA 0.9 0.6 -1.1 0.6 0.6 1.2 0.6 1.2 -0.5 0.6 0.5 0.6 0.6 1.3 0.6 -0.1 GC 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 0.6 1.7 0.3 1.7 1.7 1.8 1.7 1.0 GG 0.4 0.1 -0.3 0.1 0.1 0.1 0.1 0.1 0.3 0.1 1.3 0.1 0.1 0.2 0.1 0.7 GU 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 0.6 1.7 0.3 1.7 1.7 1.8 1.7 1.0 UA 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 0.5 1.6 0.2 1.6 1.6 1.7 1.6 0.9 UC 1.9 1.7 0.5 1.7 1.6 1.7 1.6 1.7 1.1 1.7 0.3 1.7 1.6 1.7 1.6 0.9 UG 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 0.5 1.6 0.2 1.6 1.6 1.7 1.6 0.9 UU 1.6 0.8 -1.0 0.8 0.7 0.8 0.7 0.8 -0.3 0.8 0.7 0.8 0.7 0.8 0.7 0.0 # 5' ------> 3' A X1 Y1 G U X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.8 AC 1.8 1.8 0.9 1.8 2.2 2.1 2.2 1.9 0.9 1.8 0.3 1.8 2.2 1.9 2.2 1.0 AG 1.4 1.4 0.5 1.4 1.8 2.3 1.8 2.1 0.5 1.4 1.2 1.4 1.8 2.1 1.8 0.6 AU 1.8 1.8 0.9 1.8 2.2 2.1 2.2 1.9 0.9 1.8 0.3 1.8 2.2 1.9 2.2 1.0 CA 1.7 1.7 0.8 1.7 2.1 2.0 2.1 1.8 0.8 1.7 0.2 1.7 2.1 1.8 2.1 0.9 CC 1.8 1.7 1.4 1.7 2.2 2.0 2.2 1.9 1.4 1.7 0.3 1.7 2.2 1.9 2.2 1.0 CG 1.7 1.7 0.8 1.7 2.1 2.0 2.1 1.8 0.8 1.7 0.2 1.7 2.1 1.8 2.1 0.9 CU 1.8 1.7 1.4 1.7 2.2 2.0 2.2 1.9 1.4 1.7 0.3 1.7 2.2 1.9 2.2 1.0 GA 0.7 0.7 -0.2 0.7 1.1 1.6 1.1 1.4 -0.2 0.7 0.5 0.7 1.1 1.4 1.1 0.0 GC 1.8 1.8 0.9 1.8 2.2 2.1 2.2 1.9 0.9 1.8 0.3 1.8 2.2 1.9 2.2 1.0 GG 0.2 0.2 0.6 0.2 0.6 0.5 0.6 0.3 0.6 0.2 1.3 0.2 0.6 0.3 0.6 0.7 GU 1.8 1.8 0.9 1.8 2.2 2.1 2.2 1.9 0.9 1.8 0.3 1.8 2.2 1.9 2.2 1.0 UA 1.7 1.7 0.8 1.7 2.1 2.0 2.1 1.8 0.8 1.7 0.2 1.7 2.1 1.8 2.1 0.9 UC 1.8 1.7 1.4 1.7 2.2 2.0 2.2 1.9 1.4 1.7 0.3 1.7 2.2 1.9 2.2 1.0 UG 1.7 1.7 0.8 1.7 2.1 2.0 2.1 1.8 0.8 1.7 0.2 1.7 2.1 1.8 2.1 0.9 UU 1.5 0.8 0.0 0.8 1.3 1.1 1.3 1.0 0.0 0.8 0.7 0.8 1.3 1.0 1.3 0.1 # 5' ------> 3' A X1 Y1 G U X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 3.4 AC 2.3 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.9 2.6 1.3 2.6 2.6 2.6 2.6 2.6 AG 1.9 2.2 0.9 2.2 2.2 2.8 2.2 2.8 2.5 2.2 2.2 2.2 2.2 2.8 2.2 2.2 AU 2.3 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.9 2.6 1.3 2.6 2.6 2.6 2.6 2.6 CA 2.2 2.5 1.2 2.5 2.5 2.5 2.5 2.5 2.8 2.5 1.2 2.5 2.5 2.5 2.5 2.5 CC 2.2 2.6 1.8 2.6 2.6 2.6 2.6 2.6 3.5 2.6 1.3 2.6 2.6 2.6 2.6 2.6 CG 2.2 2.5 1.2 2.5 2.5 2.5 2.5 2.5 2.8 2.5 1.2 2.5 2.5 2.5 2.5 2.5 CU 2.2 2.6 1.8 2.6 2.6 2.6 2.6 2.6 3.5 2.6 1.3 2.6 2.6 2.6 2.6 2.6 GA 1.2 1.5 0.2 1.5 1.5 2.1 1.5 2.1 1.8 1.5 1.5 1.5 1.5 2.1 1.5 1.5 GC 2.3 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.9 2.6 1.3 2.6 2.6 2.6 2.6 2.6 GG 0.7 1.0 1.0 1.0 1.0 1.0 1.0 1.0 2.6 1.0 2.3 1.0 1.0 1.0 1.0 2.3 GU 2.3 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.9 2.6 1.3 2.6 2.6 2.6 2.6 2.6 UA 2.2 2.5 1.2 2.5 2.5 2.5 2.5 2.5 2.8 2.5 1.2 2.5 2.5 2.5 2.5 2.5 UC 2.2 2.6 1.8 2.6 2.6 2.6 2.6 2.6 3.5 2.6 1.3 2.6 2.6 2.6 2.6 2.6 UG 2.2 2.5 1.2 2.5 2.5 2.5 2.5 2.5 2.8 2.5 1.2 2.5 2.5 2.5 2.5 2.5 UU 1.9 1.7 0.3 1.7 1.7 1.7 1.7 1.7 2.0 1.7 1.7 1.7 1.7 1.7 1.7 1.7 # 5' ------> 3' A X1 Y1 U U X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.3 AC 2.6 2.4 1.4 2.4 2.5 2.4 2.5 2.4 2.1 2.4 0.9 2.4 2.5 2.4 2.5 1.5 AG 2.2 2.0 1.0 2.0 2.1 2.6 2.1 2.6 1.7 2.0 1.8 2.0 2.1 2.6 2.1 1.1 AU 2.6 2.4 1.4 2.4 2.5 2.4 2.5 2.4 2.1 2.4 0.9 2.4 2.5 2.4 2.5 1.5 CA 2.5 2.3 1.3 2.3 2.4 2.3 2.4 2.3 2.0 2.3 0.8 2.3 2.4 2.3 2.4 1.4 CC 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.6 2.3 0.8 2.3 2.4 2.4 2.4 1.5 CG 2.5 2.3 1.3 2.3 2.4 2.3 2.4 2.3 2.0 2.3 0.8 2.3 2.4 2.3 2.4 1.4 CU 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.6 2.3 0.8 2.3 2.4 2.4 2.4 1.5 GA 1.5 1.3 0.3 1.3 1.4 1.9 1.4 1.9 1.0 1.3 1.1 1.3 1.4 1.9 1.4 0.4 GC 2.6 2.4 1.4 2.4 2.5 2.4 2.5 2.4 2.1 2.4 0.9 2.4 2.5 2.4 2.5 1.5 GG 1.0 0.8 1.1 0.8 0.9 0.8 0.9 0.8 1.8 0.8 1.9 0.8 0.9 0.8 0.9 1.2 GU 2.6 2.4 1.4 2.4 2.5 2.4 2.5 2.4 2.1 2.4 0.9 2.4 2.5 2.4 2.5 1.5 UA 2.5 2.3 1.3 2.3 2.4 2.3 2.4 2.3 2.0 2.3 0.8 2.3 2.4 2.3 2.4 1.4 UC 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.6 2.3 0.8 2.3 2.4 2.4 2.4 1.5 UG 2.5 2.3 1.3 2.3 2.4 2.3 2.4 2.3 2.0 2.3 0.8 2.3 2.4 2.3 2.4 1.4 UU 2.3 1.4 0.4 1.4 1.5 1.5 1.5 1.5 1.1 1.4 1.2 1.4 1.5 1.5 1.5 0.6 # 5' ------> 3' A X1 Y1 U U X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.7 AC 3.3 2.9 2.1 2.9 2.9 2.9 2.9 2.9 2.5 2.9 1.6 2.9 2.9 2.9 2.9 2.9 AG 2.9 2.5 1.7 2.5 2.5 3.1 2.5 3.1 2.1 2.5 2.5 2.5 2.5 3.1 2.5 2.5 AU 3.3 2.9 2.1 2.9 2.9 2.9 2.9 2.9 2.5 2.9 1.6 2.9 2.9 2.9 2.9 2.9 CA 3.2 2.8 2.0 2.8 2.8 2.8 2.8 2.8 2.4 2.8 1.5 2.8 2.8 2.8 2.8 2.8 CC 3.2 2.9 2.7 2.9 2.9 2.9 2.9 2.9 3.1 2.9 1.6 2.9 2.9 2.9 2.9 2.9 CG 3.2 2.8 2.0 2.8 2.8 2.8 2.8 2.8 2.4 2.8 1.5 2.8 2.8 2.8 2.8 2.8 CU 3.2 2.9 2.7 2.9 2.9 2.9 2.9 2.9 3.1 2.9 1.6 2.9 2.9 2.9 2.9 2.9 GA 2.2 1.8 1.0 1.8 1.8 2.4 1.8 2.4 1.4 1.8 1.8 1.8 1.8 2.4 1.8 1.8 GC 3.3 2.9 2.1 2.9 2.9 2.9 2.9 2.9 2.5 2.9 1.6 2.9 2.9 2.9 2.9 2.9 GG 1.7 1.3 1.8 1.3 1.3 1.3 1.3 1.3 2.2 1.3 2.6 1.3 1.3 1.3 1.3 2.6 GU 3.3 2.9 2.1 2.9 2.9 2.9 2.9 2.9 2.5 2.9 1.6 2.9 2.9 2.9 2.9 2.9 UA 3.2 2.8 2.0 2.8 2.8 2.8 2.8 2.8 2.4 2.8 1.5 2.8 2.8 2.8 2.8 2.8 UC 3.2 2.9 2.7 2.9 2.9 2.9 