#Data tables for asymmetric interior loops of size 3 #The Enthalpy at 37 degrees for RNA #Data Arrangement: #For the 4x4 tables, each starting pair needs its own table. #This is the AA table: # 5' --> 3' # X # A A # U U # YA # 3' <-- 5' # Y-> # ---------------------------- # (X) A C G U # | ---------------------------- # V # (A) 13.5 13.5 13.5 13.5 # (C) 13.5 13.5 13.5 13.5 # (G) 7.8 7.8 7.8 7.8 # (U) 13.5 13.5 13.5 3.4 #An energy of "." is "infinity," i.e. not allowed. # 5' --> 3' X A A U U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X A C U G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 8.5 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X A G U C YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 8.5 8.5 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X A U U A YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X A G U U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X A U U G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X A A U U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X A C U G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 8.5 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X A G U C YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 8.5 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X A U U A YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X A G U U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X A U U G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X A A U U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 7.8 7.8 7.8 7.8 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X A C U G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.8 2.8 2.8 2.8 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X A G U C YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.8 2.8 2.8 2.8 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X A U U A YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 7.8 7.8 7.8 7.8 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X A G U U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 7.8 7.8 7.8 7.8 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X A U U G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 7.8 7.8 7.8 7.8 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X A A U U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 3.4 3.4 3.4 3.4 # 5' --> 3' X A C U G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 8.5 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U -1.6 -1.6 -1.6 -1.6 # 5' --> 3' X A G U C YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 8.5 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U -1.6 -1.6 -1.6 -1.6 # 5' --> 3' X A U U A YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 3.4 3.4 3.4 3.4 # 5' --> 3' X A G U U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 3.4 3.4 3.4 3.4 # 5' --> 3' X A U U G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 3.4 3.4 3.4 3.4 # 5' --> 3' X C A G U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X C C G G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.6 3.5 2.5 3.5 C 1.6 3.5 3.5 3.5 G -1.6 3.5 -4.1 3.5 U 3.5 3.5 3.5 -6.7 # 5' --> 3' X C G G C YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.5 3.5 -2.3 3.5 C 3.5 3.5 3.5 3.5 G -2.3 -2.3 -2.3 -2.3 U 3.5 3.5 3.5 -6.7 # 5' --> 3' X C U G A YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X C G G U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X C U G G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X C A G U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X C C G G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.5 -2.5 -2.3 3.5 C 3.5 7.8 3.5 3.5 G -2.3 3.5 -2.3 3.5 U 3.5 5.8 3.5 -5.8 # 5' --> 3' X C G G C YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.5 3.5 -2.3 3.5 C 3.5 3.5 3.5 3.5 G -2.3 3.5 -2.3 3.5 U 3.5 3.5 3.5 -6.7 # 5' --> 3' X C U G A YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X C G G U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X C U G G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X C A G U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.8 2.8 2.8 2.8 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X C C G G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A -2.3 -2.3 -2.3 -2.3 C 3.5 3.5 3.5 3.5 G -3.1 -2.3 -2.3 -2.3 U 3.5 3.5 3.5 -6.7 # 5' --> 3' X C G G C YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A -2.3 -2.3 -2.3 -2.3 C 3.5 3.5 3.5 3.5 G -2.3 -2.3 -2.3 -2.3 U 3.5 3.5 3.5 -6.7 # 5' --> 3' X C U G A YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.8 2.8 2.8 2.8 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X C G G U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.8 2.8 2.8 2.8 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X C U G G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.8 2.8 2.8 2.8 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X C A G U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U -1.6 -1.6 -1.6 -1.6 # 5' --> 3' X C C G G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.5 3.5 -2.3 3.5 C 6.4 3.5 3.5 3.5 G -2.3 3.5 -2.3 3.5 U -6.7 -6.9 -6.7 -7.0 # 5' --> 3' X C G G C YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.5 3.5 -2.3 3.5 C 3.5 3.5 3.5 3.5 G -2.3 3.5 -2.3 3.5 U -6.7 -6.7 -6.7 -6.7 # 5' --> 3' X C U G A YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U -1.6 -1.6 -1.6 -1.6 # 5' --> 3' X C G G U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U -1.6 -1.6 -1.6 -1.6 # 5' --> 3' X C U G G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U -1.6 -1.6 -1.6 -1.6 # 5' --> 3' X G A C U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 8.5 8.5 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X G C C G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.5 3.5 3.5 3.5 C 3.5 3.5 3.5 3.5 G -2.3 3.5 -2.3 3.5 U 3.5 3.5 3.5 -6.7 # 5' --> 3' X G G C C YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 6.9 3.5 2.4 3.5 C 3.5 3.5 3.5 3.5 G -2.3 -2.3 -2.3 -2.3 U 3.5 3.5 3.5 -6.7 # 5' --> 3' X G U C A YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 8.5 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X G G C U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 6.9 8.5 2.4 8.5 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X G U C G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 8.5 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X G A C U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 8.5 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X G C C G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.5 3.5 3.5 3.5 C 3.5 3.5 3.5 3.5 G -2.3 3.5 -2.3 3.5 U 3.5 3.5 3.5 -6.7 # 5' --> 3' X G G C C YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.5 3.5 3.5 3.5 C 3.5 3.5 3.5 3.5 G -2.3 3.5 -2.3 3.5 U 3.5 3.5 3.5 -6.7 # 5' --> 3' X G U C A YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 8.5 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X G G C U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 8.5 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X G U C G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 8.5 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X G A C U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.8 2.8 2.8 2.8 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X G C C G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A -2.3 -2.3 -2.3 -2.3 C 3.5 3.5 3.5 3.5 G -2.3 -2.3 -2.3 -2.3 U 3.5 3.5 3.5 -6.7 # 5' --> 3' X G G C C YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A -5.0 -2.3 -2.3 -2.3 C 3.5 3.5 3.5 3.5 G -2.3 -2.3 -2.3 -2.3 U 3.5 3.5 3.5 -6.7 # 5' --> 3' X G U C A YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.8 2.8 2.8 2.8 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X G G C U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A -5.0 2.8 2.8 2.8 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X G U C G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.8 