# Data tables for 2x2 interior loops # Free energies at 37 degrees for DNA # Data arrangement: # # 5' ------> 3' # A X1 Y1 A # T X2 Y2 T # 3' <------ 5' # # Y--> # ---------------------------------------------------------------------------------------------------------------------------- # (X) A A A A C C C C G G G G T T T T # | A C G T A C G T A C G T A C G T # V ---------------------------------------------------------------------------------------------------------------------------- # (AA) 1.8 1.9 1.8 2.4 1.9 2.1 2.4 2.0 1.8 1.9 1.8 2.3 2.4 2.0 2.4 1.8 # (AC) 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0 # (AG) 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9 # (AT) 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5 # (CA) 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0 # (CC) 2.2 2.3 2.2 2.8 2.3 2.5 2.8 2.4 2.2 2.3 2.2 2.7 2.8 2.4 2.8 2.2 # (CG) 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1 # (CT) 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1 # (GA) 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9 # (GC) 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3 # (GG) 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9 # (GT) 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5 # (TA) 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5 # (TC) 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1 # (TG) 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5 # (TT) 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9 # 5' ------> 3' A X1 Y1 A T X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.8 1.9 1.8 2.4 1.9 2.1 2.4 2.0 1.8 1.9 1.8 2.3 2.4 2.0 2.4 1.8 AC 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0 AG 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9 AT 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5 CA 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0 CC 2.2 2.3 2.2 2.8 2.3 2.5 2.8 2.4 2.2 2.3 2.2 2.7 2.8 2.4 2.8 2.2 CG 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1 CT 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1 GA 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9 GC 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3 GG 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9 GT 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5 TA 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5 TC 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1 TG 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5 TT 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9 # 5' ------> 3' A X1 Y1 C T X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.3 1.6 1.4 2.0 1.6 1.8 1.6 1.7 1.4 1.1 1.4 2.0 1.9 1.7 2.1 1.5 AC 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7 AG 1.4 1.7 1.5 2.1 1.7 1.9 1.7 1.8 1.5 1.2 1.5 2.1 2.0 1.8 2.2 1.6 AT 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2 CA 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7 CC 1.7 2.0 1.8 2.4 2.0 2.2 2.0 2.1 1.8 1.5 1.8 2.4 2.3 2.1 2.5 1.9 CG 1.6 1.9 1.7 2.3 1.9 2.1 1.9 2.0 1.7 1.4 1.7 2.3 2.2 2.0 2.4 1.8 CT 1.6 1.9 1.7 2.3 1.9 2.1 1.9 2.0 1.7 1.4 1.7 2.3 2.2 2.0 2.4 1.8 GA 1.4 1.7 1.5 2.1 1.7 1.9 1.7 1.8 1.5 1.2 1.5 2.1 2.0 1.8 2.2 1.6 GC 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0 GG 1.4 1.7 1.5 2.1 1.7 1.9 1.7 1.8 1.5 1.2 1.5 2.1 2.0 1.8 2.2 1.6 GT 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2 TA 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2 TC 1.6 1.9 1.7 2.3 1.9 2.1 1.9 2.0 1.7 1.4 1.7 2.3 2.2 2.0 2.4 1.8 TG 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2 TT 1.4 1.7 1.5 2.1 1.7 1.9 1.7 1.8 1.5 1.2 1.5 2.1 2.0 1.8 2.2 1.6 # 5' ------> 3' A X1 Y1 G T X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.4 1.7 1.5 2.2 1.7 1.9 1.3 1.7 1.5 1.6 1.5 2.0 2.0 1.7 1.9 1.5 AC 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7 AG 1.5 1.8 1.6 2.3 1.8 2.0 1.4 1.8 1.6 1.7 1.6 2.1 2.1 1.8 2.0 1.6 AT 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2 CA 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7 CC 1.8 2.1 1.9 2.6 2.1 2.3 1.7 2.1 1.9 2.0 1.9 2.4 2.4 2.1 2.3 1.9 CG 1.7 2.0 1.8 2.5 2.0 2.2 1.6 2.0 1.8 1.9 1.8 2.3 2.3 2.0 2.2 1.8 CT 1.7 2.0 1.8 2.5 2.0 2.2 1.6 2.0 1.8 1.9 1.8 2.3 2.3 2.0 2.2 1.8 GA 1.5 1.8 1.6 2.3 1.8 2.0 1.4 1.8 1.6 1.7 1.6 2.1 2.1 1.8 2.0 1.6 GC 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0 GG 1.5 1.8 1.6 2.3 1.8 2.0 1.4 1.8 1.6 1.7 1.6 2.1 2.1 1.8 2.0 1.6 GT 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2 TA 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2 TC 1.7 2.0 1.8 2.5 2.0 2.2 1.6 2.0 1.8 1.9 1.8 2.3 2.3 2.0 2.2 1.8 TG 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2 TT 1.5 1.8 1.6 2.3 1.8 2.0 1.4 1.8 1.6 1.7 1.6 2.1 2.1 1.8 2.0 1.6 # 5' ------> 3' A X1 Y1 T T X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.7 1.9 1.8 2.4 1.9 2.1 2.2 2.0 1.8 2.0 1.8 2.4 2.4 2.0 2.4 1.8 AC 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0 AG 1.8 2.0 1.9 2.5 2.0 2.2 2.3 2.1 1.9 2.1 1.9 2.5 2.5 2.1 2.5 1.9 AT 