# Data tables for 2x2 interior loops
# The Enthalpies for DNA
# Data arrangement:
#
# 5' ------> 3'
# A X1 Y1 A
# T X2 Y2 T
# 3' <------ 5'
#
# Y-->
# ----------------------------------------------------------------------------------------------------------------------------
# (X) A A A A C C C C G G G G T T T T
# | A C G T A C G T A C G T A C G T
# V ----------------------------------------------------------------------------------------------------------------------------
# (AA) 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8
# (AC) 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6
# (AG) 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1
# (AT) 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5
# (CA) 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8
# (CC) 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6
# (CG) 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1
# (CT) 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5
# (GA) 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8
# (GC) 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6
# (GG) 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1
# (GT) 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5
# (TA) 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8
# (TC) 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6
# (TG) 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1
# (TT) 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5
# 5' ------> 3'
A X1 Y1 A
T X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8
AC 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6
AG 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1
AT 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5
CA 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8
CC 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6
CG 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1
CT 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5
GA 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8
GC 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6
GG 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1
GT 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5
TA 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8
TC 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6
TG 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1
TT 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5
# 5' ------> 3'
A X1 Y1 C
T X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -2.2 -2.2 -2.2 -2.2 0.7 0.7 0.7 0.7 -1.1 -1.1 -1.1 -1.1 3.1 3.1 3.1 3.1
AC -1.0 -1.0 -1.0 -1.0 1.9 1.9 1.9 1.9 0.1 0.1 0.1 0.1 4.3 4.3 4.3 4.3
AG -1.5 -1.5 -1.5 -1.5 1.4 1.4 1.4 1.4 -0.4 -0.4 -0.4 -0.4 3.8 3.8 3.8 3.8
AT -1.9 -1.9 -1.9 -1.9 1.0 1.0 1.0 1.0 -0.8 -0.8 -0.8 -0.8 3.4 3.4 3.4 3.4
CA -2.2 -2.2 -2.2 -2.2 0.7 0.7 0.7 0.7 -1.1 -1.1 -1.1 -1.1 3.1 3.1 3.1 3.1
CC -1.0 -1.0 -1.0 -1.0 1.9 1.9 1.9 1.9 0.1 0.1 0.1 0.1 4.3 4.3 4.3 4.3
CG -1.5 -1.5 -1.5 -1.5 1.4 1.4 1.4 1.4 -0.4 -0.4 -0.4 -0.4 3.8 3.8 3.8 3.8
CT -1.9 -1.9 -1.9 -1.9 1.0 1.0 1.0 1.0 -0.8 -0.8 -0.8 -0.8 3.4 3.4 3.4 3.4
GA -2.2 -2.2 -2.2 -2.2 0.7 0.7 0.7 0.7 -1.1 -1.1 -1.1 -1.1 3.1 3.1 3.1 3.1
GC -1.0 -1.0 -1.0 -1.0 1.9 1.9 1.9 1.9 0.1 0.1 0.1 0.1 4.3 4.3 4.3 4.3
GG -1.5 -1.5 -1.5 -1.5 1.4 1.4 1.4 1.4 -0.4 -0.4 -0.4 -0.4 3.8 3.8 3.8 3.8
GT -1.9 -1.9 -1.9 -1.9 1.0 1.0 1.0 1.0 -0.8 -0.8 -0.8 -0.8 3.4 3.4 3.4 3.4
TA -2.2 -2.2 -2.2 -2.2 0.7 0.7 0.7 0.7 -1.1 -1.1 -1.1 -1.1 3.1 3.1 3.1 3.1
TC -1.0 -1.0 -1.0 -1.0 1.9 1.9 1.9 1.9 0.1 0.1 0.1 0.1 4.3 4.3 4.3 4.3
TG -1.5 -1.5 -1.5 -1.5 1.4 1.4 1.4 1.4 -0.4 -0.4 -0.4 -0.4 3.8 3.8 3.8 3.8
TT -1.9 -1.9 -1.9 -1.9 1.0 1.0 1.0 1.0 -0.8 -0.8 -0.8 -0.8 3.4 3.4 3.4 3.4
# 5' ------> 3'
A X1 Y1 G
T X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -0.6 -0.6 -0.6 -0.6 -0.2 -0.2 -0.2 -0.2 -0.7 -0.7 -0.7 -0.7 -1.0 -1.0 -1.0 -1.0
AC 0.6 0.6 0.6 0.6 1.0 1.0 1.0 1.0 0.5 0.5 0.5 0.5 0.2 0.2 0.2 0.2
AG 0.1 0.1 0.1 0.1 0.5 0.5 0.5 0.5 0.0 0.0 0.0 0.0 -0.3 -0.3 -0.3 -0.3
AT -0.3 -0.3 -0.3 -0.3 0.1 0.1 0.1 0.1 -0.4 -0.4 -0.4 -0.4 -0.7 -0.7 -0.7 -0.7
CA -0.6 -0.6 -0.6 -0.6 -0.2 -0.2 -0.2 -0.2 -0.7 -0.7 -0.7 -0.7 -1.0 -1.0 -1.0 -1.0
CC 0.6 0.6 0.6 0.6 1.0 1.0 1.0 1.0 0.5 0.5 0.5 0.5 0.2 0.2 0.2 0.2
CG 0.1 0.1 0.1 0.1 0.5 0.5 0.5 0.5 0.0 0.0 0.0 0.0 -0.3 -0.3 -0.3 -0.3
CT -0.3 -0.3 -0.3 -0.3 0.1 0.1 0.1 0.1 -0.4 -0.4 -0.4 -0.4 -0.7 -0.7 -0.7 -0.7
GA -0.6 -0.6 -0.6 -0.6 -0.2 -0.2 -0.2 -0.2 -0.7 -0.7 -0.7 -0.7 -1.0 -1.0 -1.0 -1.0
GC 0.6 0.6 0.6 0.6 1.0 1.0 1.0 1.0 0.5 0.5 0.5 0.5 0.2 0.2 0.2 0.2
GG 0.1 0.1 0.1 0.1 0.5 0.5 0.5 0.5 0.0 0.0 0.0 0.0 -0.3 -0.3 -0.3 -0.3
GT -0.3 -0.3 -0.3 -0.3 0.1 0.1 0.1 0.1 -0.4 -0.4 -0.4 -0.4 -0.7 -0.7 -0.7 -0.7
TA -0.6 -0.6 -0.6 -0.6 -0.2 -0.2 -0.2 -0.2 -0.7 -0.7 -0.7 -0.7 -1.0 -1.0 -1.0 -1.0
TC 0.6 0.6 0.6 0.6 1.0 1.0 1.0 1.0 0.5 0.5 0.5 0.5 0.2 0.2 0.2 0.2
TG 0.1 0.1 0.1 0.1 0.5 0.5 0.5 0.5 0.0 0.0 0.0 0.0 -0.3 -0.3 -0.3 -0.3
TT -0.3 -0.3 -0.3 -0.3 0.1 0.1 0.1 0.1 -0.4 -0.4 -0.4 -0.4 -0.7 -0.7 -0.7 -0.7
# 5' ------> 3'
A X1 Y1 G
T X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8
AC 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6
AG 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1
AT 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5
CA 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8
CC 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6
CG 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1
CT 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5
GA 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8
GC 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6
GG 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1
GT 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5
TA 6.3 6.3 6.3 6.3 6.6 6.6 6.6 6.6 4.7 4.7 4.7 4.7 -1.8 -1.8 -1.8 -1.8
TC 7.5 7.5 7.5 7.5 7.8 7.8 7.8 7.8 5.9 5.9 5.9 5.9 -0.6 -0.6 -0.6 -0.6