2.9 2.9 3.1 2.9 1.6 2.9 2.9 2.9 2.9 2.9 UG 3.2 2.8 2.0 2.8 2.8 2.8 2.8 2.8 2.4 2.8 1.5 2.8 2.8 2.8 2.8 2.8 UU 2.9 2.0 1.2 2.0 2.0 2.0 2.0 2.0 1.6 2.0 2.0 2.0 2.0 2.0 2.0 2.0 # 5' ------> 3' C X1 Y1 A G X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 2.0 1.5 0.9 1.5 2.0 2.0 2.0 2.0 1.0 1.5 0.4 1.5 2.0 1.7 2.0 1.7 AC 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 1.4 1.9 0.8 1.9 2.4 2.1 2.4 1.5 AG 1.0 0.6 0.0 0.6 1.0 1.6 1.0 1.6 0.1 0.6 0.8 0.6 1.0 1.3 1.0 0.2 AU 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 1.4 1.9 0.8 1.9 2.4 2.1 2.4 1.5 CA 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.0 1.5 0.4 1.5 1.9 1.6 1.9 1.1 CC 2.2 1.8 1.8 1.8 2.2 2.2 2.2 2.2 1.9 1.8 0.7 1.8 2.2 1.9 2.2 1.4 CG 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.0 1.5 0.4 1.5 1.9 1.6 1.9 1.1 CU 2.1 1.6 1.6 1.6 2.1 2.1 2.1 2.1 1.7 1.6 0.5 1.6 2.1 1.8 2.1 1.2 GA 1.0 0.6 0.0 0.6 1.0 1.6 1.0 1.6 0.1 0.6 0.8 0.6 1.0 1.3 1.0 0.2 GC 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 1.4 1.9 0.8 1.9 2.4 2.1 2.4 1.5 GG 0.5 0.0 0.7 0.0 0.5 0.5 0.5 0.5 0.8 0.0 1.5 0.0 0.5 0.2 0.5 0.9 GU 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 1.4 1.9 0.8 1.9 2.4 2.1 2.4 1.5 UA 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.0 1.5 0.4 1.5 1.9 1.6 1.9 1.1 UC 2.1 1.6 1.6 1.6 2.1 2.1 2.1 2.1 1.7 1.6 0.5 1.6 2.1 1.8 2.1 1.2 UG 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.0 1.5 0.4 1.5 1.9 1.6 1.9 1.1 UU 1.8 0.7 0.1 0.7 1.2 1.2 1.2 1.2 0.2 0.7 0.9 0.7 1.2 0.9 1.2 0.3 # 5' ------> 3' C X1 Y1 C G X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 1.3 1.1 -0.3 1.1 1.0 1.1 1.0 1.1 0.4 1.1 -0.3 1.1 1.0 1.1 1.0 1.5 AC 0.6 1.5 0.1 1.5 0.5 1.5 1.4 1.5 0.3 1.5 -0.3 1.5 1.4 1.5 1.4 0.0 AG 0.0 -0.7 -1.6 0.1 -1.0 -0.6 0.1 0.7 -0.7 0.1 0.0 0.1 0.1 0.8 0.1 0.9 AU 1.7 1.5 -0.3 1.5 1.4 1.5 1.4 1.5 0.3 1.5 0.1 1.5 1.4 1.5 1.4 0.7 CA 1.3 1.0 -0.7 1.0 1.1 1.0 1.0 1.0 0.7 1.0 -0.4 1.0 1.0 1.1 1.0 -0.2 CC 2.2 1.3 0.7 1.3 1.9 1.3 1.3 1.3 0.7 1.3 -0.1 1.3 1.3 1.4 1.3 -0.1 CG 1.3 1.0 -0.7 1.0 1.0 1.0 1.0 1.0 -0.1 1.0 -0.4 1.0 1.0 1.1 1.0 0.3 CU 1.4 1.2 0.0 1.2 1.1 1.2 1.1 1.7 0.6 1.2 0.2 1.2 1.1 1.2 1.1 0.2 GA -0.2 -0.4 -1.7 0.1 0.7 0.7 0.1 0.7 -0.5 0.1 -0.3 0.1 0.1 0.8 0.1 0.9 GC 1.7 1.5 -0.3 1.5 1.4 1.5 1.4 1.5 0.3 1.5 0.1 1.5 1.4 1.5 1.4 0.7 GG -0.1 -0.4 -0.9 -0.4 -0.5 -0.4 -0.5 0.2 -0.3 -0.4 0.8 -0.4 -0.5 -0.5 -0.5 1.4 GU 1.7 1.5 -0.3 1.5 1.4 1.5 1.4 1.5 0.3 1.5 0.1 1.5 1.4 1.5 1.4 0.7 UA 1.3 1.0 -0.7 1.0 1.0 1.0 1.0 1.0 -0.1 1.0 -0.4 1.0 1.0 1.1 1.0 0.3 UC 1.4 1.2 0.0 1.2 1.1 1.2 1.1 1.2 0.5 1.2 -0.6 1.2 1.1 1.2 1.1 0.4 UG 1.3 1.0 -0.7 1.0 1.0 1.0 1.0 1.0 -0.1 1.0 -0.4 1.0 1.0 1.1 1.0 0.3 UU 1.4 0.3 0.5 0.3 0.3 0.3 0.2 0.3 1.4 0.3 0.7 0.3 0.2 0.3 0.2 -0.6 # 5' ------> 3' C X1 Y1 G G X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 1.2 1.1 0.2 1.1 1.6 1.4 1.6 1.3 0.2 1.1 -0.3 1.1 1.6 1.3 1.6 1.0 AC 1.6 1.5 0.6 1.5 2.0 1.8 2.0 1.7 0.6 1.5 0.1 1.5 2.0 1.7 2.0 0.8 AG 0.2 0.2 -0.7 0.2 0.6 1.1 0.6 0.9 -0.7 0.2 0.0 0.2 0.6 0.9 0.6 -0.5 AU 1.6 1.5 0.6 1.5 2.0 1.8 2.0 1.7 0.6 1.5 0.1 1.5 2.0 1.7 2.0 0.8 CA 1.1 1.1 0.2 1.1 1.5 1.4 1.5 1.2 0.2 1.1 -0.4 1.1 1.5 1.2 1.5 0.3 CC 1.4 1.4 1.1 1.4 1.8 1.7 1.8 1.5 1.1 1.4 -0.1 1.4 1.8 1.5 1.8 0.6 CG 1.1 1.1 0.2 1.1 1.5 1.4 1.5 1.2 0.2 1.1 -0.4 1.1 1.5 1.2 1.5 0.3 CU 1.3 1.2 0.9 1.2 1.7 1.5 1.7 1.4 0.9 1.2 -0.2 1.2 1.7 1.4 1.7 0.5 GA 0.2 0.2 -0.7 0.2 0.6 1.1 0.6 0.9 -0.7 0.2 0.0 0.2 0.6 0.9 0.6 -0.5 GC 1.6 1.5 0.6 1.5 2.0 1.8 2.0 1.7 0.6 1.5 0.1 1.5 2.0 1.7 2.0 0.8 GG -0.3 -0.4 0.0 -0.4 0.1 -0.1 0.1 -0.2 0.0 -0.4 0.8 -0.4 0.1 -0.2 0.1 0.2 GU 1.6 1.5 0.6 1.5 2.0 1.8 2.0 1.7 0.6 1.5 0.1 1.5 2.0 1.7 2.0 0.8 UA 1.1 1.1 0.2 1.1 1.5 1.4 1.5 1.2 0.2 1.1 -0.4 1.1 1.5 1.2 1.5 0.3 UC 1.3 1.2 0.9 1.2 1.7 1.5 1.7 1.4 0.9 1.2 -0.2 1.2 1.7 1.4 1.7 0.5 UG 1.1 1.1 0.2 1.1 1.5 1.4 1.5 1.2 0.2 1.1 -0.4 1.1 1.5 1.2 1.5 0.3 UU 1.0 0.3 -0.5 0.3 0.8 0.6 0.8 0.5 -0.5 0.3 0.2 0.3 0.8 0.5 0.8 -0.4 # 5' ------> 3' C X1 Y1 G G X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 1.6 2.0 0.6 2.0 2.0 2.0 2.0 2.0 2.3 2.0 0.7 2.0 2.0 2.0 2.0 2.6 AC 2.0 2.4 1.0 2.4 2.4 2.4 2.4 2.4 2.7 2.4 1.1 2.4 2.4 2.4 2.4 2.4 AG 0.7 1.0 -0.3 1.0 1.0 1.6 1.0 1.6 1.3 1.0 1.0 1.0 1.0 1.6 1.0 1.0 AU 2.0 2.4 1.0 2.4 2.4 2.4 2.4 2.4 2.7 2.4 1.1 2.4 2.4 2.4 2.4 2.4 CA 1.6 1.9 0.6 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 CC 1.9 2.2 1.5 2.2 2.2 2.2 2.2 2.2 3.1 2.2 0.9 2.2 2.2 2.2 2.2 2.2 CG 1.6 1.9 0.6 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 CU 1.7 2.1 1.3 2.1 2.1 2.1 2.1 2.1 3.0 2.1 0.8 2.1 2.1 2.1 2.1 2.1 GA 0.7 1.0 -0.3 1.0 1.0 1.6 1.0 1.6 1.3 1.0 1.0 1.0 1.0 1.6 1.0 1.0 GC 2.0 2.4 1.0 2.4 2.4 2.4 2.4 2.4 2.7 2.4 1.1 2.4 2.4 2.4 2.4 2.4 GG 0.1 0.5 0.4 0.5 0.5 0.5 0.5 0.5 2.1 0.5 1.8 0.5 0.5 0.5 0.5 1.8 GU 2.0 2.4 1.0 2.4 2.4 2.4 2.4 2.4 2.7 2.4 1.1 2.4 2.4 2.4 2.4 2.4 UA 1.6 1.9 0.6 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 UC 1.7 2.1 1.3 2.1 2.1 2.1 2.1 2.1 3.0 2.1 0.8 2.1 2.1 2.1 2.1 2.1 UG 1.6 1.9 0.6 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 UU 1.4 1.2 -0.1 1.2 1.2 1.2 1.2 1.2 1.5 1.2 1.2 1.2 1.2 1.2 1.2 1.2 # 5' ------> 3' C X1 Y1 U G X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 2.0 1.7 0.7 1.7 1.8 1.8 1.8 1.8 1.4 1.7 0.2 1.7 1.8 1.8 1.8 1.5 AC 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 1.8 2.1 0.6 2.1 2.2 2.2 2.2 1.3 AG 1.0 0.8 -0.2 0.8 0.9 1.4 0.9 1.4 0.5 0.8 0.6 0.8 0.9 1.4 0.9 0.0 AU 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 1.8 2.1 0.6 2.1 2.2 2.2 2.2 1.3 CA 1.9 1.7 0.7 1.7 1.8 1.7 1.8 1.7 1.4 1.7 0.2 1.7 1.8 1.7 1.8 0.8 CC 2.2 2.0 1.6 2.0 2.1 2.0 2.1 2.0 2.3 2.0 0.5 2.0 2.1 2.0 2.1 1.1 CG 1.9 1.7 0.7 1.7 1.8 1.7 1.8 1.7 1.4 1.7 0.2 1.7 1.8 1.7 1.8 0.8 CU 2.1 1.8 1.4 1.8 1.9 1.9 1.9 1.9 2.1 1.8 0.3 1.8 1.9 1.9 1.9 1.0 GA 1.0 0.8 -0.2 0.8 0.9 1.4 0.9 1.4 0.5 0.8 0.6 0.8 0.9 1.4 0.9 0.0 GC 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 1.8 2.1 0.6 2.1 2.2 2.2 2.2 1.3 GG 0.5 0.2 0.5 0.2 0.3 0.3 0.3 0.3 1.2 0.2 1.3 0.2 0.3 0.3 0.3 0.7 GU 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 1.8 2.1 0.6 2.1 2.2 2.2 2.2 1.3 UA 1.9 1.7 0.7 1.7 1.8 1.7 1.8 1.7 1.4 1.7 0.2 1.7 1.8 1.7 1.8 0.8 UC 2.1 1.8 1.4 1.8 1.9 1.9 1.9 1.9 2.1 1.8 0.3 1.8 1.9 1.9 1.9 1.0 UG 1.9 1.7 0.7 1.7 1.8 1.7 1.8 1.7 1.4 1.7 0.2 1.7 1.8 1.7 1.8 0.8 UU 1.8 0.9 0.0 0.9 1.0 1.0 1.0 1.0 0.6 0.9 0.7 0.9 1.0 1.0 1.0 0.1 # 5' ------> 3' C X1 Y1 U G X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 2.7 2.3 1.5 2.3 2.3 2.3 2.3 2.3 1.9 2.3 1.0 2.3 2.3 2.3 2.3 2.9 AC 3.0 2.7 1.9 2.7 2.7 2.7 2.7 2.7 2.3 2.7 1.4 2.7 2.7 2.7 2.7 2.7 AG 1.7 1.3 0.5 1.3 1.3 1.9 1.3 1.9 0.9 1.3 1.3 1.3 1.3 1.9 1.3 1.3 AU 3.0 2.7 1.9 2.7 2.7 2.7 2.7 2.7 2.3 2.7 1.4 2.7 2.7 2.7 2.7 2.7 CA 2.6 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2 CC 2.9 2.5 2.3 2.5 2.5 2.5 2.5 2.5 2.7 2.5 1.2 2.5 2.5 2.5 2.5 2.5 CG 2.6 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2 CU 2.7 2.4 2.2 2.4 2.4 2.4 2.4 2.4 2.6 2.4 1.1 2.4 2.4 2.4 2.4 2.4 GA 1.7 1.3 0.5 1.3 1.3 1.9 1.3 1.9 0.9 1.3 1.3 1.3 1.3 1.9 1.3 1.3 GC 3.0 2.7 1.9 2.7 2.7 2.7 2.7 2.7 2.3 2.7 1.4 2.7 2.7 2.7 2.7 2.7 GG 1.1 0.8 1.3 0.8 0.8 0.8 0.8 0.8 1.7 0.8 2.1 0.8 0.8 0.8 0.8 2.1 GU 3.0 2.7 1.9 2.7 2.7 2.7 2.7 2.7 2.3 2.7 1.4 2.7 2.7 2.7 2.7 2.7 UA 2.6 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2 UC 2.7 2.4 2.2 2.4 2.4 2.4 2.4 2.4 2.6 2.4 1.1 2.4 2.4 2.4 2.4 2.4 UG 2.6 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2 UU 2.4 1.5 0.7 1.5 1.5 1.5 1.5 1.5 1.1 1.5 1.5 1.5 1.5 1.5 1.5 1.5 # 5' ------> 3' G X1 Y1 A C X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 2.1 1.7 1.1 1.7 2.1 2.1 2.1 2.1 1.2 1.7 0.6 1.7 2.1 1.8 2.1 1.9 AC 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 0.9 1.4 0.3 1.4 1.8 1.5 1.8 1.0 AG 0.7 0.3 -0.3 0.3 0.7 1.3 0.7 1.3 -0.2 0.3 0.5 0.3 0.7 1.0 0.7 -0.1 AU 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 0.9 1.4 0.3 1.4 1.8 1.5 1.8 1.0 CA 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 0.9 1.4 0.3 1.4 1.9 1.6 1.9 1.0 CC 1.9 1.4 1.4 1.4 1.9 1.9 1.9 1.9 1.5 1.4 0.3 1.4 1.9 1.6 1.9 1.0 CG 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 0.9 1.4 0.3 1.4 1.9 1.6 1.9 1.0 CU 1.9 1.5 1.5 1.5 1.9 1.9 1.9 1.9 1.6 1.5 0.4 1.5 1.9 1.6 1.9 1.1 GA 0.1 -0.3 -0.9 -0.3 0.1 0.7 0.1 0.7 -0.8 -0.3 -0.1 -0.3 0.1 0.4 0.1 -0.7 GC 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 0.9 1.4 0.3 1.4 1.8 1.5 1.8 1.0 GG 0.5 0.0 0.7 0.0 0.5 0.5 0.5 0.5 0.8 0.0 1.5 0.0 0.5 0.2 0.5 0.9 GU 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 0.9 1.4 0.3 1.4 1.8 1.5 1.8 1.0 UA 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 0.9 1.4 0.3 1.4 1.9 1.6 1.9 1.0 UC 1.9 1.4 1.4 1.4 1.9 1.9 1.9 1.9 1.5 1.4 0.3 1.4 1.9 1.6 1.9 1.0 UG 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 0.9 1.4 0.3 1.4 1.9 1.6 1.9 1.0 UU 1.7 0.7 0.1 0.7 1.1 1.1 1.1 1.1 0.2 0.7 0.9 0.7 1.1 0.8 1.1 0.3 # 5' ------> 3' G X1 Y1 C C X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 1.5 1.2 -0.5 1.2 1.2 1.2 1.2 1.2 0.1 1.2 -0.2 1.2 1.2 1.3 1.2 1.1 AC 1.2 0.9 -0.8 0.9 0.9 0.9 0.9 0.9 -0.2 0.9 -0.5 0.9 0.9 1.0 0.9 0.2 AG 0.1 -0.1 -1.9 -0.1 -0.2 0.5 -0.2 0.5 -1.3 -0.1 -0.2 -0.1 -0.2 0.5 -0.2 -0.9 AU 1.2 0.9 -0.8 0.9 0.9 0.9 0.9 0.9 -0.2 0.9 -0.5 0.9 0.9 1.0 0.9 0.2 CA 1.2 1.0 -0.8 1.0 0.9 1.0 0.9 1.0 -0.1 1.0 -0.4 1.0 0.9 1.0 0.9 0.2 CC 1.2 1.0 -0.2 1.0 0.9 1.0 0.9 1.0 0.5 1.0 -0.4 1.0 0.9 1.0 0.9 0.2 CG 1.2 1.0 -0.8 1.0 0.9 1.0 0.9 1.0 -0.1 1.0 -0.4 1.0 0.9 1.0 0.9 0.2 CU 1.3 1.0 -0.1 1.0 1.0 1.0 1.0 1.0 0.5 1.0 -0.4 1.0 1.0 1.1 1.0 0.3 GA -0.5 -0.8 -2.6 -0.8 -0.8 -0.2 -0.8 -0.2 -1.9 -0.8 -0.9 -0.8 -0.8 -0.1 -0.8 -1.5 GC 1.2 0.9 -0.8 0.9 0.9 0.9 0.9 0.9 -0.2 0.9 -0.5 0.9 0.9 1.0 0.9 0.2 GG -0.2 -0.4 -0.9 -0.4 -0.5 -0.4 -0.5 -0.4 -0.2 -0.4 0.8 -0.4 -0.5 -0.4 -0.5 0.1 GU 1.2 0.9 -0.8 0.9 0.9 0.9 0.9 0.9 -0.2 0.9 -0.5 0.9 0.9 1.0 0.9 0.2 UA 1.2 1.0 -0.8 1.0 0.9 1.0 0.9 1.0 -0.1 1.0 -0.4 1.0 0.9 1.0 0.9 0.2 UC 1.2 1.0 -0.2 1.0 0.9 1.0 0.9 1.0 0.5 1.0 -0.4 1.0 0.9 1.0 0.9 0.2 UG 1.2 1.0 -0.8 1.0 0.9 1.0 0.9 1.0 -0.1 1.0 -0.4 1.0 0.9 1.0 0.9 0.2 UU 1.1 0.2 -1.5 0.2 0.2 0.2 0.2 0.2 -0.9 0.2 0.1 