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5 CA 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0 CC 2.1 2.3 2.2 2.8 2.3 2.5 2.6 2.4 2.2 2.4 2.2 2.8 2.8 2.4 2.8 2.2 CG 2.0 2.2 2.1 2.7 2.2 2.4 2.5 2.3 2.1 2.3 2.1 2.7 2.7 2.3 2.7 2.1 CT 2.0 2.2 2.1 2.7 2.2 2.4 2.5 2.3 2.1 2.3 2.1 2.7 2.7 2.3 2.7 2.1 GA 1.8 2.0 1.9 2.5 2.0 2.2 2.3 2.1 1.9 2.1 1.9 2.5 2.5 2.1 2.5 1.9 GC 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3 GG 1.8 2.0 1.9 2.5 2.0 2.2 2.3 2.1 1.9 2.1 1.9 2.5 2.5 2.1 2.5 1.9 GT 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5 TA 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5 TC 2.0 2.2 2.1 2.7 2.2 2.4 2.5 2.3 2.1 2.3 2.1 2.7 2.7 2.3 2.7 2.1 TG 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5 TT 1.8 2.0 1.9 2.5 2.0 2.2 2.3 2.1 1.9 2.1 1.9 2.5 2.5 2.1 2.5 1.9 # 5' ------> 3' A X1 Y1 G T X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.9 2.2 1.9 2.4 2.2 2.2 1.9 2.2 1.9 2.1 1.9 2.4 2.4 2.2 2.4 2.2 AC 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4 AG 2.0 2.3 2.0 2.5 2.3 2.3 2.0 2.3 2.0 2.2 2.0 2.5 2.5 2.3 2.5 2.3 AT 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9 CA 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4 CC 2.3 2.6 2.3 2.8 2.6 2.6 2.3 2.6 2.3 2.5 2.3 2.8 2.8 2.6 2.8 2.6 CG 2.2 2.5 2.2 2.7 2.5 2.5 2.2 2.5 2.2 2.4 2.2 2.7 2.7 2.5 2.7 2.5 CT 2.2 2.5 2.2 2.7 2.5 2.5 2.2 2.5 2.2 2.4 2.2 2.7 2.7 2.5 2.7 2.5 GA 2.0 2.3 2.0 2.5 2.3 2.3 2.0 2.3 2.0 2.2 2.0 2.5 2.5 2.3 2.5 2.3 GC 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7 GG 2.0 2.3 2.0 2.5 2.3 2.3 2.0 2.3 2.0 2.2 2.0 2.5 2.5 2.3 2.5 2.3 GT 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9 TA 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9 TC 2.2 2.5 2.2 2.7 2.5 2.5 2.2 2.5 2.2 2.4 2.2 2.7 2.7 2.5 2.7 2.5 TG 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9 TT 2.0 2.3 2.0 2.5 2.3 2.3 2.0 2.3 2.0 2.2 2.0 2.5 2.5 2.3 2.5 2.3 # 5' ------> 3' A X1 Y1 T T X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.9 2.2 1.9 2.4 2.2 2.2 2.0 2.2 1.9 2.0 1.9 2.4 2.2 2.2 2.4 2.2 AC 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4 AG 2.0 2.3 2.0 2.5 2.3 2.3 2.1 2.3 2.0 2.1 2.0 2.5 2.3 2.3 2.5 2.3 AT 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9 CA 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4 CC 2.3 2.6 2.3 2.8 2.6 2.6 2.4 2.6 2.3 2.4 2.3 2.8 2.6 2.6 2.8 2.6 CG 2.2 2.5 2.2 2.7 2.5 2.5 2.3 2.5 2.2 2.3 2.2 2.7 2.5 2.5 2.7 2.5 CT 2.2 2.5 2.2 2.7 2.5 2.5 2.3 2.5 2.2 2.3 2.2 2.7 2.5 2.5 2.7 2.5 GA 2.0 2.3 2.0 2.5 2.3 2.3 2.1 2.3 2.0 2.1 2.0 2.5 2.3 2.3 2.5 2.3 GC 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7 GG 2.0 2.3 2.0 2.5 2.3 2.3 2.1 2.3 2.0 2.1 2.0 2.5 2.3 2.3 2.5 2.3 GT 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9 TA 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9 TC 2.2 2.5 2.2 2.7 2.5 2.5 2.3 2.5 2.2 2.3 2.2 2.7 2.5 2.5 2.7 2.5 TG 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9 TT 2.0 2.3 2.0 2.5 2.3 2.3 2.1 2.3 2.0 2.1 2.0 2.5 2.3 2.3 2.5 2.3 # 5' ------> 3' C X1 Y1 A G X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.5 1.6 1.5 2.1 1.6 1.8 2.1 1.7 1.5 1.6 1.5 2.0 2.1 1.7 2.1 1.5 AC 1.8 1.9 1.8 2.4 1.9 2.1 2.4 2.0 1.8 1.9 1.8 2.3 2.4 2.0 2.4 1.8 AG 1.6 1.7 1.6 2.2 1.7 1.9 2.2 1.8 1.6 1.7 1.6 2.1 2.2 1.8 2.2 1.6 AT 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1 CA 1.8 1.9 1.8 2.4 1.9 2.1 2.4 2.0 1.8 1.9 1.8 2.3 2.4 2.0 2.4 1.8 CC 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0 CG 1.7 1.8 1.7 2.3 1.8 2.0 2.3 1.9 1.7 1.8 1.7 2.2 2.3 1.9 2.3 1.7 CT 1.8 1.9 1.8 2.4 1.9 2.1 2.4 2.0 1.8 1.9 1.8 2.3 2.4 2.0 2.4 1.8 GA 1.6 1.7 1.6 2.2 1.7 1.9 2.2 1.8 1.6 1.7 1.6 2.1 2.2 1.8 2.2 1.6 GC 1.4 1.5 1.4 2.0 1.5 1.7 2.0 1.6 1.4 1.5 1.4 1.9 2.0 1.6 2.0 1.4 GG 1.6 1.7 1.6 2.2 1.7 1.9 2.2 1.8 1.6 1.7 1.6 2.1 2.2 1.8 2.2 1.6 GT 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0 TA 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3 TC 1.8 1.9 1.8 2.4 1.9 2.1 2.4 2.0 1.8 1.9 1.8 2.3 2.4 2.0 2.4 1.8 TG 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1 TT 1.6 1.7 1.6 2.2 1.7 1.9 2.2 1.8 1.6 1.7 1.6 2.1 2.2 1.8 2.2 1.6 # 5' ------> 3' C X1 Y1 C G X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.0 1.3 1.1 1.7 1.3 1.5 1.3 1.4 1.1 0.8 1.1 1.7 1.6 1.4 1.8 1.2 AC 1.3 1.6 1.4 2.0 1.6 1.8 1.6 1.7 1.4 1.1 1.4 2.0 1.9 1.7 2.1 1.5 AG 1.1 1.4 1.2 1.8 1.4 1.6 1.4 1.5 1.2 0.9 1.2 1.8 1.7 1.5 1.9 1.3 AT 1.6 1.9 1.7 2.3 1.9 2.1 1.9 2.0 1.7 1.4 1.7 2.3 2.2 2.0 2.4 1.8 CA 1.3 1.6 1.4 2.0 1.6 1.8 1.6 1.7 1.4 1.1 1.4 2.0 1.9 1.7 2.1 1.5 CC 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7 CG 1.2 1.5 1.3 1.9 1.5 1.7 1.5 1.6 1.3 1.0 1.3 1.9 1.8 1.6 2.0 1.4 CT 1.3 1.6 1.4 2.0 1.6 1.8 1.6 1.7 1.4 1.1 1.4 2.0 1.9 1.7 2.1 1.5 GA 1.1 1.4 1.2 1.8 1.4 1.6 1.4 1.5 1.2 0.9 1.2 1.8 1.7 1.5 1.9 1.3 GC 0.9 1.2 1.0 1.6 1.2 1.4 1.2 1.3 1.0 0.7 1.0 1.6 1.5 1.3 1.7 1.1 GG 1.1 1.4 1.2 1.8 1.4 1.6 1.4 1.5 1.2 0.9 1.2 1.8 1.7 1.5 1.9 1.3 GT 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7 TA 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0 