TG 7.0 7.0 7.0 7.0 7.3 7.3 7.3 7.3 5.4 5.4 5.4 5.4 -1.1 -1.1 -1.1 -1.1
TT 6.6 6.6 6.6 6.6 6.9 6.9 6.9 6.9 5.0 5.0 5.0 5.0 -1.5 -1.5 -1.5 -1.5
# 5' ------> 3'
A X1 Y1 T
T X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 8.0 8.0 8.0 8.0 9.2 9.2 9.2 9.2 8.7 8.7 8.7 8.7 8.3 8.3 8.3 8.3
AC 9.2 9.2 9.2 9.2 10.4 10.4 10.4 10.4 9.9 9.9 9.9 9.9 9.5 9.5 9.5 9.5
AG 8.7 8.7 8.7 8.7 9.9 9.9 9.9 9.9 9.4 9.4 9.4 9.4 9.0 9.0 9.0 9.0
AT 8.3 8.3 8.3 8.3 9.5 9.5 9.5 9.5 9.0 9.0 9.0 9.0 8.6 8.6 8.6 8.6
CA 8.0 8.0 8.0 8.0 9.2 9.2 9.2 9.2 8.7 8.7 8.7 8.7 8.3 8.3 8.3 8.3
CC 9.2 9.2 9.2 9.2 10.4 10.4 10.4 10.4 9.9 9.9 9.9 9.9 9.5 9.5 9.5 9.5
CG 8.7 8.7 8.7 8.7 9.9 9.9 9.9 9.9 9.4 9.4 9.4 9.4 9.0 9.0 9.0 9.0
CT 8.3 8.3 8.3 8.3 9.5 9.5 9.5 9.5 9.0 9.0 9.0 9.0 8.6 8.6 8.6 8.6
GA 8.0 8.0 8.0 8.0 9.2 9.2 9.2 9.2 8.7 8.7 8.7 8.7 8.3 8.3 8.3 8.3
GC 9.2 9.2 9.2 9.2 10.4 10.4 10.4 10.4 9.9 9.9 9.9 9.9 9.5 9.5 9.5 9.5
GG 8.7 8.7 8.7 8.7 9.9 9.9 9.9 9.9 9.4 9.4 9.4 9.4 9.0 9.0 9.0 9.0
GT 8.3 8.3 8.3 8.3 9.5 9.5 9.5 9.5 9.0 9.0 9.0 9.0 8.6 8.6 8.6 8.6
TA 8.0 8.0 8.0 8.0 9.2 9.2 9.2 9.2 8.7 8.7 8.7 8.7 8.3 8.3 8.3 8.3
TC 9.2 9.2 9.2 9.2 10.4 10.4 10.4 10.4 9.9 9.9 9.9 9.9 9.5 9.5 9.5 9.5
TG 8.7 8.7 8.7 8.7 9.9 9.9 9.9 9.9 9.4 9.4 9.4 9.4 9.0 9.0 9.0 9.0
TT 8.3 8.3 8.3 8.3 9.5 9.5 9.5 9.5 9.0 9.0 9.0 9.0 8.6 8.6 8.6 8.6
# 5' ------> 3'
A X1 Y1 T
T X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.0 1.0 1.0 1.0 3.9 3.9 3.9 3.9 2.1 2.1 2.1 2.1 6.3 6.3 6.3 6.3
AC 2.2 2.2 2.2 2.2 5.1 5.1 5.1 5.1 3.3 3.3 3.3 3.3 7.5 7.5 7.5 7.5
AG 1.7 1.7 1.7 1.7 4.6 4.6 4.6 4.6 2.8 2.8 2.8 2.8 7.0 7.0 7.0 7.0
AT 1.3 1.3 1.3 1.3 4.2 4.2 4.2 4.2 2.4 2.4 2.4 2.4 6.6 6.6 6.6 6.6
CA 1.0 1.0 1.0 1.0 3.9 3.9 3.9 3.9 2.1 2.1 2.1 2.1 6.3 6.3 6.3 6.3
CC 2.2 2.2 2.2 2.2 5.1 5.1 5.1 5.1 3.3 3.3 3.3 3.3 7.5 7.5 7.5 7.5
CG 1.7 1.7 1.7 1.7 4.6 4.6 4.6 4.6 2.8 2.8 2.8 2.8 7.0 7.0 7.0 7.0
CT 1.3 1.3 1.3 1.3 4.2 4.2 4.2 4.2 2.4 2.4 2.4 2.4 6.6 6.6 6.6 6.6
GA 1.0 1.0 1.0 1.0 3.9 3.9 3.9 3.9 2.1 2.1 2.1 2.1 6.3 6.3 6.3 6.3
GC 2.2 2.2 2.2 2.2 5.1 5.1 5.1 5.1 3.3 3.3 3.3 3.3 7.5 7.5 7.5 7.5
GG 1.7 1.7 1.7 1.7 4.6 4.6 4.6 4.6 2.8 2.8 2.8 2.8 7.0 7.0 7.0 7.0
GT 1.3 1.3 1.3 1.3 4.2 4.2 4.2 4.2 2.4 2.4 2.4 2.4 6.6 6.6 6.6 6.6
TA 1.0 1.0 1.0 1.0 3.9 3.9 3.9 3.9 2.1 2.1 2.1 2.1 6.3 6.3 6.3 6.3
TC 2.2 2.2 2.2 2.2 5.1 5.1 5.1 5.1 3.3 3.3 3.3 3.3 7.5 7.5 7.5 7.5
TG 1.7 1.7 1.7 1.7 4.6 4.6 4.6 4.6 2.8 2.8 2.8 2.8 7.0 7.0 7.0 7.0
TT 1.3 1.3 1.3 1.3 4.2 4.2 4.2 4.2 2.4 2.4 2.4 2.4 6.6 6.6 6.6 6.6
# 5' ------> 3'
C X1 Y1 A
G X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -2.3 -2.3 -2.3 -2.3 -2.0 -2.0 -2.0 -2.0 -3.9 -3.9 -3.9 -3.9 -10.4 -10.4 -10.4 -10.4
AC -1.9 -1.9 -1.9 -1.9 -1.6 -1.6 -1.6 -1.6 -3.5 -3.5 -3.5 -3.5 -10.0 -10.0 -10.0 -10.0
AG -2.4 -2.4 -2.4 -2.4 -2.1 -2.1 -2.1 -2.1 -4.0 -4.0 -4.0 -4.0 -10.5 -10.5 -10.5 -10.5
AT -2.7 -2.7 -2.7 -2.7 -2.4 -2.4 -2.4 -2.4 -4.3 -4.3 -4.3 -4.3 -10.8 -10.8 -10.8 -10.8
CA -2.3 -2.3 -2.3 -2.3 -2.0 -2.0 -2.0 -2.0 -3.9 -3.9 -3.9 -3.9 -10.4 -10.4 -10.4 -10.4
CC -1.9 -1.9 -1.9 -1.9 -1.6 -1.6 -1.6 -1.6 -3.5 -3.5 -3.5 -3.5 -10.0 -10.0 -10.0 -10.0
CG -2.4 -2.4 -2.4 -2.4 -2.1 -2.1 -2.1 -2.1 -4.0 -4.0 -4.0 -4.0 -10.5 -10.5 -10.5 -10.5
CT -2.7 -2.7 -2.7 -2.7 -2.4 -2.4 -2.4 -2.4 -4.3 -4.3 -4.3 -4.3 -10.8 -10.8 -10.8 -10.8
GA -2.3 -2.3 -2.3 -2.3 -2.0 -2.0 -2.0 -2.0 -3.9 -3.9 -3.9 -3.9 -10.4 -10.4 -10.4 -10.4
GC -1.9 -1.9 -1.9 -1.9 -1.6 -1.6 -1.6 -1.6 -3.5 -3.5 -3.5 -3.5 -10.0 -10.0 -10.0 -10.0
GG -2.4 -2.4 -2.4 -2.4 -2.1 -2.1 -2.1 -2.1 -4.0 -4.0 -4.0 -4.0 -10.5 -10.5 -10.5 -10.5
GT -2.7 -2.7 -2.7 -2.7 -2.4 -2.4 -2.4 -2.4 -4.3 -4.3 -4.3 -4.3 -10.8 -10.8 -10.8 -10.8
TA -2.3 -2.3 -2.3 -2.3 -2.0 -2.0 -2.0 -2.0 -3.9 -3.9 -3.9 -3.9 -10.4 -10.4 -10.4 -10.4
TC -1.9 -1.9 -1.9 -1.9 -1.6 -1.6 -1.6 -1.6 -3.5 -3.5 -3.5 -3.5 -10.0 -10.0 -10.0 -10.0
TG -2.4 -2.4 -2.4 -2.4 -2.1 -2.1 -2.1 -2.1 -4.0 -4.0 -4.0 -4.0 -10.5 -10.5 -10.5 -10.5
TT -2.7 -2.7 -2.7 -2.7 -2.4 -2.4 -2.4 -2.4 -4.3 -4.3 -4.3 -4.3 -10.8 -10.8 -10.8 -10.8
# 5' ------> 3'
C X1 Y1 C
G X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -10.8 -10.8 -10.8 -10.8 -7.9 -7.9 -7.9 -7.9 -9.7 -9.7 -9.7 -9.7 -5.5 -5.5 -5.5 -5.5
AC -10.4 -10.4 -10.4 -10.4 -7.5 -7.5 -7.5 -7.5 -9.3 -9.3 -9.3 -9.3 -5.1 -5.1 -5.1 -5.1
AG -10.9 -10.9 -10.9 -10.9 -8.0 -8.0 -8.0 -8.0 -9.8 -9.8 -9.8 -9.8 -5.6 -5.6 -5.6 -5.6
AT -11.2 -11.2 -11.2 -11.2 -8.3 -8.3 -8.3 -8.3 -10.1 -10.1 -10.1 -10.1 -5.9 -5.9 -5.9 -5.9
CA -10.8 -10.8 -10.8 -10.8 -7.9 -7.9 -7.9 -7.9 -9.7 -9.7 -9.7 -9.7 -5.5 -5.5 -5.5 -5.5
CC -10.4 -10.4 -10.4 -10.4 -7.5 -7.5 -7.5 -7.5 -9.3 -9.3 -9.3 -9.3 -5.1 -5.1 -5.1 -5.1
CG -10.9 -10.9 -10.9 -10.9 -8.0 -8.0 -8.0 -8.0 -9.8 -9.8 -9.8 -9.8 -5.6 -5.6 -5.6 -5.6
CT -11.2 -11.2 -11.2 -11.2 -8.3 -8.3 -8.3 -8.3 -10.1 -10.1 -10.1 -10.1 -5.9 -5.9 -5.9 -5.9
GA -10.8 -10.8 -10.8 -10.8 -7.9 -7.9 -7.9 -7.9 -9.7 -9.7 -9.7 -9.7 -5.5 -5.5 -5.5 -5.5
GC -10.4 -10.4 -10.4 -10.4 -7.5 -7.5 -7.5 -7.5 -9.3 -9.3 -9.3 -9.3 -5.1 -5.1 -5.1 -5.1
GG -10.9 -10.9 -10.9 -10.9 -8.0 -8.0 -8.0 -8.0 -9.8 -9.8 -9.8 -9.8 -5.6 -5.6 -5.6 -5.6
GT -11.2 -11.2 -11.2 -11.2 -8.3 -8.3 -8.3 -8.3 -10.1 -10.1 -10.1 -10.1 -5.9 -5.9 -5.9 -5.9
TA -10.8 -10.8 -10.8 -10.8 -7.9 -7.9 -7.9 -7.9 -9.7 -9.7 -9.7 -9.7 -5.5 -5.5 -5.5 -5.5
TC -10.4 -10.4 -10.4 -10.4 -7.5 -7.5 -7.5 -7.5 -9.3 -9.3 -9.3 -9.3 -5.1 -5.1 -5.1 -5.1
TG -10.9 -10.9 -10.9 -10.9 -8.0 -8.0 -8.0 -8.0 -9.8 -9.8 -9.8 -9.8 -5.6 -5.6 -5.6 -5.6
TT -11.2 -11.2 -11.2 -11.2 -8.3 -8.3 -8.3 -8.3 -10.1 -10.1 -10.1 -10.1 -5.9 -5.9 -5.9 -5.9
# 5' ------> 3'
C X1 Y1 G
G X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -9.2 -9.2 -9.2 -9.2 -8.8 -8.8 -8.8 -8.8 -9.3 -9.3 -9.3 -9.3 -9.6 -9.6 -9.6 -9.6
AC -8.8 -8.8 -8.8 -8.8 -8.4 -8.4 -8.4 -8.4 -8.9 -8.9 -8.9 -8.9 -9.2 -9.2 -9.2 -9.2
AG -9.3 -9.3 -9.3 -9.3 -8.9 -8.9 -8.9 -8.9 -9.4 -9.4 -9.4 -9.4 -9.7 -9.7 -9.7 -9.7
AT -9.6 -9.6 -9.6 -9.6 -9.2 -9.2 -9.2 -9.2 -9.7 -9.7 -9.7 -9.7 -10.0 -10.0 -10.0 -10.0