0.2 0.2 0.3 0.2 -0.5 # 5' ------> 3' G X1 Y1 G C X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 1.3 1.3 -0.2 1.3 0.6 2.2 1.7 1.4 0.0 1.3 -0.1 1.3 1.7 1.4 1.7 1.4 AC 1.0 1.1 0.7 1.0 0.5 1.9 1.4 1.1 -1.0 1.0 -0.5 1.0 1.4 1.1 1.4 0.3 AG 0.4 0.7 -0.5 -0.1 0.3 0.7 0.3 0.5 -0.7 -0.1 -0.3 -0.1 0.3 0.6 0.3 1.4 AU 1.0 1.0 0.1 1.0 1.4 1.3 1.4 1.1 0.1 1.0 -0.5 1.0 1.4 1.1 1.4 0.2 CA 1.1 1.0 -0.4 1.0 1.5 1.3 1.5 1.2 -0.7 1.0 -0.4 1.0 1.5 1.2 1.5 0.3 CC 1.1 1.0 0.7 1.0 1.5 1.3 1.5 1.2 -0.6 1.0 -0.4 1.0 1.5 1.2 1.5 0.3 CG 1.1 1.0 0.1 1.0 1.5 1.3 1.5 1.2 0.1 1.0 -0.4 1.0 1.5 1.2 1.5 0.3 CU 1.1 1.1 0.8 1.1 1.5 1.4 1.5 1.2 0.8 1.1 -0.5 1.1 1.5 1.2 1.5 0.3 GA -0.3 -0.7 -1.7 -0.7 0.1 0.7 -0.3 0.0 -1.6 -0.7 -0.9 -0.7 -0.3 0.0 -0.3 0.5 GC 1.0 1.0 0.1 1.0 1.4 1.3 1.4 1.1 0.1 1.0 -0.5 1.0 1.4 1.1 1.4 0.2 GG -0.3 -0.4 -0.3 -0.4 -0.3 -0.1 0.1 -0.6 0.0 -0.4 0.8 -0.4 0.1 0.2 0.1 0.7 GU 1.0 1.0 0.1 1.0 1.4 1.3 1.4 1.1 0.1 1.0 -0.5 1.0 1.4 1.1 1.4 0.2 UA 1.1 1.0 0.1 1.0 1.5 1.3 1.5 1.2 0.1 1.0 -0.4 1.0 1.5 1.2 1.5 0.3 UC 1.1 1.0 0.7 1.0 1.5 1.3 1.5 1.2 0.7 1.0 0.2 1.0 1.5 1.7 1.5 0.3 UG 1.1 1.0 0.1 1.0 1.5 1.3 1.5 1.2 0.1 1.0 -0.4 1.0 1.5 1.2 1.5 0.3 UU 1.5 -0.2 0.9 0.3 0.0 -0.1 0.7 0.4 0.9 0.3 1.4 0.3 0.7 0.2 0.7 -0.6 # 5' ------> 3' G X1 Y1 G C X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 1.9 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.7 AC 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 AG 0.4 0.7 -0.6 0.7 0.7 1.3 0.7 1.3 1.0 0.7 0.7 0.7 0.7 1.3 0.7 0.7 AU 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 CA 1.5 1.9 0.5 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 CC 1.5 1.9 1.1 1.9 1.9 1.9 1.9 1.9 2.8 1.9 0.6 1.9 1.9 1.9 1.9 1.9 CG 1.5 1.9 0.5 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 CU 1.6 1.9 1.2 1.9 1.9 1.9 1.9 1.9 2.8 1.9 0.6 1.9 1.9 1.9 1.9 1.9 GA -0.2 0.1 -1.2 0.1 0.1 0.7 0.1 0.7 0.4 0.1 0.1 0.1 0.1 0.7 0.1 0.1 GC 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 GG 0.1 0.5 0.4 0.5 0.5 0.5 0.5 0.5 2.1 0.5 1.8 0.5 0.5 0.5 0.5 1.8 GU 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 UA 1.5 1.9 0.5 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 UC 1.5 1.9 1.1 1.9 1.9 1.9 1.9 1.9 2.8 1.9 0.6 1.9 1.9 1.9 1.9 1.9 UG 1.5 1.9 0.5 1.9 1.9 1.9 1.9 1.9 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 UU 1.4 1.1 -0.2 1.1 1.1 1.1 1.1 1.1 1.4 1.1 1.1 1.1 1.1 1.1 1.1 1.1 # 5' ------> 3' G X1 Y1 U C X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 2.1 1.9 0.9 1.9 2.0 1.9 2.0 1.9 1.6 1.9 0.4 1.9 2.0 1.9 2.0 1.6 AC 1.8 1.6 0.6 1.6 1.7 1.6 1.7 1.6 1.3 1.6 0.1 1.6 1.7 1.6 1.7 0.7 AG 0.7 0.5 -0.5 0.5 0.6 1.1 0.6 1.1 0.2 0.5 0.3 0.5 0.6 1.1 0.6 -0.3 AU 1.8 1.6 0.6 1.6 1.7 1.6 1.7 1.6 1.3 1.6 0.1 1.6 1.7 1.6 1.7 0.7 CA 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.3 1.6 0.1 1.6 1.7 1.7 1.7 0.8 CC 1.9 1.6 1.2 1.6 1.7 1.7 1.7 1.7 1.9 1.6 0.1 1.6 1.7 1.7 1.7 0.8 CG 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.3 1.6 0.1 1.6 1.7 1.7 1.7 0.8 CU 1.9 1.7 1.3 1.7 1.8 1.7 1.8 1.7 2.0 1.7 0.2 1.7 1.8 1.7 1.8 0.8 GA 0.1 -0.1 -1.1 -0.1 0.0 0.5 0.0 0.5 -0.4 -0.1 -0.3 -0.1 0.0 0.5 0.0 -1.0 GC 1.8 1.6 0.6 1.6 1.7 1.6 1.7 1.6 1.3 1.6 0.1 1.6 1.7 1.6 1.7 0.7 GG 0.5 0.2 0.5 0.2 0.3 0.3 0.3 0.3 1.2 0.2 1.3 0.2 0.3 0.3 0.3 0.7 GU 1.8 1.6 0.6 1.6 1.7 1.6 1.7 1.6 1.3 1.6 0.1 1.6 1.7 1.6 1.7 0.7 UA 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.3 1.6 0.1 1.6 1.7 1.7 1.7 0.8 UC 1.9 1.6 1.2 1.6 1.7 1.7 1.7 1.7 1.9 1.6 0.1 1.6 1.7 1.7 1.7 0.8 UG 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.3 1.6 0.1 1.6 1.7 1.7 1.7 0.8 UU 1.7 0.9 -0.1 0.9 1.0 0.9 1.0 0.9 0.6 0.9 0.7 0.9 1.0 0.9 1.0 0.0 # 5' ------> 3' G X1 Y1 U C X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 2.8 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.0 2.4 1.1 2.4 2.4 2.4 2.4 3.0 AC 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 AG 1.4 1.0 0.2 1.0 1.0 1.6 1.0 1.6 0.6 1.0 1.0 1.0 1.0 1.6 1.0 1.0 AU 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 CA 2.5 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2 CC 2.5 2.2 2.0 2.2 2.2 2.2 2.2 2.2 2.4 2.2 0.9 2.2 2.2 2.2 2.2 2.2 CG 2.5 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2 CU 2.6 2.2 2.0 2.2 2.2 2.2 2.2 2.2 2.4 2.2 0.9 2.2 2.2 2.2 2.2 2.2 GA 0.7 0.4 -0.4 0.4 0.4 1.0 0.4 1.0 0.0 0.4 0.4 0.4 0.4 1.0 0.4 0.4 GC 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 GG 1.1 0.8 1.3 0.8 0.8 0.8 0.8 0.8 1.7 0.8 2.1 0.8 0.8 0.8 0.8 2.1 GU 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 UA 2.5 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2 UC 2.5 2.2 2.0 2.2 2.2 2.2 2.2 2.2 2.4 2.2 0.9 2.2 2.2 2.2 2.2 2.2 UG 2.5 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2 UU 2.4 1.4 0.6 1.4 1.4 1.4 1.4 1.4 1.0 1.4 1.4 1.4 1.4 1.4 1.4 1.4 # 5' ------> 3' G X1 Y1 A U X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 3.4 3.0 2.4 3.0 3.4 3.4 3.4 3.4 2.5 3.0 1.9 3.0 3.4 3.1 3.4 3.2 AC 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2 AG 2.7 2.2 1.6 2.2 2.7 3.3 2.7 3.3 1.7 2.2 2.4 2.2 