TC 1.3 1.6 1.4 2.0 1.6 1.8 1.6 1.7 1.4 1.1 1.4 2.0 1.9 1.7 2.1 1.5 TG 1.6 1.9 1.7 2.3 1.9 2.1 1.9 2.0 1.7 1.4 1.7 2.3 2.2 2.0 2.4 1.8 TT 1.1 1.4 1.2 1.8 1.4 1.6 1.4 1.5 1.2 0.9 1.2 1.8 1.7 1.5 1.9 1.3 # 5' ------> 3' C X1 Y1 G G X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.1 1.4 1.2 1.9 1.4 1.6 1.0 1.4 1.2 1.3 1.2 1.7 1.7 1.4 1.6 1.2 AC 1.4 1.7 1.5 2.2 1.7 1.9 1.3 1.7 1.5 1.6 1.5 2.0 2.0 1.7 1.9 1.5 AG 1.2 1.5 1.3 2.0 1.5 1.7 1.1 1.5 1.3 1.4 1.3 1.8 1.8 1.5 1.7 1.3 AT 1.7 2.0 1.8 2.5 2.0 2.2 1.6 2.0 1.8 1.9 1.8 2.3 2.3 2.0 2.2 1.8 CA 1.4 1.7 1.5 2.2 1.7 1.9 1.3 1.7 1.5 1.6 1.5 2.0 2.0 1.7 1.9 1.5 CC 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7 CG 1.3 1.6 1.4 2.1 1.6 1.8 1.2 1.6 1.4 1.5 1.4 1.9 1.9 1.6 1.8 1.4 CT 1.4 1.7 1.5 2.2 1.7 1.9 1.3 1.7 1.5 1.6 1.5 2.0 2.0 1.7 1.9 1.5 GA 1.2 1.5 1.3 2.0 1.5 1.7 1.1 1.5 1.3 1.4 1.3 1.8 1.8 1.5 1.7 1.3 GC 1.0 1.3 1.1 1.8 1.3 1.5 0.9 1.3 1.1 1.2 1.1 1.6 1.6 1.3 1.5 1.1 GG 1.2 1.5 1.3 2.0 1.5 1.7 1.1 1.5 1.3 1.4 1.3 1.8 1.8 1.5 1.7 1.3 GT 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7 TA 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0 TC 1.4 1.7 1.5 2.2 1.7 1.9 1.3 1.7 1.5 1.6 1.5 2.0 2.0 1.7 1.9 1.5 TG 1.7 2.0 1.8 2.5 2.0 2.2 1.6 2.0 1.8 1.9 1.8 2.3 2.3 2.0 2.2 1.8 TT 1.2 1.5 1.3 2.0 1.5 1.7 1.1 1.5 1.3 1.4 1.3 1.8 1.8 1.5 1.7 1.3 # 5' ------> 3' C X1 Y1 T G X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.4 1.6 1.5 2.1 1.6 1.8 1.9 1.7 1.5 1.7 1.5 2.1 2.1 1.7 2.1 1.5 AC 1.7 1.9 1.8 2.4 1.9 2.1 2.2 2.0 1.8 2.0 1.8 2.4 2.4 2.0 2.4 1.8 AG 1.5 1.7 1.6 2.2 1.7 1.9 2.0 1.8 1.6 1.8 1.6 2.2 2.2 1.8 2.2 1.6 AT 2.0 2.2 2.1 2.7 2.2 2.4 2.5 2.3 2.1 2.3 2.1 2.7 2.7 2.3 2.7 2.1 CA 1.7 1.9 1.8 2.4 1.9 2.1 2.2 2.0 1.8 2.0 1.8 2.4 2.4 2.0 2.4 1.8 CC 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0 CG 1.6 1.8 1.7 2.3 1.8 2.0 2.1 1.9 1.7 1.9 1.7 2.3 2.3 1.9 2.3 1.7 CT 1.7 1.9 1.8 2.4 1.9 2.1 2.2 2.0 1.8 2.0 1.8 2.4 2.4 2.0 2.4 1.8 GA 1.5 1.7 1.6 2.2 1.7 1.9 2.0 1.8 1.6 1.8 1.6 2.2 2.2 1.8 2.2 1.6 GC 1.3 1.5 1.4 2.0 1.5 1.7 1.8 1.6 1.4 1.6 1.4 2.0 2.0 1.6 2.0 1.4 GG 1.5 1.7 1.6 2.2 1.7 1.9 2.0 1.8 1.6 1.8 1.6 2.2 2.2 1.8 2.2 1.6 GT 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0 TA 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3 TC 1.7 1.9 1.8 2.4 1.9 2.1 2.2 2.0 1.8 2.0 1.8 2.4 2.4 2.0 2.4 1.8 TG 2.0 2.2 2.1 2.7 2.2 2.4 2.5 2.3 2.1 2.3 2.1 2.7 2.7 2.3 2.7 2.1 TT 1.5 1.7 1.6 2.2 1.7 1.9 2.0 1.8 1.6 1.8 1.6 2.2 2.2 1.8 2.2 1.6 # 5' ------> 3' C X1 Y1 G G X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.6 1.9 1.6 2.1 1.9 1.9 1.6 1.9 1.6 1.8 1.6 2.1 2.1 1.9 2.1 1.9 AC 1.9 2.2 1.9 2.4 2.2 2.2 1.9 2.2 1.9 2.1 1.9 2.4 2.4 2.2 2.4 2.2 AG 1.7 2.0 1.7 2.2 2.0 2.0 1.7 2.0 1.7 1.9 1.7 2.2 2.2 2.0 2.2 2.0 AT 2.2 2.5 2.2 2.7 2.5 2.5 2.2 2.5 2.2 2.4 2.2 2.7 2.7 2.5 2.7 2.5 CA 1.9 2.2 1.9 2.4 2.2 2.2 1.9 2.2 1.9 2.1 1.9 2.4 2.4 2.2 2.4 2.2 CC 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4 CG 1.8 2.1 1.8 2.3 2.1 2.1 1.8 2.1 1.8 2.0 1.8 2.3 2.3 2.1 2.3 2.1 CT 1.9 2.2 1.9 2.4 2.2 2.2 1.9 2.2 1.9 2.1 1.9 2.4 2.4 2.2 2.4 2.2 GA 1.7 2.0 1.7 2.2 2.0 2.0 1.7 2.0 1.7 1.9 1.7 2.2 2.2 2.0 2.2 2.0 GC 1.5 1.8 1.5 2.0 1.8 1.8 1.5 1.8 1.5 1.7 1.5 2.0 2.0 1.8 2.0 1.8 GG 1.7 2.0 1.7 2.2 2.0 2.0 1.7 2.0 1.7 1.9 1.7 2.2 2.2 2.0 2.2 2.0 GT 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4 TA 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7 TC 1.9 2.2 1.9 2.4 2.2 2.2 1.9 2.2 1.9 2.1 1.9 2.4 2.4 2.2 2.4 2.2 TG 2.2 2.5 2.2 2.7 2.5 2.5 2.2 2.5 2.2 2.4 2.2 2.7 2.7 2.5 2.7 2.5 TT 1.7 2.0 1.7 2.2 2.0 2.0 1.7 2.0 1.7 1.9 1.7 2.2 2.2 2.0 2.2 2.0 # 5' ------> 3' C X1 Y1 T G X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.6 1.9 1.6 2.1 1.9 1.9 1.7 1.9 1.6 1.7 1.6 2.1 1.9 1.9 2.1 1.9 AC 1.9 2.2 1.9 2.4 2.2 2.2 2.0 2.2 1.9 2.0 1.9 2.4 2.2 2.2 2.4 2.2 AG 1.7 2.0 1.7 2.2 2.0 2.0 1.8 2.0 1.7 1.8 1.7 2.2 2.0 2.0 2.2 2.0 AT 2.2 2.5 2.2 2.7 2.5 2.5 2.3 2.5 2.2 2.3 2.2 2.7 2.5 2.5 2.7 2.5 CA 1.9 2.2 1.9 2.4 2.2 2.2 2.0 2.2 1.9 2.0 1.9 2.4 2.2 2.2 2.4 2.2 CC 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4 CG 1.8 2.1 1.8 2.3 2.1 2.1 1.9 2.1 1.8 1.9 1.8 2.3 2.1 2.1 2.3 2.1 CT 1.9 2.2 1.9 2.4 2.2 2.2 2.0 2.2 1.9 2.0 1.9 2.4 2.2 2.2 2.4 2.2 GA 1.7 2.0 1.7 2.2 2.0 2.0 1.8 2.0 1.7 1.8 1.7 2.2 2.0 2.0 2.2 2.0 GC 1.5 1.8 1.5 2.0 1.8 1.8 1.6 1.8 1.5 1.6 1.5 2.0 1.8 1.8 2.0 1.8 GG 1.7 2.0 1.7 2.2 2.0 2.0 1.8 2.0 1.7 1.8 1.7 2.2 2.0 2.0 2.2 2.0 GT 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4 TA 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7 TC 1.9 2.2 1.9 2.4 2.2 2.2 2.0 2.2 1.9 2.0 1.9 2.4 2.2 2.2 2.4 2.2 TG 2.2 2.5 2.2 2.7 2.5 2.5 2.3 2.5 2.2 2.3 2.2 2.7 2.5 2.5 2.7 2.5 TT 1.7 2.0 1.7 2.2 2.0 2.0 1.8 2.0 1.7 1.8 1.7 2.2 2.0 2.0 2.2 2.0 # 5' ------> 3' G X1 Y1 A C X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.4 1.5 1.4 2.0 1.5 1.7 2.0 1.6 1.4 1.5 1.4 1.9 2.0 1.6 2.0 1.4 AC 1.7 1.8 1.7 2.3 1.8 2.0 2.3 1.9 1.7 1.8 1.7 2.2 2.3 1.9 2.3 1.7 AG 1.5 1.6 1.5 2.1 1.6 1.8 2.1 1.7 1.5 1.6 1.5 2.0 2.1 1.7 2.1 