# 5' ------> 3' A X1 Y1 A U X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 MA 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 MC 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 MG 2.2 2.2 1.8 1.2 1.8 2.2 2.2 1.8 1.2 1.8 2.2 2.2 2.8 2.2 2.8 1.3 1.3 1.8 2.0 1.8 2.2 2.2 2.5 2.2 1.4 MU 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 AM 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 AA 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 AC 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 AG 2.2 2.2 1.8 1.2 1.8 2.2 2.2 1.8 1.2 1.8 2.2 2.2 2.8 2.2 2.8 1.3 1.3 1.8 2.0 1.8 2.2 2.2 2.5 2.2 1.4 AU 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 CM 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 CA 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 CC 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 CG 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 CU 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 GM 1.5 1.5 1.1 0.5 1.1 1.5 1.5 1.1 0.5 1.1 1.5 1.5 2.1 1.5 2.1 0.6 0.6 1.1 1.3 1.1 1.5 1.5 1.8 1.5 0.7 GA 1.5 1.5 1.1 0.5 1.1 1.5 1.5 1.1 0.5 1.1 1.5 1.5 2.1 1.5 2.1 0.6 0.6 1.1 1.3 1.1 1.5 1.5 1.8 1.5 0.7 GC 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 GG 1.0 1.0 0.6 1.3 0.6 1.0 1.0 0.6 1.3 0.6 1.0 1.0 1.0 1.0 1.0 1.4 1.4 0.6 2.1 0.6 1.0 1.0 0.7 1.0 1.5 GU 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 UM 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 UA 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 UC 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 UG 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 UU 2.3 2.3 1.2 0.6 1.2 2.3 2.3 1.2 0.6 1.2 1.7 1.7 1.7 1.7 1.7 0.7 0.7 1.2 1.4 1.2 1.7 1.7 1.4 1.7 0.8 # 5' ------> 3' A X1 Y1 M U X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 MA 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 MC 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 MG 2.2 2.2 1.8 1.2 1.8 2.2 2.2 1.8 1.2 1.8 2.2 2.2 2.8 2.2 2.8 1.3 1.3 1.8 2.0 1.8 2.2 2.2 2.5 2.2 1.4 MU 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 AM 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 AA 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 AC 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 AG 2.2 2.2 1.8 1.2 1.8 2.2 2.2 1.8 1.2 1.8 2.2 2.2 2.8 2.2 2.8 1.3 1.3 1.8 2.0 1.8 2.2 2.2 2.5 2.2 1.4 AU 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 CM 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 CA 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 CC 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 CG 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 CU 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 GM 1.5 1.5 1.1 0.5 1.1 1.5 1.5 1.1 0.5 1.1 1.5 1.5 2.1 1.5 2.1 0.6 0.6 1.1 1.3 1.1 1.5 1.5 1.8 1.5 0.7 GA 1.5 1.5 1.1 0.5 1.1 1.5 1.5 1.1 0.5 1.1 1.5 1.5 2.1 1.5 2.1 0.6 0.6 1.1 1.3 1.1 1.5 1.5 1.8 1.5 0.7 GC 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 GG 1.0 1.0 0.6 1.3 0.6 1.0 1.0 0.6 1.3 0.6 1.0 1.0 1.0 1.0 1.0 1.4 1.4 0.6 2.1 0.6 1.0 1.0 0.7 1.0 1.5 GU 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 UM 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 UA 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 UC 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 UG 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 UU 2.3 2.3 1.2 0.6 1.2 2.3 2.3 1.2 0.6 1.2 1.7 1.7 1.7 1.7 1.7 0.7 0.7 1.2 1.4 1.2 1.7 1.7 1.4 1.7 0.8 # 5' ------> 3' A X1 Y1 C U X2 Y2 G # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.7 MA 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.7 MC 2.0 2.0 1.7 0.0 1.7 2.0 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 1.7 0.6 0.6 1.7 0.3 1.7 1.7 1.7 1.8 1.7 1.0 MG 1.6 1.6 1.3 -0.4 1.3 1.6 1.6 1.3 -0.4 1.3 1.3 1.3 1.9 1.3 1.9 0.2 0.2 1.3 1.2 1.3 1.3 1.3 2.0 1.3 0.6 MU 2.0 2.0 1.7 0.0 1.7 2.0 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 1.7 0.6 0.6 1.7 0.3 1.7 1.7 1.7 1.8 1.7 1.0 AM 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.7 AA 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.7 AC 2.0 2.0 1.7 0.0 1.7 2.0 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 1.7 0.6 0.6 1.7 0.3 1.7 1.7 1.7 1.8 1.7 1.0 AG 1.6 1.6 1.3 -0.4 1.3 1.6 1.6 1.3 -0.4 1.3 1.3 1.3 1.9 1.3 1.9 0.2 0.2 1.3 1.2 1.3 1.3 1.3 2.0 1.3 0.6 AU 2.0 2.0 1.7 0.0 1.7 2.0 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 1.7 0.6 0.6 1.7 0.3 1.7 1.7 1.7 1.8 1.7 1.0 CM 1.9 1.9 1.6 -0.1 1.6 1.9 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 1.6 0.5 0.5 1.6 0.2 1.6 1.6 1.6 1.7 1.6 0.9 CA 1.9 1.9 1.6 -0.1 1.6 1.9 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 1.6 0.5 0.5 1.6 0.2 1.6 1.6 1.6 1.7 1.6 0.9 CC 1.9 1.9 1.7 0.5 1.7 1.9 1.9 1.7 0.5 1.7 1.6 1.6 1.7 1.6 1.7 1.1 1.1 1.7 0.3 1.7 1.6 1.6 1.7 1.6 0.9 CG 1.9 1.9 1.6 -0.1 1.6 1.9 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 1.6 0.5 0.5 1.6 0.2 1.6 1.6 1.6 1.7 1.6 0.9 CU 1.9 1.9 1.7 0.5 1.7 1.9 1.9 1.7 0.5 1.7 1.6 1.6 1.7 1.6 1.7 1.1 1.1 1.7 0.3 1.7 1.6 1.6 1.7 1.6 0.9 GM 0.9 0.9 0.6 -1.1 0.6 0.9 0.9 0.6 -1.1 0.6 0.6 0.6 1.2 0.6 1.2 -0.5 -0.5 0.6 0.5 0.6 0.6 0.6 1.3 0.6 -0.1 GA 0.9 0.9 0.6 -1.1 0.6 0.9 0.9 0.6 -1.1 0.6 0.6 0.6 1.2 0.6 1.2 -0.5 -0.5 0.6 0.5 0.6 0.6 0.6 1.3 0.6 -0.1 GC 2.0 2.0 1.7 0.0 1.7 2.0 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 1.7 0.6 0.6 1.7 0.3 1.7 1.7 1.7 1.8 1.7 1.0 GG 0.4 0.4 0.1 -0.3 0.1 0.4 0.4 0.1 -0.3 0.1 0.1 0.1 0.1 0.1 0.1 0.3 0.3 0.1 1.3 0.1 0.1 0.1 0.2 0.1 0.7 GU 2.0 2.0 1.7 0.0 1.7 2.0 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 1.7 0.6 0.6 1.7 0.3 1.7 1.7 1.7 1.8 1.7 1.0 UM 1.9 1.9 1.6 -0.1 1.6 1.9 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 1.6 0.5 0.5 1.6 0.2 1.6 1.6 1.6 1.7 1.6 0.9 UA 1.9 1.9 1.6 -0.1 1.6 1.9 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 1.6 0.5 0.5 1.6 0.2 1.6 1.6 1.6 1.7 1.6 0.9 UC 1.9 1.9 1.7 0.5 1.7 1.9 1.9 1.7 0.5 1.7 1.6 1.6 1.7 1.6 1.7 1.1 1.1 1.7 0.3 1.7 1.6 1.6 1.7 1.6 0.9 UG 1.9 1.9 1.6 -0.1 1.6 1.9 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 1.6 0.5 0.5 1.6 0.2 1.6 1.6 1.6 1.7 1.6 0.9 UU 1.6 1.6 0.8 -1.0 0.8 1.6 1.6 0.8 -1.0 0.8 0.7 0.7 0.8 0.7 0.8 -0.3 -0.3 0.8 0.7 0.8 0.7 0.7 0.8 0.7 0.0 # 5' ------> 3' A X1 Y1 G U X2 Y2 C # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.8 MA 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.8 MC 1.8 1.8 1.8 0.9 1.8 1.8 1.8 1.8 0.9 1.8 2.2 2.2 2.1 2.2 1.9 0.9 0.9 1.8 0.3 1.8 2.2 2.2 1.9 2.2 1.0 MG 1.4 1.4 1.4 0.5 1.4 1.4 1.4 1.4 0.5 1.4 1.8 1.8 2.3 1.8 2.1 0.5 0.5 1.4 1.2 1.4 1.8 1.8 2.1 1.8 0.6 MU 1.8 1.8 1.8 0.9 1.8 1.8 1.8 1.8 0.9 1.8 2.2 2.2 2.1 2.2 1.9 0.9 0.9 1.8 0.3 1.8 2.2 2.2 1.9 2.2 1.0 AM 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.8 AA 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.8 AC 1.8 1.8 1.8 0.9 1.8 1.8 1.8 1.8 0.9 1.8 2.2 2.2 2.1 2.2 1.9 0.9 0.9 1.8 0.3 1.8 2.2 2.2 1.9 2.2 1.0 AG 1.4 1.4 1.4 0.5 1.4 1.4 1.4 1.4 0.5 1.4 1.8 1.8 2.3 1.8 2.1 0.5 0.5 1.4 1.2 1.4 1.8 1.8 2.1 1.8 0.6 AU 1.8 1.8 1.8 0.9 1.8 1.8 1.8 1.8 0.9 1.8 2.2 2.2 2.1 2.2 1.9 0.9 0.9 1.8 0.3 1.8 2.2 2.2 1.9 2.2 1.0 CM 1.7 1.7 1.7 0.8 1.7 1.7 1.7 1.7 0.8 1.7 2.1 2.1 2.0 2.1 1.8 0.8 0.8 1.7 0.2 1.7 2.1 2.1 1.8 2.1 0.9 CA 1.7 1.7 1.7 0.8 1.7 1.7 1.7 1.7 0.8 1.7 2.1 2.1 2.0 2.1 1.8 0.8 0.8 1.7 0.2 1.7 2.1 2.1 1.8 2.1 0.9 CC 1.8 1.8 1.7 1.4 1.7 1.8 1.8 1.7 1.4 1.7 2.2 2.2 2.0 2.2 1.9 1.4 1.4 1.7 0.3 1.7 2.2 2.2 1.9 2.2 1.0 CG 1.7 1.7 1.7 0.8 1.7 1.7 1.7 1.7 0.8 1.7 2.1 2.1 2.0 2.1 1.8 0.8 0.8 1.7 0.2 1.7 2.1 2.1 1.8 2.1 0.9 CU 1.8 1.8 1.7 1.4 1.7 1.8 1.8 1.7 1.4 1.7 2.2 2.2 2.0 2.2 1.9 1.4 1.4 1.7 0.3 1.7 2.2 2.2 1.9 2.2 1.0 GM 0.7 0.7 0.7 -0.2 0.7 0.7 0.7 0.7 -0.2 0.7 1.1 1.1 1.6 1.1 1.4 -0.2 -0.2 0.7 0.5 0.7 1.1 1.1 1.4 1.1 0.0 GA 0.7 0.7 0.7 -0.2 0.7 0.7 0.7 0.7 -0.2 0.7 1.1 1.1 1.6 1.1 1.4 -0.2 -0.2 0.7 0.5 0.7 1.1 1.1 1.4 1.1 0.0 GC 1.8 1.8 1.8 0.9 1.8 1.8 1.8 1.8 0.9 1.8 2.2 2.2 2.1 2.2 1.9 0.9 0.9 1.8 0.3 1.8 2.2 2.2 1.9 2.2 1.0 GG 0.2 0.2 0.2 0.6 0.2 0.2 0.2 0.2 0.6 0.2 0.6 0.6 0.5 0.6 0.3 0.6 0.6 0.2 1.3 0.2 0.6 0.6 0.3 0.6 0.7 GU 1.8 1.8 1.8 0.9 1.8 1.8 1.8 1.8 0.9 1.8 2.2 2.2 2.1 2.2 1.9 0.9 0.9 1.8 0.3 1.8 2.2 2.2 1.9 2.2 1.0 UM 1.7 1.7 1.7 0.8 1.7 1.7 1.7 1.7 0.8 1.7 2.1 2.1 2.0 2.1 1.8 0.8 0.8 1.7 0.2 1.7 2.1 2.1 1.8 2.1 0.9 UA 1.7 1.7 1.7 0.8 1.7 1.7 1.7 1.7 0.8 1.7 2.1 2.1 2.0 2.1 1.8 0.8 0.8 1.7 0.2 1.7 2.1 2.1 1.8 2.1 0.9 UC 1.8 1.8 1.7 1.4 1.7 1.8 1.8 1.7 1.4 1.7 2.2 2.2 2.0 2.2 1.9 1.4 1.4 1.7 0.3 1.7 2.2 2.2 1.9 2.2 1.0 UG 1.7 1.7 1.7 0.8 1.7 1.7 1.7 1.7 0.8 1.7 2.1 2.1 2.0 2.1 1.8 0.8 0.8 1.7 0.2 1.7 2.1 2.1 1.8 2.1 0.9 UU 1.5 1.5 0.8 0.0 0.8 1.5 1.5 0.8 0.0 0.8 1.3 1.3 1.1 1.3 1.0 0.0 0.0 0.8 0.7 0.8 1.3 1.3 1.0 1.3 0.1 # 5' ------> 3' A X1 Y1 U U X2 Y2 A # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 MA 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 MC 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 MG 2.2 2.2 2.0 1.0 2.0 2.2 2.2 2.0 1.0 2.0 2.1 2.1 2.6 2.1 2.6 1.7 1.7 2.0 1.8 2.0 2.1 2.1 2.6 2.1 1.1 MU 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 AM 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 AA 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 AC 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 AG 2.2 2.2 2.0 1.0 2.0 2.2 2.2 2.0 1.0 2.0 2.1 2.1 2.6 2.1 2.6 1.7 1.7 2.0 1.8 2.0 2.1 2.1 2.6 2.1 1.1 AU 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 CM 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 CA 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 CC 2.6 2.6 2.3 1.9 2.3 2.6 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 CG 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 CU 2.6 2.6 2.3 1.9 2.3 2.6 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 GM 1.5 1.5 1.3 0.3 1.3 1.5 1.5 1.3 0.3 1.3 1.4 1.4 1.9 1.4 1.9 1.0 1.0 1.3 1.1 1.3 1.4 1.4 1.9 1.4 0.4 GA 1.5 1.5 1.3 0.3 1.3 1.5 1.5 1.3 0.3 1.3 1.4 1.4 1.9 1.4 1.9 1.0 1.0 1.3 1.1 1.3 1.4 1.4 1.9 1.4 0.4 GC 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 GG 1.0 1.0 0.8 1.1 0.8 1.0 1.0 0.8 1.1 0.8 0.9 0.9 0.8 0.9 0.8 1.8 1.8 0.8 1.9 0.8 0.9 0.9 0.8 0.9 1.2 GU 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 UM 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 UA 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 UC 2.6 2.6 2.3 1.9 2.3 2.6 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 UG 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 UU 2.3 2.3 1.4 0.4 1.4 2.3 2.3 1.4 0.4 1.4 1.5 1.5 1.5 1.5 1.5 1.1 1.1 1.4 1.2 1.4 1.5 1.5 1.5 1.5 0.6 # 5' ------> 3' A X1 Y1 U U X2 Y2 M # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 MA 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 MC 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 MG 2.2 2.2 2.0 1.0 2.0 2.2 2.2 2.0 1.0 2.0 2.1 2.1 2.6 2.1 2.6 1.7 1.7 2.0 1.8 2.0 2.1 2.1 2.6 2.1 1.1 MU 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 AM 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 AA 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 AC 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 AG 2.2 2.2 2.0 1.0 2.0 2.2 2.2 2.0 1.0 2.0 2.1 2.1 2.6 2.1 2.6 1.7 1.7 2.0 1.8 2.0 2.1 2.1 2.6 2.1 1.1 AU 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 CM 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 CA 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 CC 2.6 2.6 2.3 1.9 2.3 2.6 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 CG 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 CU 2.6 2.6 2.3 1.9 2.3 2.6 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 GM 1.5 1.5 1.3 0.3 1.3 1.5 1.5 1.3 0.3 1.3 1.4 1.4 1.9 1.4 1.9 1.0 1.0 1.3 1.1 1.3 1.4 1.4 1.9 1.4 0.4 GA 1.5 1.5 1.3 0.3 1.3 1.5 1.5 1.3 0.3 1.3 1.4 1.4 1.9 1.4 1.9 1.0 1.0 1.3 1.1 1.3 1.4 1.4 1.9 1.4 0.4 GC 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 GG 1.0 1.0 0.8 1.1 0.8 1.0 1.0 0.8 1.1 0.8 0.9 0.9 0.8 0.9 0.8 1.8 1.8 0.8 1.9 0.8 0.9 0.9 0.8 0.9 1.2 GU 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 UM 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 UA 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 UC 2.6 2.6 2.3 1.9 2.3 2.6 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 UG 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 UU 2.3 2.3 1.4 0.4 1.4 2.3 2.3 1.4 0.4 1.4 1.5 1.5 1.5 1.5 1.5 1.1 1.1 1.4 1.2 1.4 1.5 1.5 1.5 1.5 0.6 # 5' ------> 3' A X1 Y1 G U X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.9 MA 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.9 MC 1.8 1.8 2.1 0.8 2.1 1.8 1.8 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 MG 1.4 1.4 1.7 0.4 1.7 1.4 1.4 1.7 0.4 1.7 1.7 1.7 2.3 1.7 2.3 2.0 2.0 1.7 1.7 1.7 1.7 1.7 2.3 1.7 1.7 MU 1.8 1.8 2.1 0.8 2.1 1.8 1.8 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 AM 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.9 AA 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.9 AC 1.8 1.8 2.1 0.8 2.1 1.8 1.8 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 AG 1.4 1.4 1.7 0.4 1.7 1.4 1.4 1.7 0.4 1.7 1.7 1.7 2.3 1.7 2.3 2.0 2.0 1.7 1.7 1.7 1.7 1.7 2.3 1.7 1.7 AU 1.8 1.8 2.1 0.8 2.1 1.8 1.8 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 CM 1.7 1.7 2.0 0.7 2.0 1.7 1.7 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 2.3 2.3 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 CA 1.7 1.7 2.0 0.7 2.0 1.7 1.7 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 2.3 2.3 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 CC 1.7 1.7 2.1 1.3 2.1 1.7 1.7 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 3.0 3.0 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 CG 1.7 1.7 2.0 0.7 2.0 1.7 1.7 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 2.3 2.3 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 CU 1.7 1.7 2.1 1.3 2.1 1.7 1.7 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 3.0 3.0 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 GM 0.7 0.7 1.0 -0.3 1.0 0.7 0.7 1.0 -0.3 1.0 1.0 1.0 1.6 1.0 1.6 1.3 1.3 1.0 1.0 1.0 1.0 1.0 1.6 1.0 1.0 GA 0.7 0.7 1.0 -0.3 1.0 0.7 0.7 1.0 -0.3 1.0 1.0 1.0 1.6 1.0 1.6 1.3 1.3 1.0 1.0 1.0 1.0 1.0 1.6 1.0 1.0 GC 1.8 1.8 2.1 0.8 2.1 1.8 1.8 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 GG 0.2 0.2 0.5 0.5 0.5 0.2 0.2 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 2.1 2.1 0.5 1.8 0.5 0.5 0.5 0.5 0.5 1.8 GU 1.8 1.8 2.1 0.8 2.1 1.8 1.8 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 UM 1.7 1.7 2.0 0.7 2.0 1.7 1.7 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 2.3 2.3 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 UA 1.7 1.7 2.0 0.7 2.0 1.7 1.7 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 2.3 2.3 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 UC 1.7 1.7 2.1 1.3 2.1 1.7 1.7 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 3.0 3.0 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 UG 1.7 1.7 2.0 0.7 2.0 1.7 1.7 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 2.3 2.3 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 UU 1.4 1.4 1.2 -0.2 1.2 1.4 1.4 1.2 -0.2 1.2 1.2 1.2 1.2 1.2 1.2 1.5 1.5 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 # 5' ------> 3' A X1 Y1 U U X2 Y2 G # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 3.2 MA 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 3.2 MC 2.8 2.8 2.4 1.6 2.4 2.8 2.8 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 MG 2.4 2.4 2.0 1.2 2.0 2.4 2.4 2.0 1.2 2.0 2.0 2.0 2.6 2.0 2.6 1.6 1.6 2.0 2.0 2.0 2.0 2.0 2.6 2.0 2.0 MU 2.8 2.8 2.4 1.6 2.4 2.8 2.8 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 AM 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 3.2 AA 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 3.2 AC 2.8 2.8 2.4 1.6 2.4 2.8 2.8 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 AG 2.4 2.4 2.0 1.2 2.0 2.4 2.4 2.0 1.2 2.0 2.0 2.0 2.6 2.0 2.6 1.6 1.6 2.0 2.0 2.0 2.0 2.0 2.6 2.0 2.0 AU 2.8 2.8 2.4 1.6 2.4 2.8 2.8 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 CM 2.7 2.7 2.3 1.5 2.3 2.7 2.7 2.3 1.5 2.3 2.3 2.3 2.3 2.3 2.3 1.9 1.9 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 CA 2.7 2.7 2.3 1.5 2.3 2.7 2.7 2.3 1.5 2.3 2.3 2.3 2.3 2.3 2.3 1.9 1.9 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 CC 2.7 2.7 2.4 2.2 2.4 2.7 2.7 2.4 2.2 2.4 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 CG 2.7 2.7 2.3 1.5 2.3 2.7 2.7 2.3 1.5 2.3 2.3 2.3 2.3 2.3 2.3 1.9 1.9 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 CU 2.7 2.7 2.4 2.2 2.4 2.7 2.7 2.4 2.2 2.4 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 GM 1.7 1.7 1.3 0.5 1.3 1.7 1.7 1.3 0.5 1.3 1.3 1.3 1.9 1.3 1.9 0.9 0.9 1.3 1.3 1.3 1.3 1.3 1.9 1.3 1.3 GA 1.7 1.7 1.3 0.5 1.3 1.7 1.7 1.3 0.5 1.3 1.3 1.3 1.9 1.3 1.9 0.9 0.9 1.3 1.3 1.3 1.3 1.3 1.9 1.3 1.3 GC 2.8 2.8 2.4 1.6 2.4 2.8 2.8 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 GG 1.2 1.2 0.8 1.3 0.8 1.2 1.2 0.8 1.3 0.8 0.8 0.8 0.8 0.8 0.8 1.7 1.7 0.8 2.1 0.8 0.8 0.8 0.8 0.8 2.1 GU 2.8 2.8 2.4 1.6 2.4 2.8 2.8 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 UM 2.7 2.7 2.3 1.5 2.3 2.7 2.7 2.3 1.5 2.3 2.3 2.3 2.3 2.3 2.3 1.9 1.9 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 UA 2.7 2.7 2.3 1.5 2.3 2.7 2.7 2.3 1.5 2.3 2.3 2.3 2.3 2.3 2.3 1.9 1.9 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 UC 2.7 2.7 2.4 2.2 2.4 2.7 2.7 2.4 2.2 2.4 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 UG 2.7 2.7 2.3 1.5 2.3 2.7 2.7 2.3 1.5 2.3 2.3 2.3 2.3 2.3 2.3 1.9 1.9 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 UU 2.4 2.4 1.5 0.7 1.5 2.4 2.4 1.5 0.7 1.5 1.5 1.5 1.5 1.5 1.5 1.1 1.1 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 # 5' ------> 3' M X1 Y1 A U X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 MA 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 MC 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 MG 2.2 2.2 1.8 1.2 1.8 2.2 2.2 1.8 1.2 1.8 2.2 2.2 2.8 2.2 2.8 1.3 1.3 1.8 2.0 1.8 2.2 2.2 2.5 2.2 1.4 MU 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 AM 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 AA 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 AC 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 AG 2.2 2.2 1.8 1.2 1.8 2.2 2.2 1.8 1.2 1.8 2.2 2.2 2.8 2.2 2.8 1.3 1.3 1.8 2.0 1.8 2.2 2.2 2.5 2.2 1.4 AU 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 CM 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 CA 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 CC 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 CG 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 CU 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 GM 1.5 1.5 1.1 0.5 1.1 1.5 1.5 1.1 0.5 1.1 1.5 1.5 2.1 1.5 2.1 0.6 0.6 1.1 1.3 1.1 1.5 1.5 1.8 1.5 0.7 GA 1.5 1.5 1.1 0.5 1.1 1.5 1.5 1.1 0.5 1.1 1.5 1.5 2.1 1.5 2.1 0.6 0.6 1.1 1.3 1.1 1.5 1.5 1.8 1.5 0.7 GC 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 GG 1.0 1.0 0.6 1.3 0.6 1.0 1.0 0.6 1.3 0.6 1.0 1.0 1.0 1.0 1.0 1.4 1.4 0.6 2.1 0.6 1.0 1.0 0.7 1.0 1.5 GU 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 UM 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 UA 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 