CA -9.2 -9.2 -9.2 -9.2 -8.8 -8.8 -8.8 -8.8 -9.3 -9.3 -9.3 -9.3 -9.6 -9.6 -9.6 -9.6
CC -8.8 -8.8 -8.8 -8.8 -8.4 -8.4 -8.4 -8.4 -8.9 -8.9 -8.9 -8.9 -9.2 -9.2 -9.2 -9.2
CG -9.3 -9.3 -9.3 -9.3 -8.9 -8.9 -8.9 -8.9 -9.4 -9.4 -9.4 -9.4 -9.7 -9.7 -9.7 -9.7
CT -9.6 -9.6 -9.6 -9.6 -9.2 -9.2 -9.2 -9.2 -9.7 -9.7 -9.7 -9.7 -10.0 -10.0 -10.0 -10.0
GA -9.2 -9.2 -9.2 -9.2 -8.8 -8.8 -8.8 -8.8 -9.3 -9.3 -9.3 -9.3 -9.6 -9.6 -9.6 -9.6
GC -8.8 -8.8 -8.8 -8.8 -8.4 -8.4 -8.4 -8.4 -8.9 -8.9 -8.9 -8.9 -9.2 -9.2 -9.2 -9.2
GG -9.3 -9.3 -9.3 -9.3 -8.9 -8.9 -8.9 -8.9 -9.4 -9.4 -9.4 -9.4 -9.7 -9.7 -9.7 -9.7
GT -9.6 -9.6 -9.6 -9.6 -9.2 -9.2 -9.2 -9.2 -9.7 -9.7 -9.7 -9.7 -10.0 -10.0 -10.0 -10.0
TA -9.2 -9.2 -9.2 -9.2 -8.8 -8.8 -8.8 -8.8 -9.3 -9.3 -9.3 -9.3 -9.6 -9.6 -9.6 -9.6
TC -8.8 -8.8 -8.8 -8.8 -8.4 -8.4 -8.4 -8.4 -8.9 -8.9 -8.9 -8.9 -9.2 -9.2 -9.2 -9.2
TG -9.3 -9.3 -9.3 -9.3 -8.9 -8.9 -8.9 -8.9 -9.4 -9.4 -9.4 -9.4 -9.7 -9.7 -9.7 -9.7
TT -9.6 -9.6 -9.6 -9.6 -9.2 -9.2 -9.2 -9.2 -9.7 -9.7 -9.7 -9.7 -10.0 -10.0 -10.0 -10.0
# 5' ------> 3'
C X1 Y1 G
G X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -2.3 -2.3 -2.3 -2.3 -2.0 -2.0 -2.0 -2.0 -3.9 -3.9 -3.9 -3.9 -10.4 -10.4 -10.4 -10.4
AC -1.9 -1.9 -1.9 -1.9 -1.6 -1.6 -1.6 -1.6 -3.5 -3.5 -3.5 -3.5 -10.0 -10.0 -10.0 -10.0
AG -2.4 -2.4 -2.4 -2.4 -2.1 -2.1 -2.1 -2.1 -4.0 -4.0 -4.0 -4.0 -10.5 -10.5 -10.5 -10.5
AT -2.7 -2.7 -2.7 -2.7 -2.4 -2.4 -2.4 -2.4 -4.3 -4.3 -4.3 -4.3 -10.8 -10.8 -10.8 -10.8
CA -2.3 -2.3 -2.3 -2.3 -2.0 -2.0 -2.0 -2.0 -3.9 -3.9 -3.9 -3.9 -10.4 -10.4 -10.4 -10.4
CC -1.9 -1.9 -1.9 -1.9 -1.6 -1.6 -1.6 -1.6 -3.5 -3.5 -3.5 -3.5 -10.0 -10.0 -10.0 -10.0
CG -2.4 -2.4 -2.4 -2.4 -2.1 -2.1 -2.1 -2.1 -4.0 -4.0 -4.0 -4.0 -10.5 -10.5 -10.5 -10.5
CT -2.7 -2.7 -2.7 -2.7 -2.4 -2.4 -2.4 -2.4 -4.3 -4.3 -4.3 -4.3 -10.8 -10.8 -10.8 -10.8
GA -2.3 -2.3 -2.3 -2.3 -2.0 -2.0 -2.0 -2.0 -3.9 -3.9 -3.9 -3.9 -10.4 -10.4 -10.4 -10.4
GC -1.9 -1.9 -1.9 -1.9 -1.6 -1.6 -1.6 -1.6 -3.5 -3.5 -3.5 -3.5 -10.0 -10.0 -10.0 -10.0
GG -2.4 -2.4 -2.4 -2.4 -2.1 -2.1 -2.1 -2.1 -4.0 -4.0 -4.0 -4.0 -10.5 -10.5 -10.5 -10.5
GT -2.7 -2.7 -2.7 -2.7 -2.4 -2.4 -2.4 -2.4 -4.3 -4.3 -4.3 -4.3 -10.8 -10.8 -10.8 -10.8
TA -2.3 -2.3 -2.3 -2.3 -2.0 -2.0 -2.0 -2.0 -3.9 -3.9 -3.9 -3.9 -10.4 -10.4 -10.4 -10.4
TC -1.9 -1.9 -1.9 -1.9 -1.6 -1.6 -1.6 -1.6 -3.5 -3.5 -3.5 -3.5 -10.0 -10.0 -10.0 -10.0
TG -2.4 -2.4 -2.4 -2.4 -2.1 -2.1 -2.1 -2.1 -4.0 -4.0 -4.0 -4.0 -10.5 -10.5 -10.5 -10.5
TT -2.7 -2.7 -2.7 -2.7 -2.4 -2.4 -2.4 -2.4 -4.3 -4.3 -4.3 -4.3 -10.8 -10.8 -10.8 -10.8
# 5' ------> 3'
C X1 Y1 T
G X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -0.6 -0.6 -0.6 -0.6 0.6 0.6 0.6 0.6 0.1 0.1 0.1 0.1 -0.3 -0.3 -0.3 -0.3
AC -0.2 -0.2 -0.2 -0.2 1.0 1.0 1.0 1.0 0.5 0.5 0.5 0.5 0.1 0.1 0.1 0.1
AG -0.7 -0.7 -0.7 -0.7 0.5 0.5 0.5 0.5 0.0 0.0 0.0 0.0 -0.4 -0.4 -0.4 -0.4
AT -1.0 -1.0 -1.0 -1.0 0.2 0.2 0.2 0.2 -0.3 -0.3 -0.3 -0.3 -0.7 -0.7 -0.7 -0.7
CA -0.6 -0.6 -0.6 -0.6 0.6 0.6 0.6 0.6 0.1 0.1 0.1 0.1 -0.3 -0.3 -0.3 -0.3
CC -0.2 -0.2 -0.2 -0.2 1.0 1.0 1.0 1.0 0.5 0.5 0.5 0.5 0.1 0.1 0.1 0.1
CG -0.7 -0.7 -0.7 -0.7 0.5 0.5 0.5 0.5 0.0 0.0 0.0 0.0 -0.4 -0.4 -0.4 -0.4
CT -1.0 -1.0 -1.0 -1.0 0.2 0.2 0.2 0.2 -0.3 -0.3 -0.3 -0.3 -0.7 -0.7 -0.7 -0.7
GA -0.6 -0.6 -0.6 -0.6 0.6 0.6 0.6 0.6 0.1 0.1 0.1 0.1 -0.3 -0.3 -0.3 -0.3
GC -0.2 -0.2 -0.2 -0.2 1.0 1.0 1.0 1.0 0.5 0.5 0.5 0.5 0.1 0.1 0.1 0.1
GG -0.7 -0.7 -0.7 -0.7 0.5 0.5 0.5 0.5 0.0 0.0 0.0 0.0 -0.4 -0.4 -0.4 -0.4
GT -1.0 -1.0 -1.0 -1.0 0.2 0.2 0.2 0.2 -0.3 -0.3 -0.3 -0.3 -0.7 -0.7 -0.7 -0.7
TA -0.6 -0.6 -0.6 -0.6 0.6 0.6 0.6 0.6 0.1 0.1 0.1 0.1 -0.3 -0.3 -0.3 -0.3
TC -0.2 -0.2 -0.2 -0.2 1.0 1.0 1.0 1.0 0.5 0.5 0.5 0.5 0.1 0.1 0.1 0.1
TG -0.7 -0.7 -0.7 -0.7 0.5 0.5 0.5 0.5 0.0 0.0 0.0 0.0 -0.4 -0.4 -0.4 -0.4
TT -1.0 -1.0 -1.0 -1.0 0.2 0.2 0.2 0.2 -0.3 -0.3 -0.3 -0.3 -0.7 -0.7 -0.7 -0.7
# 5' ------> 3'
C X1 Y1 T
G X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -7.6 -7.6 -7.6 -7.6 -4.7 -4.7 -4.7 -4.7 -6.5 -6.5 -6.5 -6.5 -2.3 -2.3 -2.3 -2.3
AC -7.2 -7.2 -7.2 -7.2 -4.3 -4.3 -4.3 -4.3 -6.1 -6.1 -6.1 -6.1 -1.9 -1.9 -1.9 -1.9
AG -7.7 -7.7 -7.7 -7.7 -4.8 -4.8 -4.8 -4.8 -6.6 -6.6 -6.6 -6.6 -2.4 -2.4 -2.4 -2.4
AT -8.0 -8.0 -8.0 -8.0 -5.1 -5.1 -5.1 -5.1 -6.9 -6.9 -6.9 -6.9 -2.7 -2.7 -2.7 -2.7
CA -7.6 -7.6 -7.6 -7.6 -4.7 -4.7 -4.7 -4.7 -6.5 -6.5 -6.5 -6.5 -2.3 -2.3 -2.3 -2.3
CC -7.2 -7.2 -7.2 -7.2 -4.3 -4.3 -4.3 -4.3 -6.1 -6.1 -6.1 -6.1 -1.9 -1.9 -1.9 -1.9
CG -7.7 -7.7 -7.7 -7.7 -4.8 -4.8 -4.8 -4.8 -6.6 -6.6 -6.6 -6.6 -2.4 -2.4 -2.4 -2.4
CT -8.0 -8.0 -8.0 -8.0 -5.1 -5.1 -5.1 -5.1 -6.9 -6.9 -6.9 -6.9 -2.7 -2.7 -2.7 -2.7
GA -7.6 -7.6 -7.6 -7.6 -4.7 -4.7 -4.7 -4.7 -6.5 -6.5 -6.5 -6.5 -2.3 -2.3 -2.3 -2.3
GC -7.2 -7.2 -7.2 -7.2 -4.3 -4.3 -4.3 -4.3 -6.1 -6.1 -6.1 -6.1 -1.9 -1.9 -1.9 -1.9
GG -7.7 -7.7 -7.7 -7.7 -4.8 -4.8 -4.8 -4.8 -6.6 -6.6 -6.6 -6.6 -2.4 -2.4 -2.4 -2.4
GT -8.0 -8.0 -8.0 -8.0 -5.1 -5.1 -5.1 -5.1 -6.9 -6.9 -6.9 -6.9 -2.7 -2.7 -2.7 -2.7
TA -7.6 -7.6 -7.6 -7.6 -4.7 -4.7 -4.7 -4.7 -6.5 -6.5 -6.5 -6.5 -2.3 -2.3 -2.3 -2.3
TC -7.2 -7.2 -7.2 -7.2 -4.3 -4.3 -4.3 -4.3 -6.1 -6.1 -6.1 -6.1 -1.9 -1.9 -1.9 -1.9
TG -7.7 -7.7 -7.7 -7.7 -4.8 -4.8 -4.8 -4.8 -6.6 -6.6 -6.6 -6.6 -2.4 -2.4 -2.4 -2.4
TT -8.0 -8.0 -8.0 -8.0 -5.1 -5.1 -5.1 -5.1 -6.9 -6.9 -6.9 -6.9 -2.7 -2.7 -2.7 -2.7
# 5' ------> 3'
G X1 Y1 A
C X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -3.9 -3.9 -3.9 -3.9 -3.6 -3.6 -3.6 -3.6 -5.5 -5.5 -5.5 -5.5 -12.0 -12.0 -12.0 -12.0
AC -1.0 -1.0 -1.0 -1.0 -0.7 -0.7 -0.7 -0.7 -2.6 -2.6 -2.6 -2.6 -9.1 -9.1 -9.1 -9.1
AG -2.8 -2.8 -2.8 -2.8 -2.5 -2.5 -2.5 -2.5 -4.4 -4.4 -4.4 -4.4 -10.9 -10.9 -10.9 -10.9
AT 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.7 -0.2 -0.2 -0.2 -0.2 -6.7 -6.7 -6.7 -6.7
CA -3.9 -3.9 -3.9 -3.9 -3.6 -3.6 -3.6 -3.6 -5.5 -5.5 -5.5 -5.5 -12.0 -12.0 -12.0 -12.0
CC -1.0 -1.0 -1.0 -1.0 -0.7 -0.7 -0.7 -0.7 -2.6 -2.6 -2.6 -2.6 -9.1 -9.1 -9.1 -9.1
CG -2.8 -2.8 -2.8 -2.8 -2.5 -2.5 -2.5 -2.5 -4.4 -4.4 -4.4 -4.4 -10.9 -10.9 -10.9 -10.9
