# Data tables for 2x2 interior loops # The Enthalpies for DNA # Data arrangement: # # 5' ------> 3' # A X1 Y1 A # T X2 Y2 T # 3' <------ 5' # # Y--> # ---------------------------------------------------------------------------------------------------------------------------- # (X) A A A A C C C C G G G G T T T T # | A C G T A C G T A C G T A C G T # V ---------------------------------------------------------------------------------------------------------------------------- # (AA) 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8 # (AC) 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6 # (AG) 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1 # (AT) 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5 # (CA) 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8 # (CC) 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6 # (CG) 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1 # (CT) 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5 # (GA) 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8 # (GC) 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6 # (GG) 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1 # (GT) 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5 # (TA) 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8 # (TC) 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6 # (TG) 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1 # (TT) 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5 # 5' ------> 3' A X1 Y1 A T X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8 AC 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6 AG 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1 AT 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5 CA 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8 CC 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6 CG 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1 CT 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5 GA 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8 GC 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6 GG 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1 GT 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5 TA 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8 TC 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6 TG 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1 TT 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5 # 5' ------> 3' A X1 Y1 C T X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -2.2 -2.2 -2.2 -2.2 0.7 0.7 0.7 0.7 -1.1 -1.1 -1.1 -1.1 3.1 3.1 3.1 3.1 AC -1.0 -1.0 -1.0 -1.0 1.9 1.9 1.9 1.9 0.1 0.1 0.1 0.1 4.3 4.3 4.3 4.3 AG -1.5 -1.5 -1.5 -1.5 1.4 1.4 1.4 1.4 -0.4 -0.4 -0.4 -0.4 3.8 3.8 3.8 3.8 AT -1.9 -1.9 -1.9 -1.9 1.0 1.0 1.0 1.0 -0.8 -0.8 -0.8 -0.8 3.4 3.4 3.4 3.4 CA -2.2 -2.2 -2.2 -2.2 0.7 0.7 0.7 0.7 -1.1 -1.1 -1.1 -1.1 3.1 3.1 3.1 3.1 CC -1.0 -1.0 -1.0 -1.0 1.9 1.9 1.9 1.9 0.1 0.1 0.1 0.1 4.3 4.3 4.3 4.3 CG -1.5 -1.5 -1.5 -1.5 1.4 1.4 1.4 1.4 -0.4 -0.4 -0.4 -0.4 3.8 3.8 3.8 3.8 CT -1.9 -1.9 -1.9 -1.9 1.0 1.0 1.0 1.0 -0.8 -0.8 -0.8 -0.8 3.4 3.4 3.4 3.4 GA -2.2 -2.2 -2.2 -2.2 0.7 0.7 0.7 0.7 -1.1 -1.1 -1.1 -1.1 3.1 3.1 3.1 3.1 GC -1.0 -1.0 -1.0 -1.0 1.9 1.9 1.9 1.9 0.1 0.1 0.1 0.1 4.3 4.3 4.3 4.3 GG -1.5 -1.5 -1.5 -1.5 1.4 1.4 1.4 1.4 -0.4 -0.4 -0.4 -0.4 3.8 3.8 3.8 3.8 GT -1.9 -1.9 -1.9 -1.9 1.0 1.0 1.0 1.0 -0.8 -0.8 -0.8 -0.8 3.4 3.4 3.4 3.4 TA -2.2 -2.2 -2.2 -2.2 0.7 0.7 0.7 0.7 -1.1 -1.1 -1.1 -1.1 3.1 3.1 3.1 3.1 TC -1.0 -1.0 -1.0 -1.0 1.9 1.9 1.9 1.9 0.1 0.1 0.1 0.1 4.3 4.3 4.3 4.3 TG -1.5 -1.5 -1.5 -1.5 1.4 1.4 1.4 1.4 -0.4 -0.4 -0.4 -0.4 3.8 3.8 3.8 3.8 TT -1.9 -1.9 -1.9 -1.9 1.0 1.0 1.0 1.0 -0.8 -0.8 -0.8 -0.8 3.4 3.4 3.4 3.4 # 5' ------> 3' A X1 Y1 G T X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -0.6 -0.6 -0.6 -0.6 -0.2 -0.2 -0.2 -0.2 -0.7 -0.7 -0.7 -0.7 -1.0 -1.0 -1.0 -1.0 AC 0.6 0.6 0.6 0.6 1.0 1.0 1.0 1.0 0.5 0.5 0.5 0.5 0.2 0.2 0.2 0.2 AG 0.1 0.1 0.1 0.1 0.5 0.5 0.5 0.5 0.0 0.0 0.0 0.0 -0.3 -0.3 -0.3 -0.3 AT -0.3 -0.3 -0.3 -0.3 0.1 0.1 0.1 0.1 -0.4 -0.4 -0.4 -0.4 -0.7 -0.7 -0.7 -0.7 CA -0.6 -0.6 -0.6 -0.6 -0.2 -0.2 -0.2 -0.2 -0.7 -0.7 -0.7 -0.7 -1.0 -1.0 -1.0 -1.0 CC 0.6 0.6 0.6 0.6 1.0 1.0 1.0 1.0 0.5 0.5 0.5 0.5 0.2 0.2 0.2 0.2 CG 0.1 0.1 0.1 0.1 0.5 0.5 0.5 0.5 0.0 0.0 0.0 0.0 -0.3 -0.3 -0.3 -0.3 CT -0.3 -0.3 -0.3 -0.3 0.1 0.1 0.1 0.1 -0.4 -0.4 -0.4 -0.4 -0.7 -0.7 -0.7 -0.7 GA -0.6 -0.6 -0.6 -0.6 -0.2 -0.2 -0.2 -0.2 -0.7 -0.7 -0.7 -0.7 -1.0 -1.0 -1.0 -1.0 GC 0.6 0.6 0.6 0.6 1.0 1.0 1.0 1.0 0.5 0.5 0.5 0.5 0.2 0.2 0.2 0.2 GG 0.1 0.1 0.1 0.1 0.5 0.5 0.5 0.5 0.0 0.0 0.0 0.0 -0.3 -0.3 -0.3 -0.3 GT -0.3 -0.3 -0.3 -0.3 0.1 0.1 0.1 0.1 -0.4 -0.4 -0.4 -0.4 -0.7 -0.7 -0.7 -0.7 TA -0.6 -0.6 -0.6 -0.6 -0.2 -0.2 -0.2 -0.2 -0.7 -0.7 -0.7 -0.7 -1.0 -1.0 -1.0 -1.0 TC 0.6 0.6 0.6 0.6 1.0 1.0 1.0 1.0 0.5 0.5 0.5 0.5 0.2 0.2 0.2 0.2 TG 0.1 0.1 0.1 0.1 0.5 0.5 0.5 0.5 0.0 0.0 0.0 0.0 -0.3 -0.3 -0.3 -0.3 TT -0.3 -0.3 -0.3 -0.3 0.1 0.1 0.1 0.1 -0.4 -0.4 -0.4 -0.4 -0.7 -0.7 -0.7 -0.7 # 5' ------> 3' A X1 Y1 G T X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8 AC 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6 AG 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1 AT 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5 CA 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8 CC 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6 CG 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1 CT 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5 GA 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8 GC 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6 GG 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1 GT 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5 TA 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8 TC 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6 TG 