UC 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 UG 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 UU 2.3 2.3 1.2 0.6 1.2 2.3 2.3 1.2 0.6 1.2 1.7 1.7 1.7 1.7 1.7 0.7 0.7 1.2 1.4 1.2 1.7 1.7 1.4 1.7 0.8 # 5' ------> 3' M X1 Y1 M U X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 MA 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 MC 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 MG 2.2 2.2 1.8 1.2 1.8 2.2 2.2 1.8 1.2 1.8 2.2 2.2 2.8 2.2 2.8 1.3 1.3 1.8 2.0 1.8 2.2 2.2 2.5 2.2 1.4 MU 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 AM 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 AA 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 AC 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 AG 2.2 2.2 1.8 1.2 1.8 2.2 2.2 1.8 1.2 1.8 2.2 2.2 2.8 2.2 2.8 1.3 1.3 1.8 2.0 1.8 2.2 2.2 2.5 2.2 1.4 AU 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 CM 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 CA 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 CC 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 CG 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 CU 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 GM 1.5 1.5 1.1 0.5 1.1 1.5 1.5 1.1 0.5 1.1 1.5 1.5 2.1 1.5 2.1 0.6 0.6 1.1 1.3 1.1 1.5 1.5 1.8 1.5 0.7 GA 1.5 1.5 1.1 0.5 1.1 1.5 1.5 1.1 0.5 1.1 1.5 1.5 2.1 1.5 2.1 0.6 0.6 1.1 1.3 1.1 1.5 1.5 1.8 1.5 0.7 GC 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 GG 1.0 1.0 0.6 1.3 0.6 1.0 1.0 0.6 1.3 0.6 1.0 1.0 1.0 1.0 1.0 1.4 1.4 0.6 2.1 0.6 1.0 1.0 0.7 1.0 1.5 GU 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.2 1.6 2.2 2.6 2.6 2.6 2.6 2.6 1.7 1.7 2.2 1.1 2.2 2.6 2.6 2.3 2.6 1.8 UM 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 UA 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 UC 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 UG 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.1 1.5 2.1 2.5 2.5 2.5 2.5 2.5 1.6 1.6 2.1 1.0 2.1 2.5 2.5 2.2 2.5 1.7 UU 2.3 2.3 1.2 0.6 1.2 2.3 2.3 1.2 0.6 1.2 1.7 1.7 1.7 1.7 1.7 0.7 0.7 1.2 1.4 1.2 1.7 1.7 1.4 1.7 0.8 # 5' ------> 3' M X1 Y1 C U X2 Y2 G # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.7 MA 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.7 MC 2.0 2.0 1.7 0.0 1.7 2.0 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 1.7 0.6 0.6 1.7 0.3 1.7 1.7 1.7 1.8 1.7 1.0 MG 1.6 1.6 1.3 -0.4 1.3 1.6 1.6 1.3 -0.4 1.3 1.3 1.3 1.9 1.3 1.9 0.2 0.2 1.3 1.2 1.3 1.3 1.3 2.0 1.3 0.6 MU 2.0 2.0 1.7 0.0 1.7 2.0 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 1.7 0.6 0.6 1.7 0.3 1.7 1.7 1.7 1.8 1.7 1.0 AM 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.7 AA 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.7 AC 2.0 2.0 1.7 0.0 1.7 2.0 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 1.7 0.6 0.6 1.7 0.3 1.7 1.7 1.7 1.8 1.7 1.0 AG 1.6 1.6 1.3 -0.4 1.3 1.6 1.6 1.3 -0.4 1.3 1.3 1.3 1.9 1.3 1.9 0.2 0.2 1.3 1.2 1.3 1.3 1.3 2.0 1.3 0.6 AU 2.0 2.0 1.7 0.0 1.7 2.0 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 1.7 0.6 0.6 1.7 0.3 1.7 1.7 1.7 1.8 1.7 1.0 CM 1.9 1.9 1.6 -0.1 1.6 1.9 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 1.6 0.5 0.5 1.6 0.2 1.6 1.6 1.6 1.7 1.6 0.9 CA 1.9 1.9 1.6 -0.1 1.6 1.9 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 1.6 0.5 0.5 1.6 0.2 1.6 1.6 1.6 1.7 1.6 0.9 CC 1.9 1.9 1.7 0.5 1.7 1.9 1.9 1.7 0.5 1.7 1.6 1.6 1.7 1.6 1.7 1.1 1.1 1.7 0.3 1.7 1.6 1.6 1.7 1.6 0.9 CG 1.9 1.9 1.6 -0.1 1.6 1.9 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 1.6 0.5 0.5 1.6 0.2 1.6 1.6 1.6 1.7 1.6 0.9 CU 1.9 1.9 1.7 0.5 1.7 1.9 1.9 1.7 0.5 1.7 1.6 1.6 1.7 1.6 1.7 1.1 1.1 1.7 0.3 1.7 1.6 1.6 1.7 1.6 0.9 GM 0.9 0.9 0.6 -1.1 0.6 0.9 0.9 0.6 -1.1 0.6 0.6 0.6 1.2 0.6 1.2 -0.5 -0.5 0.6 0.5 0.6 0.6 0.6 1.3 0.6 -0.1 GA 0.9 0.9 0.6 -1.1 0.6 0.9 0.9 0.6 -1.1 0.6 0.6 0.6 1.2 0.6 1.2 -0.5 -0.5 0.6 0.5 0.6 0.6 0.6 1.3 0.6 -0.1 GC 2.0 2.0 1.7 0.0 1.7 2.0 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 1.7 0.6 0.6 1.7 0.3 1.7 1.7 1.7 1.8 1.7 1.0 GG 0.4 0.4 0.1 -0.3 0.1 0.4 0.4 0.1 -0.3 0.1 0.1 0.1 0.1 0.1 0.1 0.3 0.3 0.1 1.3 0.1 0.1 0.1 0.2 0.1 0.7 GU 2.0 2.0 1.7 0.0 1.7 2.0 2.0 1.7 0.0 1.7 1.7 1.7 1.7 1.7 1.7 0.6 0.6 1.7 0.3 1.7 1.7 1.7 1.8 1.7 1.0 UM 1.9 1.9 1.6 -0.1 1.6 1.9 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 1.6 0.5 0.5 1.6 0.2 1.6 1.6 1.6 1.7 1.6 0.9 UA 1.9 1.9 1.6 -0.1 1.6 1.9 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 1.6 0.5 0.5 1.6 0.2 1.6 1.6 1.6 1.7 1.6 0.9 UC 1.9 1.9 1.7 0.5 1.7 1.9 1.9 1.7 0.5 1.7 1.6 1.6 1.7 1.6 1.7 1.1 1.1 1.7 0.3 1.7 1.6 1.6 1.7 1.6 0.9 UG 1.9 1.9 1.6 -0.1 1.6 1.9 1.9 1.6 -0.1 1.6 1.6 1.6 1.6 1.6 1.6 0.5 0.5 1.6 0.2 1.6 1.6 1.6 1.7 1.6 0.9 UU 1.6 1.6 0.8 -1.0 0.8 1.6 1.6 0.8 -1.0 0.8 0.7 0.7 0.8 0.7 0.8 -0.3 -0.3 0.8 0.7 0.8 0.7 0.7 0.8 0.7 0.0 # 5' ------> 3' M X1 Y1 G U X2 Y2 C # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.8 MA 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.8 MC 1.8 1.8 1.8 0.9 1.8 1.8 1.8 1.8 0.9 1.8 2.2 2.2 2.1 2.2 1.9 0.9 0.9 1.8 0.3 1.8 2.2 2.2 1.9 2.2 1.0 MG 1.4 1.4 1.4 0.5 1.4 1.4 1.4 1.4 0.5 1.4 1.8 1.8 2.3 1.8 2.1 0.5 0.5 1.4 1.2 1.4 1.8 1.8 2.1 1.8 0.6 MU 1.8 1.8 1.8 0.9 1.8 1.8 1.8 1.8 0.9 1.8 2.2 2.2 2.1 2.2 1.9 0.9 0.9 1.8 0.3 1.8 2.2 2.2 1.9 2.2 1.0 AM 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.8 AA 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.8 AC 1.8 1.8 1.8 0.9 1.8 1.8 1.8 1.8 0.9 1.8 2.2 2.2 2.1 2.2 1.9 0.9 0.9 1.8 0.3 1.8 2.2 2.2 1.9 2.2 1.0 AG 1.4 1.4 1.4 0.5 1.4 1.4 1.4 1.4 0.5 1.4 1.8 1.8 2.3 1.8 2.1 0.5 0.5 1.4 1.2 1.4 1.8 1.8 2.1 1.8 0.6 AU 1.8 1.8 1.8 0.9 1.8 1.8 1.8 1.8 0.9 1.8 2.2 2.2 2.1 2.2 1.9 0.9 0.9 1.8 0.3 1.8 2.2 2.2 1.9 2.2 1.0 CM 1.7 1.7 1.7 0.8 1.7 1.7 1.7 1.7 0.8 1.7 2.1 2.1 2.0 2.1 1.8 0.8 0.8 1.7 0.2 1.7 2.1 2.1 1.8 2.1 0.9 CA 1.7 1.7 1.7 0.8 1.7 1.7 1.7 1.7 0.8 1.7 2.1 2.1 2.0 2.1 1.8 0.8 0.8 1.7 0.2 1.7 2.1 2.1 1.8 2.1 0.9 CC 1.8 1.8 1.7 1.4 1.7 1.8 1.8 1.7 1.4 1.7 2.2 2.2 2.0 2.2 1.9 1.4 1.4 1.7 0.3 1.7 2.2 2.2 1.9 2.2 1.0 CG 1.7 1.7 1.7 0.8 1.7 1.7 1.7 1.7 0.8 1.7 2.1 2.1 2.0 2.1 1.8 0.8 0.8 1.7 0.2 1.7 2.1 2.1 1.8 2.1 0.9 CU 1.8 1.8 1.7 1.4 1.7 1.8 1.8 1.7 1.4 1.7 2.2 2.2 2.0 2.2 1.9 1.4 1.4 1.7 0.3 1.7 2.2 2.2 1.9 2.2 1.0 GM 0.7 0.7 0.7 -0.2 0.7 0.7 0.7 0.7 -0.2 0.7 1.1 1.1 1.6 1.1 1.4 -0.2 -0.2 0.7 0.5 0.7 1.1 1.1 1.4 1.1 0.0 GA 0.7 0.7 0.7 -0.2 0.7 0.7 0.7 0.7 -0.2 0.7 1.1 1.1 1.6 1.1 1.4 -0.2 -0.2 0.7 0.5 0.7 1.1 1.1 1.4 1.1 0.0 GC 1.8 1.8 1.8 0.9 1.8 1.8 1.8 1.8 0.9 1.8 2.2 2.2 2.1 2.2 1.9 0.9 0.9 1.8 0.3 1.8 2.2 2.2 1.9 2.2 1.0 GG 0.2 0.2 0.2 0.6 0.2 0.2 0.2 0.2 0.6 0.2 0.6 0.6 0.5 0.6 0.3 0.6 0.6 0.2 1.3 0.2 0.6 0.6 0.3 0.6 0.7 GU 1.8 1.8 1.8 0.9 1.8 1.8 1.8 1.8 0.9 1.8 2.2 2.2 2.1 2.2 1.9 0.9 0.9 1.8 0.3 1.8 2.2 2.2 1.9 2.2 1.0 UM 1.7 1.7 1.7 0.8 1.7 1.7 1.7 1.7 0.8 1.7 2.1 2.1 2.0 2.1 1.8 0.8 0.8 1.7 0.2 1.7 2.1 2.1 1.8 2.1 0.9 UA 1.7 1.7 1.7 0.8 1.7 1.7 1.7 1.7 0.8 1.7 2.1 2.1 2.0 2.1 1.8 0.8 0.8 1.7 0.2 1.7 2.1 2.1 1.8 2.1 0.9 UC 1.8 1.8 1.7 1.4 1.7 1.8 1.8 1.7 1.4 1.7 2.2 2.2 2.0 2.2 1.9 1.4 1.4 1.7 0.3 1.7 2.2 2.2 1.9 2.2 1.0 UG 1.7 1.7 1.7 0.8 1.7 1.7 1.7 1.7 0.8 1.7 2.1 2.1 2.0 2.1 1.8 0.8 0.8 1.7 0.2 1.7 2.1 2.1 1.8 2.1 0.9 UU 1.5 1.5 0.8 0.0 0.8 1.5 1.5 0.8 0.0 0.8 1.3 1.3 1.1 1.3 1.0 0.0 0.0 0.8 0.7 0.8 1.3 1.3 1.0 1.3 0.1 # 5' ------> 3' M X1 Y1 U U X2 Y2 A # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 MA 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 MC 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 MG 2.2 2.2 2.0 1.0 2.0 2.2 2.2 2.0 1.0 2.0 2.1 2.1 2.6 2.1 2.6 1.7 1.7 2.0 1.8 2.0 2.1 2.1 2.6 2.1 1.1 MU 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 AM 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 AA 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 AC 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 AG 2.2 2.2 2.0 1.0 2.0 2.2 2.2 2.0 1.0 2.0 2.1 2.1 2.6 2.1 2.6 1.7 1.7 2.0 1.8 2.0 2.1 2.1 2.6 2.1 1.1 AU 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 CM 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 CA 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 CC 2.6 2.6 2.3 1.9 2.3 2.6 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 CG 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 CU 2.6 2.6 2.3 1.9 2.3 2.6 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 GM 1.5 1.5 1.3 0.3 1.3 1.5 1.5 1.3 0.3 1.3 1.4 1.4 1.9 1.4 1.9 1.0 1.0 1.3 1.1 1.3 1.4 1.4 1.9 1.4 0.4 GA 1.5 1.5 1.3 0.3 1.3 1.5 1.5 1.3 0.3 1.3 1.4 1.4 1.9 1.4 1.9 1.0 1.0 1.3 1.1 1.3 1.4 1.4 1.9 1.4 0.4 GC 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 GG 1.0 1.0 0.8 1.1 0.8 1.0 1.0 0.8 1.1 0.8 0.9 0.9 0.8 0.9 0.8 1.8 1.8 0.8 1.9 0.8 0.9 0.9 0.8 0.9 1.2 GU 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 UM 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 UA 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 UC 2.6 2.6 2.3 1.9 2.3 2.6 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 UG 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 UU 2.3 2.3 1.4 0.4 1.4 2.3 2.3 1.4 0.4 1.4 1.5 1.5 1.5 1.5 1.5 1.1 1.1 1.4 1.2 1.4 1.5 1.5 1.5 1.5 0.6 # 5' ------> 3' M X1 Y1 U U X2 Y2 M # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 MA 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 MC 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 MG 2.2 2.2 2.0 1.0 2.0 2.2 2.2 2.0 1.0 2.0 2.1 2.1 2.6 2.1 2.6 1.7 1.7 2.0 1.8 2.0 2.1 2.1 2.6 2.1 1.1 MU 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 AM 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 AA 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 AC 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 AG 2.2 2.2 2.0 1.0 2.0 2.2 2.2 2.0 1.0 2.0 2.1 2.1 2.6 2.1 2.6 1.7 1.7 2.0 1.8 2.0 2.1 2.1 2.6 2.1 1.1 AU 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 CM 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 CA 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 CC 2.6 2.6 2.3 1.9 2.3 2.6 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 CG 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 CU 2.6 2.6 2.3 1.9 2.3 2.6 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 GM 1.5 1.5 1.3 0.3 1.3 1.5 1.5 1.3 0.3 1.3 1.4 1.4 1.9 1.4 1.9 1.0 1.0 1.3 1.1 1.3 1.4 1.4 1.9 1.4 0.4 GA 1.5 1.5 1.3 0.3 1.3 1.5 1.5 1.3 0.3 1.3 1.4 1.4 1.9 1.4 1.9 1.0 1.0 1.3 1.1 1.3 1.4 1.4 1.9 1.4 0.4 GC 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 GG 1.0 1.0 0.8 1.1 0.8 1.0 1.0 0.8 1.1 0.8 0.9 0.9 0.8 0.9 0.8 1.8 1.8 0.8 1.9 0.8 0.9 0.9 0.8 0.9 1.2 GU 2.6 2.6 2.4 1.4 2.4 2.6 2.6 2.4 1.4 2.4 2.5 2.5 2.4 2.5 2.4 2.1 2.1 2.4 0.9 2.4 2.5 2.5 2.4 2.5 1.5 UM 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 UA 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 UC 2.6 2.6 2.3 1.9 2.3 2.6 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 UG 2.5 2.5 2.3 1.3 2.3 2.5 2.5 2.3 1.3 2.3 2.4 2.4 2.3 2.4 2.3 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.3 2.4 1.4 UU 2.3 2.3 1.4 0.4 1.4 2.3 2.3 1.4 0.4 1.4 1.5 1.5 1.5 1.5 1.5 1.1 1.1 1.4 1.2 1.4 1.5 1.5 1.5 1.5 0.6 # 5' ------> 3' M X1 Y1 G U X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.9 MA 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.9 MC 1.8 1.8 2.1 0.8 2.1 1.8 1.8 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 MG 1.4 1.4 1.7 0.4 1.7 1.4 1.4 1.7 0.4 1.7 1.7 1.7 2.3 1.7 2.3 2.0 2.0 1.7 1.7 1.7 1.7 1.7 2.3 1.7 1.7 MU 1.8 1.8 2.1 0.8 2.1 1.8 1.8 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 AM 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.9 AA 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.9 AC 1.8 1.8 2.1 0.8 2.1 1.8 1.8 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 AG 1.4 1.4 1.7 0.4 1.7 1.4 1.4 1.7 0.4 1.7 1.7 1.7 2.3 1.7 2.3 2.0 2.0 1.7 1.7 1.7 1.7 1.7 2.3 1.7 1.7 AU 1.8 1.8 2.1 0.8 2.1 1.8 1.8 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 CM 1.7 1.7 2.0 0.7 2.0 1.7 1.7 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 2.3 2.3 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 CA 1.7 1.7 2.0 0.7 2.0 1.7 1.7 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 2.3 2.3 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 CC 1.7 1.7 2.1 1.3 2.1 1.7 1.7 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 3.0 3.0 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 CG 1.7 1.7 2.0 0.7 2.0 1.7 1.7 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 2.3 2.3 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 CU 1.7 1.7 2.1 1.3 2.1 1.7 1.7 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 3.0 3.0 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 GM 0.7 0.7 1.0 -0.3 1.0 0.7 0.7 1.0 -0.3 1.0 1.0 1.0 1.6 1.0 1.6 1.3 1.3 1.0 1.0 1.0 1.0 1.0 1.6 1.0 1.0 GA 0.7 0.7 1.0 -0.3 1.0 0.7 0.7 1.0 -0.3 1.0 1.0 1.0 1.6 1.0 1.6 1.3 1.3 1.0 1.0 1.0 1.0 1.0 1.6 1.0 1.0 GC 1.8 1.8 2.1 0.8 2.1 1.8 1.8 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 GG 0.2 0.2 0.5 0.5 0.5 0.2 0.2 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 2.1 2.1 0.5 1.8 0.5 0.5 0.5 0.5 0.5 1.8 GU 1.8 1.8 2.1 0.8 2.1 1.8 1.8 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 UM 1.7 1.7 2.0 0.7 2.0 1.7 1.7 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 2.3 2.3 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 UA 1.7 1.7 2.0 0.7 2.0 1.7 1.7 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 2.3 2.3 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 UC 1.7 1.7 2.1 1.3 2.1 1.7 1.7 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 3.0 3.0 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 UG 1.7 1.7 2.0 0.7 2.0 1.7 1.7 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 2.3 2.3 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 UU 1.4 1.4 1.2 -0.2 1.2 1.4 1.4 1.2 -0.2 1.2 1.2 1.2 1.2 1.2 1.2 1.5 1.5 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 # 5' ------> 3' M X1 Y1 U U X2 Y2 G # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 3.2 MA 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 3.2 MC 2.8 2.8 2.4 1.6 2.4 2.8 2.8 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 MG 2.4 2.4 2.0 1.2 2.0 2.4 2.4 2.0 1.2 2.0 2.0 2.0 2.6 2.0 2.6 1.6 1.6 2.0 2.0 2.0 2.0 2.0 2.6 2.0 2.0 MU 2.8 2.8 2.4 1.6 2.4 2.8 2.8 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 AM 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 3.2 AA 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 3.2 AC 2.8 2.8 2.4 1.6 2.4 2.8 2.8 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 AG 2.4 2.4 2.0 1.2 2.0 2.4 2.4 2.0 1.2 2.0 2.0 2.0 2.6 2.0 2.6 1.6 1.6 2.0 2.0 2.0 2.0 2.0 2.6 2.0 2.0 AU 2.8 2.8 2.4 1.6 2.4 2.8 2.8 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 CM 2.7 2.7 2.3 1.5 2.3 2.7 2.7 2.3 1.5 2.3 2.3 2.3 2.3 2.3 2.3 1.9 1.9 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 CA 2.7 2.7 2.3 1.5 2.3 2.7 2.7 2.3 1.5 2.3 2.3 2.3 2.3 2.3 2.3 1.9 1.9 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 CC 2.7 2.7 2.4 2.2 2.4 2.7 2.7 2.4 2.2 2.4 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 CG 2.7 2.7 2.3 1.5 2.3 2.7 2.7 2.3 1.5 2.3 2.3 2.3 2.3 2.3 2.3 1.9 1.9 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 CU 2.7 2.7 2.4 2.2 2.4 2.7 2.7 2.4 2.2 2.4 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 GM 1.7 1.7 1.3 0.5 1.3 1.7 1.7 1.3 0.5 1.3 1.3 1.3 1.9 1.3 1.9 0.9 0.9 1.3 1.3 1.3 1.3 1.3 1.9 1.3 1.3 GA 1.7 1.7 1.3 0.5 1.3 1.7 1.7 1.3 0.5 1.3 1.3 1.3 1.9 1.3 1.9 0.9 0.9 1.3 1.3 1.3 1.3 1.3 1.9 1.3 1.3 GC 2.8 2.8 2.4 1.6 2.4 2.8 2.8 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 GG 1.2 1.2 0.8 1.3 0.8 1.2 1.2 0.8 1.3 0.8 0.8 0.8 0.8 0.8 0.8 1.7 1.7 0.8 2.1 0.8 0.8 0.8 0.8 0.8 2.1 GU 2.8 2.8 2.4 1.6 2.4 2.8 2.8 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 UM 2.7 2.7 2.3 1.5 2.3 2.7 2.7 2.3 1.5 2.3 2.3 2.3 2.3 2.3 2.3 1.9 1.9 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 UA 2.7 2.7 2.3 1.5 2.3 2.7 2.7 2.3 1.5 2.3 2.3 2.3 2.3 2.3 2.3 1.9 1.9 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 UC 2.7 2.7 2.4 2.2 2.4 2.7 2.7 2.4 2.2 2.4 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 UG 2.7 2.7 2.3 1.5 2.3 2.7 2.7 2.3 1.5 2.3 2.3 2.3 2.3 2.3 2.3 1.9 1.9 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 UU 2.4 2.4 1.5 0.7 1.5 2.4 2.4 1.5 0.7 1.5 1.5 1.5 1.5 1.5 1.5 1.1 1.1 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 # 5' ------> 3' C X1 Y1 A G X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.0 2.0 1.5 0.9 1.5 2.0 2.0 1.5 0.9 1.5 2.0 2.0 2.0 2.0 2.0 1.0 1.0 1.5 0.4 1.5 2.0 2.0 1.7 2.0 1.7 MA 2.0 2.0 1.5 0.9 1.5 2.0 2.0 1.5 0.9 1.5 2.0 2.0 2.0 2.0 2.0 1.0 1.0 1.5 0.4 1.5 2.0 2.0 1.7 2.0 1.7 MC 2.4 2.4 1.9 1.3 1.9 2.4 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 2.4 1.4 1.4 1.9 0.8 1.9 2.4 2.4 2.1 2.4 1.5 MG 1.0 1.0 0.6 0.0 0.6 1.0 1.0 0.6 0.0 0.6 1.0 1.0 1.6 1.0 1.6 0.1 0.1 0.6 0.8 0.6 1.0 1.0 1.3 1.0 0.2 MU 2.4 2.4 1.9 1.3 1.9 2.4 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 2.4 1.4 1.4 1.9 0.8 1.9 2.4 2.4 2.1 2.4 1.5 AM 2.0 2.0 1.5 0.9 1.5 2.0 2.0 1.5 0.9 1.5 2.0 2.0 2.0 2.0 2.0 1.0 1.0 1.5 0.4 1.5 2.0 2.0 1.7 2.0 1.7 AA 2.0 2.0 1.5 0.9 1.5 2.0 2.0 1.5 0.9 1.5 2.0 2.0 2.0 2.0 2.0 1.0 1.0 1.5 0.4 1.5 2.0 2.0 1.7 2.0 1.7 AC 2.4 2.4 1.9 1.3 1.9 2.4 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 2.4 1.4 1.4 1.9 0.8 1.9 2.4 2.4 2.1 2.4 1.5 AG 1.0 1.0 0.6 0.0 0.6 1.0 1.0 0.6 0.0 0.6 1.0 1.0 1.6 1.0 1.6 0.1 0.1 0.6 0.8 0.6 1.0 1.0 1.3 1.0 0.2 AU 2.4 2.4 1.9 1.3 1.9 2.4 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 2.4 1.4 1.4 1.9 0.8 1.9 2.4 2.4 2.1 2.4 1.5 CM 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 0.4 1.5 1.9 1.9 1.6 1.9 1.1 CA 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 0.4 1.5 1.9 1.9 1.6 1.9 1.1 CC 2.2 2.2 1.8 1.8 1.8 2.2 2.2 1.8 1.8 1.8 2.2 2.2 2.2 2.2 2.2 1.9 1.9 1.8 0.7 1.8 2.2 2.2 1.9 2.2 1.4 CG 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 0.4 1.5 1.9 1.9 1.6 1.9 1.1 CU 2.1 2.1 1.6 1.6 1.6 2.1 2.1 1.6 1.6 1.6 2.1 2.1 2.1 2.1 2.1 1.7 1.7 1.6 0.5 1.6 2.1 2.1 1.8 2.1 1.2 GM 1.0 1.0 0.6 0.0 0.6 1.0 1.0 0.6 0.0 0.6 1.0 1.0 1.6 1.0 1.6 0.1 0.1 0.6 0.8 0.6 1.0 1.0 1.3 1.0 0.2 GA 1.0 1.0 0.6 0.0 0.6 1.0 1.0 0.6 0.0 0.6 1.0 1.0 1.6 1.0 1.6 0.1 0.1 0.6 0.8 0.6 1.0 1.0 1.3 1.0 0.2 GC 2.4 2.4 1.9 1.3 1.9 2.4 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 2.4 1.4 1.4 1.9 0.8 1.9 2.4 2.4 2.1 2.4 1.5 GG 0.5 0.5 0.0 0.7 0.0 0.5 0.5 0.0 0.7 0.0 0.5 0.5 0.5 0.5 0.5 0.8 0.8 0.0 1.5 0.0 0.5 0.5 0.2 0.5 0.9 GU 2.4 2.4 1.9 1.3 1.9 2.4 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 2.4 1.4 1.4 1.9 0.8 1.9 2.4 2.4 2.1 2.4 1.5 UM 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 0.4 1.5 1.9 1.9 1.6 1.9 1.1 UA 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 0.4 1.5 1.9 1.9 1.6 1.9 1.1 UC 2.1 2.1 1.6 1.6 1.6 2.1 2.1 1.6 1.6 1.6 2.1 2.1 2.1 2.1 2.1 1.7 1.7 1.6 0.5 1.6 2.1 2.1 1.8 2.1 1.2 UG 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 0.4 1.5 1.9 1.9 1.6 1.9 1.1 UU 1.8 1.8 0.7 0.1 0.7 1.8 1.8 0.7 0.1 0.7 1.2 1.2 1.2 1.2 1.2 0.2 0.2 0.7 0.9 0.7 1.2 1.2 0.9 1.2 0.3 # 5' ------> 3' C X1 Y1 M G X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.0 2.0 1.5 0.9 1.5 2.0 2.0 1.5 0.9 1.5 