# Data tables for 2x2 interior loops
# Free energies at 37 degrees for DNA
# Data arrangement:
#
# 5' ------> 3'
# A X1 Y1 A
# T X2 Y2 T
# 3' <------ 5'
#
# Y-->
# ----------------------------------------------------------------------------------------------------------------------------
# (X) A A A A C C C C G G G G T T T T
# | A C G T A C G T A C G T A C G T
# V ----------------------------------------------------------------------------------------------------------------------------
# (AA) 1.8 1.9 1.8 2.4 1.9 2.1 2.4 2.0 1.8 1.9 1.8 2.3 2.4 2.0 2.4 1.8
# (AC) 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0
# (AG) 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9
# (AT) 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5
# (CA) 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0
# (CC) 2.2 2.3 2.2 2.8 2.3 2.5 2.8 2.4 2.2 2.3 2.2 2.7 2.8 2.4 2.8 2.2
# (CG) 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1
# (CT) 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1
# (GA) 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9
# (GC) 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3
# (GG) 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9
# (GT) 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5
# (TA) 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5
# (TC) 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1
# (TG) 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5
# (TT) 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9
# 5' ------> 3'
A X1 Y1 A
T X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.8 1.9 1.8 2.4 1.9 2.1 2.4 2.0 1.8 1.9 1.8 2.3 2.4 2.0 2.4 1.8
AC 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0
AG 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9
AT 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5
CA 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0
CC 2.2 2.3 2.2 2.8 2.3 2.5 2.8 2.4 2.2 2.3 2.2 2.7 2.8 2.4 2.8 2.2
CG 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1
CT 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1
GA 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9
GC 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3
GG 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9
GT 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5
TA 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5
TC 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1
TG 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5
TT 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9
# 5' ------> 3'
A X1 Y1 C
T X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.3 1.6 1.4 2.0 1.6 1.8 1.6 1.7 1.4 1.1 1.4 2.0 1.9 1.7 2.1 1.5
AC 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7
AG 1.4 1.7 1.5 2.1 1.7 1.9 1.7 1.8 1.5 1.2 1.5 2.1 2.0 1.8 2.2 1.6