CT 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.7 -0.2 -0.2 -0.2 -0.2 -6.7 -6.7 -6.7 -6.7
GA -3.9 -3.9 -3.9 -3.9 -3.6 -3.6 -3.6 -3.6 -5.5 -5.5 -5.5 -5.5 -12.0 -12.0 -12.0 -12.0
GC -1.0 -1.0 -1.0 -1.0 -0.7 -0.7 -0.7 -0.7 -2.6 -2.6 -2.6 -2.6 -9.1 -9.1 -9.1 -9.1
GG -2.8 -2.8 -2.8 -2.8 -2.5 -2.5 -2.5 -2.5 -4.4 -4.4 -4.4 -4.4 -10.9 -10.9 -10.9 -10.9
GT 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.7 -0.2 -0.2 -0.2 -0.2 -6.7 -6.7 -6.7 -6.7
TA -3.9 -3.9 -3.9 -3.9 -3.6 -3.6 -3.6 -3.6 -5.5 -5.5 -5.5 -5.5 -12.0 -12.0 -12.0 -12.0
TC -1.0 -1.0 -1.0 -1.0 -0.7 -0.7 -0.7 -0.7 -2.6 -2.6 -2.6 -2.6 -9.1 -9.1 -9.1 -9.1
TG -2.8 -2.8 -2.8 -2.8 -2.5 -2.5 -2.5 -2.5 -4.4 -4.4 -4.4 -4.4 -10.9 -10.9 -10.9 -10.9
TT 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.7 -0.2 -0.2 -0.2 -0.2 -6.7 -6.7 -6.7 -6.7
# 5' ------> 3'
G X1 Y1 C
C X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -12.4 -12.4 -12.4 -12.4 -9.5 -9.5 -9.5 -9.5 -11.3 -11.3 -11.3 -11.3 -7.1 -7.1 -7.1 -7.1
AC -9.5 -9.5 -9.5 -9.5 -6.6 -6.6 -6.6 -6.6 -8.4 -8.4 -8.4 -8.4 -4.2 -4.2 -4.2 -4.2
AG -11.3 -11.3 -11.3 -11.3 -8.4 -8.4 -8.4 -8.4 -10.2 -10.2 -10.2 -10.2 -6.0 -6.0 -6.0 -6.0
AT -7.1 -7.1 -7.1 -7.1 -4.2 -4.2 -4.2 -4.2 -6.0 -6.0 -6.0 -6.0 -1.8 -1.8 -1.8 -1.8
CA -12.4 -12.4 -12.4 -12.4 -9.5 -9.5 -9.5 -9.5 -11.3 -11.3 -11.3 -11.3 -7.1 -7.1 -7.1 -7.1
CC -9.5 -9.5 -9.5 -9.5 -6.6 -6.6 -6.6 -6.6 -8.4 -8.4 -8.4 -8.4 -4.2 -4.2 -4.2 -4.2
CG -11.3 -11.3 -11.3 -11.3 -8.4 -8.4 -8.4 -8.4 -10.2 -10.2 -10.2 -10.2 -6.0 -6.0 -6.0 -6.0
CT -7.1 -7.1 -7.1 -7.1 -4.2 -4.2 -4.2 -4.2 -6.0 -6.0 -6.0 -6.0 -1.8 -1.8 -1.8 -1.8
GA -12.4 -12.4 -12.4 -12.4 -9.5 -9.5 -9.5 -9.5 -11.3 -11.3 -11.3 -11.3 -7.1 -7.1 -7.1 -7.1
GC -9.5 -9.5 -9.5 -9.5 -6.6 -6.6 -6.6 -6.6 -8.4 -8.4 -8.4 -8.4 -4.2 -4.2 -4.2 -4.2
GG -11.3 -11.3 -11.3 -11.3 -8.4 -8.4 -8.4 -8.4 -10.2 -10.2 -10.2 -10.2 -6.0 -6.0 -6.0 -6.0
GT -7.1 -7.1 -7.1 -7.1 -4.2 -4.2 -4.2 -4.2 -6.0 -6.0 -6.0 -6.0 -1.8 -1.8 -1.8 -1.8
TA -12.4 -12.4 -12.4 -12.4 -9.5 -9.5 -9.5 -9.5 -11.3 -11.3 -11.3 -11.3 -7.1 -7.1 -7.1 -7.1
TC -9.5 -9.5 -9.5 -9.5 -6.6 -6.6 -6.6 -6.6 -8.4 -8.4 -8.4 -8.4 -4.2 -4.2 -4.2 -4.2
TG -11.3 -11.3 -11.3 -11.3 -8.4 -8.4 -8.4 -8.4 -10.2 -10.2 -10.2 -10.2 -6.0 -6.0 -6.0 -6.0
TT -7.1 -7.1 -7.1 -7.1 -4.2 -4.2 -4.2 -4.2 -6.0 -6.0 -6.0 -6.0 -1.8 -1.8 -1.8 -1.8
# 5' ------> 3'
G X1 Y1 G
C X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -10.8 -10.8 -10.8 -10.8 -10.4 -10.4 -10.4 -10.4 -10.9 -10.9 -10.9 -10.9 -11.2 -11.2 -11.2 -11.2
AC -7.9 -7.9 -7.9 -7.9 -7.5 -7.5 -7.5 -7.5 -8.0 -8.0 -8.0 -8.0 -8.3 -8.3 -8.3 -8.3
AG -9.7 -9.7 -9.7 -9.7 -9.3 -9.3 -9.3 -9.3 -9.8 -9.8 -9.8 -9.8 -10.1 -10.1 -10.1 -10.1
AT -5.5 -5.5 -5.5 -5.5 -5.1 -5.1 -5.1 -5.1 -5.6 -5.6 -5.6 -5.6 -5.9 -5.9 -5.9 -5.9
CA -10.8 -10.8 -10.8 -10.8 -10.4 -10.4 -10.4 -10.4 -10.9 -10.9 -10.9 -10.9 -11.2 -11.2 -11.2 -11.2
CC -7.9 -7.9 -7.9 -7.9 -7.5 -7.5 -7.5 -7.5 -8.0 -8.0 -8.0 -8.0 -8.3 -8.3 -8.3 -8.3
CG -9.7 -9.7 -9.7 -9.7 -9.3 -9.3 -9.3 -9.3 -9.8 -9.8 -9.8 -9.8 -10.1 -10.1 -10.1 -10.1
CT -5.5 -5.5 -5.5 -5.5 -5.1 -5.1 -5.1 -5.1 -5.6 -5.6 -5.6 -5.6 -5.9 -5.9 -5.9 -5.9
GA -10.8 -10.8 -10.8 -10.8 -10.4 -10.4 -10.4 -10.4 -10.9 -10.9 -10.9 -10.9 -11.2 -11.2 -11.2 -11.2
GC -7.9 -7.9 -7.9 -7.9 -7.5 -7.5 -7.5 -7.5 -8.0 -8.0 -8.0 -8.0 -8.3 -8.3 -8.3 -8.3
GG -9.7 -9.7 -9.7 -9.7 -9.3 -9.3 -9.3 -9.3 -9.8 -9.8 -9.8 -9.8 -10.1 -10.1 -10.1 -10.1
GT -5.5 -5.5 -5.5 -5.5 -5.1 -5.1 -5.1 -5.1 -5.6 -5.6 -5.6 -5.6 -5.9 -5.9 -5.9 -5.9
TA -10.8 -10.8 -10.8 -10.8 -10.4 -10.4 -10.4 -10.4 -10.9 -10.9 -10.9 -10.9 -11.2 -11.2 -11.2 -11.2
TC -7.9 -7.9 -7.9 -7.9 -7.5 -7.5 -7.5 -7.5 -8.0 -8.0 -8.0 -8.0 -8.3 -8.3 -8.3 -8.3
TG -9.7 -9.7 -9.7 -9.7 -9.3 -9.3 -9.3 -9.3 -9.8 -9.8 -9.8 -9.8 -10.1 -10.1 -10.1 -10.1
TT -5.5 -5.5 -5.5 -5.5 -5.1 -5.1 -5.1 -5.1 -5.6 -5.6 -5.6 -5.6 -5.9 -5.9 -5.9 -5.9
# 5' ------> 3'
G X1 Y1 G
C X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -3.9 -3.9 -3.9 -3.9 -3.6 -3.6 -3.6 -3.6 -5.5 -5.5 -5.5 -5.5 -12.0 -12.0 -12.0 -12.0
AC -1.0 -1.0 -1.0 -1.0 -0.7 -0.7 -0.7 -0.7 -2.6 -2.6 -2.6 -2.6 -9.1 -9.1 -9.1 -9.1
AG -2.8 -2.8 -2.8 -2.8 -2.5 -2.5 -2.5 -2.5 -4.4 -4.4 -4.4 -4.4 -10.9 -10.9 -10.9 -10.9
AT 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.7 -0.2 -0.2 -0.2 -0.2 -6.7 -6.7 -6.7 -6.7
CA -3.9 -3.9 -3.9 -3.9 -3.6 -3.6 -3.6 -3.6 -5.5 -5.5 -5.5 -5.5 -12.0 -12.0 -12.0 -12.0
CC -1.0 -1.0 -1.0 -1.0 -0.7 -0.7 -0.7 -0.7 -2.6 -2.6 -2.6 -2.6 -9.1 -9.1 -9.1 -9.1
CG -2.8 -2.8 -2.8 -2.8 -2.5 -2.5 -2.5 -2.5 -4.4 -4.4 -4.4 -4.4 -10.9 -10.9 -10.9 -10.9
CT 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.7 -0.2 -0.2 -0.2 -0.2 -6.7 -6.7 -6.7 -6.7
GA -3.9 -3.9 -3.9 -3.9 -3.6 -3.6 -3.6 -3.6 -5.5 -5.5 -5.5 -5.5 -12.0 -12.0 -12.0 -12.0
GC -1.0 -1.0 -1.0 -1.0 -0.7 -0.7 -0.7 -0.7 -2.6 -2.6 -2.6 -2.6 -9.1 -9.1 -9.1 -9.1
GG -2.8 -2.8 -2.8 -2.8 -2.5 -2.5 -2.5 -2.5 -4.4 -4.4 -4.4 -4.4 -10.9 -10.9 -10.9 -10.9
GT 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.7 -0.2 -0.2 -0.2 -0.2 -6.7 -6.7 -6.7 -6.7
TA -3.9 -3.9 -3.9 -3.9 -3.6 -3.6 -3.6 -3.6 -5.5 -5.5 -5.5 -5.5 -12.0 -12.0 -12.0 -12.0
TC -1.0 -1.0 -1.0 -1.0 -0.7 -0.7 -0.7 -0.7 -2.6 -2.6 -2.6 -2.6 -9.1 -9.1 -9.1 -9.1
TG -2.8 -2.8 -2.8 -2.8 -2.5 -2.5 -2.5 -2.5 -4.4 -4.4 -4.4 -4.4 -10.9 -10.9 -10.9 -10.9
TT 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.7 -0.2 -0.2 -0.2 -0.2 -6.7 -6.7 -6.7 -6.7
# 5' ------> 3'
G X1 Y1 T
C X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -2.2 -2.2 -2.2 -2.2 -1.0 -1.0 -1.0 -1.0 -1.5 -1.5 -1.5 -1.5 -1.9 -1.9 -1.9 -1.9
AC 0.7 0.7 0.7 0.7 1.9 1.9 1.9 1.9 1.4 1.4 1.4 1.4 1.0 1.0 1.0 1.0
AG -1.1 -1.1 -1.1 -1.1 0.1 0.1 0.1 0.1 -0.4 -0.4 -0.4 -0.4 -0.8 -0.8 -0.8 -0.8
AT 3.1 3.1 3.1 3.1 4.3 4.3 4.3 4.3 3.8 3.8 3.8 3.8 3.4 3.4 3.4 3.4
CA -2.2 -2.2 -2.2 -2.2 -1.0 -1.0 -1.0 -1.0 -1.5 -1.5 -1.5 -1.5 -1.9 -1.9 -1.9 -1.9
CC 0.7 0.7 0.7 0.7 1.9 1.9 1.9 1.9 1.4 1.4 1.4 1.4 1.0 1.0 1.0 1.0