2.0 2.0 2.0 2.0 2.0 1.0 1.0 1.5 0.4 1.5 2.0 2.0 1.7 2.0 1.7 MA 2.0 2.0 1.5 0.9 1.5 2.0 2.0 1.5 0.9 1.5 2.0 2.0 2.0 2.0 2.0 1.0 1.0 1.5 0.4 1.5 2.0 2.0 1.7 2.0 1.7 MC 2.4 2.4 1.9 1.3 1.9 2.4 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 2.4 1.4 1.4 1.9 0.8 1.9 2.4 2.4 2.1 2.4 1.5 MG 1.0 1.0 0.6 0.0 0.6 1.0 1.0 0.6 0.0 0.6 1.0 1.0 1.6 1.0 1.6 0.1 0.1 0.6 0.8 0.6 1.0 1.0 1.3 1.0 0.2 MU 2.4 2.4 1.9 1.3 1.9 2.4 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 2.4 1.4 1.4 1.9 0.8 1.9 2.4 2.4 2.1 2.4 1.5 AM 2.0 2.0 1.5 0.9 1.5 2.0 2.0 1.5 0.9 1.5 2.0 2.0 2.0 2.0 2.0 1.0 1.0 1.5 0.4 1.5 2.0 2.0 1.7 2.0 1.7 AA 2.0 2.0 1.5 0.9 1.5 2.0 2.0 1.5 0.9 1.5 2.0 2.0 2.0 2.0 2.0 1.0 1.0 1.5 0.4 1.5 2.0 2.0 1.7 2.0 1.7 AC 2.4 2.4 1.9 1.3 1.9 2.4 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 2.4 1.4 1.4 1.9 0.8 1.9 2.4 2.4 2.1 2.4 1.5 AG 1.0 1.0 0.6 0.0 0.6 1.0 1.0 0.6 0.0 0.6 1.0 1.0 1.6 1.0 1.6 0.1 0.1 0.6 0.8 0.6 1.0 1.0 1.3 1.0 0.2 AU 2.4 2.4 1.9 1.3 1.9 2.4 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 2.4 1.4 1.4 1.9 0.8 1.9 2.4 2.4 2.1 2.4 1.5 CM 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 0.4 1.5 1.9 1.9 1.6 1.9 1.1 CA 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 0.4 1.5 1.9 1.9 1.6 1.9 1.1 CC 2.2 2.2 1.8 1.8 1.8 2.2 2.2 1.8 1.8 1.8 2.2 2.2 2.2 2.2 2.2 1.9 1.9 1.8 0.7 1.8 2.2 2.2 1.9 2.2 1.4 CG 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 0.4 1.5 1.9 1.9 1.6 1.9 1.1 CU 2.1 2.1 1.6 1.6 1.6 2.1 2.1 1.6 1.6 1.6 2.1 2.1 2.1 2.1 2.1 1.7 1.7 1.6 0.5 1.6 2.1 2.1 1.8 2.1 1.2 GM 1.0 1.0 0.6 0.0 0.6 1.0 1.0 0.6 0.0 0.6 1.0 1.0 1.6 1.0 1.6 0.1 0.1 0.6 0.8 0.6 1.0 1.0 1.3 1.0 0.2 GA 1.0 1.0 0.6 0.0 0.6 1.0 1.0 0.6 0.0 0.6 1.0 1.0 1.6 1.0 1.6 0.1 0.1 0.6 0.8 0.6 1.0 1.0 1.3 1.0 0.2 GC 2.4 2.4 1.9 1.3 1.9 2.4 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 2.4 1.4 1.4 1.9 0.8 1.9 2.4 2.4 2.1 2.4 1.5 GG 0.5 0.5 0.0 0.7 0.0 0.5 0.5 0.0 0.7 0.0 0.5 0.5 0.5 0.5 0.5 0.8 0.8 0.0 1.5 0.0 0.5 0.5 0.2 0.5 0.9 GU 2.4 2.4 1.9 1.3 1.9 2.4 2.4 1.9 1.3 1.9 2.4 2.4 2.4 2.4 2.4 1.4 1.4 1.9 0.8 1.9 2.4 2.4 2.1 2.4 1.5 UM 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 0.4 1.5 1.9 1.9 1.6 1.9 1.1 UA 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 0.4 1.5 1.9 1.9 1.6 1.9 1.1 UC 2.1 2.1 1.6 1.6 1.6 2.1 2.1 1.6 1.6 1.6 2.1 2.1 2.1 2.1 2.1 1.7 1.7 1.6 0.5 1.6 2.1 2.1 1.8 2.1 1.2 UG 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 0.4 1.5 1.9 1.9 1.6 1.9 1.1 UU 1.8 1.8 0.7 0.1 0.7 1.8 1.8 0.7 0.1 0.7 1.2 1.2 1.2 1.2 1.2 0.2 0.2 0.7 0.9 0.7 1.2 1.2 0.9 1.2 0.3 # 5' ------> 3' C X1 Y1 C G X2 Y2 G # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 1.3 1.3 1.1 -0.3 1.1 1.3 1.3 1.1 -0.3 1.1 1.0 1.0 1.1 1.0 1.1 0.4 0.4 1.1 -0.3 1.1 1.0 1.0 1.1 1.0 1.5 MA 1.3 1.3 1.1 -0.3 1.1 1.3 1.3 1.1 -0.3 1.1 1.0 1.0 1.1 1.0 1.1 0.4 0.4 1.1 -0.3 1.1 1.0 1.0 1.1 1.0 1.5 MC 0.6 0.6 1.5 0.1 1.5 0.6 0.6 1.5 0.1 1.5 0.5 0.5 1.5 1.4 1.5 0.3 0.3 1.5 -0.3 1.5 1.4 1.4 1.5 1.4 0.0 MG 0.0 0.0 -0.7 -1.6 0.1 0.0 0.0 -0.7 -1.6 0.1 -1.0 -1.0 -0.6 0.1 0.7 -0.7 -0.7 0.1 0.0 0.1 0.1 0.1 0.8 0.1 0.9 MU 1.7 1.7 1.5 -0.3 1.5 1.7 1.7 1.5 -0.3 1.5 1.4 1.4 1.5 1.4 1.5 0.3 0.3 1.5 0.1 1.5 1.4 1.4 1.5 1.4 0.7 AM 1.3 1.3 1.1 -0.3 1.1 1.3 1.3 1.1 -0.3 1.1 1.0 1.0 1.1 1.0 1.1 0.4 0.4 1.1 -0.3 1.1 1.0 1.0 1.1 1.0 1.5 AA 1.3 1.3 1.1 -0.3 1.1 1.3 1.3 1.1 -0.3 1.1 1.0 1.0 1.1 1.0 1.1 0.4 0.4 1.1 -0.3 1.1 1.0 1.0 1.1 1.0 1.5 AC 0.6 0.6 1.5 0.1 1.5 0.6 0.6 1.5 0.1 1.5 0.5 0.5 1.5 1.4 1.5 0.3 0.3 1.5 -0.3 1.5 1.4 1.4 1.5 1.4 0.0 AG 0.0 0.0 -0.7 -1.6 0.1 0.0 0.0 -0.7 -1.6 0.1 -1.0 -1.0 -0.6 0.1 0.7 -0.7 -0.7 0.1 0.0 0.1 0.1 0.1 0.8 0.1 0.9 AU 1.7 1.7 1.5 -0.3 1.5 1.7 1.7 1.5 -0.3 1.5 1.4 1.4 1.5 1.4 1.5 0.3 0.3 1.5 0.1 1.5 1.4 1.4 1.5 1.4 0.7 CM 1.3 1.3 1.0 -0.7 1.0 1.3 1.3 1.0 -0.7 1.0 1.1 1.1 1.0 1.0 1.0 0.7 0.7 1.0 -0.4 1.0 1.0 1.0 1.1 1.0 -0.2 CA 1.3 1.3 1.0 -0.7 1.0 1.3 1.3 1.0 -0.7 1.0 1.1 1.1 1.0 1.0 1.0 0.7 0.7 1.0 -0.4 1.0 1.0 1.0 1.1 1.0 -0.2 CC 2.2 2.2 1.3 0.7 1.3 2.2 2.2 1.3 0.7 1.3 1.9 1.9 1.3 1.3 1.3 0.7 0.7 1.3 -0.1 1.3 1.3 1.3 1.4 1.3 -0.1 CG 1.3 1.3 1.0 -0.7 1.0 1.3 1.3 1.0 -0.7 1.0 1.0 1.0 1.0 1.0 1.0 -0.1 -0.1 1.0 -0.4 1.0 1.0 1.0 1.1 1.0 0.3 CU 1.4 1.4 1.2 0.0 1.2 1.4 1.4 1.2 0.0 1.2 1.1 1.1 1.2 1.1 1.7 0.6 0.6 1.2 0.2 1.2 1.1 1.1 1.2 1.1 0.2 GM -0.2 -0.2 -0.4 -1.7 0.1 -0.2 -0.2 -0.4 -1.7 0.1 0.7 0.7 0.7 0.1 0.7 -0.5 -0.5 0.1 -0.3 0.1 0.1 0.1 0.8 0.1 0.9 GA -0.2 -0.2 -0.4 -1.7 0.1 -0.2 -0.2 -0.4 -1.7 0.1 0.7 0.7 0.7 0.1 0.7 -0.5 -0.5 0.1 -0.3 0.1 0.1 0.1 0.8 0.1 0.9 GC 1.7 1.7 1.5 -0.3 1.5 1.7 1.7 1.5 -0.3 1.5 1.4 1.4 1.5 1.4 1.5 0.3 0.3 1.5 0.1 1.5 1.4 1.4 1.5 1.4 0.7 GG -0.1 -0.1 -0.4 -0.9 -0.4 -0.1 -0.1 -0.4 -0.9 -0.4 -0.5 -0.5 -0.4 -0.5 0.2 -0.3 -0.3 -0.4 0.8 -0.4 -0.5 -0.5 -0.5 -0.5 1.4 GU 1.7 1.7 1.5 -0.3 1.5 1.7 1.7 1.5 -0.3 1.5 1.4 1.4 1.5 1.4 1.5 0.3 0.3 1.5 0.1 1.5 1.4 1.4 1.5 1.4 0.7 UM 1.3 1.3 1.0 -0.7 1.0 1.3 1.3 1.0 -0.7 1.0 1.0 1.0 1.0 1.0 1.0 -0.1 -0.1 1.0 -0.4 1.0 1.0 1.0 1.1 1.0 0.3 UA 1.3 1.3 1.0 -0.7 1.0 1.3 1.3 1.0 -0.7 1.0 1.0 1.0 1.0 1.0 1.0 -0.1 -0.1 1.0 -0.4 1.0 1.0 1.0 1.1 1.0 0.3 UC 1.4 1.4 1.2 0.0 1.2 1.4 1.4 1.2 0.0 1.2 1.1 1.1 1.2 1.1 1.2 0.5 0.5 1.2 -0.6 1.2 1.1 1.1 1.2 1.1 0.4 UG 1.3 1.3 1.0 -0.7 1.0 1.3 1.3 1.0 -0.7 1.0 1.0 1.0 1.0 1.0 1.0 -0.1 -0.1 1.0 -0.4 1.0 1.0 1.0 1.1 1.0 0.3 UU 1.4 1.4 0.3 0.5 0.3 1.4 1.4 0.3 0.5 0.3 0.3 0.3 0.3 0.2 0.3 1.4 1.4 0.3 0.7 0.3 0.2 0.2 0.3 0.2 -0.6 # 5' ------> 3' C X1 Y1 G G X2 Y2 C # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 1.2 1.2 1.1 0.2 1.1 1.2 1.2 1.1 0.2 1.1 1.6 1.6 1.4 1.6 1.3 0.2 0.2 1.1 -0.3 1.1 1.6 1.6 1.3 1.6 1.0 MA 1.2 1.2 1.1 0.2 1.1 1.2 1.2 1.1 0.2 1.1 1.6 1.6 1.4 1.6 1.3 0.2 0.2 1.1 -0.3 1.1 1.6 1.6 1.3 1.6 1.0 MC 1.6 1.6 1.5 0.6 1.5 1.6 1.6 1.5 0.6 1.5 2.0 2.0 1.8 2.0 1.7 0.6 0.6 1.5 0.1 1.5 2.0 2.0 1.7 2.0 0.8 MG 0.2 0.2 0.2 -0.7 0.2 0.2 0.2 0.2 -0.7 0.2 0.6 0.6 1.1 0.6 0.9 -0.7 -0.7 0.2 0.0 0.2 0.6 0.6 0.9 0.6 -0.5 MU 1.6 1.6 1.5 0.6 1.5 1.6 1.6 1.5 0.6 1.5 2.0 2.0 1.8 2.0 1.7 0.6 0.6 1.5 0.1 1.5 2.0 2.0 1.7 2.0 0.8 AM 1.2 1.2 1.1 0.2 1.1 1.2 1.2 1.1 0.2 1.1 1.6 1.6 1.4 1.6 1.3 0.2 0.2 1.1 -0.3 1.1 1.6 1.6 1.3 1.6 1.0 AA 1.2 1.2 1.1 0.2 1.1 1.2 1.2 1.1 0.2 1.1 1.6 1.6 1.4 1.6 1.3 0.2 0.2 1.1 -0.3 1.1 1.6 1.6 1.3 1.6 1.0 AC 1.6 1.6 1.5 0.6 1.5 1.6 1.6 1.5 0.6 1.5 2.0 2.0 1.8 2.0 1.7 0.6 0.6 1.5 0.1 1.5 2.0 2.0 1.7 2.0 0.8 AG 0.2 0.2 0.2 -0.7 0.2 0.2 0.2 0.2 -0.7 0.2 0.6 0.6 1.1 0.6 0.9 -0.7 -0.7 0.2 0.0 0.2 0.6 0.6 0.9 0.6 -0.5 AU 1.6 1.6 1.5 0.6 1.5 1.6 1.6 1.5 0.6 1.5 2.0 2.0 1.8 2.0 1.7 0.6 0.6 1.5 0.1 1.5 2.0 2.0 1.7 2.0 0.8 CM 1.1 1.1 1.1 0.2 1.1 1.1 1.1 1.1 0.2 1.1 1.5 1.5 1.4 1.5 1.2 0.2 0.2 1.1 -0.4 1.1 1.5 1.5 1.2 1.5 0.3 CA 1.1 1.1 1.1 0.2 1.1 1.1 1.1 1.1 0.2 1.1 1.5 1.5 1.4 1.5 1.2 0.2 0.2 1.1 -0.4 1.1 1.5 1.5 1.2 1.5 0.3 CC 1.4 1.4 1.4 1.1 1.4 1.4 1.4 1.4 1.1 1.4 1.8 1.8 1.7 1.8 1.5 1.1 1.1 1.4 -0.1 1.4 1.8 1.8 1.5 1.8 0.6 CG 1.1 1.1 1.1 0.2 1.1 1.1 1.1 1.1 0.2 1.1 1.5 1.5 1.4 1.5 1.2 0.2 0.2 1.1 -0.4 1.1 1.5 1.5 1.2 1.5 0.3 CU 1.3 1.3 1.2 0.9 1.2 1.3 1.3 1.2 0.9 1.2 1.7 1.7 1.5 1.7 1.4 0.9 0.9 1.2 -0.2 1.2 1.7 1.7 1.4 1.7 0.5 GM 0.2 0.2 0.2 -0.7 0.2 0.2 0.2 0.2 -0.7 0.2 0.6 0.6 1.1 0.6 0.9 -0.7 -0.7 0.2 0.0 0.2 0.6 0.6 0.9 0.6 -0.5 GA 0.2 0.2 0.2 -0.7 0.2 0.2 0.2 0.2 -0.7 0.2 0.6 0.6 1.1 0.6 0.9 -0.7 -0.7 0.2 0.0 0.2 0.6 0.6 0.9 0.6 -0.5 GC 1.6 1.6 1.5 0.6 1.5 1.6 1.6 1.5 0.6 1.5 2.0 2.0 1.8 2.0 1.7 0.6 0.6 1.5 0.1 1.5 2.0 2.0 1.7 2.0 0.8 GG -0.3 -0.3 -0.4 0.0 -0.4 -0.3 -0.3 -0.4 0.0 -0.4 0.1 0.1 -0.1 0.1 -0.2 0.0 0.0 -0.4 0.8 -0.4 0.1 0.1 -0.2 0.1 0.2 GU 1.6 1.6 1.5 0.6 1.5 1.6 1.6 1.5 0.6 1.5 2.0 2.0 1.8 2.0 1.7 0.6 0.6 1.5 0.1 1.5 2.0 2.0 1.7 2.0 0.8 UM 1.1 1.1 1.1 0.2 1.1 1.1 1.1 1.1 0.2 1.1 1.5 1.5 1.4 1.5 1.2 0.2 0.2 1.1 -0.4 1.1 1.5 1.5 1.2 1.5 0.3 UA 1.1 1.1 1.1 0.2 1.1 1.1 1.1 1.1 0.2 1.1 1.5 1.5 1.4 1.5 1.2 0.2 0.2 1.1 -0.4 1.1 1.5 1.5 1.2 1.5 0.3 UC 1.3 1.3 1.2 0.9 1.2 1.3 1.3 1.2 0.9 1.2 1.7 1.7 1.5 1.7 1.4 0.9 0.9 1.2 -0.2 1.2 1.7 1.7 1.4 1.7 0.5 UG 1.1 1.1 1.1 0.2 1.1 1.1 1.1 1.1 0.2 1.1 1.5 1.5 1.4 1.5 1.2 0.2 0.2 1.1 -0.4 1.1 1.5 1.5 1.2 1.5 0.3 UU 1.0 1.0 0.3 -0.5 0.3 1.0 1.0 0.3 -0.5 0.3 0.8 0.8 0.6 0.8 0.5 -0.5 -0.5 0.3 0.2 0.3 0.8 0.8 0.5 0.8 -0.4 # 5' ------> 3' C X1 Y1 U G X2 Y2 A # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.0 2.0 1.7 0.7 1.7 2.0 2.0 1.7 0.7 1.7 1.8 1.8 1.8 1.8 1.8 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.8 1.8 1.5 MA 2.0 2.0 1.7 0.7 1.7 2.0 2.0 1.7 0.7 1.7 1.8 1.8 1.8 1.8 1.8 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.8 1.8 1.5 MC 2.4 2.4 2.1 1.1 2.1 2.4 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 2.2 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.2 2.2 1.3 MG 1.0 1.0 0.8 -0.2 0.8 1.0 1.0 0.8 -0.2 0.8 0.9 0.9 1.4 0.9 1.4 0.5 0.5 0.8 0.6 0.8 0.9 0.9 1.4 0.9 0.0 MU 2.4 2.4 2.1 1.1 2.1 2.4 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 2.2 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.2 2.2 1.3 AM 2.0 2.0 1.7 0.7 1.7 2.0 2.0 1.7 0.7 1.7 1.8 1.8 1.8 1.8 1.8 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.8 1.8 1.5 AA 2.0 2.0 1.7 0.7 1.7 2.0 2.0 1.7 0.7 1.7 1.8 1.8 1.8 1.8 1.8 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.8 1.8 1.5 AC 2.4 2.4 2.1 1.1 2.1 2.4 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 2.2 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.2 2.2 1.3 AG 1.0 1.0 0.8 -0.2 0.8 1.0 1.0 0.8 -0.2 0.8 0.9 0.9 1.4 0.9 1.4 0.5 0.5 0.8 0.6 0.8 0.9 0.9 1.4 0.9 0.0 AU 2.4 2.4 2.1 1.1 2.1 2.4 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 2.2 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.2 2.2 1.3 CM 1.9 1.9 1.7 0.7 1.7 1.9 1.9 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.7 1.8 0.8 CA 1.9 1.9 1.7 0.7 1.7 1.9 1.9 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.7 1.8 0.8 CC 2.2 2.2 2.0 1.6 2.0 2.2 2.2 2.0 1.6 2.0 2.1 2.1 2.0 2.1 2.0 2.3 2.3 2.0 0.5 2.0 2.1 2.1 2.0 2.1 1.1 CG 1.9 1.9 1.7 0.7 1.7 1.9 1.9 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.7 1.8 0.8 CU 2.1 2.1 1.8 1.4 1.8 2.1 2.1 1.8 1.4 1.8 1.9 1.9 1.9 1.9 1.9 2.1 2.1 1.8 0.3 1.8 1.9 1.9 1.9 1.9 1.0 GM 1.0 1.0 0.8 -0.2 0.8 1.0 1.0 0.8 -0.2 0.8 0.9 0.9 1.4 0.9 1.4 0.5 0.5 0.8 0.6 0.8 0.9 0.9 1.4 0.9 0.0 GA 1.0 1.0 0.8 -0.2 0.8 1.0 1.0 0.8 -0.2 0.8 0.9 0.9 1.4 0.9 1.4 0.5 0.5 0.8 0.6 0.8 0.9 0.9 1.4 0.9 0.0 GC 2.4 2.4 2.1 1.1 2.1 2.4 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 2.2 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.2 2.2 1.3 GG 0.5 0.5 0.2 0.5 0.2 0.5 0.5 0.2 0.5 0.2 0.3 0.3 0.3 0.3 0.3 1.2 1.2 0.2 1.3 0.2 0.3 0.3 0.3 0.3 0.7 GU 2.4 2.4 2.1 1.1 2.1 2.4 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 2.2 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.2 2.2 1.3 UM 1.9 1.9 1.7 0.7 1.7 1.9 1.9 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.7 1.8 0.8 UA 1.9 1.9 1.7 0.7 1.7 1.9 1.9 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.7 1.8 0.8 UC 2.1 2.1 1.8 1.4 1.8 2.1 2.1 1.8 1.4 1.8 1.9 1.9 1.9 1.9 1.9 2.1 2.1 1.8 0.3 1.8 1.9 1.9 1.9 1.9 1.0 UG 1.9 1.9 1.7 0.7 1.7 1.9 1.9 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.7 1.8 0.8 UU 1.8 1.8 0.9 0.0 0.9 1.8 1.8 0.9 0.0 0.9 1.0 1.0 1.0 1.0 1.0 0.6 0.6 0.9 0.7 0.9 1.0 1.0 1.0 1.0 0.1 # 5' ------> 3' C X1 Y1 U G X2 Y2 M # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.0 2.0 1.7 0.7 1.7 2.0 2.0 1.7 0.7 1.7 1.8 1.8 1.8 1.8 1.8 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.8 1.8 1.5 MA 2.0 2.0 1.7 0.7 1.7 2.0 2.0 1.7 0.7 1.7 1.8 1.8 1.8 1.8 1.8 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.8 1.8 1.5 MC 2.4 2.4 2.1 1.1 2.1 2.4 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 2.2 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.2 2.2 1.3 MG 1.0 1.0 0.8 -0.2 0.8 1.0 1.0 0.8 -0.2 0.8 0.9 0.9 1.4 0.9 1.4 0.5 0.5 0.8 0.6 0.8 0.9 0.9 1.4 0.9 0.0 MU 2.4 2.4 2.1 1.1 2.1 2.4 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 2.2 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.2 2.2 1.3 AM 2.0 2.0 1.7 0.7 1.7 2.0 2.0 1.7 0.7 1.7 1.8 1.8 1.8 1.8 1.8 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.8 1.8 1.5 AA 2.0 2.0 1.7 0.7 1.7 2.0 2.0 1.7 0.7 1.7 1.8 1.8 1.8 1.8 1.8 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.8 1.8 1.5 AC 2.4 2.4 2.1 1.1 2.1 2.4 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 2.2 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.2 2.2 1.3 AG 1.0 1.0 0.8 -0.2 0.8 1.0 1.0 0.8 -0.2 0.8 0.9 0.9 1.4 0.9 1.4 0.5 0.5 0.8 0.6 0.8 0.9 0.9 1.4 0.9 0.0 AU 2.4 2.4 2.1 1.1 2.1 2.4 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 2.2 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.2 2.2 1.3 CM 1.9 1.9 1.7 0.7 1.7 1.9 1.9 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.7 1.8 0.8 CA 1.9 1.9 1.7 0.7 1.7 1.9 1.9 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.7 1.8 0.8 CC 2.2 2.2 2.0 1.6 2.0 2.2 2.2 2.0 1.6 2.0 2.1 2.1 2.0 2.1 2.0 2.3 2.3 2.0 0.5 2.0 2.1 2.1 2.0 2.1 1.1 CG 1.9 1.9 1.7 0.7 1.7 1.9 1.9 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.7 1.8 0.8 CU 2.1 2.1 1.8 1.4 1.8 2.1 2.1 1.8 1.4 1.8 1.9 1.9 1.9 1.9 1.9 2.1 2.1 1.8 0.3 1.8 1.9 1.9 1.9 1.9 1.0 GM 1.0 1.0 0.8 -0.2 0.8 1.0 1.0 0.8 -0.2 0.8 0.9 0.9 1.4 0.9 1.4 0.5 0.5 0.8 0.6 0.8 0.9 0.9 1.4 0.9 0.0 GA 1.0 1.0 0.8 -0.2 0.8 1.0 1.0 0.8 -0.2 0.8 0.9 0.9 1.4 0.9 1.4 0.5 0.5 0.8 0.6 0.8 0.9 0.9 1.4 0.9 0.0 GC 2.4 2.4 2.1 1.1 2.1 2.4 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 2.2 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.2 2.2 1.3 GG 0.5 0.5 0.2 0.5 0.2 0.5 0.5 0.2 0.5 0.2 0.3 0.3 0.3 0.3 0.3 1.2 1.2 0.2 1.3 0.2 0.3 0.3 0.3 0.3 0.7 GU 2.4 2.4 2.1 1.1 2.1 2.4 2.4 2.1 1.1 2.1 2.2 2.2 2.2 2.2 2.2 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.2 2.2 1.3 UM 1.9 1.9 1.7 0.7 1.7 1.9 1.9 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.7 1.8 0.8 UA 1.9 1.9 1.7 0.7 1.7 1.9 1.9 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.7 1.8 0.8 UC 2.1 2.1 1.8 1.4 1.8 2.1 2.1 1.8 1.4 1.8 1.9 1.9 1.9 1.9 1.9 2.1 2.1 1.8 0.3 1.8 1.9 1.9 1.9 1.9 1.0 UG 1.9 1.9 1.7 0.7 1.7 1.9 1.9 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.7 1.8 0.8 UU 1.8 1.8 0.9 0.0 0.9 1.8 1.8 0.9 0.0 0.9 1.0 1.0 1.0 1.0 1.0 0.6 0.6 0.9 0.7 0.9 1.0 1.0 1.0 1.0 0.1 # 5' ------> 3' C X1 Y1 G G X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 1.1 1.1 1.5 0.1 1.5 1.1 1.1 1.5 0.1 1.5 1.5 1.5 1.5 1.5 1.5 1.8 1.8 1.5 0.2 1.5 1.5 1.5 1.5 1.5 2.1 MA 1.1 1.1 1.5 0.1 1.5 1.1 1.1 1.5 0.1 1.5 1.5 1.5 1.5 1.5 1.5 1.8 1.8 1.5 0.2 1.5 1.5 1.5 1.5 1.5 2.1 MC 1.5 1.5 1.9 0.5 1.9 1.5 1.5 1.9 0.5 1.9 1.9 1.9 1.9 1.9 1.9 2.2 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 1.9 MG 0.2 0.2 0.5 -0.8 0.5 0.2 0.2 0.5 -0.8 0.5 0.5 0.5 1.1 0.5 1.1 0.8 0.8 0.5 0.5 0.5 0.5 0.5 1.1 0.5 0.5 MU 1.5 1.5 1.9 0.5 1.9 1.5 1.5 1.9 0.5 1.9 1.9 1.9 1.9 1.9 1.9 2.2 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 1.9 AM 1.1 1.1 1.5 0.1 1.5 1.1 1.1 1.5 0.1 1.5 1.5 1.5 1.5 1.5 1.5 1.8 1.8 1.5 0.2 1.5 1.5 1.5 1.5 1.5 2.1 AA 1.1 1.1 1.5 0.1 1.5 1.1 1.1 1.5 0.1 1.5 1.5 1.5 1.5 1.5 1.5 1.8 1.8 1.5 0.2 1.5 1.5 1.5 1.5 1.5 2.1 AC 1.5 1.5 1.9 0.5 1.9 1.5 1.5 1.9 0.5 1.9 1.9 1.9 1.9 1.9 1.9 2.2 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 1.9 AG 0.2 0.2 0.5 -0.8 0.5 0.2 0.2 0.5 -0.8 0.5 0.5 0.5 1.1 0.5 1.1 0.8 0.8 0.5 0.5 0.5 0.5 0.5 1.1 0.5 0.5 AU 1.5 1.5 1.9 0.5 1.9 1.5 1.5 1.9 0.5 1.9 1.9 1.9 1.9 1.9 1.9 2.2 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 1.9 CM 1.1 1.1 1.4 0.1 1.4 1.1 1.1 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 CA 1.1 1.1 1.4 0.1 1.4 1.1 1.1 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 CC 1.4 1.4 1.7 1.0 1.7 1.4 1.4 1.7 1.0 1.7 1.7 1.7 1.7 1.7 1.7 2.6 2.6 1.7 0.4 1.7 1.7 1.7 1.7 1.7 1.7 CG 1.1 1.1 1.4 0.1 1.4 1.1 1.1 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 CU 1.2 1.2 1.6 0.8 1.6 1.2 1.2 1.6 0.8 1.6 1.6 1.6 1.6 1.6 1.6 2.5 2.5 1.6 0.3 1.6 1.6 1.6 1.6 1.6 1.6 GM 0.2 0.2 0.5 -0.8 0.5 0.2 0.2 0.5 -0.8 0.5 0.5 0.5 1.1 0.5 1.1 0.8 0.8 0.5 0.5 0.5 0.5 0.5 1.1 0.5 0.5 GA 0.2 0.2 0.5 -0.8 0.5 0.2 0.2 0.5 -0.8 0.5 0.5 0.5 1.1 0.5 1.1 0.8 0.8 0.5 0.5 0.5 0.5 0.5 1.1 0.5 0.5 GC 1.5 1.5 1.9 0.5 1.9 1.5 1.5 1.9 0.5 1.9 1.9 1.9 1.9 1.9 1.9 2.2 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 1.9 GG -0.4 -0.4 0.0 -0.1 0.0 -0.4 -0.4 0.0 -0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.6 1.6 0.0 1.3 0.0 0.0 0.0 0.0 0.0 1.3 GU 1.5 1.5 1.9 0.5 1.9 1.5 1.5 1.9 0.5 1.9 1.9 1.9 1.9 1.9 1.9 2.2 2.2 1.9 0.6 1.9 1.9 1.9 1.9 1.9 1.9 UM 1.1 1.1 1.4 0.1 1.4 1.1 1.1 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 UA 1.1 1.1 1.4 0.1 1.4 1.1 1.1 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 UC 1.2 1.2 1.6 0.8 1.6 1.2 1.2 1.6 0.8 1.6 1.6 1.6 1.6 1.6 1.6 2.5 2.5 1.6 0.3 1.6 1.6 1.6 1.6 1.6 1.6 UG 1.1 1.1 1.4 0.1 1.4 1.1 1.1 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 UU 0.9 0.9 0.7 -0.6 0.7 0.9 0.9 0.7 -0.6 0.7 0.7 0.7 0.7 0.7 0.7 1.0 1.0 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 # 5' ------> 3' C X1 Y1 U G X2 Y2 G # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.2 2.2 1.8 1.0 1.8 2.2 2.2 1.8 1.0 1.8 1.8 1.8 1.8 1.8 1.8 1.4 1.4 1.8 0.5 1.8 1.8 1.8 1.8 1.8 2.4 MA 2.2 2.2 1.8 1.0 1.8 2.2 2.2 1.8 1.0 1.8 1.8 1.8 1.8 1.8 1.8 1.4 1.4 1.8 0.5 1.8 1.8 1.8 1.8 1.8 2.4 MC 2.5 2.5 2.2 1.4 2.2 2.5 2.5 2.2 1.4 2.2 2.2 2.2 2.2 2.2 2.2 1.8 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2 2.2 MG 1.2 1.2 0.8 0.0 0.8 1.2 1.2 0.8 0.0 0.8 0.8 0.8 1.4 0.8 1.4 0.4 0.4 0.8 0.8 0.8 0.8 0.8 1.4 0.8 0.8 MU 2.5 2.5 2.2 1.4 2.2 2.5 2.5 2.2 1.4 2.2 2.2 2.2 2.2 2.2 2.2 1.8 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2 2.2 AM 2.2 2.2 1.8 1.0 1.8 2.2 2.2 1.8 1.0 1.8 1.8 1.8 1.8 1.8 1.8 1.4 1.4 1.8 0.5 1.8 1.8 1.8 1.8 1.8 2.4 AA 2.2 2.2 1.8 1.0 1.8 2.2 2.2 1.8 1.0 1.8 1.8 1.8 1.8 1.8 1.8 1.4 1.4 1.8 0.5 1.8 1.8 1.8 1.8 1.8 2.4 AC 2.5 2.5 2.2 1.4 2.2 2.5 2.5 2.2 1.4 2.2 2.2 2.2 2.2 2.2 2.2 1.8 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2 2.2 AG 1.2 1.2 0.8 0.0 0.8 1.2 1.2 0.8 0.0 0.8 0.8 0.8 1.4 0.8 1.4 0.4 0.4 0.8 0.8 0.8 0.8 0.8 1.4 0.8 0.8 AU 2.5 2.5 2.2 1.4 2.2 2.5 2.5 2.2 1.4 2.2 2.2 2.2 2.2 2.2 2.2 1.8 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2 2.2 CM 2.1 2.1 1.7 0.9 1.7 2.1 2.1 1.7 0.9 1.7 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.7 0.4 1.7 1.7 1.7 1.7 1.7 1.7 CA 2.1 2.1 1.7 0.9 1.7 2.1 2.1 1.7 0.9 1.7 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.7 0.4 1.7 1.7 1.7 1.7 1.7 1.7 CC 2.4 2.4 2.0 1.8 2.0 2.4 2.4 2.0 1.8 2.0 2.0 2.0 2.0 2.0 2.0 2.2 2.2 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 CG 2.1 2.1 1.7 0.9 1.7 2.1 2.1 1.7 0.9 1.7 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.7 0.4 1.7 1.7 1.7 1.7 1.7 1.7 CU 2.2 2.2 1.9 1.7 1.9 2.2 2.2 1.9 1.7 1.9 1.9 1.9 1.9 1.9 1.9 2.1 2.1 1.9 0.6 1.9 1.9 1.9 1.9 1.9 1.9 GM 1.2 1.2 0.8 0.0 0.8 1.2 1.2 0.8 0.0 0.8 0.8 0.8 1.4 0.8 1.4 0.4 0.4 0.8 0.8 0.8 0.8 0.8 1.4 0.8 0.8 GA 1.2 1.2 0.8 0.0 0.8 1.2 1.2 0.8 0.0 0.8 0.8 0.8 1.4 0.8 1.4 0.4 0.4 0.8 0.8 0.8 0.8 0.8 1.4 0.8 0.8 GC 2.5 2.5 2.2 1.4 2.2 2.5 2.5 2.2 1.4 2.2 2.2 2.2 2.2 2.2 2.2 1.8 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2 2.2 GG 0.6 0.6 0.3 0.8 0.3 0.6 0.6 0.3 0.8 0.3 0.3 0.3 0.3 0.3 0.3 1.2 1.2 0.3 1.6 0.3 0.3 0.3 0.3 0.3 1.6 GU 2.5 2.5 