1.5 AT 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0 CA 1.7 1.8 1.7 2.3 1.8 2.0 2.3 1.9 1.7 1.8 1.7 2.2 2.3 1.9 2.3 1.7 CC 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9 CG 1.2 1.3 1.2 1.8 1.3 1.5 1.8 1.4 1.2 1.3 1.2 1.7 1.8 1.4 1.8 1.2 CT 1.8 1.9 1.8 2.4 1.9 2.1 2.4 2.0 1.8 1.9 1.8 2.3 2.4 2.0 2.4 1.8 GA 1.5 1.6 1.5 2.1 1.6 1.8 2.1 1.7 1.5 1.6 1.5 2.0 2.1 1.7 2.1 1.5 GC 1.7 1.8 1.7 2.3 1.8 2.0 2.3 1.9 1.7 1.8 1.7 2.2 2.3 1.9 2.3 1.7 GG 1.5 1.6 1.5 2.1 1.6 1.8 2.1 1.7 1.5 1.6 1.5 2.0 2.1 1.7 2.1 1.5 GT 2.2 2.3 2.2 2.8 2.3 2.5 2.8 2.4 2.2 2.3 2.2 2.7 2.8 2.4 2.8 2.2 TA 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1 TC 1.8 1.9 1.8 2.4 1.9 2.1 2.4 2.0 1.8 1.9 1.8 2.3 2.4 2.0 2.4 1.8 TG 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1 TT 1.6 1.7 1.6 2.2 1.7 1.9 2.2 1.8 1.6 1.7 1.6 2.1 2.2 1.8 2.2 1.6 # 5' ------> 3' G X1 Y1 C C X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 0.9 1.2 1.0 1.6 1.2 1.4 1.2 1.3 1.0 0.7 1.0 1.6 1.5 1.3 1.7 1.1 AC 1.2 1.5 1.3 1.9 1.5 1.7 1.5 1.6 1.3 1.0 1.3 1.9 1.8 1.6 2.0 1.4 AG 1.0 1.3 1.1 1.7 1.3 1.5 1.3 1.4 1.1 0.8 1.1 1.7 1.6 1.4 1.8 1.2 AT 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7 CA 1.2 1.5 1.3 1.9 1.5 1.7 1.5 1.6 1.3 1.0 1.3 1.9 1.8 1.6 2.0 1.4 CC 1.4 1.7 1.5 2.1 1.7 1.9 1.7 1.8 1.5 1.2 1.5 2.1 2.0 1.8 2.2 1.6 CG 0.7 1.0 0.8 1.4 1.0 1.2 1.0 1.1 0.8 0.5 0.8 1.4 1.3 1.1 1.5 0.9 CT 1.3 1.6 1.4 2.0 1.6 1.8 1.6 1.7 1.4 1.1 1.4 2.0 1.9 1.7 2.1 1.5 GA 1.0 1.3 1.1 1.7 1.3 1.5 1.3 1.4 1.1 0.8 1.1 1.7 1.6 1.4 1.8 1.2 GC 1.2 1.5 1.3 1.9 1.5 1.7 1.5 1.6 1.3 1.0 1.3 1.9 1.8 1.6 2.0 1.4 GG 1.0 1.3 1.1 1.7 1.3 1.5 1.3 1.4 1.1 0.8 1.1 1.7 1.6 1.4 1.8 1.2 GT 1.7 2.0 1.8 2.4 2.0 2.2 2.0 2.1 1.8 1.5 1.8 2.4 2.3 2.1 2.5 1.9 TA 1.6 1.9 1.7 2.3 1.9 2.1 1.9 2.0 1.7 1.4 1.7 2.3 2.2 2.0 2.4 1.8 TC 1.3 1.6 1.4 2.0 1.6 1.8 1.6 1.7 1.4 1.1 1.4 2.0 1.9 1.7 2.1 1.5 TG 1.6 1.9 1.7 2.3 1.9 2.1 1.9 2.0 1.7 1.4 1.7 2.3 2.2 2.0 2.4 1.8 TT 1.1 1.4 1.2 1.8 1.4 1.6 1.4 1.5 1.2 0.9 1.2 1.8 1.7 1.5 1.9 1.3 # 5' ------> 3' G X1 Y1 G C X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.0 1.3 1.1 1.8 1.3 1.5 0.9 1.3 1.1 1.2 1.1 1.6 1.6 1.3 1.5 1.1 AC 1.3 1.6 1.4 2.1 1.6 1.8 1.2 1.6 1.4 1.5 1.4 1.9 1.9 1.6 1.8 1.4 AG 1.1 1.4 1.2 1.9 1.4 1.6 1.0 1.4 1.2 1.3 1.2 1.7 1.7 1.4 1.6 1.2 AT 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7 CA 1.3 1.6 1.4 2.1 1.6 1.8 1.2 1.6 1.4 1.5 1.4 1.9 1.9 1.6 1.8 1.4 CC 1.5 1.8 1.6 2.3 1.8 2.0 1.4 1.8 1.6 1.7 1.6 2.1 2.1 1.8 2.0 1.6 CG 0.8 1.1 0.9 1.6 1.1 1.3 0.7 1.1 0.9 1.0 0.9 1.4 1.4 1.1 1.3 0.9 CT 1.4 1.7 1.5 2.2 1.7 1.9 1.3 1.7 1.5 1.6 1.5 2.0 2.0 1.7 1.9 1.5 GA 1.1 1.4 1.2 1.9 1.4 1.6 1.0 1.4 1.2 1.3 1.2 1.7 1.7 1.4 1.6 1.2 GC 1.3 1.6 1.4 2.1 1.6 1.8 1.2 1.6 1.4 1.5 1.4 1.9 1.9 1.6 1.8 1.4 GG 1.1 1.4 1.2 1.9 1.4 1.6 1.0 1.4 1.2 1.3 1.2 1.7 1.7 1.4 1.6 1.2 GT 1.8 2.1 1.9 2.6 2.1 2.3 1.7 2.1 1.9 2.0 1.9 2.4 2.4 2.1 2.3 1.9 TA 1.7 2.0 1.8 2.5 2.0 2.2 1.6 2.0 1.8 1.9 1.8 2.3 2.3 2.0 2.2 1.8 TC 1.4 1.7 1.5 2.2 1.7 1.9 1.3 1.7 1.5 1.6 1.5 2.0 2.0 1.7 1.9 1.5 TG 1.7 2.0 1.8 2.5 2.0 2.2 1.6 2.0 1.8 1.9 1.8 2.3 2.3 2.0 2.2 1.8 TT 1.2 1.5 1.3 2.0 1.5 1.7 1.1 1.5 1.3 1.4 1.3 1.8 1.8 1.5 1.7 1.3 # 5' ------> 3' G X1 Y1 T C X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.3 1.5 1.4 2.0 1.5 1.7 1.8 1.6 1.4 1.6 1.4 2.0 2.0 1.6 2.0 1.4 AC 1.6 1.8 1.7 2.3 1.8 2.0 2.1 1.9 1.7 1.9 1.7 2.3 2.3 1.9 2.3 1.7 AG 1.4 1.6 1.5 2.1 1.6 1.8 1.9 1.7 1.5 1.7 1.5 2.1 2.1 1.7 2.1 1.5 AT 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0 CA 1.6 1.8 1.7 2.3 1.8 2.0 2.1 1.9 1.7 1.9 1.7 2.3 2.3 1.9 2.3 1.7 CC 1.8 2.0 1.9 2.5 2.0 2.2 2.3 2.1 1.9 2.1 1.9 2.5 2.5 2.1 2.5 1.9 CG 1.1 1.3 1.2 1.8 1.3 1.5 1.6 1.4 1.2 1.4 1.2 1.8 1.8 1.4 1.8 1.2 CT 1.7 1.9 1.8 2.4 1.9 2.1 2.2 2.0 1.8 2.0 1.8 2.4 2.4 2.0 2.4 1.8 GA 1.4 1.6 1.5 2.1 1.6 1.8 1.9 1.7 1.5 1.7 1.5 2.1 2.1 1.7 2.1 1.5 GC 1.6 1.8 1.7 2.3 1.8 2.0 2.1 1.9 1.7 1.9 1.7 2.3 2.3 1.9 2.3 1.7 GG 1.4 1.6 1.5 2.1 1.6 1.8 1.9 1.7 1.5 1.7 1.5 2.1 2.1 1.7 2.1 1.5 GT 2.1 2.3 2.2 2.8 2.3 2.5 2.6 2.4 2.2 2.4 2.2 2.8 2.8 2.4 2.8 2.2 TA 2.0 2.2 2.1 2.7 2.2 2.4 2.5 2.3 2.1 2.3 2.1 2.7 2.7 2.3 2.7 2.1 TC 1.7 1.9 1.8 2.4 1.9 2.1 2.2 2.0 1.8 2.0 1.8 2.4 2.4 2.0 2.4 1.8 TG 2.0 2.2 2.1 2.7 2.2 2.4 2.5 2.3 2.1 2.3 2.1 2.7 2.7 2.3 2.7 2.1 TT 1.5 1.7 1.6 2.2 1.7 1.9 2.0 1.8 1.6 1.8 1.6 2.2 2.2 1.8 2.2 1.6 # 5' ------> 3' G X1 Y1 G C X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.5 1.8 1.5 2.0 1.8 1.8 1.5 1.8 1.5 1.7 1.5 2.0 2.0 1.8 2.0 1.8 AC 1.8 2.1 1.8 2.3 2.1 2.1 1.8 2.1 1.8 2.0 1.8 2.3 2.3 2.1 2.3 2.1 AG 1.6 1.9 1.6 2.1 1.9 1.9 1.6 1.9 1.6 1.8 1.6 2.1 2.1 1.9 2.1 1.9 AT 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4 CA 1.8 2.1 1.8 2.3 2.1 2.1 1.8 2.1 1.8 2.0 1.8 2.3 2.3 2.1 2.3 2.1 CC 2.0 2.3 2.0 2.5 2.3 2.3 2.0 2.3 2.0 2.2 2.0 2.5 2.5 2.3 2.5 2.3 CG 1.3 1.6 1.3 1.8 1.6 1.6 1.3 1.6 1.3 1.5 1.3 1.8 1.8 1.6 1.8 1.6 CT 1.9 2.2 1.9 2.4 2.2 2.2 1.9 2.2 1.9 2.1 1.9 2.4 2.4 2.2 2.4 2.2 GA 1.6 1.9 1.6 2.1 1.9 1.9 1.6 1.9 1.6 1.8 1.6 2.1 2.1 1.9 2.1 1.9 GC 1.8 2.1 1.8 2.3 2.1 2.1 1.8 2.1 1.8 2.0 1.8 2.3 