2.8 2.8 2.8 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X G A C U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 8.5 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U -1.6 -1.6 -1.6 -1.6 # 5' --> 3' X G C C G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.5 3.5 3.5 3.5 C 3.5 3.5 3.5 3.5 G -2.3 3.5 -2.3 3.5 U -6.7 -6.7 -6.7 -6.7 # 5' --> 3' X G G C C YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.5 3.5 3.5 3.5 C 3.5 1.3 3.5 3.5 G -2.3 3.5 -2.3 3.5 U -6.7 -6.7 -6.7 -6.7 # 5' --> 3' X G U C A YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 8.5 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U -1.6 -1.6 -1.6 -1.6 # 5' --> 3' X G G C U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 8.5 8.5 C 8.5 1.3 8.5 8.5 G 2.8 8.5 2.8 8.5 U -1.6 -1.6 -1.6 -1.6 # 5' --> 3' X G U C G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 8.5 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U -1.6 -1.6 -1.6 -1.6 # 5' --> 3' X U A A U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U C A G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X U G A C YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X U U A A YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U G A U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U U A G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U A A U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U C A G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X U G A C YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X U U A A YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U G A U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U U A G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U A A U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 7.8 7.8 7.8 7.8 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U C A G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.8 2.8 2.8 2.8 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X U G A C YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.8 2.8 2.8 2.8 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X U U A A YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 7.8 7.8 7.8 7.8 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U G A U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 7.8 7.8 7.8 7.8 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U U A G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 7.8 7.8 7.8 7.8 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U A A U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 3.4 3.4 3.4 3.4 # 5' --> 3' X U C A G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U -1.6 -1.6 -1.6 -1.6 # 5' --> 3' X U G A C YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U -1.6 -1.6 -1.6 -1.6 # 5' --> 3' X U U A A YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 3.4 3.4 3.4 3.4 # 5' --> 3' X U G A U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 3.4 3.4 3.4 3.4 # 5' --> 3' X U U A G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 3.4 3.4 3.4 3.4 # 5' --> 3' X G A U U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X G C U G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 8.5 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X G G U C YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 6.9 8.5 2.4 8.5 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X G U U A YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X G G U U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 6.9 13.5 2.4 13.5 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X G U U G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X G A U U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X G C U G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 8.5 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X G G U C YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 8.5 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X G U U A YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X G G U U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X G U U G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X G A U U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 7.8 7.8 7.8 7.8 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X G C U G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.8 2.8 2.8 2.8 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X G G U C YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A -5.0 2.8 2.8 2.8 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X G U U A YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 7.8 7.8 7.8 7.8 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X G G U U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A -5.0 7.8 7.8 7.8 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X G U U G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 7.8 7.8 7.8 7.8 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X G A U U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 3.4 3.4 3.4 3.4 # 5' --> 3' X G C U G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 8.5 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U -1.6 -1.6 -1.6 -1.6 # 5' --> 3' X G G U C YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 8.5 8.5 C 8.5 1.3 8.5 8.5 G 2.8 8.5 2.8 8.5 U -1.6 -1.6 -1.6 -1.6 # 5' --> 3' X G U U A YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 3.4 3.4 3.4 3.4 # 5' --> 3' X G G U U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 1.3 13.5 13.5 G 7.8 13.5 7.8 13.5 U 3.4 3.4 3.4 3.4 # 5' --> 3' X G U U G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 13.5 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 3.4 3.4 3.4 3.4 # 5' --> 3' X U A G U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U C G G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X U G G C YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X U U G A YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U G G U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U U G G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U A G U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U C G G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X U G G C YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X U U G A YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U G G U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U U G G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U A G U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 7.8 7.8 7.8 7.8 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U C G G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.8 2.8 2.8 2.8 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X U G G C YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.8 2.8 2.8 2.8 C 8.5 8.5 8.5 8.5 G 2.8 2.8 2.8 2.8 U 8.5 8.5 8.5 -1.6 # 5' --> 3' X U U G A YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 7.8 7.8 7.8 7.8 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U G G U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 7.8 7.8 7.8 7.8 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U U G G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 7.8 7.8 7.8 7.8 C 13.5 13.5 13.5 13.5 G 7.8 7.8 7.8 7.8 U 13.5 13.5 13.5 3.4 # 5' --> 3' X U A G U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 3.4 3.4 3.4 3.4 # 5' --> 3' X U C G G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U -1.6 -1.6 -1.6 -1.6 # 5' --> 3' X U G G C YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 8.5 8.5 2.8 8.5 C 8.5 8.5 8.5 8.5 G 2.8 8.5 2.8 8.5 U -1.6 -1.6 -1.6 -1.6 # 5' --> 3' X U U G A YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 3.4 3.4 3.4 3.4 # 5' --> 3' X U G G U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 3.4 3.4 3.4 3.4 # 5' --> 3' X U U G G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 13.5 13.5 7.8 13.5 C 13.5 13.5 13.5 13.5 G 7.8 13.5 7.8 13.5 U 3.4 3.4 3.4 3.4