2.2 1.4 2.2 2.5 2.5 2.2 1.4 2.2 2.2 2.2 2.2 2.2 2.2 1.8 1.8 2.2 0.9 2.2 2.2 2.2 2.2 2.2 2.2 UM 2.1 2.1 1.7 0.9 1.7 2.1 2.1 1.7 0.9 1.7 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.7 0.4 1.7 1.7 1.7 1.7 1.7 1.7 UA 2.1 2.1 1.7 0.9 1.7 2.1 2.1 1.7 0.9 1.7 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.7 0.4 1.7 1.7 1.7 1.7 1.7 1.7 UC 2.2 2.2 1.9 1.7 1.9 2.2 2.2 1.9 1.7 1.9 1.9 1.9 1.9 1.9 1.9 2.1 2.1 1.9 0.6 1.9 1.9 1.9 1.9 1.9 1.9 UG 2.1 2.1 1.7 0.9 1.7 2.1 2.1 1.7 0.9 1.7 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.7 0.4 1.7 1.7 1.7 1.7 1.7 1.7 UU 1.9 1.9 1.0 0.2 1.0 1.9 1.9 1.0 0.2 1.0 1.0 1.0 1.0 1.0 1.0 0.6 0.6 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 # 5' ------> 3' G X1 Y1 A C X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.1 2.1 1.7 1.1 1.7 2.1 2.1 1.7 1.1 1.7 2.1 2.1 2.1 2.1 2.1 1.2 1.2 1.7 0.6 1.7 2.1 2.1 1.8 2.1 1.9 MA 2.1 2.1 1.7 1.1 1.7 2.1 2.1 1.7 1.1 1.7 2.1 2.1 2.1 2.1 2.1 1.2 1.2 1.7 0.6 1.7 2.1 2.1 1.8 2.1 1.9 MC 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 1.8 0.9 0.9 1.4 0.3 1.4 1.8 1.8 1.5 1.8 1.0 MG 0.7 0.7 0.3 -0.3 0.3 0.7 0.7 0.3 -0.3 0.3 0.7 0.7 1.3 0.7 1.3 -0.2 -0.2 0.3 0.5 0.3 0.7 0.7 1.0 0.7 -0.1 MU 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 1.8 0.9 0.9 1.4 0.3 1.4 1.8 1.8 1.5 1.8 1.0 AM 2.1 2.1 1.7 1.1 1.7 2.1 2.1 1.7 1.1 1.7 2.1 2.1 2.1 2.1 2.1 1.2 1.2 1.7 0.6 1.7 2.1 2.1 1.8 2.1 1.9 AA 2.1 2.1 1.7 1.1 1.7 2.1 2.1 1.7 1.1 1.7 2.1 2.1 2.1 2.1 2.1 1.2 1.2 1.7 0.6 1.7 2.1 2.1 1.8 2.1 1.9 AC 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 1.8 0.9 0.9 1.4 0.3 1.4 1.8 1.8 1.5 1.8 1.0 AG 0.7 0.7 0.3 -0.3 0.3 0.7 0.7 0.3 -0.3 0.3 0.7 0.7 1.3 0.7 1.3 -0.2 -0.2 0.3 0.5 0.3 0.7 0.7 1.0 0.7 -0.1 AU 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 1.8 0.9 0.9 1.4 0.3 1.4 1.8 1.8 1.5 1.8 1.0 CM 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 1.9 0.9 0.9 1.4 0.3 1.4 1.9 1.9 1.6 1.9 1.0 CA 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 1.9 0.9 0.9 1.4 0.3 1.4 1.9 1.9 1.6 1.9 1.0 CC 1.9 1.9 1.4 1.4 1.4 1.9 1.9 1.4 1.4 1.4 1.9 1.9 1.9 1.9 1.9 1.5 1.5 1.4 0.3 1.4 1.9 1.9 1.6 1.9 1.0 CG 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 1.9 0.9 0.9 1.4 0.3 1.4 1.9 1.9 1.6 1.9 1.0 CU 1.9 1.9 1.5 1.5 1.5 1.9 1.9 1.5 1.5 1.5 1.9 1.9 1.9 1.9 1.9 1.6 1.6 1.5 0.4 1.5 1.9 1.9 1.6 1.9 1.1 GM 0.1 0.1 -0.3 -0.9 -0.3 0.1 0.1 -0.3 -0.9 -0.3 0.1 0.1 0.7 0.1 0.7 -0.8 -0.8 -0.3 -0.1 -0.3 0.1 0.1 0.4 0.1 -0.7 GA 0.1 0.1 -0.3 -0.9 -0.3 0.1 0.1 -0.3 -0.9 -0.3 0.1 0.1 0.7 0.1 0.7 -0.8 -0.8 -0.3 -0.1 -0.3 0.1 0.1 0.4 0.1 -0.7 GC 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 1.8 0.9 0.9 1.4 0.3 1.4 1.8 1.8 1.5 1.8 1.0 GG 0.5 0.5 0.0 0.7 0.0 0.5 0.5 0.0 0.7 0.0 0.5 0.5 0.5 0.5 0.5 0.8 0.8 0.0 1.5 0.0 0.5 0.5 0.2 0.5 0.9 GU 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 1.8 0.9 0.9 1.4 0.3 1.4 1.8 1.8 1.5 1.8 1.0 UM 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 1.9 0.9 0.9 1.4 0.3 1.4 1.9 1.9 1.6 1.9 1.0 UA 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 1.9 0.9 0.9 1.4 0.3 1.4 1.9 1.9 1.6 1.9 1.0 UC 1.9 1.9 1.4 1.4 1.4 1.9 1.9 1.4 1.4 1.4 1.9 1.9 1.9 1.9 1.9 1.5 1.5 1.4 0.3 1.4 1.9 1.9 1.6 1.9 1.0 UG 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 1.9 0.9 0.9 1.4 0.3 1.4 1.9 1.9 1.6 1.9 1.0 UU 1.7 1.7 0.7 0.1 0.7 1.7 1.7 0.7 0.1 0.7 1.1 1.1 1.1 1.1 1.1 0.2 0.2 0.7 0.9 0.7 1.1 1.1 0.8 1.1 0.3 # 5' ------> 3' G X1 Y1 M C X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.1 2.1 1.7 1.1 1.7 2.1 2.1 1.7 1.1 1.7 2.1 2.1 2.1 2.1 2.1 1.2 1.2 1.7 0.6 1.7 2.1 2.1 1.8 2.1 1.9 MA 2.1 2.1 1.7 1.1 1.7 2.1 2.1 1.7 1.1 1.7 2.1 2.1 2.1 2.1 2.1 1.2 1.2 1.7 0.6 1.7 2.1 2.1 1.8 2.1 1.9 MC 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 1.8 0.9 0.9 1.4 0.3 1.4 1.8 1.8 1.5 1.8 1.0 MG 0.7 0.7 0.3 -0.3 0.3 0.7 0.7 0.3 -0.3 0.3 0.7 0.7 1.3 0.7 1.3 -0.2 -0.2 0.3 0.5 0.3 0.7 0.7 1.0 0.7 -0.1 MU 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 1.8 0.9 0.9 1.4 0.3 1.4 1.8 1.8 1.5 1.8 1.0 AM 2.1 2.1 1.7 1.1 1.7 2.1 2.1 1.7 1.1 1.7 2.1 2.1 2.1 2.1 2.1 1.2 1.2 1.7 0.6 1.7 2.1 2.1 1.8 2.1 1.9 AA 2.1 2.1 1.7 1.1 1.7 2.1 2.1 1.7 1.1 1.7 2.1 2.1 2.1 2.1 2.1 1.2 1.2 1.7 0.6 1.7 2.1 2.1 1.8 2.1 1.9 AC 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 1.8 0.9 0.9 1.4 0.3 1.4 1.8 1.8 1.5 1.8 1.0 AG 0.7 0.7 0.3 -0.3 0.3 0.7 0.7 0.3 -0.3 0.3 0.7 0.7 1.3 0.7 1.3 -0.2 -0.2 0.3 0.5 0.3 0.7 0.7 1.0 0.7 -0.1 AU 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 1.8 0.9 0.9 1.4 0.3 1.4 1.8 1.8 1.5 1.8 1.0 CM 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 1.9 0.9 0.9 1.4 0.3 1.4 1.9 1.9 1.6 1.9 1.0 CA 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 1.9 0.9 0.9 1.4 0.3 1.4 1.9 1.9 1.6 1.9 1.0 CC 1.9 1.9 1.4 1.4 1.4 1.9 1.9 1.4 1.4 1.4 1.9 1.9 1.9 1.9 1.9 1.5 1.5 1.4 0.3 1.4 1.9 1.9 1.6 1.9 1.0 CG 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 1.9 0.9 0.9 1.4 0.3 1.4 1.9 1.9 1.6 1.9 1.0 CU 1.9 1.9 1.5 1.5 1.5 1.9 1.9 1.5 1.5 1.5 1.9 1.9 1.9 1.9 1.9 1.6 1.6 1.5 0.4 1.5 1.9 1.9 1.6 1.9 1.1 GM 0.1 0.1 -0.3 -0.9 -0.3 0.1 0.1 -0.3 -0.9 -0.3 0.1 0.1 0.7 0.1 0.7 -0.8 -0.8 -0.3 -0.1 -0.3 0.1 0.1 0.4 0.1 -0.7 GA 0.1 0.1 -0.3 -0.9 -0.3 0.1 0.1 -0.3 -0.9 -0.3 0.1 0.1 0.7 0.1 0.7 -0.8 -0.8 -0.3 -0.1 -0.3 0.1 0.1 0.4 0.1 -0.7 GC 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 1.8 0.9 0.9 1.4 0.3 1.4 1.8 1.8 1.5 1.8 1.0 GG 0.5 0.5 0.0 0.7 0.0 0.5 0.5 0.0 0.7 0.0 0.5 0.5 0.5 0.5 0.5 0.8 0.8 0.0 1.5 0.0 0.5 0.5 0.2 0.5 0.9 GU 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.8 1.8 1.8 0.9 0.9 1.4 0.3 1.4 1.8 1.8 1.5 1.8 1.0 UM 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 1.9 0.9 0.9 1.4 0.3 1.4 1.9 1.9 1.6 1.9 1.0 UA 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 1.9 0.9 0.9 1.4 0.3 1.4 1.9 1.9 1.6 1.9 1.0 UC 1.9 1.9 1.4 1.4 1.4 1.9 1.9 1.4 1.4 1.4 1.9 1.9 1.9 1.9 1.9 1.5 1.5 1.4 0.3 1.4 1.9 1.9 1.6 1.9 1.0 UG 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.4 0.8 1.4 1.9 1.9 1.9 1.9 1.9 0.9 0.9 1.4 0.3 1.4 1.9 1.9 1.6 1.9 1.0 UU 1.7 1.7 0.7 0.1 0.7 1.7 1.7 0.7 0.1 0.7 1.1 1.1 1.1 1.1 1.1 0.2 0.2 0.7 0.9 0.7 1.1 1.1 0.8 1.1 0.3 # 5' ------> 3' G X1 Y1 C C X2 Y2 G # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 1.5 1.5 1.2 -0.5 1.2 1.5 1.5 1.2 -0.5 1.2 1.2 1.2 1.2 1.2 1.2 0.1 0.1 1.2 -0.2 1.2 1.2 1.2 1.3 1.2 1.1 MA 1.5 1.5 1.2 -0.5 1.2 1.5 1.5 1.2 -0.5 1.2 1.2 1.2 1.2 1.2 1.2 0.1 0.1 1.2 -0.2 1.2 1.2 1.2 1.3 1.2 1.1 MC 1.2 1.2 0.9 -0.8 0.9 1.2 1.2 0.9 -0.8 0.9 0.9 0.9 0.9 0.9 0.9 -0.2 -0.2 0.9 -0.5 0.9 0.9 0.9 1.0 0.9 0.2 MG 0.1 0.1 -0.1 -1.9 -0.1 0.1 0.1 -0.1 -1.9 -0.1 -0.2 -0.2 0.5 -0.2 0.5 -1.3 -1.3 -0.1 -0.2 -0.1 -0.2 -0.2 0.5 -0.2 -0.9 MU 1.2 1.2 0.9 -0.8 0.9 1.2 1.2 0.9 -0.8 0.9 0.9 0.9 0.9 0.9 0.9 -0.2 -0.2 0.9 -0.5 0.9 0.9 0.9 1.0 0.9 0.2 AM 1.5 1.5 1.2 -0.5 1.2 1.5 1.5 1.2 -0.5 1.2 1.2 1.2 1.2 1.2 1.2 0.1 0.1 1.2 -0.2 1.2 1.2 1.2 1.3 1.2 1.1 AA 1.5 1.5 1.2 -0.5 1.2 1.5 1.5 1.2 -0.5 1.2 1.2 1.2 1.2 1.2 1.2 0.1 0.1 1.2 -0.2 1.2 1.2 1.2 1.3 1.2 1.1 AC 1.2 1.2 0.9 -0.8 0.9 1.2 1.2 0.9 -0.8 0.9 0.9 0.9 0.9 0.9 0.9 -0.2 -0.2 0.9 -0.5 0.9 0.9 0.9 1.0 0.9 0.2 AG 0.1 0.1 -0.1 -1.9 -0.1 0.1 0.1 -0.1 -1.9 -0.1 -0.2 -0.2 0.5 -0.2 0.5 -1.3 -1.3 -0.1 -0.2 -0.1 -0.2 -0.2 0.5 -0.2 -0.9 AU 1.2 1.2 0.9 -0.8 0.9 1.2 1.2 0.9 -0.8 0.9 0.9 0.9 0.9 0.9 0.9 -0.2 -0.2 0.9 -0.5 0.9 0.9 0.9 1.0 0.9 0.2 CM 1.2 1.2 1.0 -0.8 1.0 1.2 1.2 1.0 -0.8 1.0 0.9 0.9 1.0 0.9 1.0 -0.1 -0.1 1.0 -0.4 1.0 0.9 0.9 1.0 0.9 0.2 CA 1.2 1.2 1.0 -0.8 1.0 1.2 1.2 1.0 -0.8 1.0 0.9 0.9 1.0 0.9 1.0 -0.1 -0.1 1.0 -0.4 1.0 0.9 0.9 1.0 0.9 0.2 CC 1.2 1.2 1.0 -0.2 1.0 1.2 1.2 1.0 -0.2 1.0 0.9 0.9 1.0 0.9 1.0 0.5 0.5 1.0 -0.4 1.0 0.9 0.9 1.0 0.9 0.2 CG 1.2 1.2 1.0 -0.8 1.0 1.2 1.2 1.0 -0.8 1.0 0.9 0.9 1.0 0.9 1.0 -0.1 -0.1 1.0 -0.4 1.0 0.9 0.9 1.0 0.9 0.2 CU 1.3 1.3 1.0 -0.1 1.0 1.3 1.3 1.0 -0.1 1.0 1.0 1.0 1.0 1.0 1.0 0.5 0.5 1.0 -0.4 1.0 1.0 1.0 1.1 1.0 0.3 GM -0.5 -0.5 -0.8 -2.6 -0.8 -0.5 -0.5 -0.8 -2.6 -0.8 -0.8 -0.8 -0.2 -0.8 -0.2 -1.9 -1.9 -0.8 -0.9 -0.8 -0.8 -0.8 -0.1 -0.8 -1.5 GA -0.5 -0.5 -0.8 -2.6 -0.8 -0.5 -0.5 -0.8 -2.6 -0.8 -0.8 -0.8 -0.2 -0.8 -0.2 -1.9 -1.9 -0.8 -0.9 -0.8 -0.8 -0.8 -0.1 -0.8 -1.5 GC 1.2 1.2 0.9 -0.8 0.9 1.2 1.2 0.9 -0.8 0.9 0.9 0.9 0.9 0.9 0.9 -0.2 -0.2 0.9 -0.5 0.9 0.9 0.9 1.0 0.9 0.2 GG -0.2 -0.2 -0.4 -0.9 -0.4 -0.2 -0.2 -0.4 -0.9 -0.4 -0.5 -0.5 -0.4 -0.5 -0.4 -0.2 -0.2 -0.4 0.8 -0.4 -0.5 -0.5 -0.4 -0.5 0.1 GU 1.2 1.2 0.9 -0.8 0.9 1.2 1.2 0.9 -0.8 0.9 0.9 0.9 0.9 0.9 0.9 -0.2 -0.2 0.9 -0.5 0.9 0.9 0.9 1.0 0.9 0.2 UM 1.2 1.2 1.0 -0.8 1.0 1.2 1.2 1.0 -0.8 1.0 0.9 0.9 1.0 0.9 1.0 -0.1 -0.1 1.0 -0.4 1.0 0.9 0.9 1.0 0.9 0.2 UA 1.2 1.2 1.0 -0.8 1.0 1.2 1.2 1.0 -0.8 1.0 0.9 0.9 1.0 0.9 1.0 -0.1 -0.1 1.0 -0.4 1.0 0.9 0.9 1.0 0.9 0.2 UC 1.2 1.2 1.0 -0.2 1.0 1.2 1.2 1.0 -0.2 1.0 0.9 0.9 1.0 0.9 1.0 0.5 0.5 1.0 -0.4 1.0 0.9 0.9 1.0 0.9 0.2 UG 1.2 1.2 1.0 -0.8 1.0 1.2 1.2 1.0 -0.8 1.0 0.9 0.9 1.0 0.9 1.0 -0.1 -0.1 1.0 -0.4 1.0 0.9 0.9 1.0 0.9 0.2 UU 1.1 1.1 0.2 -1.5 0.2 1.1 1.1 0.2 -1.5 0.2 0.2 0.2 0.2 0.2 0.2 -0.9 -0.9 0.2 0.1 0.2 0.2 0.2 0.3 0.2 -0.5 # 5' ------> 3' G X1 Y1 G C X2 Y2 C # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 1.3 1.3 1.3 -0.2 1.3 1.3 1.3 1.3 -0.2 1.3 0.6 0.6 2.2 1.7 1.4 0.0 0.0 1.3 -0.1 1.3 1.7 1.7 1.4 1.7 1.4 MA 1.3 1.3 1.3 -0.2 1.3 1.3 1.3 1.3 -0.2 1.3 0.6 0.6 2.2 1.7 1.4 0.0 0.0 1.3 -0.1 1.3 1.7 1.7 1.4 1.7 1.4 MC 1.0 1.0 1.1 0.7 1.0 1.0 1.0 1.1 0.7 1.0 0.5 0.5 1.9 1.4 1.1 -1.0 -1.0 1.0 -0.5 1.0 1.4 1.4 1.1 1.4 0.3 MG 0.4 0.4 0.7 -0.5 -0.1 0.4 0.4 0.7 -0.5 -0.1 0.3 0.3 0.7 0.3 0.5 -0.7 -0.7 -0.1 -0.3 -0.1 0.3 0.3 0.6 0.3 1.4 MU 1.0 1.0 1.0 0.1 1.0 1.0 1.0 1.0 0.1 1.0 1.4 1.4 1.3 1.4 1.1 0.1 0.1 1.0 -0.5 1.0 1.4 1.4 1.1 1.4 0.2 AM 1.3 1.3 1.3 -0.2 1.3 1.3 1.3 1.3 -0.2 1.3 0.6 0.6 2.2 1.7 1.4 0.0 0.0 1.3 -0.1 1.3 1.7 1.7 1.4 1.7 1.4 AA 1.3 1.3 1.3 -0.2 1.3 1.3 1.3 1.3 -0.2 1.3 0.6 0.6 2.2 1.7 1.4 0.0 0.0 1.3 -0.1 1.3 1.7 1.7 1.4 1.7 1.4 AC 1.0 1.0 1.1 0.7 1.0 1.0 1.0 1.1 0.7 1.0 0.5 0.5 1.9 1.4 1.1 -1.0 -1.0 1.0 -0.5 1.0 1.4 1.4 1.1 1.4 0.3 AG 0.4 0.4 0.7 -0.5 -0.1 0.4 0.4 0.7 -0.5 -0.1 0.3 0.3 0.7 0.3 0.5 -0.7 -0.7 -0.1 -0.3 -0.1 0.3 0.3 0.6 0.3 1.4 AU 1.0 1.0 1.0 0.1 1.0 1.0 1.0 1.0 0.1 1.0 1.4 1.4 1.3 1.4 1.1 0.1 0.1 1.0 -0.5 1.0 1.4 1.4 1.1 1.4 0.2 CM 1.1 1.1 1.0 -0.4 1.0 1.1 1.1 1.0 -0.4 1.0 1.5 1.5 1.3 1.5 1.2 -0.7 -0.7 1.0 -0.4 1.0 1.5 1.5 1.2 1.5 0.3 CA 1.1 1.1 1.0 -0.4 1.0 1.1 1.1 1.0 -0.4 1.0 1.5 1.5 1.3 1.5 1.2 -0.7 -0.7 1.0 -0.4 1.0 1.5 1.5 1.2 1.5 0.3 CC 1.1 1.1 1.0 0.7 1.0 1.1 1.1 1.0 0.7 1.0 1.5 1.5 1.3 1.5 1.2 -0.6 -0.6 1.0 -0.4 1.0 1.5 1.5 1.2 1.5 0.3 CG 1.1 1.1 1.0 0.1 1.0 1.1 1.1 1.0 0.1 1.0 1.5 1.5 1.3 1.5 1.2 0.1 0.1 1.0 -0.4 1.0 1.5 1.5 1.2 1.5 0.3 CU 1.1 1.1 1.1 0.8 1.1 1.1 1.1 1.1 0.8 1.1 1.5 1.5 1.4 1.5 1.2 0.8 0.8 1.1 -0.5 1.1 1.5 1.5 1.2 1.5 0.3 GM -0.3 -0.3 -0.7 -1.7 -0.7 -0.3 -0.3 -0.7 -1.7 -0.7 0.1 0.1 0.7 -0.3 0.0 -1.6 -1.6 -0.7 -0.9 -0.7 -0.3 -0.3 0.0 -0.3 0.5 GA -0.3 -0.3 -0.7 -1.7 -0.7 -0.3 -0.3 -0.7 -1.7 -0.7 0.1 0.1 0.7 -0.3 0.0 -1.6 -1.6 -0.7 -0.9 -0.7 -0.3 -0.3 0.0 -0.3 0.5 GC 1.0 1.0 1.0 0.1 1.0 1.0 1.0 1.0 0.1 1.0 1.4 1.4 1.3 1.4 1.1 0.1 0.1 1.0 -0.5 1.0 1.4 1.4 1.1 1.4 0.2 GG -0.3 -0.3 -0.4 -0.3 -0.4 -0.3 -0.3 -0.4 -0.3 -0.4 -0.3 -0.3 -0.1 0.1 -0.6 0.0 0.0 -0.4 0.8 -0.4 0.1 0.1 0.2 0.1 0.7 GU 1.0 1.0 1.0 0.1 1.0 1.0 1.0 1.0 0.1 1.0 1.4 1.4 1.3 1.4 1.1 0.1 0.1 1.0 -0.5 1.0 1.4 1.4 1.1 1.4 0.2 UM 1.1 1.1 1.0 0.1 1.0 1.1 1.1 1.0 0.1 1.0 1.5 1.5 1.3 1.5 1.2 0.1 0.1 1.0 -0.4 1.0 1.5 1.5 1.2 1.5 0.3 UA 1.1 1.1 1.0 0.1 1.0 1.1 1.1 1.0 0.1 1.0 1.5 1.5 1.3 1.5 1.2 0.1 0.1 1.0 -0.4 1.0 1.5 1.5 1.2 1.5 0.3 UC 1.1 1.1 1.0 0.7 1.0 1.1 1.1 1.0 0.7 1.0 1.5 1.5 1.3 1.5 1.2 0.7 0.7 1.0 0.2 1.0 1.5 1.5 1.7 1.5 0.3 UG 1.1 1.1 1.0 0.1 1.0 1.1 1.1 1.0 0.1 1.0 1.5 1.5 1.3 1.5 1.2 0.1 0.1 1.0 -0.4 1.0 1.5 1.5 1.2 1.5 0.3 UU 1.5 1.5 -0.2 0.9 0.3 1.5 1.5 -0.2 0.9 0.3 0.0 0.0 -0.1 0.7 0.4 0.9 0.9 0.3 1.4 0.3 0.7 0.7 0.2 0.7 -0.6 # 5' ------> 3' G X1 Y1 U C X2 Y2 A # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.1 2.1 1.9 0.9 1.9 2.1 2.1 1.9 0.9 1.9 2.0 2.0 1.9 2.0 1.9 1.6 1.6 1.9 0.4 1.9 2.0 2.0 1.9 2.0 1.6 MA 2.1 2.1 1.9 0.9 1.9 2.1 2.1 1.9 0.9 1.9 2.0 2.0 1.9 2.0 1.9 1.6 1.6 1.9 0.4 1.9 2.0 2.0 1.9 2.0 1.6 MC 1.8 1.8 1.6 0.6 1.6 1.8 1.8 1.6 0.6 1.6 1.7 1.7 1.6 1.7 1.6 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.6 1.7 0.7 MG 0.7 0.7 0.5 -0.5 0.5 0.7 0.7 0.5 -0.5 0.5 0.6 0.6 1.1 0.6 1.1 0.2 0.2 0.5 0.3 0.5 0.6 0.6 1.1 0.6 -0.3 MU 1.8 1.8 1.6 0.6 1.6 1.8 1.8 1.6 0.6 1.6 1.7 1.7 1.6 1.7 1.6 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.6 1.7 0.7 AM 2.1 2.1 1.9 0.9 1.9 2.1 2.1 1.9 0.9 1.9 2.0 2.0 1.9 2.0 1.9 1.6 1.6 1.9 0.4 1.9 2.0 2.0 1.9 2.0 1.6 AA 2.1 2.1 1.9 0.9 1.9 2.1 2.1 1.9 0.9 1.9 2.0 2.0 1.9 2.0 1.9 1.6 1.6 1.9 0.4 1.9 2.0 2.0 1.9 2.0 1.6 AC 1.8 1.8 1.6 0.6 1.6 1.8 1.8 1.6 0.6 1.6 1.7 1.7 1.6 1.7 1.6 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.6 1.7 0.7 AG 0.7 0.7 0.5 -0.5 0.5 0.7 0.7 0.5 -0.5 0.5 0.6 0.6 1.1 0.6 1.1 0.2 0.2 0.5 0.3 0.5 0.6 0.6 1.1 0.6 -0.3 AU 1.8 1.8 1.6 0.6 1.6 1.8 1.8 1.6 0.6 1.6 1.7 1.7 1.6 1.7 1.6 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.6 1.7 0.7 CM 1.9 1.9 1.6 0.6 1.6 1.9 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.7 1.7 0.8 CA 1.9 1.9 1.6 0.6 1.6 1.9 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.7 1.7 0.8 CC 1.9 1.9 1.6 1.2 1.6 1.9 1.9 1.6 1.2 1.6 1.7 1.7 1.7 1.7 1.7 1.9 1.9 1.6 0.1 1.6 1.7 1.7 1.7 1.7 0.8 CG 1.9 1.9 1.6 0.6 1.6 1.9 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.7 1.7 0.8 CU 1.9 1.9 1.7 1.3 1.7 1.9 1.9 1.7 1.3 1.7 1.8 1.8 1.7 1.8 1.7 2.0 2.0 1.7 0.2 1.7 1.8 1.8 1.7 1.8 0.8 GM 0.1 0.1 -0.1 -1.1 -0.1 0.1 0.1 -0.1 -1.1 -0.1 0.0 0.0 0.5 0.0 0.5 -0.4 -0.4 -0.1 -0.3 -0.1 0.0 0.0 0.5 0.0 -1.0 GA 0.1 0.1 -0.1 -1.1 -0.1 0.1 0.1 -0.1 -1.1 -0.1 0.0 0.0 0.5 0.0 0.5 -0.4 -0.4 -0.1 -0.3 -0.1 0.0 0.0 0.5 0.0 -1.0 GC 1.8 1.8 1.6 0.6 1.6 1.8 1.8 1.6 0.6 1.6 1.7 1.7 1.6 1.7 1.6 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.6 1.7 0.7 GG 0.5 0.5 0.2 0.5 0.2 0.5 0.5 0.2 0.5 0.2 0.3 0.3 0.3 0.3 0.3 1.2 1.2 0.2 1.3 0.2 0.3 0.3 0.3 0.3 0.7 GU 1.8 1.8 1.6 0.6 1.6 1.8 1.8 1.6 0.6 1.6 1.7 1.7 1.6 1.7 1.6 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.6 1.7 0.7 UM 1.9 1.9 1.6 0.6 1.6 1.9 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.7 1.7 0.8 UA 1.9 1.9 1.6 0.6 1.6 1.9 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.7 1.7 0.8 UC 1.9 1.9 1.6 1.2 1.6 1.9 1.9 1.6 1.2 1.6 1.7 1.7 1.7 1.7 1.7 1.9 1.9 1.6 0.1 1.6 1.7 1.7 1.7 1.7 0.8 UG 1.9 1.9 1.6 0.6 1.6 1.9 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.7 1.7 0.8 UU 1.7 1.7 0.9 -0.1 0.9 1.7 1.7 0.9 -0.1 0.9 1.0 1.0 0.9 1.0 0.9 0.6 0.6 0.9 0.7 0.9 1.0 1.0 0.9 1.0 0.0 # 5' ------> 3' G X1 Y1 U C X2 Y2 M # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.1 2.1 1.9 0.9 1.9 2.1 2.1 1.9 0.9 1.9 2.0 2.0 1.9 2.0 1.9 1.6 1.6 1.9 0.4 1.9 2.0 2.0 1.9 2.0 1.6 MA 2.1 2.1 1.9 0.9 1.9 2.1 2.1 1.9 0.9 1.9 2.0 2.0 1.9 2.0 1.9 1.6 1.6 1.9 0.4 1.9 2.0 2.0 1.9 2.0 1.6 MC 1.8 1.8 1.6 0.6 1.6 1.8 1.8 1.6 0.6 1.6 1.7 1.7 1.6 1.7 1.6 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.6 1.7 0.7 MG 0.7 0.7 0.5 -0.5 0.5 0.7 0.7 0.5 -0.5 0.5 0.6 0.6 1.1 0.6 1.1 0.2 0.2 0.5 0.3 0.5 0.6 0.6 1.1 0.6 -0.3 MU 1.8 1.8 1.6 0.6 1.6 1.8 1.8 1.6 0.6 1.6 1.7 1.7 1.6 1.7 1.6 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.6 1.7 0.7 AM 2.1 2.1 1.9 0.9 1.9 2.1 2.1 1.9 0.9 1.9 2.0 2.0 1.9 2.0 1.9 1.6 1.6 1.9 0.4 1.9 2.0 2.0 1.9 2.0 1.6 AA 2.1 2.1 1.9 0.9 1.9 2.1 2.1 1.9 0.9 1.9 2.0 2.0 1.9 2.0 1.9 1.6 1.6 1.9 0.4 1.9 2.0 2.0 1.9 2.0 1.6 AC 1.8 1.8 1.6 0.6 1.6 1.8 1.8 1.6 0.6 1.6 1.7 1.7 1.6 1.7 1.6 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.6 1.7 0.7 AG 0.7 0.7 0.5 -0.5 0.5 0.7 0.7 0.5 -0.5 0.5 0.6 0.6 1.1 0.6 1.1 0.2 0.2 0.5 0.3 0.5 0.6 0.6 1.1 0.6 -0.3 AU 1.8 1.8 1.6 0.6 1.6 1.8 1.8 1.6 0.6 1.6 1.7 1.7 1.6 1.7 1.6 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.6 1.7 0.7 CM 1.9 1.9 1.6 0.6 1.6 1.9 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.7 1.7 0.8 CA 1.9 1.9 1.6 0.6 1.6 1.9 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.7 1.7 0.8 CC 1.9 1.9 1.6 1.2 1.6 1.9 1.9 1.6 1.2 1.6 1.7 1.7 1.7 1.7 1.7 1.9 1.9 1.6 0.1 1.6 1.7 1.7 1.7 1.7 0.8 CG 1.9 1.9 1.6 0.6 1.6 1.9 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.7 1.7 0.8 CU 1.9 1.9 1.7 1.3 1.7 1.9 1.9 1.7 1.3 1.7 1.8 1.8 1.7 1.8 1.7 2.0 2.0 1.7 0.2 1.7 1.8 1.8 1.7 1.8 0.8 GM 0.1 0.1 -0.1 -1.1 -0.1 0.1 0.1 -0.1 -1.1 -0.1 0.0 0.0 0.5 0.0 0.5 -0.4 -0.4 -0.1 -0.3 -0.1 0.0 0.0 0.5 0.0 -1.0 GA 0.1 0.1 -0.1 -1.1 -0.1 0.1 0.1 -0.1 -1.1 -0.1 0.0 0.0 0.5 0.0 0.5 -0.4 -0.4 -0.1 -0.3 -0.1 0.0 0.0 0.5 0.0 -1.0 GC 1.8 1.8 1.6 0.6 1.6 1.8 1.8 1.6 0.6 1.6 1.7 1.7 1.6 1.7 1.6 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.6 1.7 0.7 GG 0.5 0.5 0.2 0.5 0.2 0.5 0.5 0.2 0.5 0.2 0.3 0.3 0.3 0.3 0.3 1.2 1.2 0.2 1.3 0.2 0.3 0.3 0.3 0.3 0.7 GU 1.8 1.8 1.6 0.6 1.6 1.8 1.8 1.6 0.6 1.6 1.7 1.7 1.6 1.7 1.6 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.6 1.7 0.7 UM 1.9 1.9 1.6 0.6 1.6 1.9 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.7 1.7 0.8 UA 1.9 1.9 1.6 0.6 1.6 1.9 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.7 1.7 0.8 UC 1.9 1.9 1.6 1.2 1.6 1.9 1.9 1.6 1.2 1.6 1.7 1.7 1.7 1.7 1.7 1.9 1.9 1.6 0.1 1.6 1.7 1.7 1.7 1.7 0.8 UG 1.9 1.9 1.6 0.6 1.6 1.9 1.9 1.6 0.6 1.6 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.6 0.1 1.6 1.7 1.7 1.7 1.7 0.8 UU 1.7 1.7 0.9 -0.1 0.9 1.7 1.7 0.9 -0.1 0.9 1.0 1.0 0.9 1.0 0.9 0.6 0.6 0.9 0.7 0.9 1.0 1.0 0.9 1.0 0.0 # 5' ------> 3' G X1 Y1 G C X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 1.4 1.4 1.6 0.3 1.6 1.4 1.4 1.6 0.3 1.6 1.6 1.6 1.6 1.6 1.6 1.9 1.9 1.6 0.3 1.6 1.6 1.6 1.6 1.6 2.2 MA 1.4 1.4 1.6 0.3 1.6 1.4 1.4 1.6 0.3 1.6 1.6 1.6 1.6 1.6 1.6 1.9 1.9 1.6 0.3 1.6 1.6 1.6 1.6 1.6 2.2 MC 1.0 1.0 1.3 0.0 1.3 1.0 1.0 1.3 0.0 1.3 1.3 1.3 1.3 1.3 1.3 1.6 1.6 1.3 0.0 1.3 1.3 1.3 1.3 1.3 1.3 MG -0.1 -0.1 0.2 -1.1 0.2 -0.1 -0.1 0.2 -1.1 0.2 0.2 0.2 0.8 0.2 0.8 0.5 0.5 0.2 0.2 0.2 0.2 0.2 0.8 0.2 0.2 MU 1.0 1.0 1.3 0.0 1.3 1.0 1.0 1.3 0.0 1.3 1.3 1.3 1.3 1.3 1.3 1.6 1.6 1.3 0.0 1.3 1.3 1.3 1.3 1.3 1.3 AM 1.4 1.4 1.6 0.3 1.6 1.4 1.4 1.6 0.3 1.6 1.6 1.6 1.6 1.6 1.6 1.9 1.9 1.6 0.3 1.6 1.6 1.6 1.6 1.6 2.2 AA 1.4 1.4 1.6 0.3 1.6 1.4 1.4 1.6 0.3 1.6 1.6 1.6 1.6 1.6 1.6 1.9 1.9 1.6 0.3 1.6 1.6 1.6 1.6 1.6 2.2 AC 1.0 1.0 1.3 0.0 1.3 1.0 1.0 1.3 0.0 1.3 1.3 1.3 1.3 1.3 1.3 1.6 1.6 1.3 0.0 1.3 1.3 1.3 1.3 1.3 1.3 AG -0.1 -0.1 0.2 -1.1 0.2 -0.1 -0.1 0.2 -1.1 0.2 0.2 0.2 0.8 0.2 0.8 0.5 0.5 0.2 0.2 0.2 0.2 0.2 0.8 0.2 0.2 AU 1.0 1.0 1.3 0.0 1.3 1.0 1.0 1.3 0.0 1.3 1.3 1.3 1.3 1.3 1.3 1.6 1.6 1.3 0.0 1.3 1.3 1.3 1.3 1.3 1.3 CM 1.0 1.0 1.4 0.0 1.4 1.0 1.0 1.4 0.0 1.4 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 CA 1.0 1.0 1.4 0.0 1.4 1.0 1.0 1.4 0.0 1.4 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 CC 1.0 1.0 1.4 0.6 1.4 1.0 1.0 1.4 0.6 1.4 1.4 1.4 1.4 1.4 1.4 2.3 2.3 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 CG 1.0 1.0 1.4 0.0 1.4 1.0 1.0 1.4 0.0 1.4 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 CU 1.1 1.1 1.4 0.7 1.4 1.1 1.1 1.4 0.7 1.4 1.4 1.4 1.4 1.4 1.4 2.3 2.3 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 GM -0.7 -0.7 -0.4 -1.7 -0.4 -0.7 -0.7 -0.4 -1.7 -0.4 -0.4 -0.4 0.2 -0.4 0.2 -0.1 -0.1 -0.4 -0.4 -0.4 -0.4 -0.4 0.2 -0.4 -0.4 GA -0.7 -0.7 -0.4 -1.7 -0.4 -0.7 -0.7 -0.4 -1.7 -0.4 -0.4 -0.4 0.2 -0.4 0.2 -0.1 -0.1 -0.4 -0.4 -0.4 -0.4 -0.4 0.2 -0.4 -0.4 GC 1.0 1.0 1.3 0.0 1.3 1.0 1.0 1.3 0.0 1.3 1.3 1.3 1.3 1.3 1.3 1.6 1.6 1.3 0.0 1.3 1.3 1.3 1.3 1.3 1.3 GG -0.4 -0.4 0.0 -0.1 0.0 -0.4 -0.4 0.0 -0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.6 1.6 0.0 1.3 0.0 0.0 0.0 0.0 0.0 1.3 GU 1.0 1.0 1.3 0.0 1.3 1.0 1.0 1.3 0.0 1.3 1.3 1.3 1.3 1.3 1.3 1.6 1.6 1.3 0.0 1.3 1.3 1.3 1.3 1.3 1.3 UM 1.0 1.0 1.4 0.0 1.4 1.0 1.0 1.4 0.0 1.4 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 UA 1.0 1.0 1.4 0.0 1.4 1.0 1.0 1.4 0.0 1.4 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 UC 1.0 1.0 1.4 0.6 1.4 1.0 1.0 1.4 0.6 1.4 1.4 1.4 1.4 1.4 1.4 2.3 2.3 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 UG 1.0 1.0 1.4 0.0 1.4 1.0 1.0 1.4 0.0 1.4 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 UU 0.9 0.9 0.6 -0.7 0.6 0.9 0.9 0.6 -0.7 0.6 0.6 0.6 0.6 0.6 0.6 0.9 0.9 0.6 0.6 0.6 0.6 0.6 0.6 0.6 0.6 # 5' ------> 3' G X1 Y1 U C X2 Y2 G # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.3 2.3 1.9 1.1 1.9 2.3 2.3 1.9 1.1 1.9 1.9 1.9 1.9 1.9 1.9 1.5 1.5 1.9 0.6 1.9 1.9 1.9 1.9 1.9 2.5 MA 2.3 2.3 1.9 1.1 1.9 2.3 2.3 1.9 1.1 1.9 1.9 1.9 1.9 1.9 1.9 1.5 1.5 1.9 0.6 1.9 1.9 1.9 1.9 1.9 2.5 MC 2.0 2.0 1.6 0.8 1.6 2.0 2.0 1.6 0.8 1.6 1.6 1.6 1.6 1.6 1.6 1.2 1.2 1.6 0.3 1.6 1.6 1.6 1.6 1.6 1.6 MG 0.9 0.9 0.5 -0.3 0.5 0.9 0.9 0.5 -0.3 0.5 0.5 0.5 1.1 0.5 1.1 0.1 0.1 0.5 0.5 0.5 0.5 0.5 1.1 0.5 0.5 MU 2.0 2.0 1.6 0.8 1.6 2.0 2.0 1.6 0.8 1.6 1.6 1.6 1.6 1.6 1.6 1.2 1.2 1.6 0.3 1.6 1.6 1.6 1.6 1.6 1.6 AM 2.3 2.3 1.9 1.1 1.9 2.3 2.3 1.9 1.1 1.9 1.9 1.9 1.9 1.9 1.9 1.5 1.5 1.9 0.6 1.9 1.9 1.9 1.9 1.9 2.5 AA 2.3 2.3 1.9 1.1 1.9 2.3 2.3 1.9 1.1 1.9 1.9 1.9 1.9 1.9 1.9 1.5 1.5 1.9 0.6 1.9 1.9 1.9 1.9 1.9 2.5 AC 2.0 2.0 1.6 0.8 1.6 2.0 2.0 1.6 0.8 1.6 1.6 1.6 1.6 1.6 1.6 1.2 1.2 1.6 0.3 1.6 1.6 1.6 1.6 1.6 1.6 AG 0.9 0.9 0.5 -0.3 0.5 0.9 0.9 0.5 -0.3 0.5 0.5 0.5 1.1 0.5 1.1 0.1 0.1 0.5 0.5 0.5 0.5 0.5 1.1 0.5 0.5 AU 2.0 2.0 1.6 0.8 1.6 2.0 2.0 1.6 0.8 1.6 1.6 1.6 1.6 1.6 1.6 1.2 1.2 1.6 0.3 1.6 1.6 1.6 1.6 1.6 1.6 CM 2.0 2.0 1.7 0.9 1.7 2.0 2.0 1.7 0.9 1.7 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.7 0.4 1.7 1.7 1.7 1.7 1.7 1.7 CA 2.0 2.0 1.7 0.9 1.7 2.0 2.0 1.7 0.9 1.7 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.7 0.4 1.7 1.7 1.7 1.7 1.7 1.7 CC 2.0 2.0 1.7 1.5 1.7 2.0 2.0 1.7 1.5 1.7 1.7 1.7 1.7 1.7 1.7 1.9 1.9 1.7 0.4 1.7 1.7 1.7 1.7 1.7 1.7 CG 2.0 2.0 1.7 0.9 1.7 2.0 2.0 1.7 0.9 1.7 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.7 0.4 1.7 1.7 1.7 1.7 1.7 1.7 CU 2.1 2.1 1.7 1.5 1.7 2.1 2.1 1.7 1.5 1.7 1.7 1.7 1.7 1.7 1.7 1.9 1.9 1.7 0.4 1.7 1.7 1.7 1.7 1.7 1.7 GM 0.2 0.2 -0.1 -0.9 -0.1 0.2 0.2 -0.1 -0.9 -0.1 -0.1 -0.1 0.5 -0.1 0.5 -0.5 -0.5 -0.1 -0.1 -0.1 -0.1 -0.1 0.5 -0.1 -0.1 GA 0.2 0.2 -0.1 -0.9 -0.1 0.2 0.2 -0.1 -0.9 -0.1 -0.1 -0.1 0.5 -0.1 0.5 -0.5 -0.5 -0.1 -0.1 -0.1 -0.1 -0.1 0.5 -0.1 -0.1 GC 2.0 2.0 1.6 0.8 1.6 2.0 2.0 1.6 0.8 1.6 1.6 1.6 1.6 1.6 1.6 1.2 1.2 1.6 0.3 1.6 1.6 1.6 1.6 1.6 1.6 GG 0.6 0.6 0.3 0.8 0.3 0.6 0.6 0.3 0.8 0.3 0.3 0.3 0.3 0.3 0.3 1.2 1.2 0.3 1.6 0.3 0.3 0.3 0.3 0.3 1.6 GU 2.0 2.0 1.6 0.8 1.6 2.0 2.0 1.6 0.8 1.6 1.6 1.6 1.6 1.6 1.6 1.2 1.2 1.6 0.3 1.6 1.6 1.6 1.6 1.6 1.6 UM 2.0 2.0 1.7 0.9 1.7 2.0 2.0 1.7 0.9 1.7 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.7 0.4 1.7 1.7 1.7 1.7 1.7 1.7 UA 2.0 2.0 1.7 0.9 1.7 2.0 2.0 1.7 0.9 1.7 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.7 0.4 1.7 1.7 1.7 1.7 1.7 1.7 UC 2.0 2.0 1.7 1.5 1.7 2.0 2.0 1.7 1.5 1.7 1.7 1.7 1.7 1.7 1.7 1.9 1.9 1.7 0.4 1.7 1.7 1.7 1.7 1.7 1.7 UG 2.0 2.0 1.7 0.9 1.7 2.0 2.0 1.7 0.9 1.7 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.7 0.4 1.7 1.7 1.7 1.7 1.7 1.7 UU 1.9 1.9 0.9 0.1 0.9 1.9 1.9 0.9 0.1 0.9 0.9 0.9 0.9 0.9 0.9 0.5 0.5 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 # 5' ------> 3' U X1 Y1 A A X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 MA 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 MC 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 MG 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.4 0.8 1.4 1.8 1.8 2.4 1.8 2.4 0.9 0.9 1.4 1.6 1.4 1.8 1.8 2.1 1.8 1.0 MU 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 AM 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 AA 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 AC 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 AG 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.4 0.8 1.4 1.8 1.8 2.4 1.8 2.4 0.9 0.9 1.4 1.6 1.4 1.8 1.8 2.1 1.8 1.0 AU 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 CM 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 CA 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 CC 2.8 2.8 2.3 2.3 2.3 2.8 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.8 2.4 2.4 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 CG 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 CU 2.5 2.5 2.0 2.0 2.0 2.5 2.5 2.0 2.0 2.0 2.5 2.5 2.5 2.5 2.5 2.1 2.1 2.0 0.9 2.0 2.5 2.5 2.2 2.5 1.6 GM 1.7 1.7 1.3 0.7 1.3 1.7 1.7 1.3 0.7 1.3 1.7 1.7 2.3 1.7 2.3 0.8 0.8 1.3 1.5 1.3 1.7 1.7 2.0 1.7 0.9 GA 1.7 1.7 1.3 0.7 1.3 1.7 1.7 1.3 0.7 1.3 1.7 1.7 2.3 1.7 2.3 0.8 0.8 1.3 1.5 1.3 1.7 1.7 2.0 1.7 0.9 GC 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 GG 1.2 1.2 0.8 1.5 0.8 1.2 1.2 0.8 1.5 0.8 1.2 1.2 1.2 1.2 1.2 1.6 1.6 0.8 2.3 0.8 1.2 1.2 0.9 1.2 1.7 GU 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 UM 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 UA 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 UC 2.8 2.8 2.3 2.3 2.3 2.8 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.8 2.4 2.4 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 UG 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 UU 2.5 2.5 1.5 0.9 1.5 2.5 2.5 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 1.7 1.5 1.9 1.9 1.6 1.9 1.1 # 5' ------> 3' U X1 Y1 M A X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 MA 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 MC 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 MG 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.4 0.8 1.4 1.8 1.8 2.4 1.8 2.4 0.9 0.9 1.4 1.6 1.4 1.8 1.8 2.1 1.8 1.0 MU 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 AM 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 AA 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 AC 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 AG 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.4 0.8 1.4 1.8 1.8 2.4 1.8 2.4 0.9 0.9 1.4 1.6 1.4 1.8 1.8 2.1 1.8 1.0 AU 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 CM 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 CA 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 CC 2.8 2.8 2.3 2.3 2.3 2.8 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.8 2.4 2.4 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 CG 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 CU 2.5 2.5 2.0 2.0 2.0 2.5 2.5 2.0 2.0 2.0 2.5 2.5 2.5 2.5 2.5 2.1 2.1 2.0 0.9 2.0 2.5 2.5 2.2 2.5 1.6 GM 1.7 1.7 1.3 0.7 1.3 1.7 1.7 1.3 0.7 1.3 1.7 1.7 2.3 1.7 2.3 0.8 0.8 1.3 1.5 1.3 1.7 1.7 2.0 1.7 0.9 GA 1.7 1.7 1.3 0.7 1.3 1.7 1.7 1.3 0.7 1.3 1.7 1.7 2.3 1.7 2.3 0.8 0.8 1.3 1.5 1.3 1.7 1.7 2.0 1.7 0.9 GC 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 GG 1.2 1.2 0.8 1.5 0.8 1.2 1.2 0.8 1.5 0.8 1.2 1.2 1.2 1.2 1.2 1.6 1.6 0.8 2.3 0.8 1.2 1.2 0.9 1.2 1.7 GU 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 UM 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 UA 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 UC 2.8 2.8 2.3 2.3 2.3 2.8 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.8 2.4 2.4 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 UG 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 UU 2.5 2.5 1.5 0.9 1.5 2.5 2.5 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 1.7 1.5 1.9 1.9 1.6 1.9 1.1 # 5' ------> 3' U X1 Y1 C A X2 Y2 G # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.7 MA 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.7 MC 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.1 MG 1.2 1.2 0.9 -0.8 0.9 1.2 1.2 0.9 -0.8 0.9 0.9 0.9 1.5 0.9 1.5 -0.2 -0.2 0.9 0.8 0.9 0.9 0.9 1.6 0.9 0.2 MU 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.1 AM 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.7 AA 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.7 AC 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.1 AG 1.2 1.2 0.9 -0.8 0.9 1.2 1.2 0.9 -0.8 0.9 0.9 0.9 1.5 0.9 1.5 -0.2 -0.2 0.9 0.8 0.9 0.9 0.9 1.6 0.9 0.2 AU 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.1 CM 1.7 1.7 1.4 -0.3 1.4 1.7 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 1.4 0.3 0.3 1.4 0.0 1.4 1.4 1.4 1.5 1.4 0.7 CA 1.7 1.7 1.4 -0.3 1.4 1.7 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 1.4 0.3 0.3 1.4 0.0 1.4 1.4 1.4 1.5 1.4 0.7 CC 2.1 2.1 1.9 0.7 1.9 2.1 2.1 1.9 0.7 1.9 1.8 1.8 1.9 1.8 1.9 1.3 1.3 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.1 CG 1.7 1.7 1.4 -0.3 1.4 1.7 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 1.4 0.3 0.3 1.4 0.0 1.4 1.4 1.4 1.5 1.4 0.7 CU 1.8 1.8 1.6 0.4 1.6 1.8 1.8 1.6 0.4 1.6 1.5 1.5 1.6 1.5 1.6 1.0 1.0 1.6 0.2 1.6 1.5 1.5 1.6 1.5 0.8 GM 1.1 1.1 0.8 -0.9 0.8 1.1 1.1 0.8 -0.9 0.8 0.8 0.8 1.4 0.8 1.4 -0.3 -0.3 0.8 0.7 0.8 0.8 0.8 1.5 0.8 0.1 GA 1.1 1.1 0.8 -0.9 0.8 1.1 1.1 0.8 -0.9 0.8 0.8 0.8 1.4 0.8 1.4 -0.3 -0.3 0.8 0.7 0.8 0.8 0.8 1.5 0.8 0.1 GC 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.1 GG 0.6 0.6 0.3 -0.1 0.3 0.6 0.6 0.3 -0.1 0.3 0.3 0.3 0.3 0.3 0.3 0.5 0.5 0.3 1.5 0.3 0.3 0.3 0.4 0.3 0.9 GU 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.1 UM 1.7 1.7 1.4 -0.3 1.4 1.7 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 1.4 0.3 0.3 1.4 0.0 1.4 1.4 1.4 1.5 1.4 0.7 UA 1.7 1.7 1.4 -0.3 1.4 1.7 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 1.4 0.3 0.3 1.4 0.0 1.4 1.4 1.4 1.5 1.4 0.7 UC 2.1 2.1 1.9 0.7 1.9 2.1 2.1 1.9 0.7 1.9 1.8 1.8 1.9 1.8 1.9 1.3 1.3 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.1 UG 1.7 1.7 1.4 -0.3 1.4 1.7 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 1.4 0.3 0.3 1.4 0.0 1.4 1.4 1.4 1.5 1.4 0.7 UU 1.9 1.9 1.0 -0.7 1.0 1.9 1.9 1.0 -0.7 1.0 1.0 1.0 1.0 1.0 1.0 -0.1 -0.1 1.0 0.9 1.0 1.0 1.0 1.1 1.0 0.3 # 5' ------> 3' U X1 Y1 G A X2 Y2 C # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.8 MA 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.8 MC 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.2 MG 1.0 1.0 1.0 0.1 1.0 1.0 1.0 1.0 0.1 1.0 1.4 1.4 1.9 1.4 1.7 0.1 0.1 1.0 0.8 1.0 1.4 1.4 1.7 1.4 0.2 MU 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.2 AM 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.8 AA 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.8 AC 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.2 AG 1.0 1.0 1.0 0.1 1.0 1.0 1.0 1.0 0.1 1.0 1.4 1.4 1.9 1.4 1.7 0.1 0.1 1.0 0.8 1.0 1.4 1.4 1.7 1.4 0.2 AU 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.2 CM 1.5 1.5 1.5 0.6 1.5 1.5 1.5 1.5 0.6 1.5 1.9 1.9 1.8 1.9 1.6 0.6 0.6 1.5 0.0 1.5 1.9 1.9 1.6 1.9 0.7 CA 1.5 1.5 1.5 0.6 1.5 1.5 1.5 1.5 0.6 1.5 1.9 1.9 1.8 1.9 1.6 0.6 0.6 1.5 0.0 1.5 1.9 1.9 1.6 1.9 0.7 CC 2.0 2.0 1.9 1.6 1.9 2.0 2.0 1.9 1.6 1.9 2.4 2.4 2.2 2.4 2.1 1.6 1.6 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.2 CG 1.5 1.5 1.5 0.6 1.5 1.5 1.5 1.5 0.6 1.5 1.9 1.9 1.8 1.9 1.6 0.6 0.6 1.5 0.0 1.5 1.9 1.9 1.6 1.9 0.7 CU 1.7 1.7 1.6 1.3 1.6 1.7 1.7 1.6 1.3 1.6 2.1 2.1 1.9 2.1 1.8 1.3 1.3 1.6 0.2 1.6 2.1 2.1 1.8 2.1 0.9 GM 0.9 0.9 0.9 0.0 0.9 0.9 0.9 0.9 0.0 0.9 1.3 1.3 1.8 1.3 1.6 0.0 0.0 0.9 0.7 0.9 1.3 1.3 1.6 1.3 0.1 GA 0.9 0.9 0.9 0.0 0.9 0.9 0.9 0.9 0.0 0.9 1.3 1.3 1.8 1.3 1.6 0.0 0.0 0.9 0.7 0.9 1.3 1.3 1.6 1.3 0.1 GC 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.2 GG 0.4 0.4 0.4 0.8 0.4 0.4 0.4 0.4 0.8 0.4 0.8 0.8 0.7 0.8 0.5 0.8 0.8 0.4 1.5 0.4 0.8 0.8 0.5 0.8 0.9 GU 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.2 UM 1.5 1.5 1.5 0.6 1.5 1.5 1.5 1.5 0.6 1.5 1.9 1.9 1.8 1.9 1.6 0.6 0.6 1.5 0.0 1.5 1.9 1.9 1.6 1.9 0.7 UA 1.5 1.5 1.5 0.6 1.5 1.5 1.5 1.5 0.6 1.5 1.9 1.9 1.8 1.9 1.6 0.6 0.6 1.5 0.0 1.5 1.9 1.9 1.6 1.9 0.7 UC 2.0 2.0 1.9 1.6 1.9 2.0 2.0 1.9 1.6 1.9 2.4 2.4 2.2 2.4 2.1 1.6 1.6 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.2 UG 1.5 1.5 1.5 0.6 1.5 1.5 1.5 1.5 0.6 1.5 1.9 1.9 1.8 1.9 1.6 0.6 0.6 1.5 0.0 1.5 1.9 1.9 1.6 1.9 0.7 UU 1.7 1.7 1.1 0.2 1.1 1.7 1.7 1.1 0.2 1.1 1.5 1.5 1.4 1.5 1.2 0.2 0.2 1.1 0.9 1.1 1.5 1.5 1.2 1.5 0.3 # 5' ------> 3' U X1 Y1 U A X2 Y2 A # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 MA 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 MC 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 MG 1.8 1.8 1.6 0.6 1.6 1.8 1.8 1.6 0.6 1.6 1.7 1.7 2.2 1.7 2.2 1.3 1.3 1.6 1.4 1.6 1.7 1.7 2.2 1.7 0.7 MU 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 AM 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 AA 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 AC 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 AG 1.8 1.8 1.6 0.6 1.6 1.8 1.8 1.6 0.6 1.6 1.7 1.7 2.2 1.7 2.2 1.3 1.3 1.6 1.4 1.6 1.7 1.7 2.2 1.7 0.7 AU 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 CM 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 CA 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 CC 2.8 2.8 2.5 2.1 2.5 2.8 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.6 2.8 2.8 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 CG 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 CU 2.5 2.5 2.2 1.8 2.2 2.5 2.5 2.2 1.8 2.2 2.3 2.3 2.3 2.3 2.3 2.5 2.5 2.2 0.7 2.2 2.3 2.3 2.3 2.3 1.4 GM 1.7 1.7 1.5 0.5 1.5 1.7 1.7 1.5 0.5 1.5 1.6 1.6 2.1 1.6 2.1 1.2 1.2 1.5 1.3 1.5 1.6 1.6 2.1 1.6 0.6 GA 1.7 1.7 1.5 0.5 1.5 1.7 1.7 1.5 0.5 1.5 1.6 1.6 2.1 1.6 2.1 1.2 1.2 1.5 1.3 1.5 1.6 1.6 2.1 1.6 0.6 GC 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 GG 1.2 1.2 1.0 1.3 1.0 1.2 1.2 1.0 1.3 1.0 1.1 1.1 1.0 1.1 1.0 2.0 2.0 1.0 2.1 1.0 1.1 1.1 1.0 1.1 1.4 GU 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 UM 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 UA 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 UC 2.8 2.8 2.5 2.1 2.5 2.8 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.6 2.8 2.8 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 UG 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 UU 2.5 2.5 1.7 0.7 1.7 2.5 2.5 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 1.5 1.7 1.8 1.8 1.7 1.8 0.8 # 5' ------> 3' U X1 Y1 U A X2 Y2 M # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 MA 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 MC 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 MG 1.8 1.8 1.6 0.6 1.6 1.8 1.8 1.6 0.6 1.6 1.7 1.7 2.2 1.7 2.2 1.3 1.3 1.6 1.4 1.6 1.7 1.7 2.2 1.7 0.7 MU 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 AM 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 AA 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 AC 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 AG 1.8 1.8 1.6 0.6 1.6 1.8 1.8 1.6 0.6 1.6 1.7 1.7 2.2 1.7 2.2 1.3 1.3 1.6 1.4 1.6 1.7 1.7 2.2 1.7 0.7 AU 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 CM 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 CA 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 CC 2.8 2.8 2.5 2.1 2.5 2.8 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.6 2.8 2.8 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 CG 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 CU 2.5 2.5 2.2 1.8 2.2 2.5 2.5 2.2 1.8 2.2 2.3 2.3 2.3 2.3 2.3 2.5 2.5 2.2 0.7 2.2 2.3 2.3 2.3 2.3 1.4 GM 1.7 1.7 1.5 0.5 1.5 1.7 1.7 1.5 0.5 1.5 1.6 1.6 2.1 1.6 2.1 1.2 1.2 1.5 1.3 1.5 1.6 1.6 2.1 1.6 0.6 GA 1.7 1.7 1.5 0.5 1.5 1.7 1.7 1.5 0.5 1.5 1.6 1.6 2.1 1.6 2.1 1.2 1.2 1.5 1.3 1.5 1.6 1.6 2.1 1.6 0.6 GC 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 GG 1.2 1.2 1.0 1.3 1.0 1.2 1.2 1.0 1.3 1.0 1.1 1.1 1.0 1.1 1.0 2.0 2.0 1.0 2.1 1.0 1.1 1.1 1.0 1.1 1.4 GU 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 UM 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 UA 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 UC 2.8 2.8 2.5 2.1 2.5 2.8 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.6 2.8 2.8 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 UG 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 UU 2.5 2.5 1.7 0.7 1.7 2.5 2.5 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 1.5 1.7 1.8 1.8 1.7 1.8 0.8 # 5' ------> 3' U X1 Y1 G A X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.9 MA 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.9 MC 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 MG 1.0 1.0 1.3 0.0 1.3 1.0 1.0 1.3 0.0 1.3 1.3 1.3 1.9 1.3 1.9 1.6 1.6 1.3 1.3 1.3 1.3 1.3 1.9 1.3 1.3 MU 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 AM 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.9 AA 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.9 AC 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 AG 1.0 1.0 1.3 0.0 1.3 1.0 1.0 1.3 0.0 1.3 1.3 1.3 1.9 1.3 1.9 1.6 1.6 1.3 1.3 1.3 1.3 1.3 1.9 1.3 1.3 AU 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 CM 1.5 1.5 1.8 0.5 1.8 1.5 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 CA 1.5 1.5 1.8 0.5 1.8 1.5 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 CC 1.9 1.9 2.3 1.5 2.3 1.9 1.9 2.3 1.5 2.3 2.3 2.3 2.3 2.3 2.3 3.2 3.2 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 CG 1.5 1.5 1.8 0.5 1.8 1.5 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 CU 1.6 1.6 2.0 1.2 2.0 1.6 1.6 2.0 1.2 2.0 2.0 2.0 2.0 2.0 2.0 2.9 2.9 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 GM 0.9 0.9 1.2 -0.1 1.2 0.9 0.9 1.2 -0.1 1.2 1.2 1.2 1.8 1.2 1.8 1.5 1.5 1.2 1.2 1.2 1.2 1.2 1.8 1.2 1.2 GA 0.9 0.9 1.2 -0.1 1.2 0.9 0.9 1.2 -0.1 1.2 1.2 1.2 1.8 1.2 1.8 1.5 1.5 1.2 1.2 1.2 1.2 1.2 1.8 1.2 1.2 GC 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 GG 0.4 0.4 0.7 0.7 0.7 0.4 0.4 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 2.3 2.3 0.7 2.0 0.7 0.7 0.7 0.7 0.7 2.0 GU 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 UM 1.5 1.5 1.8 0.5 1.8 1.5 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 UA 1.5 1.5 1.8 0.5 1.8 1.5 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 UC 1.9 1.9 2.3 1.5 2.3 1.9 1.9 2.3 1.5 2.3 2.3 2.3 2.3 2.3 2.3 3.2 3.2 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 UG 1.5 1.5 1.8 0.5 1.8 1.5 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 UU 1.7 1.7 1.4 0.1 1.4 1.7 1.7 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 # 5' ------> 3' U X1 Y1 U A X2 Y2 G # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 3.2 MA 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 3.2 MC 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.6 MG 2.0 2.0 1.6 0.8 1.6 2.0 2.0 1.6 0.8 1.6 1.6 1.6 2.2 1.6 2.2 1.2 1.2 1.6 1.6 1.6 1.6 1.6 2.2 1.6 1.6 MU 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.6 AM 