2.3 2.1 2.3 2.1 GG 1.6 1.9 1.6 2.1 1.9 1.9 1.6 1.9 1.6 1.8 1.6 2.1 2.1 1.9 2.1 1.9 GT 2.3 2.6 2.3 2.8 2.6 2.6 2.3 2.6 2.3 2.5 2.3 2.8 2.8 2.6 2.8 2.6 TA 2.2 2.5 2.2 2.7 2.5 2.5 2.2 2.5 2.2 2.4 2.2 2.7 2.7 2.5 2.7 2.5 TC 1.9 2.2 1.9 2.4 2.2 2.2 1.9 2.2 1.9 2.1 1.9 2.4 2.4 2.2 2.4 2.2 TG 2.2 2.5 2.2 2.7 2.5 2.5 2.2 2.5 2.2 2.4 2.2 2.7 2.7 2.5 2.7 2.5 TT 1.7 2.0 1.7 2.2 2.0 2.0 1.7 2.0 1.7 1.9 1.7 2.2 2.2 2.0 2.2 2.0 # 5' ------> 3' G X1 Y1 T C X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.5 1.8 1.5 2.0 1.8 1.8 1.6 1.8 1.5 1.6 1.5 2.0 1.8 1.8 2.0 1.8 AC 1.8 2.1 1.8 2.3 2.1 2.1 1.9 2.1 1.8 1.9 1.8 2.3 2.1 2.1 2.3 2.1 AG 1.6 1.9 1.6 2.1 1.9 1.9 1.7 1.9 1.6 1.7 1.6 2.1 1.9 1.9 2.1 1.9 AT 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4 CA 1.8 2.1 1.8 2.3 2.1 2.1 1.9 2.1 1.8 1.9 1.8 2.3 2.1 2.1 2.3 2.1 CC 2.0 2.3 2.0 2.5 2.3 2.3 2.1 2.3 2.0 2.1 2.0 2.5 2.3 2.3 2.5 2.3 CG 1.3 1.6 1.3 1.8 1.6 1.6 1.4 1.6 1.3 1.4 1.3 1.8 1.6 1.6 1.8 1.6 CT 1.9 2.2 1.9 2.4 2.2 2.2 2.0 2.2 1.9 2.0 1.9 2.4 2.2 2.2 2.4 2.2 GA 1.6 1.9 1.6 2.1 1.9 1.9 1.7 1.9 1.6 1.7 1.6 2.1 1.9 1.9 2.1 1.9 GC 1.8 2.1 1.8 2.3 2.1 2.1 1.9 2.1 1.8 1.9 1.8 2.3 2.1 2.1 2.3 2.1 GG 1.6 1.9 1.6 2.1 1.9 1.9 1.7 1.9 1.6 1.7 1.6 2.1 1.9 1.9 2.1 1.9 GT 2.3 2.6 2.3 2.8 2.6 2.6 2.4 2.6 2.3 2.4 2.3 2.8 2.6 2.6 2.8 2.6 TA 2.2 2.5 2.2 2.7 2.5 2.5 2.3 2.5 2.2 2.3 2.2 2.7 2.5 2.5 2.7 2.5 TC 1.9 2.2 1.9 2.4 2.2 2.2 2.0 2.2 1.9 2.0 1.9 2.4 2.2 2.2 2.4 2.2 TG 2.2 2.5 2.2 2.7 2.5 2.5 2.3 2.5 2.2 2.3 2.2 2.7 2.5 2.5 2.7 2.5 TT 1.7 2.0 1.7 2.2 2.0 2.0 1.8 2.0 1.7 1.8 1.7 2.2 2.0 2.0 2.2 2.0 # 5' ------> 3' T X1 Y1 A A X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9 AC 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0 AG 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9 AT 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5 CA 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0 CC 2.2 2.3 2.2 2.8 2.3 2.5 2.8 2.4 2.2 2.3 2.2 2.7 2.8 2.4 2.8 2.2 CG 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0 CT 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1 GA 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9 GC 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5 GG 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9 GT 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5 TA 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5 TC 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1 TG 2.4 2.5 2.4 3.0 2.5 2.7 3.0 2.6 2.4 2.5 2.4 2.9 3.0 2.6 3.0 2.4 TT 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9 # 5' ------> 3' T X1 Y1 C A X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.4 1.7 1.5 2.1 1.7 1.9 1.7 1.8 1.5 1.2 1.5 2.1 2.0 1.8 2.2 1.6 AC 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7 AG 1.4 1.7 1.5 2.1 1.7 1.9 1.7 1.8 1.5 1.2 1.5 2.1 2.0 1.8 2.2 1.6 AT 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2 CA 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7 CC 1.7 2.0 1.8 2.4 2.0 2.2 2.0 2.1 1.8 1.5 1.8 2.4 2.3 2.1 2.5 1.9 CG 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7 CT 1.6 1.9 1.7 2.3 1.9 2.1 1.9 2.0 1.7 1.4 1.7 2.3 2.2 2.0 2.4 1.8 GA 1.4 1.7 1.5 2.1 1.7 1.9 1.7 1.8 1.5 1.2 1.5 2.1 2.0 1.8 2.2 1.6 GC 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2 GG 1.4 1.7 1.5 2.1 1.7 1.9 1.7 1.8 1.5 1.2 1.5 2.1 2.0 1.8 2.2 1.6 GT 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2 TA 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2 TC 1.6 1.9 1.7 2.3 1.9 2.1 1.9 2.0 1.7 1.4 1.7 2.3 2.2 2.0 2.4 1.8 TG 1.9 2.2 2.0 2.6 2.2 2.4 2.2 2.3 2.0 1.7 2.0 2.6 2.5 2.3 2.7 2.1 TT 1.4 1.7 1.5 2.1 1.7 1.9 1.7 1.8 1.5 1.2 1.5 2.1 2.0 1.8 2.2 1.6 # 5' ------> 3' T X1 Y1 G A X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.5 1.8 1.6 2.3 1.8 2.0 1.4 1.8 1.6 1.7 1.6 2.1 2.1 1.8 2.0 1.6 AC 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7 AG 1.5 1.8 1.6 2.3 1.8 2.0 1.4 1.8 1.6 1.7 1.6 2.1 2.1 1.8 2.0 1.6 AT 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2 CA 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7 CC 1.8 2.1 1.9 2.6 2.1 2.3 1.7 2.1 1.9 2.0 1.9 2.4 2.4 2.1 2.3 1.9 CG 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7 CT 1.7 2.0 1.8 2.5 2.0 2.2 1.6 2.0 1.8 1.9 1.8 2.3 2.3 2.0 2.2 1.8 GA 1.5 1.8 1.6 2.3 1.8 2.0 1.4 1.8 1.6 1.7 1.6 2.1 2.1 1.8 2.0 1.6 GC 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2 GG 1.5 1.8 1.6 2.3 1.8 2.0 1.4 1.8 1.6 1.7 1.6 2.1 2.1 1.8 2.0 1.6 GT 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2 TA 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2 TC 1.7 2.0 1.8 2.5 2.0 2.2 1.6 2.0 1.8 1.9 1.8 2.3 2.3 2.0 2.2 1.8 TG 2.0 2.3 2.1 2.8 2.3 2.5 1.9 2.3 2.1 2.2 2.1 2.6 2.6 2.3 2.5 2.1 TT 1.5 1.8 1.6 2.3 1.8 2.0 1.4 1.8 1.6 1.7 1.6 2.1 2.1 1.8 2.0 1.6 # 5' ------> 3' T X1 Y1 T A X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.8 2.0 1.9 2.5 2.0 2.2 2.3 2.1 1.9 2.1 1.9 2.5 2.5 2.1 2.5 1.9 AC 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0 AG 1.8 2.0 1.9 2.5 2.0 2.2 2.3 2.1 1.9 2.1 1.9 2.5 2.5 2.1 2.5 1.9 AT 