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1 TT 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5 # 5' ------> 3' A X1 Y1 T T X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 8.0 8.0 8.0 8.0 9.2 9.2 9.2 9.2 8.7 8.7 8.7 8.7 8.3 8.3 8.3 8.3 AC 9.2 9.2 9.2 9.2 10.4 10.4 10.4 10.4 9.9 9.9 9.9 9.9 9.5 9.5 9.5 9.5 AG 8.7 8.7 8.7 8.7 9.9 9.9 9.9 9.9 9.4 9.4 9.4 9.4 9.0 9.0 9.0 9.0 AT 8.3 8.3 8.3 8.3 9.5 9.5 9.5 9.5 9.0 9.0 9.0 9.0 8.6 8.6 8.6 8.6 CA 8.0 8.0 8.0 8.0 9.2 9.2 9.2 9.2 8.7 8.7 8.7 8.7 8.3 8.3 8.3 8.3 CC 9.2 9.2 9.2 9.2 10.4 10.4 10.4 10.4 9.9 9.9 9.9 9.9 9.5 9.5 9.5 9.5 CG 8.7 8.7 8.7 8.7 9.9 9.9 9.9 9.9 9.4 9.4 9.4 9.4 9.0 9.0 9.0 9.0 CT 8.3 8.3 8.3 8.3 9.5 9.5 9.5 9.5 9.0 9.0 9.0 9.0 8.6 8.6 8.6 8.6 GA 8.0 8.0 8.0 8.0 9.2 9.2 9.2 9.2 8.7 8.7 8.7 8.7 8.3 8.3 8.3 8.3 GC 9.2 9.2 9.2 9.2 10.4 10.4 10.4 10.4 9.9 9.9 9.9 9.9 9.5 9.5 9.5 9.5 GG 8.7 8.7 8.7 8.7 9.9 9.9 9.9 9.9 9.4 9.4 9.4 9.4 9.0 9.0 9.0 9.0 GT 8.3 8.3 8.3 8.3 9.5 9.5 9.5 9.5 9.0 9.0 9.0 9.0 8.6 8.6 8.6 8.6 TA 8.0 8.0 8.0 8.0 9.2 9.2 9.2 9.2 8.7 8.7 8.7 8.7 8.3 8.3 8.3 8.3 TC 9.2 9.2 9.2 9.2 10.4 10.4 10.4 10.4 9.9 9.9 9.9 9.9 9.5 9.5 9.5 9.5 TG 8.7 8.7 8.7 8.7 9.9 9.9 9.9 9.9 9.4 9.4 9.4 9.4 9.0 9.0 9.0 9.0 TT 8.3 8.3 8.3 8.3 9.5 9.5 9.5 9.5 9.0 9.0 9.0 9.0 8.6 8.6 8.6 8.6 # 5' ------> 3' A X1 Y1 T T X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.0 1.0 1.0 1.0 3.9 3.9 3.9 3.9 2.1 2.1 2.1 2.1 6.3 6.3 6.3 6.3 AC 2.2 2.2 2.2 2.2 5.1 5.1 5.1 5.1 3.3 3.3 3.3 3.3 7.5 7.5 7.5 7.5 AG 1.7 1.7 1.7 1.7 4.6 4.6 4.6 4.6 2.8 2.8 2.8 2.8 7.0 7.0 7.0 7.0 AT 1.3 1.3 1.3 1.3 4.2 4.2 4.2 4.2 2.4 2.4 2.4 2.4 6.6 6.6 6.6 6.6 CA 1.0 1.0 1.0 1.0 3.9 3.9 3.9 3.9 2.1 2.1 2.1 2.1 6.3 6.3 6.3 6.3 CC 2.2 2.2 2.2 2.2 5.1 5.1 5.1 5.1 3.3 3.3 3.3 3.3 7.5 7.5 7.5 7.5 CG 1.7 1.7 1.7 1.7 4.6 4.6 4.6 4.6 2.8 2.8 2.8 2.8 7.0 7.0 7.0 7.0 CT 1.3 1.3 1.3 1.3 4.2 4.2 4.2 4.2 2.4 2.4 2.4 2.4 6.6 6.6 6.6 6.6 GA 1.0 1.0 1.0 1.0 3.9 3.9 3.9 3.9 2.1 2.1 2.1 2.1 6.3 6.3 6.3 6.3 GC 2.2 2.2 2.2 2.2 5.1 5.1 5.1 5.1 3.3 3.3 3.3 3.3 7.5 7.5 7.5 7.5 GG 1.7 1.7 1.7 1.7 4.6 4.6 4.6 4.6 2.8 2.8 2.8 2.8 7.0 7.0 7.0 7.0 GT 1.3 1.3 1.3 1.3 4.2 4.2 4.2 4.2 2.4 2.4 2.4 2.4 6.6 6.6 6.6 6.6 TA 1.0 1.0 1.0 1.0 3.9 3.9 3.9 3.9 2.1 2.1 2.1 2.1 6.3 6.3 6.3 6.3 TC 2.2 2.2 2.2 2.2 5.1 5.1 5.1 5.1 3.3 3.3 3.3 3.3 7.5 7.5 7.5 7.5 TG 1.7 1.7 1.7 1.7 4.6 4.6 4.6 4.6 2.8 2.8 2.8 2.8 7.0 7.0 7.0 7.0 TT 1.3 1.3 1.3 1.3 4.2 4.2 4.2 4.2 2.4 2.4 2.4 2.4 6.6 6.6 6.6 6.6 # 5' ------> 3' C X1 Y1 A G X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -2.3 -2.3 -2.3 -2.3 -2.0 -2.0 -2.0 -2.0 -3.9 -3.9 -3.9 -3.9 -10.4 -10.4 -10.4 -10.4 AC -1.9 -1.9 -1.9 -1.9 -1.6 -1.6 -1.6 -1.6 -3.5 -3.5 -3.5 -3.5 -10.0 -10.0 -10.0 -10.0 AG -2.4 -2.4 -2.4 -2.4 -2.1 -2.1 -2.1 -2.1 -4.0 -4.0 -4.0 -4.0 -10.5 -10.5 -10.5 -10.5 AT -2.7 -2.7 -2.7 -2.7 -2.4 -2.4 -2.4 -2.4 -4.3 -4.3 -4.3 -4.3 -10.8 -10.8 -10.8 -10.8 CA -2.3 -2.3 -2.3 -2.3 -2.0 -2.0 -2.0 -2.0 -3.9 -3.9 -3.9 -3.9 -10.4 -10.4 -10.4 -10.4 CC -1.9 -1.9 -1.9 -1.9 -1.6 -1.6 -1.6 -1.6 -3.5 -3.5 -3.5 -3.5 -10.0 -10.0 -10.0 -10.0 CG -2.4 -2.4 -2.4 -2.4 -2.1 -2.1 -2.1 -2.1 -4.0 -4.0 -4.0 -4.0 -10.5 -10.5 -10.5 -10.5 CT -2.7 -2.7 -2.7 -2.7 -2.4 -2.4 -2.4 -2.4 -4.3 -4.3 -4.3 -4.3 -10.8 -10.8 -10.8 -10.8 GA -2.3 -2.3 -2.3 -2.3 -2.0 -2.0 -2.0 -2.0 -3.9 -3.9 -3.9 -3.9 -10.4 -10.4 -10.4 -10.4 GC -1.9 -1.9 -1.9 -1.9 -1.6 -1.6 -1.6 -1.6 -3.5 -3.5 -3.5 -3.5 -10.0 -10.0 -10.0 -10.0 GG -2.4 -2.4 -2.4 -2.4 -2.1 -2.1 -2.1 -2.1 -4.0 -4.0 -4.0 -4.0 -10.5 -10.5 -10.5 -10.5 GT -2.7 -2.7 -2.7 -2.7 -2.4 -2.4 -2.4 -2.4 -4.3 -4.3 -4.3 -4.3 -10.8 -10.8 -10.8 -10.8 TA -2.3 -2.3 -2.3 -2.3 -2.0 -2.0 -2.0 -2.0 -3.9 -3.9 -3.9 -3.9 -10.4 -10.4 -10.4 -10.4 TC -1.9 -1.9 -1.9 -1.9 -1.6 -1.6 -1.6 -1.6 -3.5 -3.5 -3.5 -3.5 -10.0 -10.0 -10.0 -10.0 TG -2.4 -2.4 -2.4 -2.4 -2.1 -2.1 -2.1 -2.1 -4.0 -4.0 -4.0 -4.0 -10.5 -10.5 -10.5 -10.5 TT -2.7 -2.7 -2.7 -2.7 -2.4 -2.4 -2.4 -2.4 -4.3 -4.3 -4.3 -4.3 -10.8 -10.8 -10.8 -10.8 # 5' ------> 3' C X1 Y1 C G X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -10.8 -10.8 -10.8 -10.8 -7.9 -7.9 -7.9 -7.9 -9.7 -9.7 -9.7 -9.7 -5.5 -5.5 -5.5 -5.5 AC -10.4 -10.4 -10.4 -10.4 -7.5 -7.5 -7.5 -7.5 -9.3 -9.3 -9.3 -9.3 -5.1 -5.1 -5.1 -5.1 AG -10.9 -10.9 -10.9 -10.9 -8.0 -8.0 -8.0 -8.0 -9.8 -9.8 -9.8 -9.8 -5.6 -5.6 -5.6 -5.6 AT -11.2 -11.2 -11.2 -11.2 -8.3 -8.3 -8.3 -8.3 -10.1 -10.1 -10.1 -10.1 -5.9 -5.9 -5.9 -5.9 CA -10.8 -10.8 -10.8 -10.8 -7.9 -7.9 -7.9 -7.9 -9.7 -9.7 -9.7 -9.7 -5.5 -5.5 -5.5 -5.5 CC -10.4 -10.4 -10.4 -10.4 -7.5 -7.5 -7.5 -7.5 -9.3 -9.3 -9.3 -9.3 -5.1 -5.1 -5.1 -5.1 CG -10.9 -10.9 -10.9 -10.9 -8.0 -8.0 -8.0 -8.0 -9.8 -9.8 -9.8 -9.8 -5.6 -5.6 -5.6 -5.6 CT -11.2 -11.2 -11.2 -11.2 -8.3 -8.3 -8.3 -8.3 -10.1 -10.1 -10.1 -10.1 -5.9 -5.9 -5.9 -5.9 GA -10.8 -10.8 -10.8 -10.8 -7.9 -7.9 -7.9 -7.9 -9.7 -9.7 -9.7 -9.7 -5.5 -5.5 -5.5 -5.5 GC -10.4 -10.4 -10.4 -10.4 -7.5 -7.5 -7.5 -7.5 -9.3 -9.3 -9.3 -9.3 -5.1 -5.1 -5.1 -5.1 GG -10.9 -10.9 -10.9 -10.9 -8.0 -8.0 -8.0 -8.0 -9.8 -9.8 -9.8 -9.8 -5.6 -5.6 -5.6 -5.6 GT -11.2 -11.2 -11.2 -11.2 -8.3 -8.3 -8.3 -8.3 -10.1 -10.1 -10.1 -10.1 -5.9 -5.9 -5.9 -5.9 TA -10.8 -10.8 -10.8 -10.8 -7.9 -7.9 -7.9 -7.9 -9.7 -9.7 -9.7 -9.7 -5.5 -5.5 -5.5 -5.5 TC -10.4 -10.4 -10.4 -10.4 -7.5 -7.5 -7.5 -7.5 -9.3 -9.3 -9.3 -9.3 -5.1 -5.1 -5.1 -5.1 TG -10.9 -10.9 -10.9 -10.9 -8.0 -8.0 -8.0 -8.0 -9.8 -9.8 -9.8 -9.8 -5.6 -5.6 -5.6 -5.6 TT -11.2 -11.2 -11.2 -11.2 -8.3 -8.3 -8.3 -8.3 -10.1 -10.1 -10.1 -10.1 -5.9 -5.9 -5.9 -5.9 # 5' ------> 3' C X1 Y1 G G X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -9.2 -9.2 -9.2 -9.2 -8.8 -8.8 -8.8 -8.8 -9.3 -9.3 -9.3 -9.3 -9.6 -9.6 -9.6 -9.6 AC -8.8 -8.8 -8.8 -8.8 -8.4 -8.4 -8.4 -8.4 -8.9 -8.9 -8.9 -8.9 -9.2 -9.2 -9.2 -9.2 AG -9.3 -9.3 -9.3 -9.3 -8.9 -8.9 -8.9 -8.9 -9.4 -9.4 -9.4 -9.4 -9.7 -9.7 -9.7 -9.7 AT -9.6 -9.6 -9.6 -9.6 -9.2 -9.2 -9.2 -9.2 -9.7 -9.7 -9.7 -9.7 -10.0 -10.0 -10.0 -10.0 CA -9.2 -9.2 -9.2 -9.2 -8.8 -8.8 -8.8 -8.8 -9.3 -9.3 -9.3 -9.3 -9.6 -9.6 -9.6 -9.6 CC -8.8 -8.8 -8.8 -8.8 -8.4 -8.4 -8.4 -8.4 -8.9 -8.9 -8.9 -8.9 -9.2 -9.2 -9.2 -9.2 CG -9.3 -9.3 -9.3 -9.3 -8.9 -8.9 -8.9 -8.9 -9.4 -9.4 -9.4 -9.4 -9.7 -9.7 -9.7 -9.7 CT -9.6 -9.6 -9.6 -9.6 -9.2 -9.2 -9.2 -9.2 -9.7 -9.7 -9.7 -9.7 -10.0 -10.0 -10.0 -10.0 GA -9.2 -9.2 -9.2 -9.2 -8.8 -8.8 -8.8 -8.8 -9.3 -9.3 -9.3 -9.3 -9.6 -9.6 -9.6 -9.6 GC -8.8 -8.8 -8.8 -8.8 -8.4 -8.4 -8.4 -8.4 -8.9 -8.9 -8.9 -8.9 -9.2 -9.2 -9.2 -9.2 GG -9.3 -9.3 -9.3 -9.3 -8.9 -8.9 -8.9 -8.9 -9.4 -9.4 -9.4 -9.4 -9.7 -9.7 -9.7 -9.7 GT -9.6 -9.6 -9.6 -9.6 -9.2 -9.2 -9.2 -9.2 -9.7 -9.7 -9.7 -9.7 -10.0 -10.0 -10.0 -10.0 TA -9.2 -9.2 -9.2 -9.2 -8.8 -8.8 -8.8 -8.8 -9.3 -9.3 -9.3 -9.3 -9.6 -9.6 -9.6 -9.6 TC -8.8 -8.8 -8.8 -8.8 -8.4 -8.4 -8.4 -8.4 -8.9 -8.9 -8.9 -8.9 -9.2 -9.2 -9.2 -9.2 TG -9.3 -9.3 -9.3 -9.3 -8.9 -8.9 -8.9 -8.9 -9.4 -9.4 -9.4 -9.4 -9.7 -9.7 -9.7 -9.7 TT -9.6 -9.6 -9.6 -9.6 -9.2 -9.2 -9.2 -9.2 -9.7 -9.7 -9.7 -9.7 -10.0 -10.0 -10.0 -10.0 # 5' ------> 3' C X1 Y1 G G X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -2.3 -2.3 -2.3 -2.3 -2.0 -2.0 -2.0 -2.0 -3.9 -3.9 -3.9 -3.9 -10.4 -10.4 -10.4 -10.4 AC -1.9 -1.9 -1.9 -1.9 -1.6 -1.6 -1.6 -1.6 -3.5 -3.5 -3.5 -3.5 -10.0 -10.0 -10.0 -10.0 AG -2.4 -2.4 -2.4 -2.4 -2.1 -2.1 -2.1 -2.1 -4.0 -4.0 -4.0 -4.0 -10.5 -10.5 -10.5 -10.5 AT -2.7 -2.7 -2.7 -2.7 -2.4 -2.4 -2.4 -2.4 -4.3 -4.3 -4.3 -4.3 -10.8 -10.8 -10.8 -10.8 CA -2.3 -2.3 -2.3 -2.3 -2.0 -2.0 -2.0 -2.0 -3.9 -3.9 -3.9 -3.9 -10.4 -10.4 -10.4 -10.4 CC -1.9 -1.9 -1.9 -1.9 -1.6 -1.6 -1.6 -1.6 -3.5 -3.5 -3.5 -3.5 -10.0 -10.0 -10.0 -10.0 CG -2.4 -2.4 -2.4 -2.4 -2.1 -2.1 -2.1 -2.1 -4.0 -4.0 -4.0 -4.0 -10.5 -10.5 -10.5 -10.5 CT -2.7 -2.7 -2.7 -2.7 -2.4 -2.4 -2.4 -2.4 -4.3 -4.3 -4.3 -4.3 -10.8 -10.8 -10.8 -10.8 GA -2.3 -2.3 -2.3 -2.3 -2.0 -2.0 -2.0 -2.0 -3.9 -3.9 -3.9 -3.9 -10.4 -10.4 -10.4 -10.4 GC -1.9 -1.9 -1.9 -1.9 -1.6 -1.6 -1.6 -1.6 -3.5 -3.5 -3.5 -3.5 -10.0 -10.0 -10.0 -10.0 GG -2.4 -2.4 -2.4 -2.4 -2.1 -2.1 -2.1 -2.1 -4.0 -4.0 -4.0 -4.0 -10.5 -10.5 -10.5 -10.5 GT -2.7 -2.7 -2.7 -2.7 -2.4 -2.4 -2.4 -2.4 -4.3 -4.3 -4.3 -4.3 -10.8 -10.8 -10.8 -10.8 TA -2.3 -2.3 -2.3 -2.3 -2.0 -2.0 -2.0 -2.0 -3.9 -3.9 -3.9 -3.9 -10.4 -10.4 -10.4 -10.4 TC -1.9 -1.9 -1.9 -1.9 -1.6 -1.6 -1.6 -1.6 -3.5 -3.5 -3.5 -3.5 -10.0 -10.0 -10.0 -10.0 TG -2.4 -2.4 -2.4 -2.4 -2.1 -2.1 -2.1 -2.1 -4.0 -4.0 -4.0 -4.0 -10.5 -10.5 -10.5 -10.5 TT -2.7 -2.7 -2.7 -2.7 -2.4 -2.4 -2.4 -2.4 -4.3 -4.3 -4.3 -4.3 -10.8 -10.8 -10.8 -10.8 # 5' ------> 3' C X1 Y1 T G X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -0.6 -0.6 -0.6 -0.6 0.6 0.6 0.6 0.6 0.1 0.1 0.1 0.1 -0.3 -0.3 -0.3 -0.3 AC -0.2 -0.2 -0.2 -0.2 1.0 1.0 1.0 1.0 0.5 0.5 0.5 0.5 0.1 0.1 0.1 0.1 AG -0.7 -0.7 -0.7 -0.7 0.5 0.5 0.5 0.5 0.0 0.0 0.0 0.0 -0.4 -0.4 -0.4 -0.4 AT -1.0 -1.0 -1.0 -1.0 0.2 0.2 0.2 0.2 -0.3 -0.3 -0.3 -0.3 -0.7 -0.7 -0.7 -0.7 CA -0.6 -0.6 -0.6 -0.6 0.6 0.6 0.6 0.6 0.1 0.1 0.1 0.1 -0.3 -0.3 -0.3 -0.3 CC -0.2 -0.2 -0.2 -0.2 1.0 1.0 1.0 1.0 0.5 0.5 0.5 0.5 0.1 0.1 0.1 0.1 CG -0.7 -0.7 -0.7 -0.7 0.5 0.5 0.5 0.5 0.0 0.0 0.0 0.0 -0.4 -0.4 -0.4 -0.4 CT -1.0 -1.0 -1.0 -1.0 0.2 0.2 0.2 0.2 -0.3 -0.3 -0.3 -0.3 -0.7 -0.7 -0.7 -0.7 GA -0.6 -0.6 -0.6 -0.6 0.6 0.6 0.6 0.6 0.1 0.1 0.1 0.1 -0.3 -0.3 -0.3 -0.3 GC -0.2 -0.2 -0.2 -0.2 1.0 1.0 1.0 1.0 0.5 0.5 0.5 0.5 0.1 0.1 0.1 0.1 GG -0.7 -0.7 -0.7 -0.7 0.5 0.5 0.5 0.5 0.0 0.0 0.0 0.0 -0.4 -0.4 -0.4 -0.4 GT -1.0 -1.0 -1.0 -1.0 0.2 0.2 0.2 0.2 -0.3 -0.3 -0.3 -0.3 -0.7 -0.7 -0.7 -0.7 TA -0.6 -0.6 -0.6 -0.6 0.6 0.6 0.6 0.6 0.1 0.1 0.1 0.1 -0.3 -0.3 -0.3 -0.3 TC -0.2 -0.2 -0.2 -0.2 1.0 1.0 1.0 1.0 0.5 0.5 0.5 0.5 0.1 0.1 0.1 0.1 TG -0.7 -0.7 -0.7 -0.7 0.5 0.5 0.5 0.5 0.0 0.0 0.0 0.0 -0.4 -0.4 -0.4 -0.4 TT -1.0 -1.0 -1.0 -1.0 0.2 0.2 0.2 0.2 -0.3 -0.3 -0.3 -0.3 -0.7 -0.7 -0.7 -0.7 # 5' ------> 3' C X1 Y1 T G X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -7.6 -7.6 -7.6 -7.6 -4.7 -4.7 -4.7 -4.7 -6.5 -6.5 -6.5 -6.5 -2.3 -2.3 -2.3 -2.3 AC -7.2 -7.2 -7.2 -7.2 -4.3 -4.3 -4.3 -4.3 -6.1 -6.1 -6.1 -6.1 -1.9 -1.9 -1.9 -1.9 AG -7.7 -7.7 -7.7 -7.7 -4.8 -4.8 -4.8 -4.8 -6.6 -6.6 -6.6 -6.6 -2.4 -2.4 -2.4 -2.4 AT -8.0 -8.0 -8.0 -8.0 -5.1 -5.1 -5.1 -5.1 -6.9 -6.9 -6.9 -6.9 -2.7 -2.7 -2.7 -2.7 CA -7.6 -7.6 -7.6 -7.6 -4.7 -4.7 -4.7 -4.7 -6.5 -6.5 -6.5 -6.5 -2.3 -2.3 -2.3 -2.3 CC -7.2 -7.2 -7.2 -7.2 -4.3 -4.3 -4.3 -4.3 -6.1 -6.1 -6.1 -6.1 -1.9 -1.9 -1.9 -1.9 CG -7.7 -7.7 -7.7 -7.7 -4.8 -4.8 -4.8 -4.8 -6.6 -6.6 -6.6 -6.6 -2.4 -2.4 -2.4 -2.4 CT -8.0 -8.0 -8.0 -8.0 -5.1 -5.1 -5.1 -5.1 -6.9 -6.9 -6.9 -6.9 -2.7 -2.7 -2.7 -2.7 GA -7.6 -7.6 -7.6 -7.6 -4.7 -4.7 -4.7 -4.7 -6.5 -6.5 -6.5 -6.5 -2.3 -2.3 -2.3 -2.3 GC -7.2 -7.2 -7.2 -7.2 -4.3 -4.3 -4.3 -4.3 -6.1 -6.1 -6.1 -6.1 -1.9 -1.9 -1.9 -1.9 GG -7.7 -7.7 -7.7 -7.7 -4.8 -4.8 -4.8 -4.8 -6.6 -6.6 -6.6 -6.6 -2.4 -2.4 -2.4 -2.4 GT -8.0 -8.0 -8.0 -8.0 -5.1 -5.1 -5.1 -5.1 -6.9 -6.9 -6.9 -6.9 -2.7 -2.7 -2.7 -2.7 TA -7.6 -7.6 -7.6 -7.6 -4.7 -4.7 -4.7 -4.7 -6.5 -6.5 -6.5 -6.5 -2.3 -2.3 -2.3 -2.3 TC -7.2 -7.2 -7.2 -7.2 -4.3 -4.3 -4.3 -4.3 -6.1 -6.1 -6.1 -6.1 -1.9 -1.9 -1.9 -1.9 TG -7.7 -7.7 -7.7 -7.7 -4.8 -4.8 -4.8 -4.8 -6.6 -6.6 -6.6 -6.6 -2.4 -2.4 -2.4 -2.4 TT -8.0 -8.0 -8.0 -8.0 -5.1 -5.1 -5.1 -5.1 -6.9 -6.9 -6.9 -6.9 -2.7 -2.7 -2.7 -2.7 # 5' ------> 3' G X1 Y1 A C X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -3.9 -3.9 -3.9 -3.9 -3.6 -3.6 -3.6 -3.6 -5.5 -5.5 -5.5 -5.5 -12.0 -12.0 -12.0 -12.0 AC -1.0 -1.0 -1.0 -1.0 -0.7 -0.7 -0.7 -0.7 -2.6 -2.6 -2.6 -2.6 -9.1 -9.1 -9.1 -9.1 AG -2.8 -2.8 -2.8 -2.8 -2.5 -2.5 -2.5 -2.5 -4.4 -4.4 -4.4 -4.4 -10.9 -10.9 -10.9 -10.9 AT 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.7 -0.2 -0.2 -0.2 -0.2 -6.7 -6.7 -6.7 -6.7 CA -3.9 -3.9 -3.9 -3.9 -3.6 -3.6 -3.6 -3.6 -5.5 -5.5 -5.5 -5.5 -12.0 -12.0 -12.0 -12.0 CC -1.0 -1.0 -1.0 -1.0 -0.7 -0.7 -0.7 -0.7 -2.6 -2.6 -2.6 -2.6 -9.1 -9.1 -9.1 -9.1 CG -2.8 -2.8 -2.8 -2.8 -2.5 -2.5 -2.5 -2.5 -4.4 -4.4 -4.4 -4.4 -10.9 -10.9 -10.9 -10.9 CT 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.7 -0.2 -0.2 -0.2 -0.2 -6.7 -6.7 -6.7 -6.7 GA -3.9 -3.9 -3.9 -3.9 -3.6 -3.6 -3.6 -3.6 -5.5 -5.5 -5.5 -5.5 -12.0 -12.0 -12.0 -12.0 GC -1.0 -1.0 -1.0 -1.0 -0.7 -0.7 -0.7 -0.7 -2.6 -2.6 -2.6 -2.6 -9.1 -9.1 -9.1 -9.1 GG -2.8 -2.8 -2.8 -2.8 -2.5 -2.5 -2.5 -2.5 -4.4 -4.4 -4.4 -4.4 -10.9 -10.9 -10.9 -10.9 GT 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.7 -0.2 -0.2 -0.2 -0.2 -6.7 -6.7 -6.7 -6.7 TA -3.9 -3.9 -3.9 -3.9 -3.6 -3.6 -3.6 -3.6 -5.5 -5.5 -5.5 -5.5 -12.0 -12.0 -12.0 -12.0 TC -1.0 -1.0 -1.0 -1.0 -0.7 -0.7 -0.7 -0.7 -2.6 -2.6 -2.6 -2.6 -9.1 -9.1 -9.1 -9.1 TG -2.8 -2.8 -2.8 -2.8 -2.5 -2.5 -2.5 -2.5 -4.4 -4.4 -4.4 -4.4 -10.9 -10.9 -10.9 -10.9 TT 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.7 -0.2 -0.2 -0.2 -0.2 -6.7 -6.7 -6.7 -6.7 # 5' ------> 3' G X1 Y1 C C X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -12.4 -12.4 -12.4 -12.4 -9.5 -9.5 -9.5 -9.5 -11.3 -11.3 -11.3 -11.3 -7.1 -7.1 -7.1 -7.1 AC -9.5 -9.5 -9.5 -9.5 -6.6 -6.6 -6.6 -6.6 -8.4 -8.4 -8.4 -8.4 -4.2 -4.2 -4.2 -4.2 AG -11.3 -11.3 -11.3 -11.3 -8.4 -8.4 -8.4 -8.4 -10.2 -10.2 -10.2 -10.2 -6.0 -6.0 -6.0 -6.0 AT -7.1 -7.1 -7.1 -7.1 -4.2 -4.2 -4.2 -4.2 -6.0 -6.0 -6.0 -6.0 -1.8 -1.8 -1.8 -1.8 CA -12.4 -12.4 -12.4 -12.4 -9.5 -9.5 -9.5 -9.5 -11.3 -11.3 -11.3 -11.3 -7.1 -7.1 -7.1 -7.1 CC -9.5 -9.5 -9.5 -9.5 -6.6 -6.6 -6.6 -6.6 -8.4 -8.4 -8.4 -8.4 -4.2 -4.2 -4.2 -4.2 CG -11.3 -11.3 -11.3 -11.3 -8.4 -8.4 -8.4 -8.4 -10.2 -10.2 -10.2 -10.2 -6.0 -6.0 -6.0 -6.0 CT -7.1 -7.1 -7.1 -7.1 -4.2 -4.2 -4.2 -4.2 -6.0 -6.0 -6.0 -6.0 -1.8 -1.8 -1.8 -1.8 GA -12.4 -12.4 -12.4 -12.4 -9.5 -9.5 -9.5 -9.5 -11.3 -11.3 -11.3 -11.3 -7.1 -7.1 -7.1 -7.1 GC -9.5 -9.5 -9.5 -9.5 -6.6 -6.6 -6.6 -6.6 -8.4 -8.4 -8.4 -8.4 -4.2 -4.2 -4.2 -4.2 GG -11.3 -11.3 -11.3 -11.3 -8.4 -8.4 -8.4 -8.4 -10.2 -10.2 -10.2 -10.2 -6.0 -6.0 -6.0 -6.0 GT -7.1 -7.1 -7.1 -7.1 -4.2 -4.2 -4.2 -4.2 -6.0 -6.0 -6.0 -6.0 -1.8 -1.8 -1.8 -1.8 TA -12.4 -12.4 -12.4 -12.4 -9.5 -9.5 -9.5 -9.5 -11.3 -11.3 -11.3 -11.3 -7.1 -7.1 -7.1 -7.1 TC -9.5 -9.5 -9.5 -9.5 -6.6 -6.6 -6.6 -6.6 -8.4 -8.4 -8.4 -8.4 -4.2 -4.2 -4.2 -4.2 TG -11.3 -11.3 -11.3 -11.3 -8.4 -8.4 -8.4 -8.4 -10.2 -10.2 -10.2 -10.2 -6.0 -6.0 -6.0 -6.0 TT -7.1 -7.1 -7.1 -7.1 -4.2 -4.2 -4.2 -4.2 -6.0 -6.0 -6.0 -6.0 -1.8 -1.8 -1.8 -1.8 # 5' ------> 3' G X1 Y1 G C X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -10.8 -10.8 -10.8 -10.8 -10.4 -10.4 -10.4 -10.4 -10.9 -10.9 -10.9 -10.9 -11.2 -11.2 -11.2 -11.2 AC -7.9 -7.9 -7.9 -7.9 -7.5 -7.5 -7.5 -7.5 -8.0 -8.0 -8.0 -8.0 -8.3 -8.3 -8.3 -8.3 AG -9.7 -9.7 -9.7 -9.7 -9.3 -9.3 -9.3 -9.3 -9.8 -9.8 -9.8 -9.8 -10.1 -10.1 -10.1 -10.1 AT -5.5 -5.5 -5.5 -5.5 -5.1 -5.1 -5.1 -5.1 -5.6 -5.6 -5.6 -5.6 -5.9 -5.9 -5.9 -5.9 CA -10.8 -10.8 -10.8 -10.8 -10.4 -10.4 -10.4 -10.4 -10.9 -10.9 -10.9 -10.9 -11.2 -11.2 -11.2 -11.2 CC -7.9 -7.9 -7.9 -7.9 -7.5 -7.5 -7.5 -7.5 -8.0 -8.0 -8.0 -8.0 -8.3 -8.3 -8.3 -8.3 CG -9.7 -9.7 -9.7 -9.7 -9.3 -9.3 -9.3 -9.3 -9.8 -9.8 -9.8 -9.8 -10.1 -10.1 -10.1 -10.1 CT -5.5 -5.5 -5.5 -5.5 -5.1 -5.1 -5.1 -5.1 -5.6 -5.6 -5.6 -5.6 -5.9 -5.9 -5.9 -5.9 GA -10.8 -10.8 -10.8 -10.8 -10.4 -10.4 -10.4 -10.4 -10.9 -10.9 -10.9 -10.9 -11.2 -11.2 -11.2 -11.2 GC -7.9 -7.9 -7.9 -7.9 -7.5 -7.5 -7.5 -7.5 -8.0 -8.0 -8.0 -8.0 -8.3 -8.3 -8.3 -8.3 GG -9.7 -9.7 -9.7 -9.7 -9.3 -9.3 -9.3 -9.3 -9.8 -9.8 -9.8 -9.8 -10.1 -10.1 -10.1 -10.1 GT -5.5 -5.5 -5.5 -5.5 -5.1 -5.1 -5.1 -5.1 -5.6 -5.6 -5.6 -5.6 -5.9 -5.9 -5.9 -5.9 TA -10.8 -10.8 -10.8 -10.8 -10.4 -10.4 -10.4 -10.4 -10.9 -10.9 -10.9 -10.9 -11.2 -11.2 -11.2 -11.2 TC -7.9 -7.9 -7.9 -7.9 -7.5 -7.5 -7.5 -7.5 -8.0 -8.0 -8.0 -8.0 -8.3 -8.3 -8.3 -8.3 TG -9.7 -9.7 -9.7 -9.7 -9.3 -9.3 -9.3 -9.3 -9.8 -9.8 -9.8 -9.8 -10.1 -10.1 -10.1 -10.1 TT -5.5 -5.5 -5.5 -5.5 -5.1 -5.1 -5.1 -5.1 -5.6 -5.6 -5.6 -5.6 -5.9 -5.9 -5.9 -5.9 # 5' ------> 3' G X1 Y1 G C X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -3.9 -3.9 -3.9 -3.9 -3.6 -3.6 -3.6 -3.6 -5.5 -5.5 -5.5 -5.5 -12.0 -12.0 -12.0 -12.0 AC -1.0 -1.0 -1.0 -1.0 -0.7 -0.7 -0.7 -0.7 -2.6 -2.6 -2.6 -2.6 -9.1 -9.1 -9.1 -9.1 AG -2.8 -2.8 -2.8 -2.8 -2.5 -2.5 -2.5 -2.5 -4.4 -4.4 -4.4 -4.4 -10.9 -10.9 -10.9 -10.9 AT 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.7 -0.2 -0.2 -0.2 -0.2 -6.7 -6.7 -6.7 -6.7 CA -3.9 -3.9 -3.9 -3.9 -3.6 -3.6 -3.6 -3.6 -5.5 -5.5 -5.5 -5.5 -12.0 -12.0 -12.0 -12.0 CC -1.0 -1.0 -1.0 -1.0 -0.7 -0.7 -0.7 -0.7 -2.6 -2.6 -2.6 -2.6 -9.1 -9.1 -9.1 -9.1 CG -2.8 -2.8 -2.8 -2.8 -2.5 -2.5 -2.5 -2.5 -4.4 -4.4 -4.4 -4.4 -10.9 -10.9 -10.9 -10.9 CT 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.7 -0.2 -0.2 -0.2 -0.2 -6.7 -6.7 -6.7 -6.7 GA -3.9 -3.9 -3.9 -3.9 -3.6 -3.6 -3.6 -3.6 -5.5 -5.5 -5.5 -5.5 -12.0 -12.0 -12.0 -12.0 GC -1.0 -1.0 -1.0 -1.0 -0.7 -0.7 -0.7 -0.7 -2.6 -2.6 -2.6 -2.6 -9.1 -9.1 -9.1 -9.1 GG -2.8 -2.8 -2.8 -2.8 -2.5 -2.5 -2.5 -2.5 -4.4 -4.4 -4.4 -4.4 -10.9 -10.9 -10.9 -10.9 GT 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.7 -0.2 -0.2 -0.2 -0.2 -6.7 -6.7 -6.7 -6.7 TA -3.9 -3.9 -3.9 -3.9 -3.6 -3.6 -3.6 -3.6 -5.5 -5.5 -5.5 -5.5 -12.0 -12.0 -12.0 -12.0 TC -1.0 -1.0 -1.0 -1.0 -0.7 -0.7 -0.7 -0.7 -2.6 -2.6 -2.6 -2.6 -9.1 -9.1 -9.1 -9.1 TG -2.8 -2.8 -2.8 -2.8 -2.5 -2.5 -2.5 -2.5 -4.4 -4.4 -4.4 -4.4 -10.9 -10.9 -10.9 -10.9 TT 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.7 -0.2 -0.2 -0.2 -0.2 -6.7 -6.7 -6.7 -6.7 # 5' ------> 3' G X1 Y1 T C X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -2.2 -2.2 -2.2 -2.2 -1.0 -1.0 -1.0 -1.0 -1.5 -1.5 -1.5 -1.5 -1.9 -1.9 -1.9 -1.9 AC 0.7 0.7 0.7 0.7 1.9 1.9 1.9 1.9 1.4 1.4 1.4 1.4 1.0 1.0 1.0 1.0 AG -1.1 -1.1 -1.1 -1.1 0.1 0.1 0.1 0.1 -0.4 -0.4 -0.4 -0.4 -0.8 -0.8 -0.8 -0.8 AT 3.1 3.1 3.1 3.1 4.3 4.3 4.3 4.3 3.8 3.8 3.8 3.8 3.4 3.4 3.4 3.4 CA -2.2 -2.2 -2.2 -2.2 -1.0 -1.0 -1.0 -1.0 -1.5 -1.5 -1.5 -1.5 -1.9 -1.9 -1.9 -1.9 CC 0.7 0.7 0.7 0.7 1.9 1.9 1.9 1.9 1.4 1.4 1.4 1.4 