#Data tables for asymmetric interior loops of size 3 #Free energies at 37 degrees for RNA #Data Arrangement: #For the 4x4 tables, each starting pair needs its own table. #This is the AA table: # 5' --> 3' # X # A A # U U # YA # 3' <-- 5' # Y-> # ---------------------------- # (X) A C G U # | ---------------------------- # V # (A) 3.7 3.7 3.7 3.7 # (C) 3.7 3.7 3.7 3.7 # (G) 2.6 2.6 2.6 2.6 # (U) 3.7 3.7 3.7 3.0 #An energy of "." is "infinity," i.e. not allowed. # 5' --> 3' X A A U U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X A C U G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 3.0 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X A G U C YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 3.0 3.0 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X A U U A YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X A G U U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X A U U G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X A A U U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X A C U G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 3.0 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X A G U C YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 3.0 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X A U U A YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X A G U U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X A U U G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X A A U U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.6 2.6 2.6 2.6 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X A C U G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 1.9 1.9 1.9 1.9 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X A G U C YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 1.9 1.9 1.9 1.9 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X A U U A YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.6 2.6 2.6 2.6 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X A G U U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.6 2.6 2.6 2.6 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X A U U G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.6 2.6 2.6 2.6 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X A A U U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.0 3.0 3.0 3.0 # 5' --> 3' X A C U G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 3.0 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 2.2 2.2 2.2 2.2 # 5' --> 3' X A G U C YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 3.0 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 2.2 2.2 2.2 2.2 # 5' --> 3' X A U U A YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.0 3.0 3.0 3.0 # 5' --> 3' X A G U U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.0 3.0 3.0 3.0 # 5' --> 3' X A U U G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.0 3.0 3.0 3.0 # 5' --> 3' X C A G U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X C C G G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.5 2.3 1.1 2.3 C 2.3 2.3 2.3 2.3 G 1.7 2.3 0.8 2.3 U 2.3 2.3 2.3 1.5 # 5' --> 3' X C G G C YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.3 2.3 1.1 2.3 C 2.3 2.3 2.3 2.3 G 1.1 1.1 1.1 1.1 U 2.3 2.3 2.3 1.5 # 5' --> 3' X C U G A YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X C G G U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X C U G G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X C A G U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X C C G G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.3 1.7 1.1 2.3 C 2.3 2.5 2.3 2.3 G 1.1 2.3 1.1 2.3 U 2.3 2.2 2.3 1.5 # 5' --> 3' X C G G C YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.3 2.3 1.1 2.3 C 2.3 2.3 2.3 2.3 G 1.1 2.3 1.1 2.3 U 2.3 2.3 2.3 1.5 # 5' --> 3' X C U G A YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X C G G U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X C U G G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X C A G U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 1.9 1.9 1.9 1.9 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X C C G G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 0.8 1.1 1.1 1.1 C 2.3 2.3 2.3 2.3 G 1.2 1.1 1.1 1.1 U 2.3 2.3 2.3 1.5 # 5' --> 3' X C G G C YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 1.1 1.1 1.1 1.1 C 2.3 2.3 2.3 2.3 G 1.1 1.1 1.1 1.1 U 2.3 2.3 2.3 1.5 # 5' --> 3' X C U G A YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 1.9 1.9 1.9 1.9 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X C G G U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 1.9 1.9 1.9 1.9 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X C U G G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 1.9 1.9 1.9 1.9 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X C A G U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 2.2 2.2 2.2 2.2 # 5' --> 3' X C C G G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.3 2.3 1.1 2.3 C 2.5 2.3 2.3 2.3 G 1.1 2.3 1.1 2.3 U 1.5 1.7 1.5 1.4 # 5' --> 3' X C G G C YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.3 2.3 1.1 2.3 C 2.3 2.3 2.3 2.3 G 1.1 2.3 1.1 2.3 U 1.5 1.5 1.5 1.5 # 5' --> 3' X C U G A YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 2.2 2.2 2.2 2.2 # 5' --> 3' X C G G U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 2.2 2.2 2.2 2.2 # 5' --> 3' X C U G G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 2.2 2.2 2.2 2.2 # 5' --> 3' X G A C U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 3.0 3.0 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X G C C G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.3 2.3 2.3 2.3 C 2.3 2.3 2.3 2.3 G 1.1 2.3 1.1 2.3 U 2.3 2.3 2.3 1.5 # 5' --> 3' X G G C C YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.5 2.3 2.1 2.3 C 2.3 2.3 2.3 2.3 G 1.1 1.1 1.1 1.1 U 2.3 2.3 2.3 1.5 # 5' --> 3' X G U C A YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 3.0 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X G G C U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.5 3.0 2.1 3.0 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X G U C G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 3.0 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X G A C U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 3.0 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X G C C G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.3 2.3 2.3 2.3 C 2.3 2.3 2.3 2.3 G 1.1 2.3 1.1 2.3 U 2.3 2.3 2.3 1.5 # 5' --> 3' X G G C C YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.3 2.3 2.3 2.3 C 2.3 2.3 2.3 2.3 G 1.1 2.3 1.1 2.3 U 2.3 2.3 2.3 1.5 # 5' --> 3' X G U C A YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 3.0 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X G G C U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 3.0 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X G U C G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 3.0 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X G A C U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 1.9 1.9 1.9 1.9 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X G C C G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 1.1 1.1 1.1 1.1 C 2.3 2.3 2.3 2.3 G 1.1 1.1 1.1 1.1 U 2.3 2.3 2.3 1.5 # 5' --> 3' X G G C C YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 1.2 1.1 1.1 1.1 C 2.3 2.3 2.3 2.3 G 1.1 1.1 1.1 1.1 U 2.3 2.3 2.3 1.5 # 5' --> 3' X G U C A YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 1.9 1.9 1.9 1.9 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X G G C U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 1.2 1.9 1.9 1.9 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X G U C G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 1.9 1.9 1.9 1.9 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X