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5 CA 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0 CC 2.1 2.3 2.2 2.8 2.3 2.5 2.6 2.4 2.2 2.4 2.2 2.8 2.8 2.4 2.8 2.2 CG 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0 CT 2.0 2.2 2.1 2.7 2.2 2.4 2.5 2.3 2.1 2.3 2.1 2.7 2.7 2.3 2.7 2.1 GA 1.8 2.0 1.9 2.5 2.0 2.2 2.3 2.1 1.9 2.1 1.9 2.5 2.5 2.1 2.5 1.9 GC 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5 GG 1.8 2.0 1.9 2.5 2.0 2.2 2.3 2.1 1.9 2.1 1.9 2.5 2.5 2.1 2.5 1.9 GT 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5 TA 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5 TC 2.0 2.2 2.1 2.7 2.2 2.4 2.5 2.3 2.1 2.3 2.1 2.7 2.7 2.3 2.7 2.1 TG 2.3 2.5 2.4 3.0 2.5 2.7 2.8 2.6 2.4 2.6 2.4 3.0 3.0 2.6 3.0 2.4 TT 1.8 2.0 1.9 2.5 2.0 2.2 2.3 2.1 1.9 2.1 1.9 2.5 2.5 2.1 2.5 1.9 # 5' ------> 3' T X1 Y1 G A X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 2.0 2.3 2.0 2.5 2.3 2.3 2.0 2.3 2.0 2.2 2.0 2.5 2.5 2.3 2.5 2.3 AC 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4 AG 2.0 2.3 2.0 2.5 2.3 2.3 2.0 2.3 2.0 2.2 2.0 2.5 2.5 2.3 2.5 2.3 AT 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9 CA 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4 CC 2.3 2.6 2.3 2.8 2.6 2.6 2.3 2.6 2.3 2.5 2.3 2.8 2.8 2.6 2.8 2.6 CG 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4 CT 2.2 2.5 2.2 2.7 2.5 2.5 2.2 2.5 2.2 2.4 2.2 2.7 2.7 2.5 2.7 2.5 GA 2.0 2.3 2.0 2.5 2.3 2.3 2.0 2.3 2.0 2.2 2.0 2.5 2.5 2.3 2.5 2.3 GC 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9 GG 2.0 2.3 2.0 2.5 2.3 2.3 2.0 2.3 2.0 2.2 2.0 2.5 2.5 2.3 2.5 2.3 GT 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9 TA 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9 TC 2.2 2.5 2.2 2.7 2.5 2.5 2.2 2.5 2.2 2.4 2.2 2.7 2.7 2.5 2.7 2.5 TG 2.5 2.8 2.5 3.0 2.8 2.8 2.5 2.8 2.5 2.7 2.5 3.0 3.0 2.8 3.0 2.8 TT 2.0 2.3 2.0 2.5 2.3 2.3 2.0 2.3 2.0 2.2 2.0 2.5 2.5 2.3 2.5 2.3 # 5' ------> 3' T X1 Y1 T A X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 2.0 2.3 2.0 2.5 2.3 2.3 2.1 2.3 2.0 2.1 2.0 2.5 2.3 2.3 2.5 2.3 AC 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4 AG 2.0 2.3 2.0 2.5 2.3 2.3 2.1 2.3 2.0 2.1 2.0 2.5 2.3 2.3 2.5 2.3 AT 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9 CA 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4 CC 2.3 2.6 2.3 2.8 2.6 2.6 2.4 2.6 2.3 2.4 2.3 2.8 2.6 2.6 2.8 2.6 CG 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4 CT 2.2 2.5 2.2 2.7 2.5 2.5 2.3 2.5 2.2 2.3 2.2 2.7 2.5 2.5 2.7 2.5 GA 2.0 2.3 2.0 2.5 2.3 2.3 2.1 2.3 2.0 2.1 2.0 2.5 2.3 2.3 2.5 2.3 GC 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9 GG 2.0 2.3 2.0 2.5 2.3 2.3 2.1 2.3 2.0 2.1 2.0 2.5 2.3 2.3 2.5 2.3 GT 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9 TA 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9 TC 2.2 2.5 2.2 2.7 2.5 2.5 2.3 2.5 2.2 2.3 2.2 2.7 2.5 2.5 2.7 2.5 TG 2.5 2.8 2.5 3.0 2.8 2.8 2.6 2.8 2.5 2.6 2.5 3.0 2.8 2.8 3.0 2.8 TT 2.0 2.3 2.0 2.5 2.3 2.3 2.1 2.3 2.0 2.1 2.0 2.5 2.3 2.3 2.5 2.3 # 5' ------> 3' G X1 Y1 A T X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0 AC 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3 AG 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0 AT 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3 CA 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3 CC 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3 CG 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1 CT 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3 GA 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0 GC 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1 GG 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0 GT 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5 TA 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5 TC 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3 TG 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5 TT 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3 # 5' ------> 3' G X1 Y1 C T X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7 AC 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0 AG 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7 AT 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0 CA 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0 CC 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0 CG 1.6 1.9 1.7 2.3 1.9 2.1 1.9 2.0 1.7 1.4 1.7 2.3 2.2 2.0 2.4 1.8 CT 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0 GA 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7 GC 1.6 1.9 1.7 2.3 1.9 2.1 1.9 2.0 1.7 1.4 1.7 2.3 2.2 2.0 2.4 1.8 GG 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7 GT 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2 TA 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2 TC 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0 TG 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2 TT 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0 # 5' ------> 3' G X1 Y1 G T X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7 