AT 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2
CA 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7
CC 1.7 2.0 1.8 2.4 2.0 2.2 2.0 2.1 1.8 1.5 1.8 2.4 2.3 2.1 2.5 1.9
CG 1.6 1.9 1.7 2.3 1.9 2.1 1.9 2.0 1.7 1.4 1.7 2.3 2.2 2.0 2.4 1.8
CT 1.6 1.9 1.7 2.3 1.9 2.1 1.9 2.0 1.7 1.4 1.7 2.3 2.2 2.0 2.4 1.8
GA 1.4 1.7 1.5 2.1 1.7 1.9 1.7 1.8 1.5 1.2 1.5 2.1 2.0 1.8 2.2 1.6
GC 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0
GG 1.4 1.7 1.5 2.1 1.7 1.9 1.7 1.8 1.5 1.2 1.5 2.1 2.0 1.8 2.2 1.6
GT 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2
TA 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2
TC 1.6 1.9 1.7 2.3 1.9 2.1 1.9 2.0 1.7 1.4 1.7 2.3 2.2 2.0 2.4 1.8
TG 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2
TT 1.4 1.7 1.5 2.1 1.7 1.9 1.7 1.8 1.5 1.2 1.5 2.1 2.0 1.8 2.2 1.6
# 5' ------> 3'
A X1 Y1 G
T X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.4 1.7 1.5 2.2 1.7 1.9 1.3 1.7 1.5 1.6 1.5 2.0 2.0 1.7 1.9 1.5
AC 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7
AG 1.5 1.8 1.6 2.3 1.8 2.0 1.4 1.8 1.6 1.7 1.6 2.1 2.1 1.8 2.0 1.6
AT 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2
CA 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7
CC 1.8 2.1 1.9 2.6 2.1 2.3 1.7 2.1 1.9 2.0 1.9 2.4 2.4 2.1 2.3 1.9
CG 1.7 2.0 1.8 2.5 2.0 2.2 1.6 2.0 1.8 1.9 1.8 2.3 2.3 2.0 2.2 1.8
CT 1.7 2.0 1.8 2.5 2.0 2.2 1.6 2.0 1.8 1.9 1.8 2.3 2.3 2.0 2.2 1.8
GA 1.5 1.8 1.6 2.3 1.8 2.0 1.4 1.8 1.6 1.7 1.6 2.1 2.1 1.8 2.0 1.6
GC 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0
GG 1.5 1.8 1.6 2.3 1.8 2.0 1.4 1.8 1.6 1.7 1.6 2.1 2.1 1.8 2.0 1.6
GT 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2
TA 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2
TC 1.7 2.0 1.8 2.5 2.0 2.2 1.6 2.0 1.8 1.9 1.8 2.3 2.3 2.0 2.2 1.8
TG 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2
TT 1.5 1.8 1.6 2.3 1.8 2.0 1.4 1.8 1.6 1.7 1.6 2.1 2.1 1.8 2.0 1.6
# 5' ------> 3'
A X1 Y1 T
T X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.7 1.9 1.8 2.4 1.9 2.1 2.2 2.0 1.8 2.0 1.8 2.4 2.4 2.0 2.4 1.8
AC 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0
AG 1.8 2.0 1.9 2.5 2.0 2.2 2.3 2.1 1.9 2.1 1.9 2.5 2.5 2.1 2.5 1.9
AT 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5
CA 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0
CC 2.1 2.3 2.2 2.8 2.3 2.5 2.6 2.4 2.2 2.4 2.2 2.8 2.8 2.4 2.8 2.2
CG 2.0 2.2 2.1 2.7 2.2 2.4 2.5 2.3 2.1 2.3 2.1 2.7 2.7 2.3 2.7 2.1
CT 2.0 2.2 2.1 2.7 2.2 2.4 2.5 2.3 2.1 2.3 2.1 2.7 2.7 2.3 2.7 2.1
GA 1.8 2.0 1.9 2.5 2.0 2.2 2.3 2.1 1.9 2.1 1.9 2.5 2.5 2.1 2.5 1.9
GC 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3
GG 1.8 2.0 1.9 2.5 2.0 2.2 2.3 2.1 1.9 2.1 1.9 2.5 2.5 2.1 2.5 1.9
GT 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5
TA 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5
TC 2.0 2.2 2.1 2.7 2.2 2.4 2.5 2.3 2.1 2.3 2.1 2.7 2.7 2.3 2.7 2.1