G A C U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 3.0 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 2.2 2.2 2.2 2.2 # 5' --> 3' X G C C G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.3 2.3 2.3 2.3 C 2.3 2.3 2.3 2.3 G 1.1 2.3 1.1 2.3 U 1.5 1.5 1.5 1.5 # 5' --> 3' X G G C C YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.3 2.3 2.3 2.3 C 2.3 1.9 2.3 2.3 G 1.1 2.3 1.1 2.3 U 1.5 1.5 1.5 1.5 # 5' --> 3' X G U C A YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 3.0 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 2.2 2.2 2.2 2.2 # 5' --> 3' X G G C U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 3.0 3.0 C 3.0 1.9 3.0 3.0 G 1.9 3.0 1.9 3.0 U 2.2 2.2 2.2 2.2 # 5' --> 3' X G U C G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 3.0 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 2.2 2.2 2.2 2.2 # 5' --> 3' X U A A U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U C A G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X U G A C YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X U U A A YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U G A U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U U A G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U A A U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U C A G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X U G A C YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X U U A A YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U G A U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U U A G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U A A U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.6 2.6 2.6 2.6 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U C A G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 1.9 1.9 1.9 1.9 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X U G A C YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 1.9 1.9 1.9 1.9 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X U U A A YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.6 2.6 2.6 2.6 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U G A U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.6 2.6 2.6 2.6 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U U A G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.6 2.6 2.6 2.6 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U A A U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.0 3.0 3.0 3.0 # 5' --> 3' X U C A G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 2.2 2.2 2.2 2.2 # 5' --> 3' X U G A C YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 2.2 2.2 2.2 2.2 # 5' --> 3' X U U A A YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.0 3.0 3.0 3.0 # 5' --> 3' X U G A U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.0 3.0 3.0 3.0 # 5' --> 3' X U U A G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.0 3.0 3.0 3.0 # 5' --> 3' X G A U U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X G C U G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 3.0 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X G G U C YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.5 3.0 2.1 3.0 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X G U U A YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X G G U U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.5 3.7 2.1 3.7 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X G U U G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X G A U U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X G C U G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 3.0 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X G G U C YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 3.0 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X G U U A YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X G G U U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X G U U G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X G A U U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.6 2.6 2.6 2.6 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X G C U G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 1.9 1.9 1.9 1.9 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X G G U C YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 1.2 1.9 1.9 1.9 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X G U U A YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.6 2.6 2.6 2.6 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X G G U U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 1.2 2.6 2.6 2.6 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X G U U G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.6 2.6 2.6 2.6 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X G A U U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.0 3.0 3.0 3.0 # 5' --> 3' X G C U G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 3.0 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 2.2 2.2 2.2 2.2 # 5' --> 3' X G G U C YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 3.0 3.0 C 3.0 1.9 3.0 3.0 G 1.9 3.0 1.9 3.0 U 2.2 2.2 2.2 2.2 # 5' --> 3' X G U U A YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.0 3.0 3.0 3.0 # 5' --> 3' X G G U U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 1.9 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.0 3.0 3.0 3.0 # 5' --> 3' X G U U G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 3.7 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.0 3.0 3.0 3.0 # 5' --> 3' X U A G U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U C G G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X U G G C YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X U U G A YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U G G U YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U U G G YA # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U A G U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U C G G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X U G G C YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 3.0 3.0 3.0 2.2 # 5' --> 3' X U U G A YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U G G U YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U U G G YC # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U A G U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.6 2.6 2.6 2.6 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U C G G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 1.9 1.9 1.9 1.9 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X U G G C YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 1.9 1.9 1.9 1.9 C 3.0 3.0 3.0 3.0 G 1.9 1.9 1.9 1.9 U 3.0 3.0 3.0 2.2 # 5' --> 3' X U U G A YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.6 2.6 2.6 2.6 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U G G U YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.6 2.6 2.6 2.6 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U U G G YG # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 2.6 2.6 2.6 2.6 C 3.7 3.7 3.7 3.7 G 2.6 2.6 2.6 2.6 U 3.7 3.7 3.7 3.0 # 5' --> 3' X U A G U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.0 3.0 3.0 3.0 # 5' --> 3' X U C G G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 2.2 2.2 2.2 2.2 # 5' --> 3' X U G G C YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.0 3.0 1.9 3.0 C 3.0 3.0 3.0 3.0 G 1.9 3.0 1.9 3.0 U 2.2 2.2 2.2 2.2 # 5' --> 3' X U U G A YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.0 3.0 3.0 3.0 # 5' --> 3' X U G G U YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.0 3.0 3.0 3.0 # 5' --> 3' X U U G G YU # 3' <-- 5' # Y # ---------------------------- A C G U # ---------------------------- A 3.7 3.7 2.6 3.7 C 3.7 3.7 3.7 3.7 G 2.6 3.7 2.6 3.7 U 3.0 3.0 3.0 3.0