CG -1.1 -1.1 -1.1 -1.1 0.1 0.1 0.1 0.1 -0.4 -0.4 -0.4 -0.4 -0.8 -0.8 -0.8 -0.8
CT 3.1 3.1 3.1 3.1 4.3 4.3 4.3 4.3 3.8 3.8 3.8 3.8 3.4 3.4 3.4 3.4
GA -2.2 -2.2 -2.2 -2.2 -1.0 -1.0 -1.0 -1.0 -1.5 -1.5 -1.5 -1.5 -1.9 -1.9 -1.9 -1.9
GC 0.7 0.7 0.7 0.7 1.9 1.9 1.9 1.9 1.4 1.4 1.4 1.4 1.0 1.0 1.0 1.0
GG -1.1 -1.1 -1.1 -1.1 0.1 0.1 0.1 0.1 -0.4 -0.4 -0.4 -0.4 -0.8 -0.8 -0.8 -0.8
GT 3.1 3.1 3.1 3.1 4.3 4.3 4.3 4.3 3.8 3.8 3.8 3.8 3.4 3.4 3.4 3.4
TA -2.2 -2.2 -2.2 -2.2 -1.0 -1.0 -1.0 -1.0 -1.5 -1.5 -1.5 -1.5 -1.9 -1.9 -1.9 -1.9
TC 0.7 0.7 0.7 0.7 1.9 1.9 1.9 1.9 1.4 1.4 1.4 1.4 1.0 1.0 1.0 1.0
TG -1.1 -1.1 -1.1 -1.1 0.1 0.1 0.1 0.1 -0.4 -0.4 -0.4 -0.4 -0.8 -0.8 -0.8 -0.8
TT 3.1 3.1 3.1 3.1 4.3 4.3 4.3 4.3 3.8 3.8 3.8 3.8 3.4 3.4 3.4 3.4
# 5' ------> 3'
G X1 Y1 T
C X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -9.2 -9.2 -9.2 -9.2 -6.3 -6.3 -6.3 -6.3 -8.1 -8.1 -8.1 -8.1 -3.9 -3.9 -3.9 -3.9
AC -6.3 -6.3 -6.3 -6.3 -3.4 -3.4 -3.4 -3.4 -5.2 -5.2 -5.2 -5.2 -1.0 -1.0 -1.0 -1.0
AG -8.1 -8.1 -8.1 -8.1 -5.2 -5.2 -5.2 -5.2 -7.0 -7.0 -7.0 -7.0 -2.8 -2.8 -2.8 -2.8
AT -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4
CA -9.2 -9.2 -9.2 -9.2 -6.3 -6.3 -6.3 -6.3 -8.1 -8.1 -8.1 -8.1 -3.9 -3.9 -3.9 -3.9
CC -6.3 -6.3 -6.3 -6.3 -3.4 -3.4 -3.4 -3.4 -5.2 -5.2 -5.2 -5.2 -1.0 -1.0 -1.0 -1.0
CG -8.1 -8.1 -8.1 -8.1 -5.2 -5.2 -5.2 -5.2 -7.0 -7.0 -7.0 -7.0 -2.8 -2.8 -2.8 -2.8
CT -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4
GA -9.2 -9.2 -9.2 -9.2 -6.3 -6.3 -6.3 -6.3 -8.1 -8.1 -8.1 -8.1 -3.9 -3.9 -3.9 -3.9
GC -6.3 -6.3 -6.3 -6.3 -3.4 -3.4 -3.4 -3.4 -5.2 -5.2 -5.2 -5.2 -1.0 -1.0 -1.0 -1.0
GG -8.1 -8.1 -8.1 -8.1 -5.2 -5.2 -5.2 -5.2 -7.0 -7.0 -7.0 -7.0 -2.8 -2.8 -2.8 -2.8
GT -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4
TA -9.2 -9.2 -9.2 -9.2 -6.3 -6.3 -6.3 -6.3 -8.1 -8.1 -8.1 -8.1 -3.9 -3.9 -3.9 -3.9
TC -6.3 -6.3 -6.3 -6.3 -3.4 -3.4 -3.4 -3.4 -5.2 -5.2 -5.2 -5.2 -1.0 -1.0 -1.0 -1.0
TG -8.1 -8.1 -8.1 -8.1 -5.2 -5.2 -5.2 -5.2 -7.0 -7.0 -7.0 -7.0 -2.8 -2.8 -2.8 -2.8
TT -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4
# 5' ------> 3'
G X1 Y1 A
T X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -0.7 -0.7 -0.7 -0.7 -0.4 -0.4 -0.4 -0.4 -2.3 -2.3 -2.3 -2.3 -8.8 -8.8 -8.8 -8.8
AC 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.5 0.6 0.6 0.6 0.6 -5.9 -5.9 -5.9 -5.9
AG 0.4 0.4 0.4 0.4 0.7 0.7 0.7 0.7 -1.2 -1.2 -1.2 -1.2 -7.7 -7.7 -7.7 -7.7
AT 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
CA -0.7 -0.7 -0.7 -0.7 -0.4 -0.4 -0.4 -0.4 -2.3 -2.3 -2.3 -2.3 -8.8 -8.8 -8.8 -8.8
CC 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.5 0.6 0.6 0.6 0.6 -5.9 -5.9 -5.9 -5.9
CG 0.4 0.4 0.4 0.4 0.7 0.7 0.7 0.7 -1.2 -1.2 -1.2 -1.2 -7.7 -7.7 -7.7 -7.7
CT 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
GA -0.7 -0.7 -0.7 -0.7 -0.4 -0.4 -0.4 -0.4 -2.3 -2.3 -2.3 -2.3 -8.8 -8.8 -8.8 -8.8
GC 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.5 0.6 0.6 0.6 0.6 -5.9 -5.9 -5.9 -5.9
GG 0.4 0.4 0.4 0.4 0.7 0.7 0.7 0.7 -1.2 -1.2 -1.2 -1.2 -7.7 -7.7 -7.7 -7.7
GT 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
TA -0.7 -0.7 -0.7 -0.7 -0.4 -0.4 -0.4 -0.4 -2.3 -2.3 -2.3 -2.3 -8.8 -8.8 -8.8 -8.8
TC 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.5 0.6 0.6 0.6 0.6 -5.9 -5.9 -5.9 -5.9
TG 0.4 0.4 0.4 0.4 0.7 0.7 0.7 0.7 -1.2 -1.2 -1.2 -1.2 -7.7 -7.7 -7.7 -7.7
TT 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
# 5' ------> 3'
G X1 Y1 C
T X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -9.2 -9.2 -9.2 -9.2 -6.3 -6.3 -6.3 -6.3 -8.1 -8.1 -8.1 -8.1 -3.9 -3.9 -3.9 -3.9
AC -6.3 -6.3 -6.3 -6.3 -3.4 -3.4 -3.4 -3.4 -5.2 -5.2 -5.2 -5.2 -1.0 -1.0 -1.0 -1.0
AG -8.1 -8.1 -8.1 -8.1 -5.2 -5.2 -5.2 -5.2 -7.0 -7.0 -7.0 -7.0 -2.8 -2.8 -2.8 -2.8
AT -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4
CA -9.2 -9.2 -9.2 -9.2 -6.3 -6.3 -6.3 -6.3 -8.1 -8.1 -8.1 -8.1 -3.9 -3.9 -3.9 -3.9
CC -6.3 -6.3 -6.3 -6.3 -3.4 -3.4 -3.4 -3.4 -5.2 -5.2 -5.2 -5.2 -1.0 -1.0 -1.0 -1.0
CG -8.1 -8.1 -8.1 -8.1 -5.2 -5.2 -5.2 -5.2 -7.0 -7.0 -7.0 -7.0 -2.8 -2.8 -2.8 -2.8
CT -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4
GA -9.2 -9.2 -9.2 -9.2 -6.3 -6.3 -6.3 -6.3 -8.1 -8.1 -8.1 -8.1 -3.9 -3.9 -3.9 -3.9
GC -6.3 -6.3 -6.3 -6.3 -3.4 -3.4 -3.4 -3.4 -5.2 -5.2 -5.2 -5.2 -1.0 -1.0 -1.0 -1.0
GG -8.1 -8.1 -8.1 -8.1 -5.2 -5.2 -5.2 -5.2 -7.0 -7.0 -7.0 -7.0 -2.8 -2.8 -2.8 -2.8
GT -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4
TA -9.2 -9.2 -9.2 -9.2 -6.3 -6.3 -6.3 -6.3 -8.1 -8.1 -8.1 -8.1 -3.9 -3.9 -3.9 -3.9
TC -6.3 -6.3 -6.3 -6.3 -3.4 -3.4 -3.4 -3.4 -5.2 -5.2 -5.2 -5.2 -1.0 -1.0 -1.0 -1.0
TG -8.1 -8.1 -8.1 -8.1 -5.2 -5.2 -5.2 -5.2 -7.0 -7.0 -7.0 -7.0 -2.8 -2.8 -2.8 -2.8
TT -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4
# 5' ------> 3'
G X1 Y1 G
T X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -7.6 -7.6 -7.6 -7.6 -7.2 -7.2 -7.2 -7.2 -7.7 -7.7 -7.7 -7.7 -8.0 -8.0 -8.0 -8.0
AC -4.7 -4.7 -4.7 -4.7 -4.3 -4.3 -4.3 -4.3 -4.8 -4.8 -4.8 -4.8 -5.1 -5.1 -5.1 -5.1
AG -6.5 -6.5 -6.5 -6.5 -6.1 -6.1 -6.1 -6.1 -6.6 -6.6 -6.6 -6.6 -6.9 -6.9 -6.9 -6.9
AT -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7
CA -7.6 -7.6 -7.6 -7.6 -7.2 -7.2 -7.2 -7.2 -7.7 -7.7 -7.7 -7.7 -8.0 -8.0 -8.0 -8.0
CC -4.7 -4.7 -4.7 -4.7 -4.3 -4.3 -4.3 -4.3 -4.8 -4.8 -4.8 -4.8 -5.1 -5.1 -5.1 -5.1
CG -6.5 -6.5 -6.5 -6.5 -6.1 -6.1 -6.1 -6.1 -6.6 -6.6 -6.6 -6.6 -6.9 -6.9 -6.9 -6.9
CT -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7
GA -7.6 -7.6 -7.6 -7.6 -7.2 -7.2 -7.2 -7.2 -7.7 -7.7 -7.7 -7.7 -8.0 -8.0 -8.0 -8.0
GC -4.7 -4.7 -4.7 -4.7 -4.3 -4.3 -4.3 -4.3 -4.8 -4.8 -4.8 -4.8 -5.1 -5.1 -5.1 -5.1
GG -6.5 -6.5 -6.5 -6.5 -6.1 -6.1 -6.1 -6.1 -6.6 -6.6 -6.6 -6.6 -6.9 -6.9 -6.9 -6.9
GT -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7
TA -7.6 -7.6 -7.6 -7.6 -7.2 -7.2 -7.2 -7.2 -7.7 -7.7 -7.7 -7.7 -8.0 -8.0 -8.0 -8.0
TC -4.7 -4.7 -4.7 -4.7 -4.3 -4.3 -4.3 -4.3 -4.8 -4.8 -4.8 -4.8 -5.1 -5.1 -5.1 -5.1