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 3.2 AA 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 3.2 AC 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.6 AG 2.0 2.0 1.6 0.8 1.6 2.0 2.0 1.6 0.8 1.6 1.6 1.6 2.2 1.6 2.2 1.2 1.2 1.6 1.6 1.6 1.6 1.6 2.2 1.6 1.6 AU 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.6 CM 2.5 2.5 2.1 1.3 2.1 2.5 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 CA 2.5 2.5 2.1 1.3 2.1 2.5 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 CC 2.9 2.9 2.6 2.4 2.6 2.9 2.9 2.6 2.4 2.6 2.6 2.6 2.6 2.6 2.6 2.8 2.8 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.6 CG 2.5 2.5 2.1 1.3 2.1 2.5 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 CU 2.6 2.6 2.3 2.1 2.3 2.6 2.6 2.3 2.1 2.3 2.3 2.3 2.3 2.3 2.3 2.5 2.5 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 GM 1.9 1.9 1.5 0.7 1.5 1.9 1.9 1.5 0.7 1.5 1.5 1.5 2.1 1.5 2.1 1.1 1.1 1.5 1.5 1.5 1.5 1.5 2.1 1.5 1.5 GA 1.9 1.9 1.5 0.7 1.5 1.9 1.9 1.5 0.7 1.5 1.5 1.5 2.1 1.5 2.1 1.1 1.1 1.5 1.5 1.5 1.5 1.5 2.1 1.5 1.5 GC 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.6 GG 1.4 1.4 1.0 1.5 1.0 1.4 1.4 1.0 1.5 1.0 1.0 1.0 1.0 1.0 1.0 1.9 1.9 1.0 2.3 1.0 1.0 1.0 1.0 1.0 2.3 GU 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.6 UM 2.5 2.5 2.1 1.3 2.1 2.5 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 UA 2.5 2.5 2.1 1.3 2.1 2.5 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 UC 2.9 2.9 2.6 2.4 2.6 2.9 2.9 2.6 2.4 2.6 2.6 2.6 2.6 2.6 2.6 2.8 2.8 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.6 UG 2.5 2.5 2.1 1.3 2.1 2.5 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 UU 2.7 2.7 1.7 0.9 1.7 2.7 2.7 1.7 0.9 1.7 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.7 # 5' ------> 3' U X1 Y1 A M X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 MA 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 MC 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 MG 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.4 0.8 1.4 1.8 1.8 2.4 1.8 2.4 0.9 0.9 1.4 1.6 1.4 1.8 1.8 2.1 1.8 1.0 MU 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 AM 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 AA 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 AC 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 AG 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.4 0.8 1.4 1.8 1.8 2.4 1.8 2.4 0.9 0.9 1.4 1.6 1.4 1.8 1.8 2.1 1.8 1.0 AU 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 CM 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 CA 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 CC 2.8 2.8 2.3 2.3 2.3 2.8 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.8 2.4 2.4 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 CG 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 CU 2.5 2.5 2.0 2.0 2.0 2.5 2.5 2.0 2.0 2.0 2.5 2.5 2.5 2.5 2.5 2.1 2.1 2.0 0.9 2.0 2.5 2.5 2.2 2.5 1.6 GM 1.7 1.7 1.3 0.7 1.3 1.7 1.7 1.3 0.7 1.3 1.7 1.7 2.3 1.7 2.3 0.8 0.8 1.3 1.5 1.3 1.7 1.7 2.0 1.7 0.9 GA 1.7 1.7 1.3 0.7 1.3 1.7 1.7 1.3 0.7 1.3 1.7 1.7 2.3 1.7 2.3 0.8 0.8 1.3 1.5 1.3 1.7 1.7 2.0 1.7 0.9 GC 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 GG 1.2 1.2 0.8 1.5 0.8 1.2 1.2 0.8 1.5 0.8 1.2 1.2 1.2 1.2 1.2 1.6 1.6 0.8 2.3 0.8 1.2 1.2 0.9 1.2 1.7 GU 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 UM 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 UA 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 UC 2.8 2.8 2.3 2.3 2.3 2.8 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.8 2.4 2.4 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 UG 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 UU 2.5 2.5 1.5 0.9 1.5 2.5 2.5 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 1.7 1.5 1.9 1.9 1.6 1.9 1.1 # 5' ------> 3' U X1 Y1 M M X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 MA 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 MC 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 MG 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.4 0.8 1.4 1.8 1.8 2.4 1.8 2.4 0.9 0.9 1.4 1.6 1.4 1.8 1.8 2.1 1.8 1.0 MU 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 AM 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 AA 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 2.5 AC 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 AG 1.8 1.8 1.4 0.8 1.4 1.8 1.8 1.4 0.8 1.4 1.8 1.8 2.4 1.8 2.4 0.9 0.9 1.4 1.6 1.4 1.8 1.8 2.1 1.8 1.0 AU 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 CM 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 CA 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 CC 2.8 2.8 2.3 2.3 2.3 2.8 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.8 2.4 2.4 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 CG 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 CU 2.5 2.5 2.0 2.0 2.0 2.5 2.5 2.0 2.0 2.0 2.5 2.5 2.5 2.5 2.5 2.1 2.1 2.0 0.9 2.0 2.5 2.5 2.2 2.5 1.6 GM 1.7 1.7 1.3 0.7 1.3 1.7 1.7 1.3 0.7 1.3 1.7 1.7 2.3 1.7 2.3 0.8 0.8 1.3 1.5 1.3 1.7 1.7 2.0 1.7 0.9 GA 1.7 1.7 1.3 0.7 1.3 1.7 1.7 1.3 0.7 1.3 1.7 1.7 2.3 1.7 2.3 0.8 0.8 1.3 1.5 1.3 1.7 1.7 2.0 1.7 0.9 GC 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 GG 1.2 1.2 0.8 1.5 0.8 1.2 1.2 0.8 1.5 0.8 1.2 1.2 1.2 1.2 1.2 1.6 1.6 0.8 2.3 0.8 1.2 1.2 0.9 1.2 1.7 GU 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.3 1.7 2.3 2.8 2.8 2.8 2.8 2.8 1.8 1.8 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 UM 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 UA 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 UC 2.8 2.8 2.3 2.3 2.3 2.8 2.8 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.8 2.4 2.4 2.3 1.2 2.3 2.8 2.8 2.5 2.8 1.9 UG 2.3 2.3 1.9 1.3 1.9 2.3 2.3 1.9 1.3 1.9 2.3 2.3 2.3 2.3 2.3 1.4 1.4 1.9 0.8 1.9 2.3 2.3 2.0 2.3 1.5 UU 2.5 2.5 1.5 0.9 1.5 2.5 2.5 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 1.7 1.5 1.9 1.9 1.6 1.9 1.1 # 5' ------> 3' U X1 Y1 C M X2 Y2 G # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.7 MA 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.7 MC 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.1 MG 1.2 1.2 0.9 -0.8 0.9 1.2 1.2 0.9 -0.8 0.9 0.9 0.9 1.5 0.9 1.5 -0.2 -0.2 0.9 0.8 0.9 0.9 0.9 1.6 0.9 0.2 MU 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.1 AM 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.7 AA 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.7 AC 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.1 AG 1.2 1.2 0.9 -0.8 0.9 1.2 1.2 0.9 -0.8 0.9 0.9 0.9 1.5 0.9 1.5 -0.2 -0.2 0.9 0.8 0.9 0.9 0.9 1.6 0.9 0.2 AU 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.1 CM 1.7 1.7 1.4 -0.3 1.4 1.7 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 1.4 0.3 0.3 1.4 0.0 1.4 1.4 1.4 1.5 1.4 0.7 CA 1.7 1.7 1.4 -0.3 1.4 1.7 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 1.4 0.3 0.3 1.4 0.0 1.4 1.4 1.4 1.5 1.4 0.7 CC 2.1 2.1 1.9 0.7 1.9 2.1 2.1 1.9 0.7 1.9 1.8 1.8 1.9 1.8 1.9 1.3 1.3 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.1 CG 1.7 1.7 1.4 -0.3 1.4 1.7 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 1.4 0.3 0.3 1.4 0.0 1.4 1.4 1.4 1.5 1.4 0.7 CU 1.8 1.8 1.6 0.4 1.6 1.8 1.8 1.6 0.4 1.6 1.5 1.5 1.6 1.5 1.6 1.0 1.0 1.6 0.2 1.6 1.5 1.5 1.6 1.5 0.8 GM 1.1 1.1 0.8 -0.9 0.8 1.1 1.1 0.8 -0.9 0.8 0.8 0.8 1.4 0.8 1.4 -0.3 -0.3 0.8 0.7 0.8 0.8 0.8 1.5 0.8 0.1 GA 1.1 1.1 0.8 -0.9 0.8 1.1 1.1 0.8 -0.9 0.8 0.8 0.8 1.4 0.8 1.4 -0.3 -0.3 0.8 0.7 0.8 0.8 0.8 1.5 0.8 0.1 GC 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.1 GG 0.6 0.6 0.3 -0.1 0.3 0.6 0.6 0.3 -0.1 0.3 0.3 0.3 0.3 0.3 0.3 0.5 0.5 0.3 1.5 0.3 0.3 0.3 0.4 0.3 0.9 GU 2.1 2.1 1.9 0.1 1.9 2.1 2.1 1.9 0.1 1.9 1.8 1.8 1.9 1.8 1.9 0.7 0.7 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.1 UM 1.7 1.7 1.4 -0.3 1.4 1.7 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 1.4 0.3 0.3 1.4 0.0 1.4 1.4 1.4 1.5 1.4 0.7 UA 1.7 1.7 1.4 -0.3 1.4 1.7 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 1.4 0.3 0.3 1.4 0.0 1.4 1.4 1.4 1.5 1.4 0.7 UC 2.1 2.1 1.9 0.7 1.9 2.1 2.1 1.9 0.7 1.9 1.8 1.8 1.9 1.8 1.9 1.3 1.3 1.9 0.5 1.9 1.8 1.8 1.9 1.8 1.1 UG 1.7 1.7 1.4 -0.3 1.4 1.7 1.7 1.4 -0.3 1.4 1.4 1.4 1.4 1.4 1.4 0.3 0.3 1.4 0.0 1.4 1.4 1.4 1.5 1.4 0.7 UU 1.9 1.9 1.0 -0.7 1.0 1.9 1.9 1.0 -0.7 1.0 1.0 1.0 1.0 1.0 1.0 -0.1 -0.1 1.0 0.9 1.0 1.0 1.0 1.1 1.0 0.3 # 5' ------> 3' U X1 Y1 G M X2 Y2 C # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.8 MA 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.8 MC 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.2 MG 1.0 1.0 1.0 0.1 1.0 1.0 1.0 1.0 0.1 1.0 1.4 1.4 1.9 1.4 1.7 0.1 0.1 1.0 0.8 1.0 1.4 1.4 1.7 1.4 0.2 MU 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.2 AM 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.8 AA 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.8 AC 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.2 AG 1.0 1.0 1.0 0.1 1.0 1.0 1.0 1.0 0.1 1.0 1.4 1.4 1.9 1.4 1.7 0.1 0.1 1.0 0.8 1.0 1.4 1.4 1.7 1.4 0.2 AU 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.2 CM 1.5 1.5 1.5 0.6 1.5 1.5 1.5 1.5 0.6 1.5 1.9 1.9 1.8 1.9 1.6 0.6 0.6 1.5 0.0 1.5 1.9 1.9 1.6 1.9 0.7 CA 1.5 1.5 1.5 0.6 1.5 1.5 1.5 1.5 0.6 1.5 1.9 1.9 1.8 1.9 1.6 0.6 0.6 1.5 0.0 1.5 1.9 1.9 1.6 1.9 0.7 CC 2.0 2.0 1.9 1.6 1.9 2.0 2.0 1.9 1.6 1.9 2.4 2.4 2.2 2.4 2.1 1.6 1.6 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.2 CG 1.5 1.5 1.5 0.6 1.5 1.5 1.5 1.5 0.6 1.5 1.9 1.9 1.8 1.9 1.6 0.6 0.6 1.5 0.0 1.5 1.9 1.9 1.6 1.9 0.7 CU 1.7 1.7 1.6 1.3 1.6 1.7 1.7 1.6 1.3 1.6 2.1 2.1 1.9 2.1 1.8 1.3 1.3 1.6 0.2 1.6 2.1 2.1 1.8 2.1 0.9 GM 0.9 0.9 0.9 0.0 0.9 0.9 0.9 0.9 0.0 0.9 1.3 1.3 1.8 1.3 1.6 0.0 0.0 0.9 0.7 0.9 1.3 1.3 1.6 1.3 0.1 GA 0.9 0.9 0.9 0.0 0.9 0.9 0.9 0.9 0.0 0.9 1.3 1.3 1.8 1.3 1.6 0.0 0.0 0.9 0.7 0.9 1.3 1.3 1.6 1.3 0.1 GC 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.2 GG 0.4 0.4 0.4 0.8 0.4 0.4 0.4 0.4 0.8 0.4 0.8 0.8 0.7 0.8 0.5 0.8 0.8 0.4 1.5 0.4 0.8 0.8 0.5 0.8 0.9 GU 2.0 2.0 1.9 1.0 1.9 2.0 2.0 1.9 1.0 1.9 2.4 2.4 2.2 2.4 2.1 1.0 1.0 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.2 UM 1.5 1.5 1.5 0.6 1.5 1.5 1.5 1.5 0.6 1.5 1.9 1.9 1.8 1.9 1.6 0.6 0.6 1.5 0.0 1.5 1.9 1.9 1.6 1.9 0.7 UA 1.5 1.5 1.5 0.6 1.5 1.5 1.5 1.5 0.6 1.5 1.9 1.9 1.8 1.9 1.6 0.6 0.6 1.5 0.0 1.5 1.9 1.9 1.6 1.9 0.7 UC 2.0 2.0 1.9 1.6 1.9 2.0 2.0 1.9 1.6 1.9 2.4 2.4 2.2 2.4 2.1 1.6 1.6 1.9 0.5 1.9 2.4 2.4 2.1 2.4 1.2 UG 1.5 1.5 1.5 0.6 1.5 1.5 1.5 1.5 0.6 1.5 1.9 1.9 1.8 1.9 1.6 0.6 0.6 1.5 0.0 1.5 1.9 1.9 1.6 1.9 0.7 UU 1.7 1.7 1.1 0.2 1.1 1.7 1.7 1.1 0.2 1.1 1.5 1.5 1.4 1.5 1.2 0.2 0.2 1.1 0.9 1.1 1.5 1.5 1.2 1.5 0.3 # 5' ------> 3' U X1 Y1 U M X2 Y2 A # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 MA 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 MC 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 MG 1.8 1.8 1.6 0.6 1.6 1.8 1.8 1.6 0.6 1.6 1.7 1.7 2.2 1.7 2.2 1.3 1.3 1.6 1.4 1.6 1.7 1.7 2.2 1.7 0.7 MU 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 AM 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 AA 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 AC 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 AG 1.8 1.8 1.6 0.6 1.6 1.8 1.8 1.6 0.6 1.6 1.7 1.7 2.2 1.7 2.2 1.3 1.3 1.6 1.4 1.6 1.7 1.7 2.2 1.7 0.7 AU 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 CM 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 CA 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 CC 2.8 2.8 2.5 2.1 2.5 2.8 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.6 2.8 2.8 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 CG 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 CU 2.5 2.5 2.2 1.8 2.2 2.5 2.5 2.2 1.8 2.2 2.3 2.3 2.3 2.3 2.3 2.5 2.5 2.2 0.7 2.2 2.3 2.3 2.3 2.3 1.4 GM 1.7 1.7 1.5 0.5 1.5 1.7 1.7 1.5 0.5 1.5 1.6 1.6 2.1 1.6 2.1 1.2 1.2 1.5 1.3 1.5 1.6 1.6 2.1 1.6 0.6 GA 1.7 1.7 1.5 0.5 1.5 1.7 1.7 1.5 0.5 1.5 1.6 1.6 2.1 1.6 2.1 1.2 1.2 1.5 1.3 1.5 1.6 1.6 2.1 1.6 0.6 GC 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 GG 1.2 1.2 1.0 1.3 1.0 1.2 1.2 1.0 1.3 1.0 1.1 1.1 1.0 1.1 1.0 2.0 2.0 1.0 2.1 1.0 1.1 1.1 1.0 1.1 1.4 GU 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 UM 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 UA 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 UC 2.8 2.8 2.5 2.1 2.5 2.8 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.6 2.8 2.8 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 UG 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 UU 2.5 2.5 1.7 0.7 1.7 2.5 2.5 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 1.5 1.7 1.8 1.8 1.7 1.8 0.8 # 5' ------> 3' U X1 Y1 U M X2 Y2 M # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 MA 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 MC 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 MG 1.8 1.8 1.6 0.6 1.6 1.8 1.8 1.6 0.6 1.6 1.7 1.7 2.2 1.7 2.2 1.3 1.3 1.6 1.4 1.6 1.7 1.7 2.2 1.7 0.7 MU 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 AM 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 AA 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 2.3 AC 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 AG 1.8 1.8 1.6 0.6 1.6 1.8 1.8 1.6 0.6 1.6 1.7 1.7 2.2 1.7 2.2 1.3 1.3 1.6 1.4 1.6 1.7 1.7 2.2 1.7 0.7 AU 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 CM 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 CA 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 CC 2.8 2.8 2.5 2.1 2.5 2.8 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.6 2.8 2.8 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 CG 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 CU 2.5 2.5 2.2 1.8 2.2 2.5 2.5 2.2 1.8 2.2 2.3 2.3 2.3 2.3 2.3 2.5 2.5 2.2 0.7 2.2 2.3 2.3 2.3 2.3 1.4 GM 1.7 1.7 1.5 0.5 1.5 1.7 1.7 1.5 0.5 1.5 1.6 1.6 2.1 1.6 2.1 1.2 1.2 1.5 1.3 1.5 1.6 1.6 2.1 1.6 0.6 GA 1.7 1.7 1.5 0.5 1.5 1.7 1.7 1.5 0.5 1.5 1.6 1.6 2.1 1.6 2.1 1.2 1.2 1.5 1.3 1.5 1.6 1.6 2.1 1.6 0.6 GC 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 GG 1.2 1.2 1.0 1.3 1.0 1.2 1.2 1.0 1.3 1.0 1.1 1.1 1.0 1.1 1.0 2.0 2.0 1.0 2.1 1.0 1.1 1.1 1.0 1.1 1.4 GU 2.8 2.8 2.5 1.5 2.5 2.8 2.8 2.5 1.5 2.5 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 UM 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 UA 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 UC 2.8 2.8 2.5 2.1 2.5 2.8 2.8 2.5 2.1 2.5 2.6 2.6 2.6 2.6 2.6 2.8 2.8 2.5 1.0 2.5 2.6 2.6 2.6 2.6 1.7 UG 2.3 2.3 2.1 1.1 2.1 2.3 2.3 2.1 1.1 2.1 2.2 2.2 2.1 2.2 2.1 1.8 1.8 2.1 0.6 2.1 2.2 2.2 2.1 2.2 1.2 UU 2.5 2.5 1.7 0.7 1.7 2.5 2.5 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 1.5 1.7 1.8 1.8 1.7 1.8 0.8 # 5' ------> 3' U X1 Y1 G M X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.9 MA 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.9 MC 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 MG 1.0 1.0 1.3 0.0 1.3 1.0 1.0 1.3 0.0 1.3 1.3 1.3 1.9 1.3 1.9 1.6 1.6 1.3 1.3 1.3 1.3 1.3 1.9 1.3 1.3 MU 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 AM 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.9 AA 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.9 AC 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 AG 1.0 1.0 1.3 0.0 1.3 1.0 1.0 1.3 0.0 1.3 1.3 1.3 1.9 1.3 1.9 1.6 1.6 1.3 1.3 1.3 1.3 1.3 1.9 1.3 1.3 AU 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 CM 1.5 1.5 1.8 0.5 1.8 1.5 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 CA 1.5 1.5 1.8 0.5 1.8 1.5 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 CC 1.9 1.9 2.3 1.5 2.3 1.9 1.9 2.3 1.5 2.3 2.3 2.3 2.3 2.3 2.3 3.2 3.2 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 CG 1.5 1.5 1.8 0.5 1.8 1.5 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 CU 1.6 1.6 2.0 1.2 2.0 1.6 1.6 2.0 1.2 2.0 2.0 2.0 2.0 2.0 2.0 2.9 2.9 2.0 0.7 2.0 2.0 2.0 2.0 2.0 2.0 GM 0.9 0.9 1.2 -0.1 1.2 0.9 0.9 1.2 -0.1 1.2 1.2 1.2 1.8 1.2 1.8 1.5 1.5 1.2 1.2 1.2 1.2 1.2 1.8 1.2 1.2 GA 0.9 0.9 1.2 -0.1 1.2 0.9 0.9 1.2 -0.1 1.2 1.2 1.2 1.8 1.2 1.8 1.5 1.5 1.2 1.2 1.2 1.2 1.2 1.8 1.2 1.2 GC 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 GG 0.4 0.4 0.7 0.7 0.7 0.4 0.4 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 2.3 2.3 0.7 2.0 0.7 0.7 0.7 0.7 0.7 2.0 GU 1.9 1.9 2.3 0.9 2.3 1.9 1.9 2.3 0.9 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 UM 1.5 1.5 1.8 0.5 1.8 1.5 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 UA 1.5 1.5 1.8 0.5 1.8 1.5 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 UC 1.9 1.9 2.3 1.5 2.3 1.9 1.9 2.3 1.5 2.3 2.3 2.3 2.3 2.3 2.3 3.2 3.2 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 UG 1.5 1.5 1.8 0.5 1.8 1.5 1.5 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 UU 1.7 1.7 1.4 0.1 1.4 1.7 1.7 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 # 5' ------> 3' U X1 Y1 U M X2 Y2 G # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 3.2 MA 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 3.2 MC 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.6 MG 2.0 2.0 1.6 0.8 1.6 2.0 2.0 1.6 0.8 1.6 1.6 1.6 2.2 1.6 2.2 1.2 1.2 1.6 1.6 1.6 1.6 1.6 2.2 1.6 1.6 MU 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.6 AM 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 3.2 AA 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 3.2 AC 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.6 AG 2.0 2.0 1.6 0.8 1.6 2.0 2.0 1.6 0.8 1.6 1.6 1.6 2.2 1.6 2.2 1.2 1.2 1.6 1.6 1.6 1.6 1.6 2.2 1.6 1.6 AU 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.6 CM 2.5 2.5 2.1 1.3 2.1 2.5 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 CA 2.5 2.5 2.1 1.3 2.1 2.5 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 CC 2.9 2.9 2.6 2.4 2.6 2.9 2.9 2.6 2.4 2.6 2.6 2.6 2.6 2.6 2.6 2.8 2.8 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.6 CG 2.5 2.5 2.1 1.3 2.1 2.5 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 CU 2.6 2.6 2.3 2.1 2.3 2.6 2.6 2.3 2.1 2.3 2.3 2.3 2.3 2.3 2.3 2.5 2.5 2.3 1.0 2.3 2.3 2.3 2.3 2.3 2.3 GM 1.9 1.9 1.5 0.7 1.5 1.9 1.9 1.5 0.7 1.5 1.5 1.5 2.1 1.5 2.1 1.1 1.1 1.5 1.5 1.5 1.5 1.5 2.1 1.5 1.5 GA 1.9 1.9 1.5 0.7 1.5 1.9 1.9 1.5 0.7 1.5 1.5 1.5 2.1 1.5 2.1 1.1 1.1 1.5 1.5 1.5 1.5 1.5 2.1 1.5 1.5 GC 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.6 GG 1.4 1.4 1.0 1.5 1.0 1.4 1.4 1.0 1.5 1.0 1.0 1.0 1.0 1.0 1.0 1.9 1.9 1.0 2.3 1.0 1.0 1.0 1.0 1.0 2.3 GU 2.9 2.9 2.6 1.8 2.6 2.9 2.9 2.6 1.8 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.6 UM 2.5 2.5 2.1 1.3 2.1 2.5 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 UA 2.5 2.5 2.1 1.3 2.1 2.5 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 UC 2.9 2.9 2.6 2.4 2.6 2.9 2.9 2.6 2.4 2.6 2.6 2.6 2.6 2.6 2.6 2.8 2.8 2.6 1.3 2.6 2.6 2.6 2.6 2.6 2.6 UG 2.5 2.5 2.1 1.3 2.1 2.5 2.5 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 UU 2.7 2.7 1.7 0.9 1.7 2.7 2.7 1.7 0.9 1.7 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.7 # 5' ------> 3' G X1 Y1 A U X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.9 2.9 2.5 1.9 2.5 2.9 2.9 2.5 1.9 2.5 2.9 2.9 2.9 2.9 2.9 2.0 2.0 2.5 1.4 2.5 2.9 2.9 2.6 2.9 2.7 MA 2.9 2.9 2.5 1.9 2.5 2.9 2.9 2.5 1.9 2.5 2.9 2.9 2.9 2.9 2.9 2.0 2.0 2.5 1.4 2.5 2.9 2.9 2.6 2.9 2.7 MC 