2.7 3.0 2.7 1.8 AU 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2 CA 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2 CC 3.1 2.6 2.6 2.6 3.1 3.1 3.1 3.1 2.7 2.6 1.5 2.6 3.1 2.8 3.1 2.2 CG 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2 CU 3.1 2.6 2.6 2.6 3.1 3.1 3.1 3.1 2.7 2.6 1.5 2.6 3.1 2.8 3.1 2.2 GA 2.3 1.8 1.2 1.8 2.3 2.9 2.3 2.9 1.3 1.8 2.0 1.8 2.3 2.6 2.3 1.4 GC 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2 GG 1.8 1.3 2.0 1.3 1.8 1.8 1.8 1.8 2.1 1.3 2.8 1.3 1.8 1.5 1.8 2.2 GU 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2 UA 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2 UC 3.1 2.6 2.6 2.6 3.1 3.1 3.1 3.1 2.7 2.6 1.5 2.6 3.1 2.8 3.1 2.2 UG 3.1 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 1.5 2.6 3.1 2.8 3.1 2.2 UU 3.7 2.6 2.0 2.6 3.1 3.1 3.1 3.1 2.1 2.6 2.8 2.6 3.1 2.8 3.1 2.2 # 5' ------> 3' G X1 Y1 C U X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 2.8 2.5 0.7 2.5 2.5 2.5 2.5 2.5 1.4 2.5 1.1 2.5 2.5 2.6 2.5 2.4 AC 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4 AG 2.0 1.8 0.0 1.8 1.7 2.4 1.7 2.4 0.6 1.8 1.7 1.8 1.7 2.4 1.7 1.0 AU 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4 CA 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4 CC 2.4 2.2 1.0 2.2 2.1 2.2 2.1 2.2 1.6 2.2 0.8 2.2 2.1 2.2 2.1 1.4 CG 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4 CU 2.4 2.2 1.0 2.2 2.1 2.2 2.1 2.2 1.6 2.2 0.8 2.2 2.1 2.2 2.1 1.4 GA 1.6 1.4 -0.4 1.4 1.3 2.0 1.3 2.0 0.2 1.4 1.3 1.4 1.3 2.0 1.3 0.6 GC 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4 GG 1.1 0.9 0.4 0.9 0.8 0.9 0.8 0.9 1.0 0.9 2.1 0.9 0.8 0.9 0.8 1.4 GU 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4 UA 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4 UC 2.4 2.2 1.0 2.2 2.1 2.2 2.1 2.2 1.6 2.2 0.8 2.2 2.1 2.2 2.1 1.4 UG 2.4 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 0.8 2.2 2.1 2.2 2.1 1.4 UU 3.0 2.2 0.4 2.2 2.1 2.2 2.1 2.2 1.0 2.2 2.1 2.2 2.1 2.2 2.1 1.4 # 5' ------> 3' G X1 Y1 G U X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 2.7 2.6 1.7 2.6 3.0 2.9 3.0 2.7 1.7 2.6 1.1 2.6 3.0 2.7 3.0 2.4 AC 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5 AG 1.9 1.8 0.9 1.8 2.3 2.7 2.3 2.6 0.9 1.8 1.7 1.8 2.3 2.6 2.3 1.1 AU 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5 CA 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5 CC 2.3 2.2 1.9 2.2 2.7 2.5 2.7 2.4 1.9 2.2 0.8 2.2 2.7 2.4 2.7 1.5 CG 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5 CU 2.3 2.2 1.9 2.2 2.7 2.5 2.7 2.4 1.9 2.2 0.8 2.2 2.7 2.4 2.7 1.5 GA 1.5 1.4 0.5 1.4 1.9 2.3 1.9 2.2 0.5 1.4 1.3 1.4 1.9 2.2 1.9 0.7 GC 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5 GG 1.0 0.9 1.3 0.9 1.4 1.2 1.4 1.1 1.3 0.9 2.1 0.9 1.4 1.1 1.4 1.5 GU 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5 UA 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5 UC 2.3 2.2 1.9 2.2 2.7 2.5 2.7 2.4 1.9 2.2 0.8 2.2 2.7 2.4 2.7 1.5 UG 2.3 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 0.8 2.2 2.7 2.4 2.7 1.5 UU 2.9 2.2 1.3 2.2 2.7 2.5 2.7 2.4 1.3 2.2 2.1 2.2 2.7 2.4 2.7 1.5 # 5' ------> 3' G X1 Y1 G U X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 3.6 3.4 2.2 3.4 3.4 3.4 3.4 3.4 3.7 3.4 2.1 3.4 3.4 3.4 3.4 4.0 AC 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1 AG 3.6 2.7 1.3 2.7 2.7 3.3 2.7 3.3 3.0 2.7 2.7 2.7 2.7 3.3 2.7 2.7 AU 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1 CA 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1 CC 2.7 3.1 2.3 3.1 3.1 3.1 3.1 3.1 4.0 3.1 1.8 3.1 3.1 3.1 3.1 3.1 CG 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1 CU 2.7 3.1 2.3 3.1 3.1 3.1 3.1 3.1 4.0 3.1 1.8 3.1 3.1 3.1 3.1 3.1 GA 1.9 2.3 0.2 2.3 2.3 2.9 2.3 2.9 2.6 2.3 2.3 2.3 2.3 2.9 2.3 2.3 GC 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1 GG 1.4 1.8 1.7 1.8 1.8 1.8 1.8 1.8 3.4 1.8 3.1 1.8 1.8 1.8 1.8 3.1 GU 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1 UA 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1 UC 2.7 3.1 2.3 3.1 3.1 3.1 3.1 3.1 4.0 3.1 1.8 3.1 3.1 3.1 3.1 3.1 UG 2.7 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 1.8 3.1 3.1 3.1 3.1 3.1 UU 3.3 3.1 1.7 3.1 3.1 3.1 3.1 3.1 3.4 3.1 3.1 3.1 3.1 3.1 3.1 3.1 # 5' ------> 3' G X1 Y1 U U X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 3.4 3.2 2.2 3.2 3.3 3.2 3.3 3.2 2.9 3.2 1.7 3.2 3.3 3.2 3.3 2.9 AC 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0 AG 2.7 2.4 1.4 2.4 2.5 3.1 2.5 3.1 2.1 2.4 2.2 2.4 2.5 3.1 2.5 1.6 AU 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0 CA 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0 CC 3.1 2.8 2.4 2.8 2.9 2.9 2.9 2.9 3.1 2.8 1.3 2.8 2.9 2.9 2.9 2.0 CG 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0 CU 3.1 2.8 2.4 2.8 2.9 2.9 2.9 2.9 3.1 2.8 1.3 2.8 2.9 2.9 2.9 2.0 GA 2.3 2.0 1.0 2.0 2.1 2.7 2.1 2.7 1.7 2.0 1.8 2.0 2.1 2.7 2.1 1.2 GC 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0 GG 1.8 1.5 1.8 1.5 1.6 1.6 1.6 1.6 2.5 1.5 2.6 1.5 1.6 1.6 1.6 2.0 GU 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0 