TG -6.5 -6.5 -6.5 -6.5 -6.1 -6.1 -6.1 -6.1 -6.6 -6.6 -6.6 -6.6 -6.9 -6.9 -6.9 -6.9
TT -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7
# 5' ------> 3'
G X1 Y1 G
T X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -0.7 -0.7 -0.7 -0.7 -0.4 -0.4 -0.4 -0.4 -2.3 -2.3 -2.3 -2.3 -8.8 -8.8 -8.8 -8.8
AC 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.5 0.6 0.6 0.6 0.6 -5.9 -5.9 -5.9 -5.9
AG 0.4 0.4 0.4 0.4 0.7 0.7 0.7 0.7 -1.2 -1.2 -1.2 -1.2 -7.7 -7.7 -7.7 -7.7
AT 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
CA -0.7 -0.7 -0.7 -0.7 -0.4 -0.4 -0.4 -0.4 -2.3 -2.3 -2.3 -2.3 -8.8 -8.8 -8.8 -8.8
CC 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.5 0.6 0.6 0.6 0.6 -5.9 -5.9 -5.9 -5.9
CG 0.4 0.4 0.4 0.4 0.7 0.7 0.7 0.7 -1.2 -1.2 -1.2 -1.2 -7.7 -7.7 -7.7 -7.7
CT 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
GA -0.7 -0.7 -0.7 -0.7 -0.4 -0.4 -0.4 -0.4 -2.3 -2.3 -2.3 -2.3 -8.8 -8.8 -8.8 -8.8
GC 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.5 0.6 0.6 0.6 0.6 -5.9 -5.9 -5.9 -5.9
GG 0.4 0.4 0.4 0.4 0.7 0.7 0.7 0.7 -1.2 -1.2 -1.2 -1.2 -7.7 -7.7 -7.7 -7.7
GT 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
TA -0.7 -0.7 -0.7 -0.7 -0.4 -0.4 -0.4 -0.4 -2.3 -2.3 -2.3 -2.3 -8.8 -8.8 -8.8 -8.8
TC 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.5 0.6 0.6 0.6 0.6 -5.9 -5.9 -5.9 -5.9
TG 0.4 0.4 0.4 0.4 0.7 0.7 0.7 0.7 -1.2 -1.2 -1.2 -1.2 -7.7 -7.7 -7.7 -7.7
TT 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
# 5' ------> 3'
G X1 Y1 T
T X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.0 1.0 1.0 1.0 2.2 2.2 2.2 2.2 1.7 1.7 1.7 1.7 1.3 1.3 1.3 1.3
AC 3.9 3.9 3.9 3.9 5.1 5.1 5.1 5.1 4.6 4.6 4.6 4.6 4.2 4.2 4.2 4.2
AG 2.1 2.1 2.1 2.1 3.3 3.3 3.3 3.3 2.8 2.8 2.8 2.8 2.4 2.4 2.4 2.4
AT 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6
CA 1.0 1.0 1.0 1.0 2.2 2.2 2.2 2.2 1.7 1.7 1.7 1.7 1.3 1.3 1.3 1.3
CC 3.9 3.9 3.9 3.9 5.1 5.1 5.1 5.1 4.6 4.6 4.6 4.6 4.2 4.2 4.2 4.2
CG 2.1 2.1 2.1 2.1 3.3 3.3 3.3 3.3 2.8 2.8 2.8 2.8 2.4 2.4 2.4 2.4
CT 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6
GA 1.0 1.0 1.0 1.0 2.2 2.2 2.2 2.2 1.7 1.7 1.7 1.7 1.3 1.3 1.3 1.3
GC 3.9 3.9 3.9 3.9 5.1 5.1 5.1 5.1 4.6 4.6 4.6 4.6 4.2 4.2 4.2 4.2
GG 2.1 2.1 2.1 2.1 3.3 3.3 3.3 3.3 2.8 2.8 2.8 2.8 2.4 2.4 2.4 2.4
GT 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6
TA 1.0 1.0 1.0 1.0 2.2 2.2 2.2 2.2 1.7 1.7 1.7 1.7 1.3 1.3 1.3 1.3
TC 3.9 3.9 3.9 3.9 5.1 5.1 5.1 5.1 4.6 4.6 4.6 4.6 4.2 4.2 4.2 4.2
TG 2.1 2.1 2.1 2.1 3.3 3.3 3.3 3.3 2.8 2.8 2.8 2.8 2.4 2.4 2.4 2.4
TT 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6
# 5' ------> 3'
G X1 Y1 T
T X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -6.0 -6.0 -6.0 -6.0 -3.1 -3.1 -3.1 -3.1 -4.9 -4.9 -4.9 -4.9 -0.7 -0.7 -0.7 -0.7
AC -3.1 -3.1 -3.1 -3.1 -0.2 -0.2 -0.2 -0.2 -2.0 -2.0 -2.0 -2.0 2.2 2.2 2.2 2.2
AG -4.9 -4.9 -4.9 -4.9 -2.0 -2.0 -2.0 -2.0 -3.8 -3.8 -3.8 -3.8 0.4 0.4 0.4 0.4
AT -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6
CA -6.0 -6.0 -6.0 -6.0 -3.1 -3.1 -3.1 -3.1 -4.9 -4.9 -4.9 -4.9 -0.7 -0.7 -0.7 -0.7
CC -3.1 -3.1 -3.1 -3.1 -0.2 -0.2 -0.2 -0.2 -2.0 -2.0 -2.0 -2.0 2.2 2.2 2.2 2.2
CG -4.9 -4.9 -4.9 -4.9 -2.0 -2.0 -2.0 -2.0 -3.8 -3.8 -3.8 -3.8 0.4 0.4 0.4 0.4
CT -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6
GA -6.0 -6.0 -6.0 -6.0 -3.1 -3.1 -3.1 -3.1 -4.9 -4.9 -4.9 -4.9 -0.7 -0.7 -0.7 -0.7
GC -3.1 -3.1 -3.1 -3.1 -0.2 -0.2 -0.2 -0.2 -2.0 -2.0 -2.0 -2.0 2.2 2.2 2.2 2.2
GG -4.9 -4.9 -4.9 -4.9 -2.0 -2.0 -2.0 -2.0 -3.8 -3.8 -3.8 -3.8 0.4 0.4 0.4 0.4
GT -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6
TA -6.0 -6.0 -6.0 -6.0 -3.1 -3.1 -3.1 -3.1 -4.9 -4.9 -4.9 -4.9 -0.7 -0.7 -0.7 -0.7
TC -3.1 -3.1 -3.1 -3.1 -0.2 -0.2 -0.2 -0.2 -2.0 -2.0 -2.0 -2.0 2.2 2.2 2.2 2.2
TG -4.9 -4.9 -4.9 -4.9 -2.0 -2.0 -2.0 -2.0 -3.8 -3.8 -3.8 -3.8 0.4 0.4 0.4 0.4
TT -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6
# 5' ------> 3'
T X1 Y1 A
A X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
AC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2
AG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1
AT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6
CA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
CC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2
CG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1
CT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6
GA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
GC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2
GG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1
GT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6
TA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
TC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2
TG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1
TT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6
# 5' ------> 3'
T X1 Y1 C
A X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4
AC -3.6 -3.6 -3.6 -3.6 -0.7 -0.7 -0.7 -0.7 -2.5 -2.5 -2.5 -2.5 1.7 1.7 1.7 1.7
AG -5.5 -5.5 -5.5 -5.5 -2.6 -2.6 -2.6 -2.6 -4.4 -4.4 -4.4 -4.4 -0.2 -0.2 -0.2 -0.2
AT -12.0 -12.0 -12.0 -12.0 -9.1 -9.1 -9.1 -9.1 -10.9 -10.9 -10.9 -10.9 -6.7 -6.7 -6.7 -6.7
CA -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4
CC -3.6 -3.6 -3.6 -3.6 -0.7 -0.7 -0.7 -0.7 -2.5 -2.5 -2.5 -2.5 1.7 1.7 1.7 1.7
CG -5.5 -5.5 -5.5 -5.5 -2.6 -2.6 -2.6 -2.6 -4.4 -4.4 -4.4 -4.4 -0.2 -0.2 -0.2 -0.2
CT -12.0 -12.0 -12.0 -12.0 -9.1 -9.1 -9.1 -9.1 -10.9 -10.9 -10.9 -10.9 -6.7 -6.7 -6.7 -6.7
GA -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4
GC -3.6 -3.6 -3.6 -3.6 -0.7 -0.7 -0.7 -0.7 -2.5 -2.5 -2.5 -2.5 1.7 1.7 1.7 1.7
GG -5.5 -5.5 -5.5 -5.5 -2.6 -2.6 -2.6 -2.6 -4.4 -4.4 -4.4 -4.4 -0.2 -0.2 -0.2 -0.2
GT -12.0 -12.0 -12.0 -12.0 -9.1 -9.1 -9.1 -9.1 -10.9 -10.9 -10.9 -10.9 -6.7 -6.7 -6.7 -6.7
TA -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4
TC -3.6 -3.6 -3.6 -3.6 -0.7 -0.7 -0.7 -0.7 -2.5 -2.5 -2.5 -2.5 1.7 1.7 1.7 1.7