TG 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5
TT 1.8 2.0 1.9 2.5 2.0 2.2 2.3 2.1 1.9 2.1 1.9 2.5 2.5 2.1 2.5 1.9
# 5' ------> 3'
A X1 Y1 G
T X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.9 2.2 1.9 2.4 2.2 2.2 1.9 2.2 1.9 2.1 1.9 2.4 2.4 2.2 2.4 2.2
AC 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4
AG 2.0 2.3 2.0 2.5 2.3 2.3 2.0 2.3 2.0 2.2 2.0 2.5 2.5 2.3 2.5 2.3
AT 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9
CA 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4
CC 2.3 2.6 2.3 2.8 2.6 2.6 2.3 2.6 2.3 2.5 2.3 2.8 2.8 2.6 2.8 2.6
CG 2.2 2.5 2.2 2.7 2.5 2.5 2.2 2.5 2.2 2.4 2.2 2.7 2.7 2.5 2.7 2.5
CT 2.2 2.5 2.2 2.7 2.5 2.5 2.2 2.5 2.2 2.4 2.2 2.7 2.7 2.5 2.7 2.5
GA 2.0 2.3 2.0 2.5 2.3 2.3 2.0 2.3 2.0 2.2 2.0 2.5 2.5 2.3 2.5 2.3
GC 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7
GG 2.0 2.3 2.0 2.5 2.3 2.3 2.0 2.3 2.0 2.2 2.0 2.5 2.5 2.3 2.5 2.3
GT 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9
TA 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9
TC 2.2 2.5 2.2 2.7 2.5 2.5 2.2 2.5 2.2 2.4 2.2 2.7 2.7 2.5 2.7 2.5
TG 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9
TT 2.0 2.3 2.0 2.5 2.3 2.3 2.0 2.3 2.0 2.2 2.0 2.5 2.5 2.3 2.5 2.3
# 5' ------> 3'
A X1 Y1 T
T X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.9 2.2 1.9 2.4 2.2 2.2 2.0 2.2 1.9 2.0 1.9 2.4 2.2 2.2 2.4 2.2
AC 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4
AG 2.0 2.3 2.0 2.5 2.3 2.3 2.1 2.3 2.0 2.1 2.0 2.5 2.3 2.3 2.5 2.3
AT 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9
CA 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4
CC 2.3 2.6 2.3 2.8 2.6 2.6 2.4 2.6 2.3 2.4 2.3 2.8 2.6 2.6 2.8 2.6
CG 2.2 2.5 2.2 2.7 2.5 2.5 2.3 2.5 2.2 2.3 2.2 2.7 2.5 2.5 2.7 2.5
CT 2.2 2.5 2.2 2.7 2.5 2.5 2.3 2.5 2.2 2.3 2.2 2.7 2.5 2.5 2.7 2.5
GA 2.0 2.3 2.0 2.5 2.3 2.3 2.1 2.3 2.0 2.1 2.0 2.5 2.3 2.3 2.5 2.3
GC 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7
GG 2.0 2.3 2.0 2.5 2.3 2.3 2.1 2.3 2.0 2.1 2.0 2.5 2.3 2.3 2.5 2.3
GT 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9
TA 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9
TC 2.2 2.5 2.2 2.7 2.5 2.5 2.3 2.5 2.2 2.3 2.2 2.7 2.5 2.5 2.7 2.5
TG 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9
TT 2.0 2.3 2.0 2.5 2.3 2.3 2.1 2.3 2.0 2.1 2.0 2.5 2.3 2.3 2.5 2.3
# 5' ------> 3'
C X1 Y1 A
G X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.5 1.6 1.5 2.1 1.6 1.8 2.1 1.7 1.5 1.6 1.5 2.0 2.1 1.7 2.1 1.5
AC 1.8 1.9 1.8 2.4 1.9 2.1 2.4 2.0 1.8 1.9 1.8 2.3 2.4 2.0 2.4 1.8
AG 1.6 1.7 1.6 2.2 1.7 1.9 2.2 1.8 1.6 1.7 1.6 2.1 2.2 1.8 2.2 1.6
AT 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1
CA 1.8 1.9 1.8 2.4 1.9 2.1 2.4 2.0 1.8 1.9 1.8 2.3 2.4 2.0 2.4 1.8
CC 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0