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 MG 2.2 2.2 1.7 1.1 1.7 2.2 2.2 1.7 1.1 1.7 2.2 2.2 2.8 2.2 2.8 1.2 1.2 1.7 1.9 1.7 2.2 2.2 2.5 2.2 1.3 MU 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 AM 2.9 2.9 2.5 1.9 2.5 2.9 2.9 2.5 1.9 2.5 2.9 2.9 2.9 2.9 2.9 2.0 2.0 2.5 1.4 2.5 2.9 2.9 2.6 2.9 2.7 AA 2.9 2.9 2.5 1.9 2.5 2.9 2.9 2.5 1.9 2.5 2.9 2.9 2.9 2.9 2.9 2.0 2.0 2.5 1.4 2.5 2.9 2.9 2.6 2.9 2.7 AC 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 AG 2.2 2.2 1.7 1.1 1.7 2.2 2.2 1.7 1.1 1.7 2.2 2.2 2.8 2.2 2.8 1.2 1.2 1.7 1.9 1.7 2.2 2.2 2.5 2.2 1.3 AU 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 CM 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 CA 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 CC 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 CG 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 CU 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 GM 1.8 1.8 1.3 0.7 1.3 1.8 1.8 1.3 0.7 1.3 1.8 1.8 2.4 1.8 2.4 0.8 0.8 1.3 1.5 1.3 1.8 1.8 2.1 1.8 0.9 GA 1.8 1.8 1.3 0.7 1.3 1.8 1.8 1.3 0.7 1.3 1.8 1.8 2.4 1.8 2.4 0.8 0.8 1.3 1.5 1.3 1.8 1.8 2.1 1.8 0.9 GC 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 GG 1.3 1.3 0.8 1.5 0.8 1.3 1.3 0.8 1.5 0.8 1.3 1.3 1.3 1.3 1.3 1.6 1.6 0.8 2.3 0.8 1.3 1.3 1.0 1.3 1.7 GU 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 UM 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 UA 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 UC 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 UG 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 UU 3.2 3.2 2.1 1.5 2.1 3.2 3.2 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 2.3 2.1 2.6 2.6 2.3 2.6 1.7 # 5' ------> 3' G X1 Y1 M U X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.9 2.9 2.5 1.9 2.5 2.9 2.9 2.5 1.9 2.5 2.9 2.9 2.9 2.9 2.9 2.0 2.0 2.5 1.4 2.5 2.9 2.9 2.6 2.9 2.7 MA 2.9 2.9 2.5 1.9 2.5 2.9 2.9 2.5 1.9 2.5 2.9 2.9 2.9 2.9 2.9 2.0 2.0 2.5 1.4 2.5 2.9 2.9 2.6 2.9 2.7 MC 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 MG 2.2 2.2 1.7 1.1 1.7 2.2 2.2 1.7 1.1 1.7 2.2 2.2 2.8 2.2 2.8 1.2 1.2 1.7 1.9 1.7 2.2 2.2 2.5 2.2 1.3 MU 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 AM 2.9 2.9 2.5 1.9 2.5 2.9 2.9 2.5 1.9 2.5 2.9 2.9 2.9 2.9 2.9 2.0 2.0 2.5 1.4 2.5 2.9 2.9 2.6 2.9 2.7 AA 2.9 2.9 2.5 1.9 2.5 2.9 2.9 2.5 1.9 2.5 2.9 2.9 2.9 2.9 2.9 2.0 2.0 2.5 1.4 2.5 2.9 2.9 2.6 2.9 2.7 AC 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 AG 2.2 2.2 1.7 1.1 1.7 2.2 2.2 1.7 1.1 1.7 2.2 2.2 2.8 2.2 2.8 1.2 1.2 1.7 1.9 1.7 2.2 2.2 2.5 2.2 1.3 AU 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 CM 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 CA 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 CC 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 CG 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 CU 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 GM 1.8 1.8 1.3 0.7 1.3 1.8 1.8 1.3 0.7 1.3 1.8 1.8 2.4 1.8 2.4 0.8 0.8 1.3 1.5 1.3 1.8 1.8 2.1 1.8 0.9 GA 1.8 1.8 1.3 0.7 1.3 1.8 1.8 1.3 0.7 1.3 1.8 1.8 2.4 1.8 2.4 0.8 0.8 1.3 1.5 1.3 1.8 1.8 2.1 1.8 0.9 GC 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 GG 1.3 1.3 0.8 1.5 0.8 1.3 1.3 0.8 1.5 0.8 1.3 1.3 1.3 1.3 1.3 1.6 1.6 0.8 2.3 0.8 1.3 1.3 1.0 1.3 1.7 GU 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 UM 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 UA 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 UC 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 UG 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 1.0 2.1 2.6 2.6 2.3 2.6 1.7 UU 3.2 3.2 2.1 1.5 2.1 3.2 3.2 2.1 1.5 2.1 2.6 2.6 2.6 2.6 2.6 1.6 1.6 2.1 2.3 2.1 2.6 2.6 2.3 2.6 1.7 # 5' ------> 3' G X1 Y1 C U X2 Y2 G # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.3 2.3 2.0 0.2 2.0 2.3 2.3 2.0 0.2 2.0 2.0 2.0 2.0 2.0 2.0 0.9 0.9 2.0 0.6 2.0 2.0 2.0 2.1 2.0 1.9 MA 2.3 2.3 2.0 0.2 2.0 2.3 2.3 2.0 0.2 2.0 2.0 2.0 2.0 2.0 2.0 0.9 0.9 2.0 0.6 2.0 2.0 2.0 2.1 2.0 1.9 MC 1.9 1.9 1.7 -0.1 1.7 1.9 1.9 1.7 -0.1 1.7 1.6 1.6 1.7 1.6 1.7 0.5 0.5 1.7 0.3 1.7 1.6 1.6 1.7 1.6 0.9 MG 1.5 1.5 1.3 -0.5 1.3 1.5 1.5 1.3 -0.5 1.3 1.2 1.2 1.9 1.2 1.9 0.1 0.1 1.3 1.2 1.3 1.2 1.2 1.9 1.2 0.5 MU 1.9 1.9 1.7 -0.1 1.7 1.9 1.9 1.7 -0.1 1.7 1.6 1.6 1.7 1.6 1.7 0.5 0.5 1.7 0.3 1.7 1.6 1.6 1.7 1.6 0.9 AM 2.3 2.3 2.0 0.2 2.0 2.3 2.3 2.0 0.2 2.0 2.0 2.0 2.0 2.0 2.0 0.9 0.9 2.0 0.6 2.0 2.0 2.0 2.1 2.0 1.9 AA 2.3 2.3 2.0 0.2 2.0 2.3 2.3 2.0 0.2 2.0 2.0 2.0 2.0 2.0 2.0 0.9 0.9 2.0 0.6 2.0 2.0 2.0 2.1 2.0 1.9 AC 1.9 1.9 1.7 -0.1 1.7 1.9 1.9 1.7 -0.1 1.7 1.6 1.6 1.7 1.6 1.7 0.5 0.5 1.7 0.3 1.7 1.6 1.6 1.7 1.6 0.9 AG 1.5 1.5 1.3 -0.5 1.3 1.5 1.5 1.3 -0.5 1.3 1.2 1.2 1.9 1.2 1.9 0.1 0.1 1.3 1.2 1.3 1.2 1.2 1.9 1.2 0.5 AU 1.9 1.9 1.7 -0.1 1.7 1.9 1.9 1.7 -0.1 1.7 1.6 1.6 1.7 1.6 1.7 0.5 0.5 1.7 0.3 1.7 1.6 1.6 1.7 1.6 0.9 CM 1.9 1.9 1.7 -0.1 1.7 1.9 1.9 1.7 -0.1 1.7 1.6 1.6 1.7 1.6 1.7 0.5 0.5 1.7 0.3 1.7 1.6 1.6 1.7 1.6 0.9 CA 1.9 1.9 1.7 -0.1 1.7 1.9 1.9 1.7 -0.1 1.7 1.6 1.6 1.7 1.6 1.7 0.5 0.5 1.7 0.3 1.7 1.6 1.6 1.7 1.6 0.9 CC 1.9 1.9 1.7 0.5 1.7 1.9 1.9 1.7 0.5 1.7 1.6 1.6 1.7 1.6 1.7 1.1 1.1 1.7 0.3 1.7 1.6 1.6 1.7 1.6 0.9 CG 1.9 1.9 1.7 -0.1 1.7 1.9 1.9 1.7 -0.1 1.7 1.6 1.6 1.7 1.6 1.7 0.5 0.5 1.7 0.3 1.7 1.6 1.6 1.7 1.6 0.9 CU 1.9 1.9 1.7 0.5 1.7 1.9 1.9 1.7 0.5 1.7 1.6 1.6 1.7 1.6 1.7 1.1 1.1 1.7 0.3 1.7 1.6 1.6 1.7 1.6 0.9 GM 1.1 1.1 0.9 -0.9 0.9 1.1 1.1 0.9 -0.9 0.9 0.8 0.8 1.5 0.8 1.5 -0.3 -0.3 0.9 0.8 0.9 0.8 0.8 1.5 0.8 0.1 GA 1.1 1.1 0.9 -0.9 0.9 1.1 1.1 0.9 -0.9 0.9 0.8 0.8 1.5 0.8 1.5 -0.3 -0.3 0.9 0.8 0.9 0.8 0.8 1.5 0.8 0.1 GC 1.9 1.9 1.7 -0.1 1.7 1.9 1.9 1.7 -0.1 1.7 1.6 1.6 1.7 1.6 1.7 0.5 0.5 1.7 0.3 1.7 1.6 1.6 1.7 1.6 0.9 GG 0.6 0.6 0.4 -0.1 0.4 0.6 0.6 0.4 -0.1 0.4 0.3 0.3 0.4 0.3 0.4 0.5 0.5 0.4 1.6 0.4 0.3 0.3 0.4 0.3 0.9 GU 1.9 1.9 1.7 -0.1 1.7 1.9 1.9 1.7 -0.1 1.7 1.6 1.6 1.7 1.6 1.7 0.5 0.5 1.7 0.3 1.7 1.6 1.6 1.7 1.6 0.9 UM 1.9 1.9 1.7 -0.1 1.7 1.9 1.9 1.7 -0.1 1.7 1.6 1.6 1.7 1.6 1.7 0.5 0.5 1.7 0.3 1.7 1.6 1.6 1.7 1.6 0.9 UA 1.9 1.9 1.7 -0.1 1.7 1.9 1.9 1.7 -0.1 1.7 1.6 1.6 1.7 1.6 1.7 0.5 0.5 1.7 0.3 1.7 1.6 1.6 1.7 1.6 0.9 UC 1.9 1.9 1.7 0.5 1.7 1.9 1.9 1.7 0.5 1.7 1.6 1.6 1.7 1.6 1.7 1.1 1.1 1.7 0.3 1.7 1.6 1.6 1.7 1.6 0.9 UG 1.9 1.9 1.7 -0.1 1.7 1.9 1.9 1.7 -0.1 1.7 1.6 1.6 1.7 1.6 1.7 0.5 0.5 1.7 0.3 1.7 1.6 1.6 1.7 1.6 0.9 UU 2.5 2.5 1.7 -0.1 1.7 2.5 2.5 1.7 -0.1 1.7 1.6 1.6 1.7 1.6 1.7 0.5 0.5 1.7 1.6 1.7 1.6 1.6 1.7 1.6 0.9 # 5' ------> 3' G X1 Y1 G U X2 Y2 C # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.2 2.2 2.1 1.2 2.1 2.2 2.2 2.1 1.2 2.1 2.5 2.5 2.4 2.5 2.2 1.2 1.2 2.1 0.6 2.1 2.5 2.5 2.2 2.5 1.9 MA 2.2 2.2 2.1 1.2 2.1 2.2 2.2 2.1 1.2 2.1 2.5 2.5 2.4 2.5 2.2 1.2 1.2 2.1 0.6 2.1 2.5 2.5 2.2 2.5 1.9 MC 1.8 1.8 1.7 0.8 1.7 1.8 1.8 1.7 0.8 1.7 2.2 2.2 2.0 2.2 1.9 0.8 0.8 1.7 0.3 1.7 2.2 2.2 1.9 2.2 1.0 MG 1.4 1.4 1.3 0.4 1.3 1.4 1.4 1.3 0.4 1.3 1.8 1.8 2.2 1.8 2.1 0.4 0.4 1.3 1.2 1.3 1.8 1.8 2.1 1.8 0.6 MU 1.8 1.8 1.7 0.8 1.7 1.8 1.8 1.7 0.8 1.7 2.2 2.2 2.0 2.2 1.9 0.8 0.8 1.7 0.3 1.7 2.2 2.2 1.9 2.2 1.0 AM 2.2 2.2 2.1 1.2 2.1 2.2 2.2 2.1 1.2 2.1 2.5 2.5 2.4 2.5 2.2 1.2 1.2 2.1 0.6 2.1 2.5 2.5 2.2 2.5 1.9 AA 2.2 2.2 2.1 1.2 2.1 2.2 2.2 2.1 1.2 2.1 2.5 2.5 2.4 2.5 2.2 1.2 1.2 2.1 0.6 2.1 2.5 2.5 2.2 2.5 1.9 AC 1.8 1.8 1.7 0.8 1.7 1.8 1.8 1.7 0.8 1.7 2.2 2.2 2.0 2.2 1.9 0.8 0.8 1.7 0.3 1.7 2.2 2.2 1.9 2.2 1.0 AG 1.4 1.4 1.3 0.4 1.3 1.4 1.4 1.3 0.4 1.3 1.8 1.8 2.2 1.8 2.1 0.4 0.4 1.3 1.2 1.3 1.8 1.8 2.1 1.8 0.6 AU 1.8 1.8 1.7 0.8 1.7 1.8 1.8 1.7 0.8 1.7 2.2 2.2 2.0 2.2 1.9 0.8 0.8 1.7 0.3 1.7 2.2 2.2 1.9 2.2 1.0 CM 1.8 1.8 1.7 0.8 1.7 1.8 1.8 1.7 0.8 1.7 2.2 2.2 2.0 2.2 1.9 0.8 0.8 1.7 0.3 1.7 2.2 2.2 1.9 2.2 1.0 CA 1.8 1.8 1.7 0.8 1.7 1.8 1.8 1.7 0.8 1.7 2.2 2.2 2.0 2.2 1.9 0.8 0.8 1.7 0.3 1.7 2.2 2.2 1.9 2.2 1.0 CC 1.8 1.8 1.7 1.4 1.7 1.8 1.8 1.7 1.4 1.7 2.2 2.2 2.0 2.2 1.9 1.4 1.4 1.7 0.3 1.7 2.2 2.2 1.9 2.2 1.0 CG 1.8 1.8 1.7 0.8 1.7 1.8 1.8 1.7 0.8 1.7 2.2 2.2 2.0 2.2 1.9 0.8 0.8 1.7 0.3 1.7 2.2 2.2 1.9 2.2 1.0 CU 1.8 1.8 1.7 1.4 1.7 1.8 1.8 1.7 1.4 1.7 2.2 2.2 2.0 2.2 1.9 1.4 1.4 1.7 0.3 1.7 2.2 2.2 1.9 2.2 1.0 GM 1.0 1.0 0.9 0.0 0.9 1.0 1.0 0.9 0.0 0.9 1.4 1.4 1.8 1.4 1.7 0.0 0.0 0.9 0.8 0.9 1.4 1.4 1.7 1.4 0.2 GA 1.0 1.0 0.9 0.0 0.9 1.0 1.0 0.9 0.0 0.9 1.4 1.4 1.8 1.4 1.7 0.0 0.0 0.9 0.8 0.9 1.4 1.4 1.7 1.4 0.2 GC 1.8 1.8 1.7 0.8 1.7 1.8 1.8 1.7 0.8 1.7 2.2 2.2 2.0 2.2 1.9 0.8 0.8 1.7 0.3 1.7 2.2 2.2 1.9 2.2 1.0 GG 0.5 0.5 0.4 0.8 0.4 0.5 0.5 0.4 0.8 0.4 0.9 0.9 0.7 0.9 0.6 0.8 0.8 0.4 1.6 0.4 0.9 0.9 0.6 0.9 1.0 GU 1.8 1.8 1.7 0.8 1.7 1.8 1.8 1.7 0.8 1.7 2.2 2.2 2.0 2.2 1.9 0.8 0.8 1.7 0.3 1.7 2.2 2.2 1.9 2.2 1.0 UM 1.8 1.8 1.7 0.8 1.7 1.8 1.8 1.7 0.8 1.7 2.2 2.2 2.0 2.2 1.9 0.8 0.8 1.7 0.3 1.7 2.2 2.2 1.9 2.2 1.0 UA 1.8 1.8 1.7 0.8 1.7 1.8 1.8 1.7 0.8 1.7 2.2 2.2 2.0 2.2 1.9 0.8 0.8 1.7 0.3 1.7 2.2 2.2 1.9 2.2 1.0 UC 1.8 1.8 1.7 1.4 1.7 1.8 1.8 1.7 1.4 1.7 2.2 2.2 2.0 2.2 1.9 1.4 1.4 1.7 0.3 1.7 2.2 2.2 1.9 2.2 1.0 UG 1.8 1.8 1.7 0.8 1.7 1.8 1.8 1.7 0.8 1.7 2.2 2.2 2.0 2.2 1.9 0.8 0.8 1.7 0.3 1.7 2.2 2.2 1.9 2.2 1.0 UU 2.4 2.4 1.7 0.8 1.7 2.4 2.4 1.7 0.8 1.7 2.2 2.2 2.0 2.2 1.9 0.8 0.8 1.7 1.6 1.7 2.2 2.2 1.9 2.2 1.0 # 5' ------> 3' G X1 Y1 U U X2 Y2 A # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.9 2.9 2.7 1.7 2.7 2.9 2.9 2.7 1.7 2.7 2.8 2.8 2.7 2.8 2.7 2.4 2.4 2.7 1.2 2.7 2.8 2.8 2.7 2.8 2.4 MA 2.9 2.9 2.7 1.7 2.7 2.9 2.9 2.7 1.7 2.7 2.8 2.8 2.7 2.8 2.7 2.4 2.4 2.7 1.2 2.7 2.8 2.8 2.7 2.8 2.4 MC 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 MG 2.2 2.2 1.9 0.9 1.9 2.2 2.2 1.9 0.9 1.9 2.0 2.0 2.6 2.0 2.6 1.6 1.6 1.9 1.7 1.9 2.0 2.0 2.6 2.0 1.1 MU 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 AM 2.9 2.9 2.7 1.7 2.7 2.9 2.9 2.7 1.7 2.7 2.8 2.8 2.7 2.8 2.7 2.4 2.4 2.7 1.2 2.7 2.8 2.8 2.7 2.8 2.4 AA 2.9 2.9 2.7 1.7 2.7 2.9 2.9 2.7 1.7 2.7 2.8 2.8 2.7 2.8 2.7 2.4 2.4 2.7 1.2 2.7 2.8 2.8 2.7 2.8 2.4 AC 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 AG 2.2 2.2 1.9 0.9 1.9 2.2 2.2 1.9 0.9 1.9 2.0 2.0 2.6 2.0 2.6 1.6 1.6 1.9 1.7 1.9 2.0 2.0 2.6 2.0 1.1 AU 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 CM 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 CA 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 CC 2.6 2.6 2.3 1.9 2.3 2.6 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 CG 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 CU 2.6 2.6 2.3 1.9 2.3 2.6 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 GM 1.8 1.8 1.5 0.5 1.5 1.8 1.8 1.5 0.5 1.5 1.6 1.6 2.2 1.6 2.2 1.2 1.2 1.5 1.3 1.5 1.6 1.6 2.2 1.6 0.7 GA 1.8 1.8 1.5 0.5 1.5 1.8 1.8 1.5 0.5 1.5 1.6 1.6 2.2 1.6 2.2 1.2 1.2 1.5 1.3 1.5 1.6 1.6 2.2 1.6 0.7 GC 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 GG 1.3 1.3 1.0 1.3 1.0 1.3 1.3 1.0 1.3 1.0 1.1 1.1 1.1 1.1 1.1 2.0 2.0 1.0 2.1 1.0 1.1 1.1 1.1 1.1 1.5 GU 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 UM 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 UA 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 UC 2.6 2.6 2.3 1.9 2.3 2.6 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 UG 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 UU 3.2 3.2 2.3 1.3 2.3 3.2 3.2 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 2.1 2.3 2.4 2.4 2.4 2.4 1.5 # 5' ------> 3' G X1 Y1 U U X2 Y2 M # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.9 2.9 2.7 1.7 2.7 2.9 2.9 2.7 1.7 2.7 2.8 2.8 2.7 2.8 2.7 2.4 2.4 2.7 1.2 2.7 2.8 2.8 2.7 2.8 2.4 MA 2.9 2.9 2.7 1.7 2.7 2.9 2.9 2.7 1.7 2.7 2.8 2.8 2.7 2.8 2.7 2.4 2.4 2.7 1.2 2.7 2.8 2.8 2.7 2.8 2.4 MC 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 MG 2.2 2.2 1.9 0.9 1.9 2.2 2.2 1.9 0.9 1.9 2.0 2.0 2.6 2.0 2.6 1.6 1.6 1.9 1.7 1.9 2.0 2.0 2.6 2.0 1.1 MU 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 AM 2.9 2.9 2.7 1.7 2.7 2.9 2.9 2.7 1.7 2.7 2.8 2.8 2.7 2.8 2.7 2.4 2.4 2.7 1.2 2.7 2.8 2.8 2.7 2.8 2.4 AA 2.9 2.9 2.7 1.7 2.7 2.9 2.9 2.7 1.7 2.7 2.8 2.8 2.7 2.8 2.7 2.4 2.4 2.7 1.2 2.7 2.8 2.8 2.7 2.8 2.4 AC 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 AG 2.2 2.2 1.9 0.9 1.9 2.2 2.2 1.9 0.9 1.9 2.0 2.0 2.6 2.0 2.6 1.6 1.6 1.9 1.7 1.9 2.0 2.0 2.6 2.0 1.1 AU 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 CM 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 CA 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 CC 2.6 2.6 2.3 1.9 2.3 2.6 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 CG 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 CU 2.6 2.6 2.3 1.9 2.3 2.6 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 GM 1.8 1.8 1.5 0.5 1.5 1.8 1.8 1.5 0.5 1.5 1.6 1.6 2.2 1.6 2.2 1.2 1.2 1.5 1.3 1.5 1.6 1.6 2.2 1.6 0.7 GA 1.8 1.8 1.5 0.5 1.5 1.8 1.8 1.5 0.5 1.5 1.6 1.6 2.2 1.6 2.2 1.2 1.2 1.5 1.3 1.5 1.6 1.6 2.2 1.6 0.7 GC 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 GG 1.3 1.3 1.0 1.3 1.0 1.3 1.3 1.0 1.3 1.0 1.1 1.1 1.1 1.1 1.1 2.0 2.0 1.0 2.1 1.0 1.1 1.1 1.1 1.1 1.5 GU 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 UM 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 UA 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 UC 2.6 2.6 2.3 1.9 2.3 2.6 2.6 2.3 1.9 2.3 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 UG 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 0.8 2.3 2.4 2.4 2.4 2.4 1.5 UU 3.2 3.2 2.3 1.3 2.3 3.2 3.2 2.3 1.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.3 2.1 2.3 2.4 2.4 2.4 2.4 1.5 # 5' ------> 3' G X1 Y1 G U X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.6 2.6 2.4 1.2 2.4 2.6 2.6 2.4 1.2 2.4 2.4 2.4 2.4 2.4 2.4 2.7 2.7 2.4 1.1 2.4 2.4 2.4 2.4 2.4 3.0 MA 2.6 2.6 2.4 1.2 2.4 2.6 2.6 2.4 1.2 2.4 2.4 2.4 2.4 2.4 2.4 2.7 2.7 2.4 1.1 2.4 2.4 2.4 2.4 2.4 3.0 MC 1.7 1.7 2.1 0.7 2.1 1.7 1.7 2.1 0.7 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 MG 2.6 2.6 1.7 0.3 1.7 2.6 2.6 1.7 0.3 1.7 1.7 1.7 2.3 1.7 2.3 2.0 2.0 1.7 1.7 1.7 1.7 1.7 2.3 1.7 1.7 MU 1.7 1.7 2.1 0.7 2.1 1.7 1.7 2.1 0.7 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 AM 2.6 2.6 2.4 1.2 2.4 2.6 2.6 2.4 1.2 2.4 2.4 2.4 2.4 2.4 2.4 2.7 2.7 2.4 1.1 2.4 2.4 2.4 2.4 2.4 3.0 AA 2.6 2.6 2.4 1.2 2.4 2.6 2.6 2.4 1.2 2.4 2.4 2.4 2.4 2.4 2.4 2.7 2.7 2.4 1.1 2.4 2.4 2.4 2.4 2.4 3.0 AC 1.7 1.7 2.1 0.7 2.1 1.7 1.7 2.1 0.7 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 AG 2.6 2.6 1.7 0.3 1.7 2.6 2.6 1.7 0.3 1.7 1.7 1.7 2.3 1.7 2.3 2.0 2.0 1.7 1.7 1.7 1.7 1.7 2.3 1.7 1.7 AU 1.7 1.7 2.1 0.7 2.1 1.7 1.7 2.1 0.7 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 CM 1.7 1.7 2.1 0.7 2.1 1.7 1.7 2.1 0.7 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 CA 1.7 1.7 2.1 0.7 2.1 1.7 1.7 2.1 0.7 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 CC 1.7 1.7 2.1 1.3 2.1 1.7 1.7 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 3.0 3.0 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 CG 1.7 1.7 2.1 0.7 2.1 1.7 1.7 2.1 0.7 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 CU 1.7 1.7 2.1 1.3 2.1 1.7 1.7 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 3.0 3.0 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 GM 0.9 0.9 1.3 -0.8 1.3 0.9 0.9 1.3 -0.8 1.3 1.3 1.3 1.9 1.3 1.9 1.6 1.6 1.3 1.3 1.3 1.3 1.3 1.9 1.3 1.3 GA 0.9 0.9 1.3 -0.8 1.3 0.9 0.9 1.3 -0.8 1.3 1.3 1.3 1.9 1.3 1.9 1.6 1.6 1.3 1.3 1.3 1.3 1.3 1.9 1.3 1.3 GC 1.7 1.7 2.1 0.7 2.1 1.7 1.7 2.1 0.7 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 GG 0.4 0.4 0.8 0.7 0.8 0.4 0.4 0.8 0.7 0.8 0.8 0.8 0.8 0.8 0.8 2.4 2.4 0.8 2.1 0.8 0.8 0.8 0.8 0.8 2.1 GU 1.7 1.7 2.1 0.7 2.1 1.7 1.7 2.1 0.7 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 UM 1.7 1.7 2.1 0.7 2.1 1.7 1.7 2.1 0.7 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 UA 1.7 1.7 2.1 0.7 2.1 1.7 1.7 2.1 0.7 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 UC 1.7 1.7 2.1 1.3 2.1 1.7 1.7 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 3.0 3.0 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 UG 1.7 1.7 2.1 0.7 2.1 1.7 1.7 2.1 0.7 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 UU 2.3 2.3 2.1 0.7 2.1 2.3 2.3 2.1 0.7 2.1 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.1 2.1 2.1 2.1 2.1 2.1 2.1 2.1 # 5' ------> 3' G X1 Y1 U U X2 Y2 G # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 3.1 3.1 2.7 1.9 2.7 3.1 3.1 2.7 1.9 2.7 2.7 2.7 2.7 2.7 2.7 2.3 2.3 2.7 1.4 2.7 2.7 2.7 2.7 2.7 3.3 MA 3.1 3.1 2.7 1.9 2.7 3.1 3.1 2.7 1.9 2.7 2.7 2.7 2.7 2.7 2.7 2.3 2.3 2.7 1.4 2.7 2.7 2.7 2.7 2.7 3.3 MC 2.7 2.7 2.4 1.6 2.4 2.7 2.7 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 MG 2.3 2.3 2.0 1.2 2.0 2.3 2.3 2.0 1.2 2.0 2.0 2.0 2.6 2.0 2.6 1.6 1.6 2.0 2.0 2.0 2.0 2.0 2.6 2.0 2.0 MU 2.7 2.7 2.4 1.6 2.4 2.7 2.7 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 AM 3.1 3.1 2.7 1.9 2.7 3.1 3.1 2.7 1.9 2.7 2.7 2.7 2.7 2.7 2.7 2.3 2.3 2.7 1.4 2.7 2.7 2.7 2.7 2.7 3.3 AA 3.1 3.1 2.7 1.9 2.7 3.1 3.1 2.7 1.9 2.7 2.7 2.7 2.7 2.7 2.7 2.3 2.3 2.7 1.4 2.7 2.7 2.7 2.7 2.7 3.3 AC 2.7 2.7 2.4 1.6 2.4 2.7 2.7 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 AG 2.3 2.3 2.0 1.2 2.0 2.3 2.3 2.0 1.2 2.0 2.0 2.0 2.6 2.0 2.6 1.6 1.6 2.0 2.0 2.0 2.0 2.0 2.6 2.0 2.0 AU 2.7 2.7 2.4 1.6 2.4 2.7 2.7 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 CM 2.7 2.7 2.4 1.6 2.4 2.7 2.7 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 CA 2.7 2.7 2.4 1.6 2.4 2.7 2.7 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 CC 2.7 2.7 2.4 2.2 2.4 2.7 2.7 2.4 2.2 2.4 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 CG 2.7 2.7 2.4 1.6 2.4 2.7 2.7 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 CU 2.7 2.7 2.4 2.2 2.4 2.7 2.7 2.4 2.2 2.4 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 GM 1.9 1.9 1.6 0.5 1.6 1.9 1.9 1.6 0.8 1.6 1.6 1.6 2.2 1.6 2.2 1.2 1.2 1.6 1.6 1.6 1.6 1.6 2.2 1.6 1.6 GA 1.9 1.9 1.6 0.8 1.6 1.9 1.9 1.6 0.8 1.6 1.6 1.6 2.2 1.6 2.2 1.2 1.2 1.6 1.6 1.6 1.6 1.6 2.2 1.6 1.6 GC 2.7 2.7 2.4 1.6 2.4 2.7 2.7 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 GG 1.4 1.4 1.1 1.6 1.1 1.4 1.4 1.1 1.6 1.1 1.1 1.1 1.1 1.1 1.1 2.0 2.0 1.1 2.4 1.1 1.1 1.1 1.1 1.1 2.4 GU 2.7 2.7 2.4 1.6 2.4 2.7 2.7 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 UM 2.7 2.7 2.4 1.6 2.4 2.7 2.7 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 UA 2.7 2.7 2.4 1.6 2.4 2.7 2.7 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 UC 2.7 2.7 2.4 2.2 2.4 2.7 2.7 2.4 2.2 2.4 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 UG 2.7 2.7 2.4 1.6 2.4 2.7 2.7 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 1.1 2.4 2.4 2.4 2.4 2.4 2.4 UU 3.3 3.3 2.4 1.6 2.4 3.3 3.3 2.4 1.6 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 # 5' ------> 3' U X1 Y1 A G X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 0.4 1.5 1.9 1.9 1.6 1.9 1.7 MA 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 0.4 1.5 1.9 1.9 1.6 1.9 1.7 MC 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 MG 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 3.2 2.6 3.2 1.6 1.6 2.1 2.3 2.1 2.6 2.6 2.9 2.6 1.7 MU 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 AM 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 0.4 1.5 1.9 1.9 1.6 1.9 1.7 AA 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 0.4 1.5 1.9 1.9 1.6 1.9 1.7 AC 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 