AC 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0 AG 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7 AT 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0 CA 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0 CC 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0 CG 1.7 2.0 1.8 2.5 2.0 2.2 1.6 2.0 1.8 1.9 1.8 2.3 2.3 2.0 2.2 1.8 CT 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0 GA 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7 GC 1.7 2.0 1.8 2.5 2.0 2.2 1.6 2.0 1.8 1.9 1.8 2.3 2.3 2.0 2.2 1.8 GG 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7 GT 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2 TA 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2 TC 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0 TG 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2 TT 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0 # 5' ------> 3' G X1 Y1 T T X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0 AC 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3 AG 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0 AT 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3 CA 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3 CC 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3 CG 2.0 2.2 2.1 2.7 2.2 2.4 2.5 2.3 2.1 2.3 2.1 2.7 2.7 2.3 2.7 2.1 CT 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3 GA 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0 GC 2.0 2.2 2.1 2.7 2.2 2.4 2.5 2.3 2.1 2.3 2.1 2.7 2.7 2.3 2.7 2.1 GG 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0 GT 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5 TA 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5 TC 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3 TG 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5 TT 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3 # 5' ------> 3' G X1 Y1 G T X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4 AC 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7 AG 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4 AT 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7 CA 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7 CC 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7 CG 2.2 2.5 2.2 2.7 2.5 2.5 2.2 2.5 2.2 2.4 2.2 2.7 2.7 2.5 2.7 2.5 CT 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7 GA 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4 GC 2.2 2.5 2.2 2.7 2.5 2.5 2.2 2.5 2.2 2.4 2.2 2.7 2.7 2.5 2.7 2.5 GG 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4 GT 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9 TA 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9 TC 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7 TG 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9 TT 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7 # 5' ------> 3' G X1 Y1 T T X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4 AC 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7 AG 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4 AT 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7 CA 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7 CC 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7 CG 2.2 2.5 2.2 2.7 2.5 2.5 2.3 2.5 2.2 2.3 2.2 2.7 2.5 2.5 2.7 2.5 CT 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7 GA 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4 GC 2.2 2.5 2.2 2.7 2.5 2.5 2.3 2.5 2.2 2.3 2.2 2.7 2.5 2.5 2.7 2.5 GG 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4 GT 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9 TA 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9 TC 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7 TG 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9 TT 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7 # 5' ------> 3' T X1 Y1 A G X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0 AC 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3 AG 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0 AT 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5 CA 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3 CC 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3 CG 2.2 2.3 2.2 2.8 2.3 2.5 2.8 2.4 2.2 2.3 2.2 2.7 2.8 2.4 2.8 2.2 CT 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3 GA 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0 GC 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0 GG 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0 GT 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5 TA 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5 TC 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3 TG 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5 TT 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3 # 5' ------> 3' T X1 Y1 C G X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7 AC 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0 AG 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7 AT 