UA 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0 UC 3.1 2.8 2.4 2.8 2.9 2.9 2.9 2.9 3.1 2.8 1.3 2.8 2.9 2.9 2.9 2.0 UG 3.1 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 1.3 2.8 2.9 2.9 2.9 2.0 UU 3.7 2.8 1.8 2.8 2.9 2.9 2.9 2.9 2.5 2.8 2.6 2.8 2.9 2.9 2.9 2.0 # 5' ------> 3' G X1 Y1 U U X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 4.1 3.7 2.9 3.7 3.7 3.7 3.7 3.7 3.3 3.7 2.4 3.7 3.7 3.7 3.7 4.3 AC 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4 AG 3.3 3.0 2.2 3.0 3.0 3.6 3.0 3.6 2.6 3.0 3.0 3.0 3.0 3.6 3.0 3.0 AU 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4 CA 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4 CC 3.7 3.4 3.2 3.4 3.4 3.4 3.4 3.4 3.6 3.4 2.1 3.4 3.4 3.4 3.4 3.4 CG 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4 CU 3.7 3.4 3.2 3.4 3.4 3.4 3.4 3.4 3.6 3.4 2.1 3.4 3.4 3.4 3.4 3.4 GA 2.9 2.6 1.8 2.6 2.6 3.2 2.6 3.2 2.2 2.6 2.6 2.6 2.6 3.2 2.6 2.6 GC 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4 GG 2.4 2.1 2.6 2.1 2.1 2.1 2.1 2.1 3.0 2.1 3.4 2.1 2.1 2.1 2.1 3.4 GU 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4 UA 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4 UC 3.7 3.4 3.2 3.4 3.4 3.4 3.4 3.4 3.6 3.4 2.1 3.4 3.4 3.4 3.4 3.4 UG 3.7 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 2.1 3.4 3.4 3.4 3.4 3.4 UU 4.3 3.4 2.6 3.4 3.4 3.4 3.4 3.4 3.0 3.4 3.4 3.4 3.4 3.4 3.4 3.4 # 5' ------> 3' U X1 Y1 A A X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 2.5 AC 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 AG 1.8 1.4 0.8 1.4 1.8 2.4 1.8 2.4 0.9 1.4 1.6 1.4 1.8 2.1 1.8 1.0 AU 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 CA 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 1.4 1.9 0.8 1.9 2.3 2.0 2.3 1.5 CC 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.4 2.3 1.2 2.3 2.8 2.5 2.8 1.9 CG 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 1.4 1.9 0.8 1.9 2.3 2.0 2.3 1.5 CU 2.5 2.0 2.0 2.0 2.5 2.5 2.5 2.5 2.1 2.0 0.9 2.0 2.5 2.2 2.5 1.6 GA 1.7 1.3 0.7 1.3 1.7 2.3 1.7 2.3 0.8 1.3 1.5 1.3 1.7 2.0 1.7 0.9 GC 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 GG 1.2 0.8 1.5 0.8 1.2 1.2 1.2 1.2 1.6 0.8 2.3 0.8 1.2 0.9 1.2 1.7 GU 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 UA 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 1.4 1.9 0.8 1.9 2.3 2.0 2.3 1.5 UC 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.4 2.3 1.2 2.3 2.8 2.5 2.8 1.9 UG 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 1.4 1.9 0.8 1.9 2.3 2.0 2.3 1.5 UU 2.5 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.0 1.5 1.7 1.5 1.9 1.6 1.9 1.1 # 5' ------> 3' U X1 Y1 C A X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.7 AC 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 AG 1.2 0.9 -0.8 0.9 0.9 1.5 0.9 1.5 -0.2 0.9 0.8 0.9 0.9 1.6 0.9 0.2 AU 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 CA 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 0.3 1.4 0.0 1.4 1.4 1.5 1.4 0.7 CC 2.1 1.9 0.7 1.9 1.8 1.9 1.8 1.9 1.3 1.9 0.5 1.9 1.8 1.9 1.8 1.1 CG 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 0.3 1.4 0.0 1.4 1.4 1.5 1.4 0.7 CU 1.8 1.6 0.4 1.6 1.5 1.6 1.5 1.6 1.0 1.6 0.2 1.6 1.5 1.6 1.5 0.8 GA 1.1 0.8 -0.9 0.8 0.8 1.4 0.8 1.4 -0.3 0.8 0.7 0.8 0.8 1.5 0.8 0.1 GC 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 GG 0.6 0.3 -0.1 0.3 0.3 0.3 0.3 0.3 0.5 0.3 1.5 0.3 0.3 0.4 0.3 0.9 GU 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 UA 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 0.3 1.4 0.0 1.4 1.4 1.5 1.4 0.7 UC 2.1 1.9 0.7 1.9 1.8 1.9 1.8 1.9 1.3 1.9 0.5 1.9 1.8 1.9 1.8 1.1 UG 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 0.3 1.4 0.0 1.4 1.4 1.5 1.4 0.7 UU 1.9 1.0 -0.7 1.0 1.0 1.0 1.0 1.0 -0.1 1.0 0.9 1.0 1.0 1.1 1.0 0.3 # 5' ------> 3' U X1 Y1 G A X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.8 AC 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 AG 1.0 1.0 0.1 1.0 1.4 1.9 1.4 1.7 0.1 1.0 0.8 1.0 1.4 1.7 1.4 0.2 AU 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 CA 1.5 1.5 0.6 1.5 1.9 1.8 1.9 1.6 0.6 1.5 0.0 1.5 1.9 1.6 1.9 0.7 CC 2.0 1.9 1.6 1.9 2.4 2.2 2.4 2.1 1.6 1.9 0.5 1.9 2.4 2.1 2.4 1.2 CG 1.5 1.5 0.6 1.5 1.9 1.8 1.9 1.6 0.6 1.5 0.0 1.5 1.9 1.6 1.9 0.7 CU 1.7 1.6 1.3 1.6 2.1 1.9 2.1 1.8 1.3 1.6 0.2 1.6 2.1 1.8 2.1 0.9 GA 0.9 0.9 0.0 0.9 1.3 1.8 1.3 1.6 0.0 0.9 0.7 0.9 1.3 1.6 1.3 0.1 GC 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 GG 0.4 0.4 0.8 0.4 0.8 0.7 0.8 0.5 0.8 0.4 1.5 0.4 0.8 0.5 0.8 0.9 GU 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 UA 1.5 1.5 0.6 1.5 1.9 1.8 1.9 1.6 0.6 1.5 0.0 1.5 1.9 1.6 1.9 0.7 UC 2.0 1.9 1.6 1.9 2.4 2.2 2.4 2.1 1.6 1.9 0.5 1.9 2.4 2.1 2.4 1.2 UG 1.5 1.5 0.6 1.5 1.9 1.8 1.9 1.6 0.6 1.5 0.0 1.5 1.9 1.6 1.9 0.7 UU 1.7 1.1 0.2 1.1 1.5 1.4 1.5 1.2 0.2 1.1 0.9 1.1 1.5 1.2 1.5 0.3 # 5' ------> 3' U X1 Y1 G A X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 3.4 AC 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 AG 1.5 1.8 0.5 1.8 1.8 