TG -5.5 -5.5 -5.5 -5.5 -2.6 -2.6 -2.6 -2.6 -4.4 -4.4 -4.4 -4.4 -0.2 -0.2 -0.2 -0.2
TT -12.0 -12.0 -12.0 -12.0 -9.1 -9.1 -9.1 -9.1 -10.9 -10.9 -10.9 -10.9 -6.7 -6.7 -6.7 -6.7
# 5' ------> 3'
T X1 Y1 G
A X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7
AC -2.0 -2.0 -2.0 -2.0 -1.6 -1.6 -1.6 -1.6 -2.1 -2.1 -2.1 -2.1 -2.4 -2.4 -2.4 -2.4
AG -3.9 -3.9 -3.9 -3.9 -3.5 -3.5 -3.5 -3.5 -4.0 -4.0 -4.0 -4.0 -4.3 -4.3 -4.3 -4.3
AT -10.4 -10.4 -10.4 -10.4 -10.0 -10.0 -10.0 -10.0 -10.5 -10.5 -10.5 -10.5 -10.8 -10.8 -10.8 -10.8
CA -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7
CC -2.0 -2.0 -2.0 -2.0 -1.6 -1.6 -1.6 -1.6 -2.1 -2.1 -2.1 -2.1 -2.4 -2.4 -2.4 -2.4
CG -3.9 -3.9 -3.9 -3.9 -3.5 -3.5 -3.5 -3.5 -4.0 -4.0 -4.0 -4.0 -4.3 -4.3 -4.3 -4.3
CT -10.4 -10.4 -10.4 -10.4 -10.0 -10.0 -10.0 -10.0 -10.5 -10.5 -10.5 -10.5 -10.8 -10.8 -10.8 -10.8
GA -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7
GC -2.0 -2.0 -2.0 -2.0 -1.6 -1.6 -1.6 -1.6 -2.1 -2.1 -2.1 -2.1 -2.4 -2.4 -2.4 -2.4
GG -3.9 -3.9 -3.9 -3.9 -3.5 -3.5 -3.5 -3.5 -4.0 -4.0 -4.0 -4.0 -4.3 -4.3 -4.3 -4.3
GT -10.4 -10.4 -10.4 -10.4 -10.0 -10.0 -10.0 -10.0 -10.5 -10.5 -10.5 -10.5 -10.8 -10.8 -10.8 -10.8
TA -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7
TC -2.0 -2.0 -2.0 -2.0 -1.6 -1.6 -1.6 -1.6 -2.1 -2.1 -2.1 -2.1 -2.4 -2.4 -2.4 -2.4
TG -3.9 -3.9 -3.9 -3.9 -3.5 -3.5 -3.5 -3.5 -4.0 -4.0 -4.0 -4.0 -4.3 -4.3 -4.3 -4.3
TT -10.4 -10.4 -10.4 -10.4 -10.0 -10.0 -10.0 -10.0 -10.5 -10.5 -10.5 -10.5 -10.8 -10.8 -10.8 -10.8
# 5' ------> 3'
T X1 Y1 G
A X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
AC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2
AG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1
AT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6
CA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
CC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2
CG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1
CT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6
GA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
GC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2
GG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1
GT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6
TA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
TC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2
TG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1
TT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6
# 5' ------> 3'
T X1 Y1 T
A X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6
AC 6.6 6.6 6.6 6.6 7.8 7.8 7.8 7.8 7.3 7.3 7.3 7.3 6.9 6.9 6.9 6.9
AG 4.7 4.7 4.7 4.7 5.9 5.9 5.9 5.9 5.4 5.4 5.4 5.4 5.0 5.0 5.0 5.0
AT -1.8 -1.8 -1.8 -1.8 -0.6 -0.6 -0.6 -0.6 -1.1 -1.1 -1.1 -1.1 -1.5 -1.5 -1.5 -1.5
CA 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6
CC 6.6 6.6 6.6 6.6 7.8 7.8 7.8 7.8 7.3 7.3 7.3 7.3 6.9 6.9 6.9 6.9
CG 4.7 4.7 4.7 4.7 5.9 5.9 5.9 5.9 5.4 5.4 5.4 5.4 5.0 5.0 5.0 5.0
CT -1.8 -1.8 -1.8 -1.8 -0.6 -0.6 -0.6 -0.6 -1.1 -1.1 -1.1 -1.1 -1.5 -1.5 -1.5 -1.5
GA 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6
GC 6.6 6.6 6.6 6.6 7.8 7.8 7.8 7.8 7.3 7.3 7.3 7.3 6.9 6.9 6.9 6.9
GG 4.7 4.7 4.7 4.7 5.9 5.9 5.9 5.9 5.4 5.4 5.4 5.4 5.0 5.0 5.0 5.0
GT -1.8 -1.8 -1.8 -1.8 -0.6 -0.6 -0.6 -0.6 -1.1 -1.1 -1.1 -1.1 -1.5 -1.5 -1.5 -1.5
TA 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6
TC 6.6 6.6 6.6 6.6 7.8 7.8 7.8 7.8 7.3 7.3 7.3 7.3 6.9 6.9 6.9 6.9
TG 4.7 4.7 4.7 4.7 5.9 5.9 5.9 5.9 5.4 5.4 5.4 5.4 5.0 5.0 5.0 5.0
TT -1.8 -1.8 -1.8 -1.8 -0.6 -0.6 -0.6 -0.6 -1.1 -1.1 -1.1 -1.1 -1.5 -1.5 -1.5 -1.5
# 5' ------> 3'
T X1 Y1 T
A X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6
AC -0.4 -0.4 -0.4 -0.4 2.5 2.5 2.5 2.5 0.7 0.7 0.7 0.7 4.9 4.9 4.9 4.9
AG -2.3 -2.3 -2.3 -2.3 0.6 0.6 0.6 0.6 -1.2 -1.2 -1.2 -1.2 3.0 3.0 3.0 3.0
AT -8.8 -8.8 -8.8 -8.8 -5.9 -5.9 -5.9 -5.9 -7.7 -7.7 -7.7 -7.7 -3.5 -3.5 -3.5 -3.5
CA -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6
CC -0.4 -0.4 -0.4 -0.4 2.5 2.5 2.5 2.5 0.7 0.7 0.7 0.7 4.9 4.9 4.9 4.9
CG -2.3 -2.3 -2.3 -2.3 0.6 0.6 0.6 0.6 -1.2 -1.2 -1.2 -1.2 3.0 3.0 3.0 3.0
CT -8.8 -8.8 -8.8 -8.8 -5.9 -5.9 -5.9 -5.9 -7.7 -7.7 -7.7 -7.7 -3.5 -3.5 -3.5 -3.5
GA -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6
GC -0.4 -0.4 -0.4 -0.4 2.5 2.5 2.5 2.5 0.7 0.7 0.7 0.7 4.9 4.9 4.9 4.9
GG -2.3 -2.3 -2.3 -2.3 0.6 0.6 0.6 0.6 -1.2 -1.2 -1.2 -1.2 3.0 3.0 3.0 3.0
GT -8.8 -8.8 -8.8 -8.8 -5.9 -5.9 -5.9 -5.9 -7.7 -7.7 -7.7 -7.7 -3.5 -3.5 -3.5 -3.5
TA -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6
TC -0.4 -0.4 -0.4 -0.4 2.5 2.5 2.5 2.5 0.7 0.7 0.7 0.7 4.9 4.9 4.9 4.9
TG -2.3 -2.3 -2.3 -2.3 0.6 0.6 0.6 0.6 -1.2 -1.2 -1.2 -1.2 3.0 3.0 3.0 3.0
TT -8.8 -8.8 -8.8 -8.8 -5.9 -5.9 -5.9 -5.9 -7.7 -7.7 -7.7 -7.7 -3.5 -3.5 -3.5 -3.5
# 5' ------> 3'
T X1 Y1 A
G X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
AC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2
AG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1
AT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6
CA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
CC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2
CG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1
CT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6
GA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
GC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2
GG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1
GT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6
TA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
TC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2
TG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1
TT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6
# 5' ------> 3'
T X1 Y1 C
G X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4
AC -3.6 -3.6 -3.6 -3.6 -0.7 -0.7 -0.7 -0.7 -2.5 -2.5 -2.5 -2.5 1.7 1.7 1.7 1.7