AG 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 3.2 2.6 3.2 1.6 1.6 2.1 2.3 2.1 2.6 2.6 2.9 2.6 1.7 AU 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 CM 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 CA 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 CC 2.3 2.3 1.8 1.8 1.8 2.3 2.3 1.8 1.8 1.8 2.3 2.3 2.3 2.3 2.3 1.9 1.9 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 CG 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 CU 2.3 2.3 1.8 1.8 1.8 2.3 2.3 1.8 1.8 1.8 2.3 2.3 2.3 2.3 2.3 1.9 1.9 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 GM 0.9 0.9 0.5 -0.1 0.5 0.9 0.9 0.5 -0.1 0.5 0.9 0.9 1.5 0.9 1.5 0.0 0.0 0.5 0.7 0.5 0.9 0.9 1.2 0.9 0.1 GA 0.9 0.9 0.5 -0.1 0.5 0.9 0.9 0.5 -0.1 0.5 0.9 0.9 1.5 0.9 1.5 0.0 0.0 0.5 0.7 0.5 0.9 0.9 1.2 0.9 0.1 GC 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 GG 1.0 1.0 0.5 1.2 0.5 1.0 1.0 0.5 1.2 0.5 1.0 1.0 1.0 1.0 1.0 1.3 1.3 0.5 2.0 0.5 1.0 1.0 0.7 1.0 1.4 GU 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 UM 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 UA 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 UC 2.3 2.3 1.8 1.8 1.8 2.3 2.3 1.8 1.8 1.8 2.3 2.3 2.3 2.3 2.3 1.9 1.9 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 UG 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 UU 2.9 2.9 1.8 1.2 1.8 2.9 2.9 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 2.0 1.8 2.3 2.3 2.0 2.3 1.4 # 5' ------> 3' U X1 Y1 M G X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 0.4 1.5 1.9 1.9 1.6 1.9 1.7 MA 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 0.4 1.5 1.9 1.9 1.6 1.9 1.7 MC 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 MG 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 3.2 2.6 3.2 1.6 1.6 2.1 2.3 2.1 2.6 2.6 2.9 2.6 1.7 MU 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 AM 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 0.4 1.5 1.9 1.9 1.6 1.9 1.7 AA 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.5 0.9 1.5 1.9 1.9 1.9 1.9 1.9 1.0 1.0 1.5 0.4 1.5 1.9 1.9 1.6 1.9 1.7 AC 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 AG 2.6 2.6 2.1 1.5 2.1 2.6 2.6 2.1 1.5 2.1 2.6 2.6 3.2 2.6 3.2 1.6 1.6 2.1 2.3 2.1 2.6 2.6 2.9 2.6 1.7 AU 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 CM 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 CA 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 CC 2.3 2.3 1.8 1.8 1.8 2.3 2.3 1.8 1.8 1.8 2.3 2.3 2.3 2.3 2.3 1.9 1.9 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 CG 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 CU 2.3 2.3 1.8 1.8 1.8 2.3 2.3 1.8 1.8 1.8 2.3 2.3 2.3 2.3 2.3 1.9 1.9 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 GM 0.9 0.9 0.5 -0.1 0.5 0.9 0.9 0.5 -0.1 0.5 0.9 0.9 1.5 0.9 1.5 0.0 0.0 0.5 0.7 0.5 0.9 0.9 1.2 0.9 0.1 GA 0.9 0.9 0.5 -0.1 0.5 0.9 0.9 0.5 -0.1 0.5 0.9 0.9 1.5 0.9 1.5 0.0 0.0 0.5 0.7 0.5 0.9 0.9 1.2 0.9 0.1 GC 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 GG 1.0 1.0 0.5 1.2 0.5 1.0 1.0 0.5 1.2 0.5 1.0 1.0 1.0 1.0 1.0 1.3 1.3 0.5 2.0 0.5 1.0 1.0 0.7 1.0 1.4 GU 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 UM 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 UA 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 UC 2.3 2.3 1.8 1.8 1.8 2.3 2.3 1.8 1.8 1.8 2.3 2.3 2.3 2.3 2.3 1.9 1.9 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 UG 2.3 2.3 1.8 1.2 1.8 2.3 2.3 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 0.7 1.8 2.3 2.3 2.0 2.3 1.4 UU 2.9 2.9 1.8 1.2 1.8 2.9 2.9 1.8 1.2 1.8 2.3 2.3 2.3 2.3 2.3 1.3 1.3 1.8 2.0 1.8 2.3 2.3 2.0 2.3 1.4 # 5' ------> 3' U X1 Y1 C G X2 Y2 G # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 1.4 1.4 1.0 -0.7 1.0 1.4 1.4 1.0 -0.7 1.0 1.0 1.0 1.0 1.0 1.0 -0.1 -0.1 1.0 -0.4 1.0 1.0 1.0 1.1 1.0 0.9 MA 1.4 1.4 1.0 -0.7 1.0 1.4 1.4 1.0 -0.7 1.0 1.0 1.0 1.0 1.0 1.0 -0.1 -0.1 1.0 -0.4 1.0 1.0 1.0 1.1 1.0 0.9 MC 1.6 1.6 1.4 -0.4 1.4 1.6 1.6 1.4 -0.4 1.4 1.3 1.3 1.4 1.3 1.4 0.2 0.2 1.4 0.0 1.4 1.3 1.3 1.4 1.3 0.6 MG 1.9 1.9 1.7 -0.1 1.7 1.9 1.9 1.7 -0.1 1.7 1.6 1.6 2.3 1.6 2.3 0.5 0.5 1.7 1.6 1.7 1.6 1.6 2.3 1.6 0.9 MU 1.6 1.6 1.4 -0.4 1.4 1.6 1.6 1.4 -0.4 1.4 1.3 1.3 1.4 1.3 1.4 0.2 0.2 1.4 0.0 1.4 1.3 1.3 1.4 1.3 0.6 AM 1.4 1.4 1.0 -0.7 1.0 1.4 1.4 1.0 -0.7 1.0 1.0 1.0 1.0 1.0 1.0 -0.1 -0.1 1.0 -0.4 1.0 1.0 1.0 1.1 1.0 0.9 AA 1.4 1.4 1.0 -0.7 1.0 1.4 1.4 1.0 -0.7 1.0 1.0 1.0 1.0 1.0 1.0 -0.1 -0.1 1.0 -0.4 1.0 1.0 1.0 1.1 1.0 0.9 AC 1.6 1.6 1.4 -0.4 1.4 1.6 1.6 1.4 -0.4 1.4 1.3 1.3 1.4 1.3 1.4 0.2 0.2 1.4 0.0 1.4 1.3 1.3 1.4 1.3 0.6 AG 1.9 1.9 1.7 -0.1 1.7 1.9 1.9 1.7 -0.1 1.7 1.6 1.6 2.3 1.6 2.3 0.5 0.5 1.7 1.6 1.7 1.6 1.6 2.3 1.6 0.9 AU 1.6 1.6 1.4 -0.4 1.4 1.6 1.6 1.4 -0.4 1.4 1.3 1.3 1.4 1.3 1.4 0.2 0.2 1.4 0.0 1.4 1.3 1.3 1.4 1.3 0.6 CM 1.6 1.6 1.4 -0.4 1.4 1.6 1.6 1.4 -0.4 1.4 1.3 1.3 1.4 1.3 1.4 0.2 0.2 1.4 0.0 1.4 1.3 1.3 1.4 1.3 0.6 CA 1.6 1.6 1.4 -0.4 1.4 1.6 1.6 1.4 -0.4 1.4 1.3 1.3 1.4 1.3 1.4 0.2 0.2 1.4 0.0 1.4 1.3 1.3 1.4 1.3 0.6 CC 1.6 1.6 1.4 0.2 1.4 1.6 1.6 1.4 0.2 1.4 1.3 1.3 1.4 1.3 1.4 0.8 0.8 1.4 0.0 1.4 1.3 1.3 1.4 1.3 0.6 CG 1.6 1.6 1.4 -0.4 1.4 1.6 1.6 1.4 -0.4 1.4 1.3 1.3 1.4 1.3 1.4 0.2 0.2 1.4 0.0 1.4 1.3 1.3 1.4 1.3 0.6 CU 1.6 1.6 1.4 0.2 1.4 1.6 1.6 1.4 0.2 1.4 1.3 1.3 1.4 1.3 1.4 0.8 0.8 1.4 0.0 1.4 1.3 1.3 1.4 1.3 0.6 GM 0.3 0.3 0.0 -1.7 0.0 0.3 0.3 0.0 -1.7 0.0 0.0 0.0 0.6 0.0 0.6 -1.1 -1.1 0.0 -0.1 0.0 0.0 0.0 0.7 0.0 -0.7 GA 0.3 0.3 0.0 -1.7 0.0 0.3 0.3 0.0 -1.7 0.0 0.0 0.0 0.6 0.0 0.6 -1.1 -1.1 0.0 -0.1 0.0 0.0 0.0 0.7 0.0 -0.7 GC 1.6 1.6 1.4 -0.4 1.4 1.6 1.6 1.4 -0.4 1.4 1.3 1.3 1.4 1.3 1.4 0.2 0.2 1.4 0.0 1.4 1.3 1.3 1.4 1.3 0.6 GG 0.3 0.3 0.1 -0.4 0.1 0.3 0.3 0.1 -0.4 0.1 0.0 0.0 0.1 0.0 0.1 0.2 0.2 0.1 1.3 0.1 0.0 0.0 0.1 0.0 0.6 GU 1.6 1.6 1.4 -0.4 1.4 1.6 1.6 1.4 -0.4 1.4 1.3 1.3 1.4 1.3 1.4 0.2 0.2 1.4 0.0 1.4 1.3 1.3 1.4 1.3 0.6 UM 1.6 1.6 1.4 -0.4 1.4 1.6 1.6 1.4 -0.4 1.4 1.3 1.3 1.4 1.3 1.4 0.2 0.2 1.4 0.0 1.4 1.3 1.3 1.4 1.3 0.6 UA 1.6 1.6 1.4 -0.4 1.4 1.6 1.6 1.4 -0.4 1.4 1.3 1.3 1.4 1.3 1.4 0.2 0.2 1.4 0.0 1.4 1.3 1.3 1.4 1.3 0.6 UC 1.6 1.6 1.4 0.2 1.4 1.6 1.6 1.4 0.2 1.4 1.3 1.3 1.4 1.3 1.4 0.8 0.8 1.4 0.0 1.4 1.3 1.3 1.4 1.3 0.6 UG 1.6 1.6 1.4 -0.4 1.4 1.6 1.6 1.4 -0.4 1.4 1.3 1.3 1.4 1.3 1.4 0.2 0.2 1.4 0.0 1.4 1.3 1.3 1.4 1.3 0.6 UU 2.2 2.2 1.4 -0.4 1.4 2.2 2.2 1.4 -0.4 1.4 1.3 1.3 1.4 1.3 1.4 0.2 0.2 1.4 1.3 1.4 1.3 1.3 1.4 1.3 0.6 # 5' ------> 3' U X1 Y1 G G X2 Y2 C # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 1.1 1.1 1.1 0.2 1.1 1.1 1.1 1.1 0.2 1.1 1.5 1.5 1.4 1.5 1.2 0.2 0.2 1.1 -0.4 1.1 1.5 1.5 1.2 1.5 0.9 MA 1.1 1.1 1.1 0.2 1.1 1.1 1.1 1.1 0.2 1.1 1.5 1.5 1.4 1.5 1.2 0.2 0.2 1.1 -0.4 1.1 1.5 1.5 1.2 1.5 0.9 MC 1.5 1.5 1.4 0.5 1.4 1.5 1.5 1.4 0.5 1.4 1.9 1.9 1.7 1.9 1.6 0.5 0.5 1.4 0.0 1.4 1.9 1.9 1.6 1.9 0.7 MG 1.8 1.8 1.7 0.8 1.7 1.8 1.8 1.7 0.8 1.7 2.2 2.2 2.6 2.2 2.5 0.8 0.8 1.7 1.6 1.7 2.2 2.2 2.5 2.2 1.0 MU 1.5 1.5 1.4 0.5 1.4 1.5 1.5 1.4 0.5 1.4 1.9 1.9 1.7 1.9 1.6 0.5 0.5 1.4 0.0 1.4 1.9 1.9 1.6 1.9 0.7 AM 1.1 1.1 1.1 0.2 1.1 1.1 1.1 1.1 0.2 1.1 1.5 1.5 1.4 1.5 1.2 0.2 0.2 1.1 -0.4 1.1 1.5 1.5 1.2 1.5 0.9 AA 1.1 1.1 1.1 0.2 1.1 1.1 1.1 1.1 0.2 1.1 1.5 1.5 1.4 1.5 1.2 0.2 0.2 1.1 -0.4 1.1 1.5 1.5 1.2 1.5 0.9 AC 1.5 1.5 1.4 0.5 1.4 1.5 1.5 1.4 0.5 1.4 1.9 1.9 1.7 1.9 1.6 0.5 0.5 1.4 0.0 1.4 1.9 1.9 1.6 1.9 0.7 AG 1.8 1.8 1.7 0.8 1.7 1.8 1.8 1.7 0.8 1.7 2.2 2.2 2.6 2.2 2.5 0.8 0.8 1.7 1.6 1.7 2.2 2.2 2.5 2.2 1.0 AU 1.5 1.5 1.4 0.5 1.4 1.5 1.5 1.4 0.5 1.4 1.9 1.9 1.7 1.9 1.6 0.5 0.5 1.4 0.0 1.4 1.9 1.9 1.6 1.9 0.7 CM 1.5 1.5 1.4 0.5 1.4 1.5 1.5 1.4 0.5 1.4 1.9 1.9 1.7 1.9 1.6 0.5 0.5 1.4 0.0 1.4 1.9 1.9 1.6 1.9 0.7 CA 1.5 1.5 1.4 0.5 1.4 1.5 1.5 1.4 0.5 1.4 1.9 1.9 1.7 1.9 1.6 0.5 0.5 1.4 0.0 1.4 1.9 1.9 1.6 1.9 0.7 CC 1.5 1.5 1.4 1.1 1.4 1.5 1.5 1.4 1.1 1.4 1.9 1.9 1.7 1.9 1.6 1.1 1.1 1.4 0.0 1.4 1.9 1.9 1.6 1.9 0.7 CG 1.5 1.5 1.4 0.5 1.4 1.5 1.5 1.4 0.5 1.4 1.9 1.9 1.7 1.9 1.6 0.5 0.5 1.4 0.0 1.4 1.9 1.9 1.6 1.9 0.7 CU 1.5 1.5 1.4 1.1 1.4 1.5 1.5 1.4 1.1 1.4 1.9 1.9 1.7 1.9 1.6 1.1 1.1 1.4 0.0 1.4 1.9 1.9 1.6 1.9 0.7 GM 0.1 0.1 0.1 -0.8 0.1 0.1 0.1 0.1 -0.8 0.1 0.5 0.5 1.0 0.5 0.8 -0.8 -0.8 0.1 -0.1 0.1 0.5 0.5 0.8 0.5 -0.6 GA 0.1 0.1 0.1 -0.8 0.1 0.1 0.1 0.1 -0.8 0.1 0.5 0.5 1.0 0.5 0.8 -0.8 -0.8 0.1 -0.1 0.1 0.5 0.5 0.8 0.5 -0.6 GC 1.5 1.5 1.4 0.5 1.4 1.5 1.5 1.4 0.5 1.4 1.9 1.9 1.7 1.9 1.6 0.5 0.5 1.4 0.0 1.4 1.9 1.9 1.6 1.9 0.7 GG 0.2 0.2 0.1 0.5 0.1 0.2 0.2 0.1 0.5 0.1 0.6 0.6 0.4 0.6 0.3 0.5 0.5 0.1 1.3 0.1 0.6 0.6 0.3 0.6 0.7 GU 1.5 1.5 1.4 0.5 1.4 1.5 1.5 1.4 0.5 1.4 1.9 1.9 1.7 1.9 1.6 0.5 0.5 1.4 0.0 1.4 1.9 1.9 1.6 1.9 0.7 UM 1.5 1.5 1.4 0.5 1.4 1.5 1.5 1.4 0.5 1.4 1.9 1.9 1.7 1.9 1.6 0.5 0.5 1.4 0.0 1.4 1.9 1.9 1.6 1.9 0.7 UA 1.5 1.5 1.4 0.5 1.4 1.5 1.5 1.4 0.5 1.4 1.9 1.9 1.7 1.9 1.6 0.5 0.5 1.4 0.0 1.4 1.9 1.9 1.6 1.9 0.7 UC 1.5 1.5 1.4 1.1 1.4 1.5 1.5 1.4 1.1 1.4 1.9 1.9 1.7 1.9 1.6 1.1 1.1 1.4 0.0 1.4 1.9 1.9 1.6 1.9 0.7 UG 1.5 1.5 1.4 0.5 1.4 1.5 1.5 1.4 0.5 1.4 1.9 1.9 1.7 1.9 1.6 0.5 0.5 1.4 0.0 1.4 1.9 1.9 1.6 1.9 0.7 UU 2.1 2.1 1.4 0.5 1.4 2.1 2.1 1.4 0.5 1.4 1.9 1.9 1.7 1.9 1.6 0.5 0.5 1.4 1.3 1.4 1.9 1.9 1.6 1.9 0.7 # 5' ------> 3' U X1 Y1 U G X2 Y2 A # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 1.9 1.9 1.7 0.7 1.7 1.9 1.9 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.7 1.8 1.4 MA 1.9 1.9 1.7 0.7 1.7 1.9 1.9 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.7 1.8 1.4 MC 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 MG 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 3.0 2.4 3.0 2.0 2.0 2.3 2.1 2.3 2.4 2.4 3.0 2.4 1.5 MU 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 AM 1.9 1.9 1.7 0.7 1.7 1.9 1.9 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.7 1.8 1.4 AA 1.9 1.9 1.7 0.7 1.7 1.9 1.9 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.7 1.8 1.4 AC 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 AG 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 3.0 2.4 3.0 2.0 2.0 2.3 2.1 2.3 2.4 2.4 3.0 2.4 1.5 AU 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 CM 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 CA 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 CC 2.3 2.3 2.0 1.6 2.0 2.3 2.3 2.0 1.6 2.0 2.1 2.1 2.1 2.1 2.1 2.3 2.3 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 CG 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 CU 2.3 2.3 2.0 1.6 2.0 2.3 2.3 2.0 1.6 2.0 2.1 2.1 2.1 2.1 2.1 2.3 2.3 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 GM 0.9 0.9 0.7 -0.3 0.7 0.9 0.9 0.7 -0.3 0.7 0.8 0.8 1.3 0.8 1.3 0.4 0.4 0.7 0.5 0.7 0.8 0.8 1.3 0.8 -0.2 GA 0.9 0.9 0.7 -0.3 0.7 0.9 0.9 0.7 -0.3 0.7 0.8 0.8 1.3 0.8 1.3 0.4 0.4 0.7 0.5 0.7 0.8 0.8 1.3 0.8 -0.2 GC 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 GG 1.0 1.0 0.7 1.0 0.7 1.0 1.0 0.7 1.0 0.7 0.8 0.8 0.8 0.8 0.8 1.7 1.7 0.7 1.8 0.7 0.8 0.8 0.8 0.8 1.2 GU 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 UM 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 UA 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 UC 2.3 2.3 2.0 1.6 2.0 2.3 2.3 2.0 1.6 2.0 2.1 2.1 2.1 2.1 2.1 2.3 2.3 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 UG 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 UU 2.9 2.9 2.0 1.0 2.0 2.9 2.9 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 1.8 2.0 2.1 2.1 2.1 2.1 1.2 # 5' ------> 3' U X1 Y1 U G X2 Y2 M # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 1.9 1.9 1.7 0.7 1.7 1.9 1.9 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.7 1.8 1.4 MA 1.9 1.9 1.7 0.7 1.7 1.9 1.9 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.7 1.8 1.4 MC 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 MG 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 3.0 2.4 3.0 2.0 2.0 2.3 2.1 2.3 2.4 2.4 3.0 2.4 1.5 MU 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 AM 1.9 1.9 1.7 0.7 1.7 1.9 1.9 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.7 1.8 1.4 AA 1.9 1.9 1.7 0.7 1.7 1.9 1.9 1.7 0.7 1.7 1.8 1.8 1.7 1.8 1.7 1.4 1.4 1.7 0.2 1.7 1.8 1.8 1.7 1.8 1.4 AC 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 AG 2.6 2.6 2.3 1.3 2.3 2.6 2.6 2.3 1.3 2.3 2.4 2.4 3.0 2.4 3.0 2.0 2.0 2.3 2.1 2.3 2.4 2.4 3.0 2.4 1.5 AU 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 CM 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 CA 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 CC 2.3 2.3 2.0 1.6 2.0 2.3 2.3 2.0 1.6 2.0 2.1 2.1 2.1 2.1 2.1 2.3 2.3 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 CG 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 CU 2.3 2.3 2.0 1.6 2.0 2.3 2.3 2.0 1.6 2.0 2.1 2.1 2.1 2.1 2.1 2.3 2.3 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 GM 0.9 0.9 0.7 -0.3 0.7 0.9 0.9 0.7 -0.3 0.7 0.8 0.8 1.3 0.8 1.3 0.4 0.4 0.7 0.5 0.7 0.8 0.8 1.3 0.8 -0.2 GA 0.9 0.9 0.7 -0.3 0.7 0.9 0.9 0.7 -0.3 0.7 0.8 0.8 1.3 0.8 1.3 0.4 0.4 0.7 0.5 0.7 0.8 0.8 1.3 0.8 -0.2 GC 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 GG 1.0 1.0 0.7 1.0 0.7 1.0 1.0 0.7 1.0 0.7 0.8 0.8 0.8 0.8 0.8 1.7 1.7 0.7 1.8 0.7 0.8 0.8 0.8 0.8 1.2 GU 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 UM 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 UA 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 UC 2.3 2.3 2.0 1.6 2.0 2.3 2.3 2.0 1.6 2.0 2.1 2.1 2.1 2.1 2.1 2.3 2.3 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 UG 2.3 2.3 2.0 1.0 2.0 2.3 2.3 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 0.5 2.0 2.1 2.1 2.1 2.1 1.2 UU 2.9 2.9 2.0 1.0 2.0 2.9 2.9 2.0 1.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.0 1.8 2.0 2.1 2.1 2.1 2.1 1.2 # 5' ------> 3' U X1 Y1 G G X2 Y2 U # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 1.1 1.1 1.4 0.1 1.4 1.1 1.1 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.4 0.1 1.4 1.4 1.4 1.4 1.4 2.0 MA 1.1 1.1 1.4 0.1 1.4 1.1 1.1 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.4 0.1 1.4 1.4 1.4 1.4 1.4 2.0 MC 1.4 1.4 1.8 0.4 1.8 1.4 1.4 1.8 0.4 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 MG 1.7 1.7 2.1 0.7 2.1 1.7 1.7 2.1 0.7 2.1 2.1 2.1 2.7 2.1 2.7 2.4 2.4 2.1 2.1 2.1 2.1 2.1 2.7 2.1 2.1 MU 1.4 1.4 1.8 0.4 1.8 1.4 1.4 1.8 0.4 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 AM 1.1 1.1 1.4 0.1 1.4 1.1 1.1 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.4 0.1 1.4 1.4 1.4 1.4 1.4 2.0 AA 1.1 1.1 1.4 0.1 1.4 1.1 1.1 1.4 0.1 1.4 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.4 0.1 1.4 1.4 1.4 1.4 1.4 2.0 AC 1.4 1.4 1.8 0.4 1.8 1.4 1.4 1.8 0.4 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 AG 1.7 1.7 2.1 0.7 2.1 1.7 1.7 2.1 0.7 2.1 2.1 2.1 2.7 2.1 2.7 2.4 2.4 2.1 2.1 2.1 2.1 2.1 2.7 2.1 2.1 AU 1.4 1.4 1.8 0.4 1.8 1.4 1.4 1.8 0.4 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 CM 1.4 1.4 1.8 0.4 1.8 1.4 1.4 1.8 0.4 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 CA 1.4 1.4 1.8 0.4 1.8 1.4 1.4 1.8 0.4 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 CC 1.4 1.4 1.8 1.0 1.8 1.4 1.4 1.8 1.0 1.8 1.8 1.8 1.8 1.8 1.8 2.7 2.7 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 CG 1.4 1.4 1.8 0.4 1.8 1.4 1.4 1.8 0.4 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 CU 1.4 1.4 1.8 1.0 1.8 1.4 1.4 1.8 1.0 1.8 1.8 1.8 1.8 1.8 1.8 2.7 2.7 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 GM 0.1 0.1 0.4 -0.9 0.4 0.1 0.1 0.4 -0.9 0.4 0.4 0.4 1.0 0.4 1.0 0.7 0.7 0.4 0.4 0.4 0.4 0.4 1.0 0.4 0.4 GA 0.1 0.1 0.4 -0.9 0.4 0.1 0.1 0.4 -0.9 0.4 0.4 0.4 1.0 0.4 1.0 0.7 0.7 0.4 0.4 0.4 0.4 0.4 1.0 0.4 0.4 GC 1.4 1.4 1.8 0.4 1.8 1.4 1.4 1.8 0.4 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 GG 0.1 0.1 0.5 0.4 0.5 0.1 0.1 0.5 0.4 0.5 0.5 0.5 0.5 0.5 0.5 2.1 2.1 0.5 1.8 0.5 0.5 0.5 0.5 0.5 1.8 GU 1.4 1.4 1.8 0.4 1.8 1.4 1.4 1.8 0.4 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 UM 1.4 1.4 1.8 0.4 1.8 1.4 1.4 1.8 0.4 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 UA 1.4 1.4 1.8 0.4 1.8 1.4 1.4 1.8 0.4 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 UC 1.4 1.4 1.8 1.0 1.8 1.4 1.4 1.8 1.0 1.8 1.8 1.8 1.8 1.8 1.8 2.7 2.7 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 UG 1.4 1.4 1.8 0.4 1.8 1.4 1.4 1.8 0.4 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 0.5 1.8 1.8 1.8 1.8 1.8 1.8 UU 2.0 2.0 1.8 0.4 1.8 2.0 2.0 1.8 0.4 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.8 # 5' ------> 3' U X1 Y1 U G X2 Y2 G # 3' <------ 5' # Y # ---------------------------------------------------------------------------------------------------------------------------------- M M M M M A A A A A C C C C C G G G G G U U U U U M A C G U M A C G U M A C G U M A C G U M A C G U #---------------------------------------------------------------------------------------------------------------------------------- MM 2.6 2.6 1.7 0.9 1.7 2.6 2.6 1.7 0.9 1.7 1.7 1.7 1.7 1.7 1.7 2.6 2.6 1.7 0.4 1.7 1.7 1.7 1.7 1.7 2.3 MA 2.6 2.6 1.7 0.9 1.7 2.6 2.6 1.7 0.9 1.7 1.7 1.7 1.7 1.7 1.7 2.6 2.6 1.7 0.4 1.7 1.7 1.7 1.7 1.7 2.3 MC 2.4 2.4 2.1 1.3 2.1 2.4 2.4 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 MG 2.7 2.7 2.4 1.6 2.4 2.7 2.7 2.4 1.6 2.4 2.4 2.4 3.0 2.4 3.0 2.0 2.0 2.4 2.4 2.4 2.4 2.4 3.0 2.4 2.4 MU 2.4 2.4 2.1 1.3 2.1 2.4 2.4 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 AM 2.6 2.6 1.7 0.9 1.7 2.6 2.6 1.7 0.9 1.7 1.7 1.7 1.7 1.7 1.7 2.6 2.6 1.7 0.4 1.7 1.7 1.7 1.7 1.7 2.3 AA 2.6 2.6 1.7 0.9 1.7 2.6 2.6 1.7 0.9 1.7 1.7 1.7 1.7 1.7 1.7 2.6 2.6 1.7 0.4 1.7 1.7 1.7 1.7 1.7 2.3 AC 2.4 2.4 2.1 1.3 2.1 2.4 2.4 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 AG 2.7 2.7 2.4 1.6 2.4 2.7 2.7 2.4 1.6 2.4 2.4 2.4 3.0 2.4 3.0 2.0 2.0 2.4 2.4 2.4 2.4 2.4 3.0 2.4 2.4 AU 2.4 2.4 2.1 1.3 2.1 2.4 2.4 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 CM 2.4 2.4 2.1 1.3 2.1 2.4 2.4 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 CA 2.4 2.4 2.1 1.3 2.1 2.4 2.4 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 CC 2.4 2.4 2.1 1.9 2.1 2.4 2.4 2.1 1.9 2.1 2.1 2.1 2.1 2.1 2.1 2.3 2.3 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 CG 2.4 2.4 2.1 1.3 2.1 2.4 2.4 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 CU 2.4 2.4 2.1 1.9 2.1 2.4 2.4 2.1 1.9 2.1 2.1 2.1 2.1 2.1 2.1 2.3 2.3 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 GM 1.2 1.2 0.7 -0.8 0.7 1.2 1.2 0.7 -0.8 0.7 0.7 0.7 1.3 0.7 1.3 0.3 0.3 0.7 0.7 0.7 0.7 0.7 1.3 0.7 0.7 GA 1.2 1.2 0.7 -0.8 0.7 1.2 1.2 0.7 -0.8 0.7 0.7 0.7 1.3 0.7 1.3 0.3 0.3 0.7 0.7 0.7 0.7 0.7 1.3 0.7 0.7 GC 2.4 2.4 2.1 1.3 2.1 2.4 2.4 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 GG 1.1 1.1 0.8 1.3 0.8 1.1 1.1 0.8 1.3 0.8 0.8 0.8 0.8 0.8 0.8 1.7 1.7 0.8 2.1 0.8 0.8 0.8 0.8 0.8 2.1 GU 2.4 2.4 2.1 1.3 2.1 2.4 2.4 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 UM 2.4 2.4 2.1 1.3 2.1 2.4 2.4 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 UA 2.4 2.4 2.1 1.3 2.1 2.4 2.4 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 UC 2.4 2.4 2.1 1.9 2.1 2.4 2.4 2.1 1.9 2.1 2.1 2.1 2.1 2.1 2.1 2.3 2.3 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 UG 2.4 2.4 2.1 1.3 2.1 2.4 2.4 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 0.8 2.1 2.1 2.1 2.1 2.1 2.1 UU 3.0 3.0 2.1 1.3 2.1 3.0 3.0 2.1 1.3 2.1 2.1 2.1 2.1 2.1 2.1 1.7 1.7 2.1 2.1 2.1 2.1 2.1 2.1 2.1 2.1