2.4 1.8 2.4 2.1 1.8 1.8 1.8 1.8 2.4 1.8 1.8 AU 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 CA 2.0 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 CC 2.4 2.8 2.0 2.8 2.8 2.8 2.8 2.8 3.7 2.8 1.5 2.8 2.8 2.8 2.8 2.8 CG 2.0 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 CU 2.1 2.5 1.7 2.5 2.5 2.5 2.5 2.5 3.4 2.5 1.2 2.5 2.5 2.5 2.5 2.5 GA 1.4 1.7 0.4 1.7 1.7 2.3 1.7 2.3 2.0 1.7 1.7 1.7 1.7 2.3 1.7 1.7 GC 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 GG 0.9 1.2 1.2 1.2 1.2 1.2 1.2 1.2 2.8 1.2 2.5 1.2 1.2 1.2 1.2 2.5 GU 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 UA 2.0 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 UC 2.4 2.8 2.0 2.8 2.8 2.8 2.8 2.8 3.7 2.8 1.5 2.8 2.8 2.8 2.8 2.8 UG 2.0 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 UU 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 2.2 1.9 1.9 1.9 1.9 1.9 1.9 1.9 # 5' ------> 3' U X1 Y1 U A X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.3 AC 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 AG 1.8 1.6 0.6 1.6 1.7 2.2 1.7 2.2 1.3 1.6 1.4 1.6 1.7 2.2 1.7 0.7 AU 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 CA 2.3 2.1 1.1 2.1 2.2 2.1 2.2 2.1 1.8 2.1 0.6 2.1 2.2 2.1 2.2 1.2 CC 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.8 2.5 1.0 2.5 2.6 2.6 2.6 1.7 CG 2.3 2.1 1.1 2.1 2.2 2.1 2.2 2.1 1.8 2.1 0.6 2.1 2.2 2.1 2.2 1.2 CU 2.5 2.2 1.8 2.2 2.3 2.3 2.3 2.3 2.5 2.2 0.7 2.2 2.3 2.3 2.3 1.4 GA 1.7 1.5 0.5 1.5 1.6 2.1 1.6 2.1 1.2 1.5 1.3 1.5 1.6 2.1 1.6 0.6 GC 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 GG 1.2 1.0 1.3 1.0 1.1 1.0 1.1 1.0 2.0 1.0 2.1 1.0 1.1 1.0 1.1 1.4 GU 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 UA 2.3 2.1 1.1 2.1 2.2 2.1 2.2 2.1 1.8 2.1 0.6 2.1 2.2 2.1 2.2 1.2 UC 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.8 2.5 1.0 2.5 2.6 2.6 2.6 1.7 UG 2.3 2.1 1.1 2.1 2.2 2.1 2.2 2.1 1.8 2.1 0.6 2.1 2.2 2.1 2.2 1.2 UU 2.5 1.7 0.7 1.7 1.8 1.7 1.8 1.7 1.4 1.7 1.5 1.7 1.8 1.7 1.8 0.8 # 5' ------> 3' U X1 Y1 U A X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.7 AC 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 AG 2.5 2.1 1.3 2.1 2.1 2.7 2.1 2.7 1.7 2.1 2.1 2.1 2.1 2.7 2.1 2.1 AU 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 CA 3.0 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 CC 3.4 3.1 2.9 3.1 3.1 3.1 3.1 3.1 3.3 3.1 1.8 3.1 3.1 3.1 3.1 3.1 CG 3.0 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 CU 3.1 2.8 2.6 2.8 2.8 2.8 2.8 2.8 3.0 2.8 1.5 2.8 2.8 2.8 2.8 2.8 GA 2.4 2.0 1.2 2.0 2.0 2.6 2.0 2.6 1.6 2.0 2.0 2.0 2.0 2.6 2.0 2.0 GC 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 GG 1.9 1.5 2.0 1.5 1.5 1.5 1.5 1.5 2.4 1.5 2.8 1.5 1.5 1.5 1.5 2.8 GU 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 UA 3.0 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 UC 3.4 3.1 2.9 3.1 3.1 3.1 3.1 3.1 3.3 3.1 1.8 3.1 3.1 3.1 3.1 3.1 UG 3.0 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 UU 3.2 2.2 1.4 2.2 2.2 2.2 2.2 2.2 1.8 2.2 2.2 2.2 2.2 2.2 2.2 2.2 # 5' ------> 3' U X1 Y1 A G X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 2.4 2.0 1.4 2.0 2.4 2.4 2.4 2.4 1.5 2.0 0.9 2.0 2.4 2.1 2.4 2.2 AC 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 AG 3.1 2.6 2.0 2.6 3.1 3.7 3.1 3.7 2.1 2.6 2.8 2.6 3.1 3.4 3.1 2.2 AU 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 CA 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 CC 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.4 2.3 1.2 2.3 2.8 2.5 2.8 1.9 CG 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 CU 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.4 2.3 1.2 2.3 2.8 2.5 2.8 1.9 GA 1.4 1.0 0.4 1.0 1.4 2.0 1.4 2.0 0.5 1.0 1.2 1.0 1.4 1.7 1.4 0.6 GC 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 GG 1.5 1.0 1.7 1.0 1.5 1.5 1.5 1.5 1.8 1.0 2.5 1.0 1.5 1.2 1.5 1.9 GU 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 UA 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 UC 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.4 2.3 1.2 2.3 2.8 2.5 2.8 1.9 UG 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 1.2 2.3 2.8 2.5 2.8 1.9 UU 3.4 2.3 1.7 2.3 2.8 2.8 2.8 2.8 1.8 2.3 2.5 2.3 2.8 2.5 2.8 1.9 # 5' ------> 3' U X1 Y1 C G X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 1.9 1.5 -0.2 1.5 1.5 1.5 1.5 1.5 0.4 1.5 0.1 1.5 1.5 1.6 1.5 1.4 AC 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 AG 2.4 2.2 0.4 2.2 2.1 2.8 2.1 2.8 1.0 2.2 2.1 2.2 2.1 2.8 2.1 1.4 AU 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 CA 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 CC 2.1 1.9 0.7 1.9 1.8 1.9 1.8 1.9 1.3 1.9 0.5 1.9 1.8 1.9 1.8 1.1 CG 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 CU 2.1 1.9 0.7 1.9 1.8 1.9 1.8 1.9 1.3 1.9 0.5 1.9 1.8 1.9 1.8 1.1 GA 0.8 0.5 -1.2 0.5 0.5 1.1 0.5 1.1 -0.6 0.5 0.4 0.5 0.5 1.2 0.5 -0.2 GC 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 GG 0.8 0.6 0.1 0.6 0.5 0.6 0.5 0.6 0.7 0.6 1.8 0.6 0.5 0.6 0.5 1.1 GU 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 