AG -5.5 -5.5 -5.5 -5.5 -2.6 -2.6 -2.6 -2.6 -4.4 -4.4 -4.4 -4.4 -0.2 -0.2 -0.2 -0.2
AT -12.0 -12.0 -12.0 -12.0 -9.1 -9.1 -9.1 -9.1 -10.9 -10.9 -10.9 -10.9 -6.7 -6.7 -6.7 -6.7
CA -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4
CC -3.6 -3.6 -3.6 -3.6 -0.7 -0.7 -0.7 -0.7 -2.5 -2.5 -2.5 -2.5 1.7 1.7 1.7 1.7
CG -5.5 -5.5 -5.5 -5.5 -2.6 -2.6 -2.6 -2.6 -4.4 -4.4 -4.4 -4.4 -0.2 -0.2 -0.2 -0.2
CT -12.0 -12.0 -12.0 -12.0 -9.1 -9.1 -9.1 -9.1 -10.9 -10.9 -10.9 -10.9 -6.7 -6.7 -6.7 -6.7
GA -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4
GC -3.6 -3.6 -3.6 -3.6 -0.7 -0.7 -0.7 -0.7 -2.5 -2.5 -2.5 -2.5 1.7 1.7 1.7 1.7
GG -5.5 -5.5 -5.5 -5.5 -2.6 -2.6 -2.6 -2.6 -4.4 -4.4 -4.4 -4.4 -0.2 -0.2 -0.2 -0.2
GT -12.0 -12.0 -12.0 -12.0 -9.1 -9.1 -9.1 -9.1 -10.9 -10.9 -10.9 -10.9 -6.7 -6.7 -6.7 -6.7
TA -3.9 -3.9 -3.9 -3.9 -1.0 -1.0 -1.0 -1.0 -2.8 -2.8 -2.8 -2.8 1.4 1.4 1.4 1.4
TC -3.6 -3.6 -3.6 -3.6 -0.7 -0.7 -0.7 -0.7 -2.5 -2.5 -2.5 -2.5 1.7 1.7 1.7 1.7
TG -5.5 -5.5 -5.5 -5.5 -2.6 -2.6 -2.6 -2.6 -4.4 -4.4 -4.4 -4.4 -0.2 -0.2 -0.2 -0.2
TT -12.0 -12.0 -12.0 -12.0 -9.1 -9.1 -9.1 -9.1 -10.9 -10.9 -10.9 -10.9 -6.7 -6.7 -6.7 -6.7
# 5' ------> 3'
T X1 Y1 G
G X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7
AC -2.0 -2.0 -2.0 -2.0 -1.6 -1.6 -1.6 -1.6 -2.1 -2.1 -2.1 -2.1 -2.4 -2.4 -2.4 -2.4
AG -3.9 -3.9 -3.9 -3.9 -3.5 -3.5 -3.5 -3.5 -4.0 -4.0 -4.0 -4.0 -4.3 -4.3 -4.3 -4.3
AT -10.4 -10.4 -10.4 -10.4 -10.0 -10.0 -10.0 -10.0 -10.5 -10.5 -10.5 -10.5 -10.8 -10.8 -10.8 -10.8
CA -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7
CC -2.0 -2.0 -2.0 -2.0 -1.6 -1.6 -1.6 -1.6 -2.1 -2.1 -2.1 -2.1 -2.4 -2.4 -2.4 -2.4
CG -3.9 -3.9 -3.9 -3.9 -3.5 -3.5 -3.5 -3.5 -4.0 -4.0 -4.0 -4.0 -4.3 -4.3 -4.3 -4.3
CT -10.4 -10.4 -10.4 -10.4 -10.0 -10.0 -10.0 -10.0 -10.5 -10.5 -10.5 -10.5 -10.8 -10.8 -10.8 -10.8
GA -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7
GC -2.0 -2.0 -2.0 -2.0 -1.6 -1.6 -1.6 -1.6 -2.1 -2.1 -2.1 -2.1 -2.4 -2.4 -2.4 -2.4
GG -3.9 -3.9 -3.9 -3.9 -3.5 -3.5 -3.5 -3.5 -4.0 -4.0 -4.0 -4.0 -4.3 -4.3 -4.3 -4.3
GT -10.4 -10.4 -10.4 -10.4 -10.0 -10.0 -10.0 -10.0 -10.5 -10.5 -10.5 -10.5 -10.8 -10.8 -10.8 -10.8
TA -2.3 -2.3 -2.3 -2.3 -1.9 -1.9 -1.9 -1.9 -2.4 -2.4 -2.4 -2.4 -2.7 -2.7 -2.7 -2.7
TC -2.0 -2.0 -2.0 -2.0 -1.6 -1.6 -1.6 -1.6 -2.1 -2.1 -2.1 -2.1 -2.4 -2.4 -2.4 -2.4
TG -3.9 -3.9 -3.9 -3.9 -3.5 -3.5 -3.5 -3.5 -4.0 -4.0 -4.0 -4.0 -4.3 -4.3 -4.3 -4.3
TT -10.4 -10.4 -10.4 -10.4 -10.0 -10.0 -10.0 -10.0 -10.5 -10.5 -10.5 -10.5 -10.8 -10.8 -10.8 -10.8
# 5' ------> 3'
T X1 Y1 G
G X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
AC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2
AG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1
AT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6
CA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
CC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2
CG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1
CT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6
GA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
GC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2
GG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1
GT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6
TA 4.6 4.6 4.6 4.6 4.9 4.9 4.9 4.9 3.0 3.0 3.0 3.0 -3.5 -3.5 -3.5 -3.5
TC 4.9 4.9 4.9 4.9 5.2 5.2 5.2 5.2 3.3 3.3 3.3 3.3 -3.2 -3.2 -3.2 -3.2
TG 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 1.4 1.4 1.4 1.4 -5.1 -5.1 -5.1 -5.1
TT -3.5 -3.5 -3.5 -3.5 -3.2 -3.2 -3.2 -3.2 -5.1 -5.1 -5.1 -5.1 -11.6 -11.6 -11.6 -11.6
# 5' ------> 3'
T X1 Y1 T
G X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6
AC 6.6 6.6 6.6 6.6 7.8 7.8 7.8 7.8 7.3 7.3 7.3 7.3 6.9 6.9 6.9 6.9
AG 4.7 4.7 4.7 4.7 5.9 5.9 5.9 5.9 5.4 5.4 5.4 5.4 5.0 5.0 5.0 5.0
AT -1.8 -1.8 -1.8 -1.8 -0.6 -0.6 -0.6 -0.6 -1.1 -1.1 -1.1 -1.1 -1.5 -1.5 -1.5 -1.5
CA 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6
CC 6.6 6.6 6.6 6.6 7.8 7.8 7.8 7.8 7.3 7.3 7.3 7.3 6.9 6.9 6.9 6.9
CG 4.7 4.7 4.7 4.7 5.9 5.9 5.9 5.9 5.4 5.4 5.4 5.4 5.0 5.0 5.0 5.0
CT -1.8 -1.8 -1.8 -1.8 -0.6 -0.6 -0.6 -0.6 -1.1 -1.1 -1.1 -1.1 -1.5 -1.5 -1.5 -1.5
GA 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6
GC 6.6 6.6 6.6 6.6 7.8 7.8 7.8 7.8 7.3 7.3 7.3 7.3 6.9 6.9 6.9 6.9
GG 4.7 4.7 4.7 4.7 5.9 5.9 5.9 5.9 5.4 5.4 5.4 5.4 5.0 5.0 5.0 5.0
GT -1.8 -1.8 -1.8 -1.8 -0.6 -0.6 -0.6 -0.6 -1.1 -1.1 -1.1 -1.1 -1.5 -1.5 -1.5 -1.5
TA 6.3 6.3 6.3 6.3 7.5 7.5 7.5 7.5 7.0 7.0 7.0 7.0 6.6 6.6 6.6 6.6
TC 6.6 6.6 6.6 6.6 7.8 7.8 7.8 7.8 7.3 7.3 7.3 7.3 6.9 6.9 6.9 6.9
TG 4.7 4.7 4.7 4.7 5.9 5.9 5.9 5.9 5.4 5.4 5.4 5.4 5.0 5.0 5.0 5.0
TT -1.8 -1.8 -1.8 -1.8 -0.6 -0.6 -0.6 -0.6 -1.1 -1.1 -1.1 -1.1 -1.5 -1.5 -1.5 -1.5
# 5' ------> 3'
T X1 Y1 T
G X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6
AC -0.4 -0.4 -0.4 -0.4 2.5 2.5 2.5 2.5 0.7 0.7 0.7 0.7 4.9 4.9 4.9 4.9
AG -2.3 -2.3 -2.3 -2.3 0.6 0.6 0.6 0.6 -1.2 -1.2 -1.2 -1.2 3.0 3.0 3.0 3.0
AT -8.8 -8.8 -8.8 -8.8 -5.9 -5.9 -5.9 -5.9 -7.7 -7.7 -7.7 -7.7 -3.5 -3.5 -3.5 -3.5
CA -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6
CC -0.4 -0.4 -0.4 -0.4 2.5 2.5 2.5 2.5 0.7 0.7 0.7 0.7 4.9 4.9 4.9 4.9
CG -2.3 -2.3 -2.3 -2.3 0.6 0.6 0.6 0.6 -1.2 -1.2 -1.2 -1.2 3.0 3.0 3.0 3.0
CT -8.8 -8.8 -8.8 -8.8 -5.9 -5.9 -5.9 -5.9 -7.7 -7.7 -7.7 -7.7 -3.5 -3.5 -3.5 -3.5
GA -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6
GC -0.4 -0.4 -0.4 -0.4 2.5 2.5 2.5 2.5 0.7 0.7 0.7 0.7 4.9 4.9 4.9 4.9
GG -2.3 -2.3 -2.3 -2.3 0.6 0.6 0.6 0.6 -1.2 -1.2 -1.2 -1.2 3.0 3.0 3.0 3.0
GT -8.8 -8.8 -8.8 -8.8 -5.9 -5.9 -5.9 -5.9 -7.7 -7.7 -7.7 -7.7 -3.5 -3.5 -3.5 -3.5
TA -0.7 -0.7 -0.7 -0.7 2.2 2.2 2.2 2.2 0.4 0.4 0.4 0.4 4.6 4.6 4.6 4.6
TC -0.4 -0.4 -0.4 -0.4 2.5 2.5 2.5 2.5 0.7 0.7 0.7 0.7 4.9 4.9 4.9 4.9
TG -2.3 -2.3 -2.3 -2.3 0.6 0.6 0.6 0.6 -1.2 -1.2 -1.2 -1.2 3.0 3.0 3.0 3.0
TT -8.8 -8.8 -8.8 -8.8 -5.9 -5.9 -5.9 -5.9 -7.7 -7.7 -7.7 -7.7 -3.5 -3.5 -3.5 -3.5