1.0 1.0 1.0 1.0 CG -1.1 -1.1 -1.1 -1.1 0.1 0.1 0.1 0.1 -0.4 -0.4 -0.4 -0.4 -0.8 -0.8 -0.8 -0.8 CT 3.1 3.1 3.1 3.1 4.3 4.3 4.3 4.3 3.8 3.8 3.8 3.8 3.4 3.4 3.4 3.4 GA -2.2 -2.2 -2.2 -2.2 -1.0 -1.0 -1.0 -1.0 -1.5 -1.5 -1.5 -1.5 -1.9 -1.9 -1.9 -1.9 GC 0.7 0.7 0.7 0.7 1.9 1.9 1.9 1.9 1.4 1.4 1.4 1.4 1.0 1.0 1.0 1.0 GG -1.1 -1.1 -1.1 -1.1 0.1 0.1 0.1 0.1 -0.4 -0.4 -0.4 -0.4 -0.8 -0.8 -0.8 -0.8 GT 3.1 3.1 3.1 3.1 4.3 4.3 4.3 4.3 3.8 3.8 3.8 3.8 3.4 3.4 3.4 3.4 TA -2.2 -2.2 -2.2 -2.2 -1.0 -1.0 -1.0 -1.0 -1.5 -1.5 -1.5 -1.5 -1.9 -1.9 -1.9 -1.9 TC 0.7 0.7 0.7 0.7 1.9 1.9 1.9 1.9 1.4 1.4 1.4 1.4 1.0 1.0 1.0 1.0 TG -1.1 -1.1 -1.1 -1.1 0.1 0.1 0.1 0.1 -0.4 -0.4 -0.4 -0.4 -0.8 -0.8 -0.8 -0.8 TT 3.1 3.1 3.1 3.1 4.3 4.3 4.3 4.3 3.8 3.8 3.8 3.8 3.4 3.4 3.4 3.4 # 5' ------> 3' G X1 Y1 T C X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -9.2 -9.2 -9.2 -9.2 -6.3 -6.3 -6.3 -6.3 -8.1 -8.1 -8.1 -8.1 -3.9 -3.9 -3.9 -3.9 AC -6.3 -6.3 -6.3 -6.3 -3.4 -3.4 -3.4 -3.4 -5.2 -5.2 -5.2 -5.2 -1.0 -1.0 -1.0 -1.0 AG -8.1 -8.1 -8.1 -8.1 -5.2 -5.2 -5.2 -5.2 -7.0 -7.0 -7.0 -7.0 -2.8 -2.8 -2.8 -2.8 AT -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4 CA -9.2 -9.2 -9.2 -9.2 -6.3 -6.3 -6.3 -6.3 -8.1 -8.1 -8.1 -8.1 -3.9 -3.9 -3.9 -3.9 CC -6.3 -6.3 -6.3 -6.3 -3.4 -3.4 -3.4 -3.4 -5.2 -5.2 -5.2 -5.2 -1.0 -1.0 -1.0 -1.0 CG -8.1 -8.1 -8.1 -8.1 -5.2 -5.2 -5.2 -5.2 -7.0 -7.0 -7.0 -7.0 -2.8 -2.8 -2.8 -2.8 CT -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4 GA -9.2 -9.2 -9.2 -9.2 -6.3 -6.3 -6.3 -6.3 -8.1 -8.1 -8.1 -8.1 -3.9 -3.9 -3.9 -3.9 GC -6.3 -6.3 -6.3 -6.3 -3.4 -3.4 -3.4 -3.4 -5.2 -5.2 -5.2 -5.2 -1.0 -1.0 -1.0 -1.0 GG -8.1 -8.1 -8.1 -8.1 -5.2 -5.2 -5.2 -5.2 -7.0 -7.0 -7.0 -7.0 -2.8 -2.8 -2.8 -2.8 GT -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4 TA -9.2 -9.2 -9.2 -9.2 -6.3 -6.3 -6.3 -6.3 -8.1 -8.1 -8.1 -8.1 -3.9 -3.9 -3.9 -3.9 TC -6.3 -6.3 -6.3 -6.3 -3.4 -3.4 -3.4 -3.4 -5.2 -5.2 -5.2 -5.2 -1.0 -1.0 -1.0 -1.0 TG -8.1 -8.1 -8.1 -8.1 -5.2 -5.2 -5.2 -5.2 -7.0 -7.0 -7.0 -7.0 -2.8 -2.8 -2.8 -2.8 TT -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4 # 5' ------> 3' G X1 Y1 A T X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -0.7 -0.7 -0.7 -0.7 -0.4 -0.4 -0.4 -0.4 -2.3 -2.3 -2.3 -2.3 -8.8 -8.8 -8.8 -8.8 AC 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.5 0.6 0.6 0.6 0.6 -5.9 -5.9 -5.9 -5.9 AG 0.4 0.4 0.4 0.4 0.7 0.7 0.7 0.7 -1.2 -1.2 -1.2 -1.2 -7.7 -7.7 -7.7 -7.7 AT 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 CA -0.7 -0.7 -0.7 -0.7 -0.4 -0.4 -0.4 -0.4 -2.3 -2.3 -2.3 -2.3 -8.8 -8.8 -8.8 -8.8 CC 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.5 0.6 0.6 0.6 0.6 -5.9 -5.9 -5.9 -5.9 CG 0.4 0.4 0.4 0.4 0.7 0.7 0.7 0.7 -1.2 -1.2 -1.2 -1.2 -7.7 -7.7 -7.7 -7.7 CT 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 GA -0.7 -0.7 -0.7 -0.7 -0.4 -0.4 -0.4 -0.4 -2.3 -2.3 -2.3 -2.3 -8.8 -8.8 -8.8 -8.8 GC 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.5 0.6 0.6 0.6 0.6 -5.9 -5.9 -5.9 -5.9 GG 0.4 0.4 0.4 0.4 0.7 0.7 0.7 0.7 -1.2 -1.2 -1.2 -1.2 -7.7 -7.7 -7.7 -7.7 GT 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 TA -0.7 -0.7 -0.7 -0.7 -0.4 -0.4 -0.4 -0.4 -2.3 -2.3 -2.3 -2.3 -8.8 -8.8 -8.8 -8.8 TC 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.5 0.6 0.6 0.6 0.6 -5.9 -5.9 -5.9 -5.9 TG 0.4 0.4 0.4 0.4 0.7 0.7 0.7 0.7 -1.2 -1.2 -1.2 -1.2 -7.7 -7.7 -7.7 -7.7 TT 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 # 5' ------> 3' G X1 Y1 C T X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -9.2 -9.2 -9.2 -9.2 -6.3 -6.3 -6.3 -6.3 -8.1 -8.1 -8.1 -8.1 -3.9 -3.9 -3.9 -3.9 AC -6.3 -6.3 -6.3 -6.3 -3.4 -3.4 -3.4 -3.4 -5.2 -5.2 -5.2 -5.2 -1.0 -1.0 -1.0 -1.0 AG -8.1 -8.1 -8.1 -8.1 -5.2 -5.2 -5.2 -5.2 -7.0 -7.0 -7.0 -7.0 -2.8 -2.8 -2.8 -2.8 AT -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4 CA -9.2 -9.2 -9.2 -9.2 -6.3 -6.3 -6.3 -6.3 -8.1 -8.1 -8.1 -8.1 -3.9 -3.9 -3.9 -3.9 CC -6.3 -6.3 -6.3 -6.3 -3.4 -3.4 -3.4 -3.4 -5.2 -5.2 -5.2 -5.2 -1.0 -1.0 -1.0 -1.0 CG -8.1 -8.1 -8.1 -8.1 -5.2 -5.2 -5.2 -5.2 -7.0 -7.0 -7.0 -7.0 -2.8 -2.8 -2.8 -2.8 CT -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4 GA -9.2 -9.2 -9.2 -9.2 -6.3 -6.3 -6.3 -6.3 -8.1 -8.1 -8.1 -8.1 -3.9 -3.9 -3.9 -3.9 GC -6.3 -6.3 -6.3 -6.3 -3.4 -3.4 -3.4 -3.4 -5.2 -5.2 -5.2 -5.2 -1.0 -1.0 -1.0 -1.0 GG -8.1 -8.1 -8.1 -8.1 -5.2 -5.2 -5.2 -5.2 -7.0 -7.0 -7.0 -7.0 -2.8 -2.8 -2.8 -2.8 GT -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4 TA -9.2 -9.2 -9.2 -9.2 -6.3 -6.3 -6.3 -6.3 -8.1 -8.1 -8.1 -8.1 -3.9 -3.9 -3.9 -3.9 TC -6.3 -6.3 -6.3 -6.3 -3.4 -3.4 -3.4 -3.4 -5.2 -5.2 -5.2 -5.2 -1.0 -1.0 -1.0 -1.0 TG -8.1 -8.1 -8.1 -8.1 -5.2 -5.2 -5.2 -5.2 -7.0 -7.0 -7.0 -7.0 -2.8 -2.8 -2.8 -2.8 TT -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4 # 5' ------> 3' G X1 Y1 G T X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -7.6 -7.6 -7.6 -7.6 -7.2 -7.2 -7.2 -7.2 -7.7 -7.7 -7.7 -7.7 -8.0 -8.0 -8.0 -8.0 AC -4.7 -4.7 -4.7 -4.7 -4.3 -4.3 -4.3 -4.3 -4.8 -4.8 -4.8 -4.8 -5.1 -5.1 -5.1 -5.1 AG -6.5 -6.5 -6.5 -6.5 -6.1 -6.1 -6.1 -6.1 -6.6 -6.6 -6.6 -6.6 -6.9 -6.9 -6.9 -6.9 AT -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7 CA -7.6 -7.6 -7.6 -7.6 -7.2 -7.2 -7.2 -7.2 -7.7 -7.7 -7.7 -7.7 -8.0 -8.0 -8.0 -8.0 CC -4.7 -4.7 -4.7 -4.7 -4.3 -4.3 -4.3 -4.3 -4.8 -4.8 -4.8 -4.8 -5.1 -5.1 -5.1 -5.1 CG -6.5 -6.5 -6.5 -6.5 -6.1 -6.1 -6.1 -6.1 -6.6 -6.6 -6.6 -6.6 -6.9 -6.9 -6.9 -6.9 CT -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7 GA -7.6 -7.6 -7.6 -7.6 -7.2 -7.2 -7.2 -7.2 -7.7 -7.7 -7.7 -7.7 -8.0 -8.0 -8.0 -8.0 GC -4.7 -4.7 -4.7 -4.7 -4.3 -4.3 -4.3 -4.3 -4.8 -4.8 -4.8 -4.8 -5.1 -5.1 -5.1 -5.1 GG -6.5 -6.5 -6.5 -6.5 -6.1 -6.1 -6.1 -6.1 -6.6 -6.6 -6.6 -6.6 -6.9 -6.9 -6.9 -6.9 GT -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7 TA -7.6 -7.6 -7.6 -7.6 -7.2 -7.2 -7.2 -7.2 -7.7 -7.7 -7.7 -7.7 -8.0 -8.0 -8.0 -8.0 TC -4.7 -4.7 -4.7 -4.7 -4.3 -4.3 -4.3 -4.3 -4.8 -4.8 -4.8 -4.8 -5.1 -5.1 -5.1 -5.1 TG -6.5 -6.5 -6.5 -6.5 -6.1 -6.1 -6.1 -6.1 -6.6 -6.6 -6.6 -6.6 -6.9 -6.9 -6.9 -6.9 TT -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7 # 5' ------> 3' G X1 Y1 G T X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -0.7 -0.7 -0.7 -0.7 -0.4 -0.4 -0.4 -0.4 -2.3 -2.3 -2.3 -2.3 -8.8 -8.8 -8.8 -8.8 AC 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.5 0.6 0.6 0.6 0.6 -5.9 -5.9 -5.9 -5.9 AG 0.4 0.4 0.4 0.4 0.7 0.7 0.7 0.7 -1.2 -1.2 -1.2 -1.2 -7.7 -7.7 -7.7 -7.7 AT 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 CA -0.7 -0.7 -0.7 -0.7 -0.4 -0.4 -0.4 -0.4 -2.3 -2.3 -2.3 -2.3 -8.8 -8.8 -8.8 -8.8 CC 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.5 0.6 0.6 0.6 0.6 -5.9 -5.9 -5.9 -5.9 CG 0.4 0.4 0.4 0.4 0.7 0.7 0.7 0.7 -1.2 -1.2 -1.2 -1.2 -7.7 -7.7 -7.7 -7.7 CT 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 GA -0.7 -0.7 -0.7 -0.7 -0.4 -0.4 -0.4 -0.4 -2.3 -2.3 -2.3 -2.3 -8.8 -8.8 -8.8 -8.8 GC 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.5 0.6 0.6 0.6 0.6 -5.9 -5.9 -5.9 -5.9 GG 0.4 0.4 0.4 0.4 0.7 0.7 0.7 0.7 -1.2 -1.2 -1.2 -1.2 -7.7 -7.7 -7.7 -7.7 GT 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 TA -0.7 -0.7 -0.7 -0.7 -0.4 -0.4 -0.4 -0.4 -2.3 -2.3 -2.3 -2.3 -8.8 -8.8 -8.8 -8.8 TC 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.5 0.6 0.6 0.6 0.6 -5.9 -5.9 -5.9 -5.9 TG 0.4 0.4 0.4 0.4 0.7 0.7 0.7 0.7 -1.2 -1.2 -1.2 -1.2 -7.7 -7.7 -7.7 -7.7 TT 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 # 5' ------> 3' G X1 Y1 T T X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.0 1.0 1.0 1.0 2.2 2.2 2.2 2.2 1.7 1.7 1.7 1.7 1.3 1.3 1.3 1.3 AC 3.9 3.9 3.9 3.9 5.1 5.1 5.1 5.1 4.6 4.6 4.6 4.6 4.2 4.2 4.2 4.2 AG 2.1 2.1 2.1 2.1 3.3 3.3 3.3 3.3 2.8 2.8 2.8 2.8 2.4 2.4 2.4 2.4 AT 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6 CA 1.0 1.0 1.0 1.0 2.2 2.2 2.2 2.2 1.7 1.7 1.7 1.7 1.3 1.3 1.3 1.3 CC 3.9 3.9 3.9 3.9 5.1 5.1 5.1 5.1 4.6 4.6 4.6 4.6 4.2 4.2 4.2 4.2 CG 2.1 2.1 2.1 2.1 3.3 3.3 3.3 3.3 2.8 2.8 2.8 2.8 2.4 2.4 2.4 2.4 CT 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6 GA 1.0 1.0 1.0 1.0 2.2 2.2 2.2 2.2 1.7 1.7 1.7 1.7 1.3 1.3 1.3 1.3 GC 3.9 3.9 3.9 3.9 5.1 5.1 5.1 5.1 4.6 4.6 4.6 4.6 4.2 4.2 4.2 4.2 GG 2.1 2.1 2.1 2.1 3.3 3.3 3.3 3.3 2.8 2.8 2.8 2.8 2.4 2.4 2.4 2.4 GT 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6 TA 1.0 1.0 1.0 1.0 2.2 2.2 2.2 2.2 1.7 1.7 1.7 1.7 1.3 1.3 1.3 1.3 TC 3.9 3.9 3.9 3.9 5.1 5.1 5.1 5.1 4.6 4.6 4.6 4.6 4.2 4.2 4.2 4.2 TG 2.1 2.1 2.1 2.1 3.3 3.3 3.3 3.3 2.8 2.8 2.8 2.8 2.4 2.4 2.4 2.4 TT 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6 # 5' ------> 3' G X1 Y1 T T X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -6.0 -6.0 -6.0 -6.0 -3.1 -3.1 -3.1 -3.1 -4.9 -4.9 -4.9 -4.9 -0.7 -0.7 -0.7 -0.7 AC -3.1 -3.1 -3.1 -3.1 -0.2 -0.2 -0.2 -0.2 -2.0 -2.0 -2.0 -2.0 2.2 2.2 2.2 2.2 AG -4.9 -4.9 -4.9 -4.9 -2.0 -2.0 -2.0 -2.0 -3.8 -3.8 -3.8 -3.8 0.4 0.4 0.4 0.4 AT -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6 CA -6.0 -6.0 -6.0 -6.0 -3.1 -3.1 -3.1 -3.1 -4.9 -4.9 -4.9 -4.9 -0.7 -0.7 -0.7 -0.7 CC -3.1 -3.1 -3.1 -3.1 -0.2 -0.2 -0.2 -0.2 -2.0 -2.0 -2.0 -2.0 2.2 2.2 2.2 2.2 CG -4.9 -4.9 -4.9 -4.9 -2.0 -2.0 -2.0 -2.0 -3.8 -3.8 -3.8 -3.8 0.4 0.4 0.4 0.4 CT -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6 GA -6.0 -6.0 -6.0 -6.0 -3.1 -3.1 -3.1 -3.1 -4.9 -4.9 -4.9 -4.9 -0.7 -0.7 -0.7 -0.7 GC -3.1 -3.1 -3.1 -3.1 -0.2 -0.2 -0.2 -0.2 -2.0 -2.0 -2.0 -2.0 2.2 2.2 2.2 2.2 GG -4.9 -4.9 -4.9 -4.9 -2.0 -2.0 -2.0 -2.0 -3.8 -3.8 -3.8 -3.8 0.4 0.4 0.4 0.4 GT -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6 TA -6.0 -6.0 -6.0 -6.0 -3.1 -3.1 -3.1 -3.1 -4.9 -4.9 -4.9 -4.9 -0.7 -0.7 -0.7 -0.7 TC -3.1 -3.1 -3.1 -3.1 -0.2 -0.2 -0.2 -0.2 -2.0 -2.0 -2.0 -2.0 2.2 2.2 2.2 2.2 TG -4.9 -4.9 -4.9 -4.9 -2.0 -2.0 -2.0 -2.0 -3.8 -3.8 -3.8 -3.8 0.4 0.4 0.4 0.4 TT -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6 # 5' ------> 3' T X1 Y1 A A X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 AC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2 AG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1 AT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6 CA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 CC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2 CG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1 CT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6 GA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 GC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2 GG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1 GT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6 TA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 TC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2 TG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1 TT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6 # 5' ------> 3' T X1 Y1 C A X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4 AC -3.6 -3.6 -3.6 -3.6 -0.7 -0.7 -0.7 -0.7 -2.5 -2.5 -2.5 -2.5 1.7 1.7 1.7 1.7 AG -5.5 -5.5 -5.5 -5.5 -2.6 -2.6 -2.6 -2.6 -4.4 -4.4 -4.4 -4.4 -0.2 -0.2 -0.2 -0.2 AT -12.0 -12.0 -12.0 -12.0 -9.1 -9.1 -9.1 -9.1 -10.9 -10.9 -10.9 -10.9 -6.7 -6.7 -6.7 -6.7 CA -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4 CC -3.6 -3.6 -3.6 -3.6 -0.7 -0.7 -0.7 -0.7 -2.5 -2.5 -2.5 -2.5 1.7 1.7 1.7 1.7 CG -5.5 -5.5 -5.5 -5.5 -2.6 -2.6 -2.6 -2.6 -4.4 -4.4 -4.4 -4.4 -0.2 -0.2 -0.2 -0.2 CT -12.0 -12.0 -12.0 -12.0 -9.1 -9.1 -9.1 -9.1 -10.9 -10.9 -10.9 -10.9 -6.7 -6.7 -6.7 -6.7 GA -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4 GC -3.6 -3.6 -3.6 -3.6 -0.7 -0.7 -0.7 -0.7 -2.5 -2.5 -2.5 -2.5 1.7 1.7 1.7 1.7 GG -5.5 -5.5 -5.5 -5.5 -2.6 -2.6 -2.6 -2.6 -4.4 -4.4 -4.4 -4.4 -0.2 -0.2 -0.2 -0.2 GT -12.0 -12.0 -12.0 -12.0 -9.1 -9.1 -9.1 -9.1 -10.9 -10.9 -10.9 -10.9 -6.7 -6.7 -6.7 -6.7 TA -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4 TC -3.6 -3.6 -3.6 -3.6 -0.7 -0.7 -0.7 -0.7 -2.5 -2.5 -2.5 -2.5 1.7 1.7 1.7 1.7 TG -5.5 -5.5 -5.5 -5.5 -2.6 -2.6 -2.6 -2.6 -4.4 -4.4 -4.4 -4.4 -0.2 -0.2 -0.2 -0.2 TT -12.0 -12.0 -12.0 -12.0 -9.1 -9.1 -9.1 -9.1 -10.9 -10.9 -10.9 -10.9 -6.7 -6.7 -6.7 -6.7 # 5' ------> 3' T X1 Y1 G A X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7 AC -2.0 -2.0 -2.0 -2.0 -1.6 -1.6 -1.6 -1.6 -2.1 -2.1 -2.1 -2.1 -2.4 -2.4 -2.4 -2.4 AG -3.9 -3.9 -3.9 -3.9 -3.5 -3.5 -3.5 -3.5 -4.0 -4.0 -4.0 -4.0 -4.3 -4.3 -4.3 -4.3 AT -10.4 -10.4 -10.4 -10.4 -10.0 -10.0 -10.0 -10.0 -10.5 -10.5 -10.5 -10.5 -10.8 -10.8 -10.8 -10.8 CA -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7 CC -2.0 -2.0 -2.0 -2.0 -1.6 -1.6 -1.6 -1.6 -2.1 -2.1 -2.1 -2.1 -2.4 -2.4 -2.4 -2.4 CG -3.9 -3.9 -3.9 -3.9 -3.5 -3.5 -3.5 -3.5 -4.0 -4.0 -4.0 -4.0 -4.3 -4.3 -4.3 -4.3 CT -10.4 -10.4 -10.4 -10.4 -10.0 -10.0 -10.0 -10.0 -10.5 -10.5 -10.5 -10.5 -10.8 -10.8 -10.8 -10.8 GA -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7 GC -2.0 -2.0 -2.0 -2.0 -1.6 -1.6 -1.6 -1.6 -2.1 -2.1 -2.1 -2.1 -2.4 -2.4 -2.4 -2.4 GG -3.9 -3.9 -3.9 -3.9 -3.5 -3.5 -3.5 -3.5 -4.0 -4.0 -4.0 -4.0 -4.3 -4.3 -4.3 -4.3 GT -10.4 -10.4 -10.4 -10.4 -10.0 -10.0 -10.0 -10.0 -10.5 -10.5 -10.5 -10.5 -10.8 -10.8 -10.8 -10.8 TA -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7 TC -2.0 -2.0 -2.0 -2.0 -1.6 -1.6 -1.6 -1.6 -2.1 -2.1 -2.1 -2.1 -2.4 -2.4 -2.4 -2.4 TG -3.9 -3.9 -3.9 -3.9 -3.5 -3.5 -3.5 -3.5 -4.0 -4.0 -4.0 -4.0 -4.3 -4.3 -4.3 -4.3 TT -10.4 -10.4 -10.4 -10.4 -10.0 -10.0 -10.0 -10.0 -10.5 -10.5 -10.5 -10.5 -10.8 -10.8 -10.8 -10.8 # 5' ------> 3' T X1 Y1 G A X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 AC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2 AG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1 AT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6 CA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 CC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2 CG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1 CT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6 GA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 GC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2 GG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1 GT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6 TA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 TC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2 TG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1 TT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6 # 5' ------> 3' T X1 Y1 T A X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6 AC 6.6 6.6 6.6 6.6 7.8 7.8 7.8 7.8 7.3 7.3 7.3 7.3 6.9 6.9 6.9 6.9 AG 4.7 4.7 4.7 4.7 5.9 5.9 5.9 5.9 5.4 5.4 5.4 5.4 5.0 5.0 5.0 5.0 AT -1.8 -1.8 -1.8 -1.8 -0.6 -0.6 -0.6 -0.6 -1.1 -1.1 -1.1 -1.1 -1.5 -1.5 -1.5 -1.5 CA 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6 CC 6.6 6.6 6.6 6.6 7.8 7.8 7.8 7.8 7.3 7.3 7.3 7.3 6.9 6.9 6.9 6.9 CG 4.7 4.7 4.7 4.7 5.9 5.9 5.9 5.9 5.4 5.4 5.4 5.4 5.0 5.0 5.0 5.0 CT -1.8 -1.8 -1.8 -1.8 -0.6 -0.6 -0.6 -0.6 -1.1 -1.1 -1.1 -1.1 -1.5 -1.5 -1.5 -1.5 GA 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6 GC 6.6 6.6 6.6 6.6 7.8 7.8 7.8 7.8 7.3 7.3 7.3 7.3 6.9 6.9 6.9 6.9 GG 4.7 4.7 4.7 4.7 5.9 5.9 5.9 5.9 5.4 5.4 5.4 5.4 5.0 5.0 5.0 5.0 GT -1.8 -1.8 -1.8 -1.8 -0.6 -0.6 -0.6 -0.6 -1.1 -1.1 -1.1 -1.1 -1.5 -1.5 -1.5 -1.5 TA 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6 TC 6.6 6.6 6.6 6.6 7.8 7.8 7.8 7.8 7.3 7.3 7.3 7.3 6.9 6.9 6.9 6.9 TG 4.7 4.7 4.7 4.7 5.9 5.9 5.9 5.9 5.4 5.4 5.4 5.4 5.0 5.0 5.0 5.0 TT -1.8 -1.8 -1.8 -1.8 -0.6 -0.6 -0.6 -0.6 -1.1 -1.1 -1.1 -1.1 -1.5 -1.5 -1.5 -1.5 # 5' ------> 3' T X1 Y1 T A X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6 AC -0.4 -0.4 -0.4 -0.4 2.5 2.5 2.5 2.5 0.7 0.7 0.7 0.7 4.9 4.9 4.9 4.9 AG -2.3 -2.3 -2.3 -2.3 0.6 0.6 0.6 0.6 -1.2 -1.2 -1.2 -1.2 3.0 3.0 3.0 3.0 AT -8.8 -8.8 -8.8 -8.8 -5.9 -5.9 -5.9 -5.9 -7.7 -7.7 -7.7 -7.7 -3.5 -3.5 -3.5 -3.5 CA -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6 CC -0.4 -0.4 -0.4 -0.4 2.5 2.5 2.5 2.5 0.7 0.7 0.7 0.7 4.9 4.9 4.9 4.9 CG -2.3 -2.3 -2.3 -2.3 0.6 0.6 0.6 0.6 -1.2 -1.2 -1.2 -1.2 3.0 3.0 3.0 3.0 CT -8.8 -8.8 -8.8 -8.8 -5.9 -5.9 -5.9 -5.9 -7.7 -7.7 -7.7 -7.7 -3.5 -3.5 -3.5 -3.5 GA -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6 GC -0.4 -0.4 -0.4 -0.4 2.5 2.5 2.5 2.5 0.7 0.7 0.7 0.7 4.9 4.9 4.9 4.9 GG -2.3 -2.3 -2.3 -2.3 0.6 0.6 0.6 0.6 -1.2 -1.2 -1.2 -1.2 3.0 3.0 3.0 3.0 GT -8.8 -8.8 -8.8 -8.8 -5.9 -5.9 -5.9 -5.9 -7.7 -7.7 -7.7 -7.7 -3.5 -3.5 -3.5 -3.5 TA -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6 TC -0.4 -0.4 -0.4 -0.4 2.5 2.5 2.5 2.5 0.7 0.7 0.7 0.7 4.9 4.9 4.9 4.9 TG -2.3 -2.3 -2.3 -2.3 0.6 0.6 0.6 0.6 -1.2 -1.2 -1.2 -1.2 3.0 3.0 3.0 3.0 TT -8.8 -8.8 -8.8 -8.8 -5.9 -5.9 -5.9 -5.9 -7.7 -7.7 -7.7 -7.7 -3.5 -3.5 -3.5 -3.5 # 5' ------> 3' T X1 Y1 A G X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 AC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2 AG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1 AT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6 CA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 CC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2 CG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1 CT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6 GA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 GC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2 GG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1 GT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6 TA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 TC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2 TG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1 TT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6 # 5' ------> 3' T