CG 1.7 1.8 1.7 2.3 1.8 2.0 2.3 1.9 1.7 1.8 1.7 2.2 2.3 1.9 2.3 1.7
CT 1.8 1.9 1.8 2.4 1.9 2.1 2.4 2.0 1.8 1.9 1.8 2.3 2.4 2.0 2.4 1.8
GA 1.6 1.7 1.6 2.2 1.7 1.9 2.2 1.8 1.6 1.7 1.6 2.1 2.2 1.8 2.2 1.6
GC 1.4 1.5 1.4 2.0 1.5 1.7 2.0 1.6 1.4 1.5 1.4 1.9 2.0 1.6 2.0 1.4
GG 1.6 1.7 1.6 2.2 1.7 1.9 2.2 1.8 1.6 1.7 1.6 2.1 2.2 1.8 2.2 1.6
GT 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0
TA 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3
TC 1.8 1.9 1.8 2.4 1.9 2.1 2.4 2.0 1.8 1.9 1.8 2.3 2.4 2.0 2.4 1.8
TG 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1
TT 1.6 1.7 1.6 2.2 1.7 1.9 2.2 1.8 1.6 1.7 1.6 2.1 2.2 1.8 2.2 1.6
# 5' ------> 3'
C X1 Y1 C
G X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.0 1.3 1.1 1.7 1.3 1.5 1.3 1.4 1.1 0.8 1.1 1.7 1.6 1.4 1.8 1.2
AC 1.3 1.6 1.4 2.0 1.6 1.8 1.6 1.7 1.4 1.1 1.4 2.0 1.9 1.7 2.1 1.5
AG 1.1 1.4 1.2 1.8 1.4 1.6 1.4 1.5 1.2 0.9 1.2 1.8 1.7 1.5 1.9 1.3
AT 1.6 1.9 1.7 2.3 1.9 2.1 1.9 2.0 1.7 1.4 1.7 2.3 2.2 2.0 2.4 1.8
CA 1.3 1.6 1.4 2.0 1.6 1.8 1.6 1.7 1.4 1.1 1.4 2.0 1.9 1.7 2.1 1.5
CC 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7
CG 1.2 1.5 1.3 1.9 1.5 1.7 1.5 1.6 1.3 1.0 1.3 1.9 1.8 1.6 2.0 1.4
CT 1.3 1.6 1.4 2.0 1.6 1.8 1.6 1.7 1.4 1.1 1.4 2.0 1.9 1.7 2.1 1.5
GA 1.1 1.4 1.2 1.8 1.4 1.6 1.4 1.5 1.2 0.9 1.2 1.8 1.7 1.5 1.9 1.3
GC 0.9 1.2 1.0 1.6 1.2 1.4 1.2 1.3 1.0 0.7 1.0 1.6 1.5 1.3 1.7 1.1
GG 1.1 1.4 1.2 1.8 1.4 1.6 1.4 1.5 1.2 0.9 1.2 1.8 1.7 1.5 1.9 1.3
GT 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7
TA 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0
TC 1.3 1.6 1.4 2.0 1.6 1.8 1.6 1.7 1.4 1.1 1.4 2.0 1.9 1.7 2.1 1.5
TG 1.6 1.9 1.7 2.3 1.9 2.1 1.9 2.0 1.7 1.4 1.7 2.3 2.2 2.0 2.4 1.8
TT 1.1 1.4 1.2 1.8 1.4 1.6 1.4 1.5 1.2 0.9 1.2 1.8 1.7 1.5 1.9 1.3
# 5' ------> 3'
C X1 Y1 G
G X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.1 1.4 1.2 1.9 1.4 1.6 1.0 1.4 1.2 1.3 1.2 1.7 1.7 1.4 1.6 1.2
AC 1.4 1.7 1.5 2.2 1.7 1.9 1.3 1.7 1.5 1.6 1.5 2.0 2.0 1.7 1.9 1.5
AG 1.2 1.5 1.3 2.0 1.5 1.7 1.1 1.5 1.3 1.4 1.3 1.8 1.8 1.5 1.7 1.3
AT 1.7 2.0 1.8 2.5 2.0 2.2 1.6 2.0 1.8 1.9 1.8 2.3 2.3 2.0 2.2 1.8
CA 1.4 1.7 1.5 2.2 1.7 1.9 1.3 1.7 1.5 1.6 1.5 2.0 2.0 1.7 1.9 1.5
CC 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7
CG 1.3 1.6 1.4 2.1 1.6 1.8 1.2 1.6 1.4 1.5 1.4 1.9 1.9 1.6 1.8 1.4
CT 1.4 1.7 1.5 2.2 1.7 1.9 1.3 1.7 1.5 1.6 1.5 2.0 2.0 1.7 1.9 1.5
GA 1.2 1.5 1.3 2.0 1.5 1.7 1.1 1.5 1.3 1.4 1.3 1.8 1.8 1.5 1.7 1.3
GC 1.0 1.3 1.1 1.8 1.3 1.5 0.9 1.3 1.1 1.2 1.1 1.6 1.6 1.3 1.5 1.1
GG 1.2 1.5 1.3 2.0 1.5 1.7 1.1 1.5 1.3 1.4 1.3 1.8 1.8 1.5 1.7 1.3
GT 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7
TA 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0
TC 1.4 1.7 1.5 2.2 1.7 1.9 1.3 1.7 1.5 1.6 1.5 2.0 2.0 1.7 1.9 1.5
TG 1.7 2.0 1.8 2.5 2.0 2.2 1.6 2.0 1.8 1.9 1.8 2.3 2.3 2.0 2.2 1.8