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2 CA 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0 CC 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0 CG 1.7 2.0 1.8 2.4 2.0 2.2 2.0 2.1 1.8 1.5 1.8 2.4 2.3 2.1 2.5 1.9 CT 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0 GA 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7 GC 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7 GG 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7 GT 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2 TA 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2 TC 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0 TG 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2 TT 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0 # 5' ------> 3' T X1 Y1 G G X2 Y2 C # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7 AC 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0 AG 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7 AT 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2 CA 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0 CC 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0 CG 1.8 2.1 1.9 2.6 2.1 2.3 1.7 2.1 1.9 2.0 1.9 2.4 2.4 2.1 2.3 1.9 CT 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0 GA 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7 GC 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7 GG 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7 GT 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2 TA 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2 TC 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0 TG 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2 TT 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0 # 5' ------> 3' T X1 Y1 T G X2 Y2 A # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0 AC 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3 AG 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0 AT 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5 CA 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3 CC 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3 CG 2.1 2.3 2.2 2.8 2.3 2.5 2.6 2.4 2.2 2.4 2.2 2.8 2.8 2.4 2.8 2.2 CT 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3 GA 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0 GC 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0 GG 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0 GT 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5 TA 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5 TC 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3 TG 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5 TT 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3 # 5' ------> 3' T X1 Y1 G G X2 Y2 T # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4 AC 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7 AG 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4 AT 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9 CA 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7 CC 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7 CG 2.3 2.6 2.3 2.8 2.6 2.6 2.3 2.6 2.3 2.5 2.3 2.8 2.8 2.6 2.8 2.6 CT 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7 GA 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4 GC 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4 GG 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4 GT 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9 TA 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9 TC 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7 TG 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9 TT 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7 # 5' ------> 3' T X1 Y1 T G X2 Y2 G # 3' <------ 5' # Y #---------------------------------------------------------------------------------------------------------------------------------- A A A A C C C C G G G G T T T T A C G T A C G T A C G T A C G T #---------------------------------------------------------------------------------------------------------------------------------- AA 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4 AC 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7 AG 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4 AT 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9 CA 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7 CC 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7 CG 2.3 2.6 2.3 2.8 2.6 2.6 2.4 2.6 2.3 2.4 2.3 2.8 2.6 2.6 2.8 2.6 CT 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7 GA 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4 GC 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4 GG 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4 GT 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9 TA 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9 TC 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7 TG 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9 TT 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7