X1 Y1 C G X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4 AC -3.6 -3.6 -3.6 -3.6 -0.7 -0.7 -0.7 -0.7 -2.5 -2.5 -2.5 -2.5 1.7 1.7 1.7 1.7 AG -5.5 -5.5 -5.5 -5.5 -2.6 -2.6 -2.6 -2.6 -4.4 -4.4 -4.4 -4.4 -0.2 -0.2 -0.2 -0.2 AT -12.0 -12.0 -12.0 -12.0 -9.1 -9.1 -9.1 -9.1 -10.9 -10.9 -10.9 -10.9 -6.7 -6.7 -6.7 -6.7 CA -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4 CC -3.6 -3.6 -3.6 -3.6 -0.7 -0.7 -0.7 -0.7 -2.5 -2.5 -2.5 -2.5 1.7 1.7 1.7 1.7 CG -5.5 -5.5 -5.5 -5.5 -2.6 -2.6 -2.6 -2.6 -4.4 -4.4 -4.4 -4.4 -0.2 -0.2 -0.2 -0.2 CT -12.0 -12.0 -12.0 -12.0 -9.1 -9.1 -9.1 -9.1 -10.9 -10.9 -10.9 -10.9 -6.7 -6.7 -6.7 -6.7 GA -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4 GC -3.6 -3.6 -3.6 -3.6 -0.7 -0.7 -0.7 -0.7 -2.5 -2.5 -2.5 -2.5 1.7 1.7 1.7 1.7 GG -5.5 -5.5 -5.5 -5.5 -2.6 -2.6 -2.6 -2.6 -4.4 -4.4 -4.4 -4.4 -0.2 -0.2 -0.2 -0.2 GT -12.0 -12.0 -12.0 -12.0 -9.1 -9.1 -9.1 -9.1 -10.9 -10.9 -10.9 -10.9 -6.7 -6.7 -6.7 -6.7 TA -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4 TC -3.6 -3.6 -3.6 -3.6 -0.7 -0.7 -0.7 -0.7 -2.5 -2.5 -2.5 -2.5 1.7 1.7 1.7 1.7 TG -5.5 -5.5 -5.5 -5.5 -2.6 -2.6 -2.6 -2.6 -4.4 -4.4 -4.4 -4.4 -0.2 -0.2 -0.2 -0.2 TT -12.0 -12.0 -12.0 -12.0 -9.1 -9.1 -9.1 -9.1 -10.9 -10.9 -10.9 -10.9 -6.7 -6.7 -6.7 -6.7 # 5' ------> 3' T X1 Y1 G G X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7 AC -2.0 -2.0 -2.0 -2.0 -1.6 -1.6 -1.6 -1.6 -2.1 -2.1 -2.1 -2.1 -2.4 -2.4 -2.4 -2.4 AG -3.9 -3.9 -3.9 -3.9 -3.5 -3.5 -3.5 -3.5 -4.0 -4.0 -4.0 -4.0 -4.3 -4.3 -4.3 -4.3 AT -10.4 -10.4 -10.4 -10.4 -10.0 -10.0 -10.0 -10.0 -10.5 -10.5 -10.5 -10.5 -10.8 -10.8 -10.8 -10.8 CA -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7 CC -2.0 -2.0 -2.0 -2.0 -1.6 -1.6 -1.6 -1.6 -2.1 -2.1 -2.1 -2.1 -2.4 -2.4 -2.4 -2.4 CG -3.9 -3.9 -3.9 -3.9 -3.5 -3.5 -3.5 -3.5 -4.0 -4.0 -4.0 -4.0 -4.3 -4.3 -4.3 -4.3 CT -10.4 -10.4 -10.4 -10.4 -10.0 -10.0 -10.0 -10.0 -10.5 -10.5 -10.5 -10.5 -10.8 -10.8 -10.8 -10.8 GA -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7 GC -2.0 -2.0 -2.0 -2.0 -1.6 -1.6 -1.6 -1.6 -2.1 -2.1 -2.1 -2.1 -2.4 -2.4 -2.4 -2.4 GG -3.9 -3.9 -3.9 -3.9 -3.5 -3.5 -3.5 -3.5 -4.0 -4.0 -4.0 -4.0 -4.3 -4.3 -4.3 -4.3 GT -10.4 -10.4 -10.4 -10.4 -10.0 -10.0 -10.0 -10.0 -10.5 -10.5 -10.5 -10.5 -10.8 -10.8 -10.8 -10.8 TA -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7 TC -2.0 -2.0 -2.0 -2.0 -1.6 -1.6 -1.6 -1.6 -2.1 -2.1 -2.1 -2.1 -2.4 -2.4 -2.4 -2.4 TG -3.9 -3.9 -3.9 -3.9 -3.5 -3.5 -3.5 -3.5 -4.0 -4.0 -4.0 -4.0 -4.3 -4.3 -4.3 -4.3 TT -10.4 -10.4 -10.4 -10.4 -10.0 -10.0 -10.0 -10.0 -10.5 -10.5 -10.5 -10.5 -10.8 -10.8 -10.8 -10.8 # 5' ------> 3' T X1 Y1 G G X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 AC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2 AG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1 AT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6 CA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 CC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2 CG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1 CT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6 GA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 GC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2 GG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1 GT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6 TA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5 TC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2 TG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1 TT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6 # 5' ------> 3' T X1 Y1 T G X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6 AC 6.6 6.6 6.6 6.6 7.8 7.8 7.8 7.8 7.3 7.3 7.3 7.3 6.9 6.9 6.9 6.9 AG 4.7 4.7 4.7 4.7 5.9 5.9 5.9 5.9 5.4 5.4 5.4 5.4 5.0 5.0 5.0 5.0 AT -1.8 -1.8 -1.8 -1.8 -0.6 -0.6 -0.6 -0.6 -1.1 -1.1 -1.1 -1.1 -1.5 -1.5 -1.5 -1.5 CA 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6 CC 6.6 6.6 6.6 6.6 7.8 7.8 7.8 7.8 7.3 7.3 7.3 7.3 6.9 6.9 6.9 6.9 CG 4.7 4.7 4.7 4.7 5.9 5.9 5.9 5.9 5.4 5.4 5.4 5.4 5.0 5.0 5.0 5.0 CT -1.8 -1.8 -1.8 -1.8 -0.6 -0.6 -0.6 -0.6 -1.1 -1.1 -1.1 -1.1 -1.5 -1.5 -1.5 -1.5 GA 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6 GC 6.6 6.6 6.6 6.6 7.8 7.8 7.8 7.8 7.3 7.3 7.3 7.3 6.9 6.9 6.9 6.9 GG 4.7 4.7 4.7 4.7 5.9 5.9 5.9 5.9 5.4 5.4 5.4 5.4 5.0 5.0 5.0 5.0 GT -1.8 -1.8 -1.8 -1.8 -0.6 -0.6 -0.6 -0.6 -1.1 -1.1 -1.1 -1.1 -1.5 -1.5 -1.5 -1.5 TA 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6 TC 6.6 6.6 6.6 6.6 7.8 7.8 7.8 7.8 7.3 7.3 7.3 7.3 6.9 6.9 6.9 6.9 TG 4.7 4.7 4.7 4.7 5.9 5.9 5.9 5.9 5.4 5.4 5.4 5.4 5.0 5.0 5.0 5.0 TT -1.8 -1.8 -1.8 -1.8 -0.6 -0.6 -0.6 -0.6 -1.1 -1.1 -1.1 -1.1 -1.5 -1.5 -1.5 -1.5 # 5' ------> 3' T X1 Y1 T G X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6 AC -0.4 -0.4 -0.4 -0.4 2.5 2.5 2.5 2.5 0.7 0.7 0.7 0.7 4.9 4.9 4.9 4.9 AG -2.3 -2.3 -2.3 -2.3 0.6 0.6 0.6 0.6 -1.2 -1.2 -1.2 -1.2 3.0 3.0 3.0 3.0 AT -8.8 -8.8 -8.8 -8.8 -5.9 -5.9 -5.9 -5.9 -7.7 -7.7 -7.7 -7.7 -3.5 -3.5 -3.5 -3.5 CA -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6 CC -0.4 -0.4 -0.4 -0.4 2.5 2.5 2.5 2.5 0.7 0.7 0.7 0.7 4.9 4.9 4.9 4.9 CG -2.3 -2.3 -2.3 -2.3 0.6 0.6 0.6 0.6 -1.2 -1.2 -1.2 -1.2 3.0 3.0 3.0 3.0 CT -8.8 -8.8 -8.8 -8.8 -5.9 -5.9 -5.9 -5.9 -7.7 -7.7 -7.7 -7.7 -3.5 -3.5 -3.5 -3.5 GA -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6 GC -0.4 -0.4 -0.4 -0.4 2.5 2.5 2.5 2.5 0.7 0.7 0.7 0.7 4.9 4.9 4.9 4.9 GG -2.3 -2.3 -2.3 -2.3 0.6 0.6 0.6 0.6 -1.2 -1.2 -1.2 -1.2 3.0 3.0 3.0 3.0 GT -8.8 -8.8 -8.8 -8.8 -5.9 -5.9 -5.9 -5.9 -7.7 -7.7 -7.7 -7.7 -3.5 -3.5 -3.5 -3.5 TA -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6 TC -0.4 -0.4 -0.4 -0.4 2.5 2.5 2.5 2.5 0.7 0.7 0.7 0.7 4.9 4.9 4.9 4.9 TG -2.3 -2.3 -2.3 -2.3 0.6 0.6 0.6 0.6 -1.2 -1.2 -1.2 -1.2 3.0 3.0 3.0 3.0 TT -8.8 -8.8 -8.8 -8.8 -5.9 -5.9 -5.9 -5.9 -7.7 -7.7 -7.7 -7.7 -3.5 -3.5 -3.5 -3.5