UA 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 UC 2.1 1.9 0.7 1.9 1.8 1.9 1.8 1.9 1.3 1.9 0.5 1.9 1.8 1.9 1.8 1.1 UG 2.1 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 0.5 1.9 1.8 1.9 1.8 1.1 UU 2.7 1.9 0.1 1.9 1.8 1.9 1.8 1.9 0.7 1.9 1.8 1.9 1.8 1.9 1.8 1.1 # 5' ------> 3' U X1 Y1 G G X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 1.6 1.6 0.7 1.6 2.0 1.9 2.0 1.7 0.7 1.6 0.1 1.6 2.0 1.7 2.0 1.4 AC 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 AG 2.3 2.2 1.3 2.2 2.7 3.1 2.7 3.0 1.3 2.2 2.1 2.2 2.7 3.0 2.7 1.5 AU 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 CA 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 CC 2.0 1.9 1.6 1.9 2.4 2.2 2.4 2.1 1.6 1.9 0.5 1.9 2.4 2.1 2.4 1.2 CG 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 CU 2.0 1.9 1.6 1.9 2.4 2.2 2.4 2.1 1.6 1.9 0.5 1.9 2.4 2.1 2.4 1.2 GA 0.6 0.6 -0.3 0.6 1.0 1.5 1.0 1.3 -0.3 0.6 0.4 0.6 1.0 1.3 1.0 -0.1 GC 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 GG 0.7 0.6 1.0 0.6 1.1 0.9 1.1 0.8 1.0 0.6 1.8 0.6 1.1 0.8 1.1 1.2 GU 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 UA 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 UC 2.0 1.9 1.6 1.9 2.4 2.2 2.4 2.1 1.6 1.9 0.5 1.9 2.4 2.1 2.4 1.2 UG 2.0 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 0.5 1.9 2.4 2.1 2.4 1.2 UU 2.6 1.9 1.0 1.9 2.4 2.2 2.4 2.1 1.0 1.9 1.8 1.9 2.4 2.1 2.4 1.2 # 5' ------> 3' U X1 Y1 G G X2 Y2 U # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 2.1 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.7 2.4 1.1 2.4 2.4 2.4 2.4 3.0 AC 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 AG 2.7 3.1 1.7 3.1 3.1 3.7 3.1 3.7 3.4 3.1 3.1 3.1 3.1 3.7 3.1 3.1 AU 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 CA 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 CC 2.4 2.8 2.0 2.8 2.8 2.8 2.8 2.8 3.7 2.8 1.5 2.8 2.8 2.8 2.8 2.8 CG 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 CU 2.4 2.8 2.0 2.8 2.8 2.8 2.8 2.8 3.7 2.8 1.5 2.8 2.8 2.8 2.8 2.8 GA 1.1 1.4 0.1 1.4 1.4 2.0 1.4 2.0 1.7 1.4 1.4 1.4 1.4 2.0 1.4 1.4 GC 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 GG 1.1 1.5 1.4 1.5 1.5 1.5 1.5 1.5 3.1 1.5 2.8 1.5 1.5 1.5 1.5 2.8 GU 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 UA 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 UC 2.4 2.8 2.0 2.8 2.8 2.8 2.8 2.8 3.7 2.8 1.5 2.8 2.8 2.8 2.8 2.8 UG 2.4 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 1.5 2.8 2.8 2.8 2.8 2.8 UU 3.0 2.8 1.4 2.8 2.8 2.8 2.8 2.8 3.1 2.8 2.8 2.8 2.8 2.8 2.8 2.8 # 5' ------> 3' U X1 Y1 U G X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 2.4 2.2 1.2 2.2 2.3 2.2 2.3 2.2 1.9 2.2 0.7 2.2 2.3 2.2 2.3 1.9 AC 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 AG 3.1 2.8 1.8 2.8 2.9 3.5 2.9 3.5 2.5 2.8 2.6 2.8 2.9 3.5 2.9 2.0 AU 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 CA 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 CC 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.8 2.5 1.0 2.5 2.6 2.6 2.6 1.7 CG 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 CU 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.8 2.5 1.0 2.5 2.6 2.6 2.6 1.7 GA 1.4 1.2 0.2 1.2 1.3 1.8 1.3 1.8 0.9 1.2 1.0 1.2 1.3 1.8 1.3 0.3 GC 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 GG 1.5 1.2 1.5 1.2 1.3 1.3 1.3 1.3 2.2 1.2 2.3 1.2 1.3 1.3 1.3 1.7 GU 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 UA 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 UC 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.8 2.5 1.0 2.5 2.6 2.6 2.6 1.7 UG 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 1.0 2.5 2.6 2.6 2.6 1.7 UU 3.4 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.2 2.5 2.3 2.5 2.6 2.6 2.6 1.7 # 5' ------> 3' U X1 Y1 U G X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G U U U U A C G U A C G U A C G U A C G U #---------------------------------------------------------------------------------------------------------------------------------- AA 3.6 2.7 1.9 2.7 2.7 2.7 2.7 2.7 3.6 2.7 1.4 2.7 2.7 2.7 2.7 3.3 AC 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 AG 3.7 3.4 2.6 3.4 3.4 4.0 3.4 4.0 3.0 3.4 3.4 3.4 3.4 4.0 3.4 3.4 AU 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 CA 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 CC 3.4 3.1 2.9 3.1 3.1 3.1 3.1 3.1 3.3 3.1 1.8 3.1 3.1 3.1 3.1 3.1 CG 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 CU 3.4 3.1 2.9 3.1 3.1 3.1 3.1 3.1 3.3 3.1 1.8 3.1 3.1 3.1 3.1 3.1 GA 2.2 1.7 0.2 1.7 1.7 2.3 1.7 2.3 1.3 1.7 1.7 1.7 1.7 2.3 1.7 1.7 GC 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 GG 2.1 1.8 2.3 1.8 1.8 1.8 1.8 1.8 2.7 1.8 3.1 1.8 1.8 1.8 1.8 3.1 GU 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 UA 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 UC 3.4 3.1 2.9 3.1 3.1 3.1 3.1 3.1 3.3 3.1 1.8 3.1 3.1 3.1 3.1 3.1 UG 3.4 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 1.8 3.1 3.1 3.1 3.1 3.1 UU 4.0 3.1 2.3 3.1 3.1 3.1 3.1 3.1 2.7 3.1 3.1 3.1 3.1 3.1 3.1 3.1