TT 1.2 1.5 1.3 2.0 1.5 1.7 1.1 1.5 1.3 1.4 1.3 1.8 1.8 1.5 1.7 1.3
# 5' ------> 3'
C X1 Y1 T
G X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.4 1.6 1.5 2.1 1.6 1.8 1.9 1.7 1.5 1.7 1.5 2.1 2.1 1.7 2.1 1.5
AC 1.7 1.9 1.8 2.4 1.9 2.1 2.2 2.0 1.8 2.0 1.8 2.4 2.4 2.0 2.4 1.8
AG 1.5 1.7 1.6 2.2 1.7 1.9 2.0 1.8 1.6 1.8 1.6 2.2 2.2 1.8 2.2 1.6
AT 2.0 2.2 2.1 2.7 2.2 2.4 2.5 2.3 2.1 2.3 2.1 2.7 2.7 2.3 2.7 2.1
CA 1.7 1.9 1.8 2.4 1.9 2.1 2.2 2.0 1.8 2.0 1.8 2.4 2.4 2.0 2.4 1.8
CC 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0
CG 1.6 1.8 1.7 2.3 1.8 2.0 2.1 1.9 1.7 1.9 1.7 2.3 2.3 1.9 2.3 1.7
CT 1.7 1.9 1.8 2.4 1.9 2.1 2.2 2.0 1.8 2.0 1.8 2.4 2.4 2.0 2.4 1.8
GA 1.5 1.7 1.6 2.2 1.7 1.9 2.0 1.8 1.6 1.8 1.6 2.2 2.2 1.8 2.2 1.6
GC 1.3 1.5 1.4 2.0 1.5 1.7 1.8 1.6 1.4 1.6 1.4 2.0 2.0 1.6 2.0 1.4
GG 1.5 1.7 1.6 2.2 1.7 1.9 2.0 1.8 1.6 1.8 1.6 2.2 2.2 1.8 2.2 1.6
GT 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0
TA 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3
TC 1.7 1.9 1.8 2.4 1.9 2.1 2.2 2.0 1.8 2.0 1.8 2.4 2.4 2.0 2.4 1.8
TG 2.0 2.2 2.1 2.7 2.2 2.4 2.5 2.3 2.1 2.3 2.1 2.7 2.7 2.3 2.7 2.1
TT 1.5 1.7 1.6 2.2 1.7 1.9 2.0 1.8 1.6 1.8 1.6 2.2 2.2 1.8 2.2 1.6
# 5' ------> 3'
C X1 Y1 G
G X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.6 1.9 1.6 2.1 1.9 1.9 1.6 1.9 1.6 1.8 1.6 2.1 2.1 1.9 2.1 1.9
AC 1.9 2.2 1.9 2.4 2.2 2.2 1.9 2.2 1.9 2.1 1.9 2.4 2.4 2.2 2.4 2.2
AG 1.7 2.0 1.7 2.2 2.0 2.0 1.7 2.0 1.7 1.9 1.7 2.2 2.2 2.0 2.2 2.0
AT 2.2 2.5 2.2 2.7 2.5 2.5 2.2 2.5 2.2 2.4 2.2 2.7 2.7 2.5 2.7 2.5
CA 1.9 2.2 1.9 2.4 2.2 2.2 1.9 2.2 1.9 2.1 1.9 2.4 2.4 2.2 2.4 2.2
CC 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4
CG 1.8 2.1 1.8 2.3 2.1 2.1 1.8 2.1 1.8 2.0 1.8 2.3 2.3 2.1 2.3 2.1
CT 1.9 2.2 1.9 2.4 2.2 2.2 1.9 2.2 1.9 2.1 1.9 2.4 2.4 2.2 2.4 2.2
GA 1.7 2.0 1.7 2.2 2.0 2.0 1.7 2.0 1.7 1.9 1.7 2.2 2.2 2.0 2.2 2.0
GC 1.5 1.8 1.5 2.0 1.8 1.8 1.5 1.8 1.5 1.7 1.5 2.0 2.0 1.8 2.0 1.8
GG 1.7 2.0 1.7 2.2 2.0 2.0 1.7 2.0 1.7 1.9 1.7 2.2 2.2 2.0 2.2 2.0
GT 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4
TA 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7
TC 1.9 2.2 1.9 2.4 2.2 2.2 1.9 2.2 1.9 2.1 1.9 2.4 2.4 2.2 2.4 2.2
TG 2.2 2.5 2.2 2.7 2.5 2.5 2.2 2.5 2.2 2.4 2.2 2.7 2.7 2.5 2.7 2.5
TT 1.7 2.0 1.7 2.2 2.0 2.0 1.7 2.0 1.7 1.9 1.7 2.2 2.2 2.0 2.2 2.0
# 5' ------> 3'
C X1 Y1 T
G X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.6 1.9 1.6 2.1 1.9 1.9 1.7 1.9 1.6 1.7 1.6 2.1 1.9 1.9 2.1 1.9
AC 1.9 2.2 1.9 2.4 2.2 2.2 2.0 2.2 1.9 2.0 1.9 2.4 2.2 2.2 2.4 2.2
AG 1.7 2.0 1.7 2.2 2.0 2.0 1.8 2.0 1.7 1.8 1.7 2.2 2.0 2.0 2.2 2.0
AT 2.2 2.5 2.2 2.7 2.5 2.5 2.3 2.5 2.2 2.3 2.2 2.7 2.5 2.5 2.7 2.5
CA 1.9 2.2 1.9 2.4 2.2 2.2 2.0 2.2 1.9 2.0 1.9 2.4 2.2 2.2 2.4 2.2
CC 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4
CG 1.8 2.1 1.8 2.3 2.1 2.1 1.9 2.1 1.8 1.9 1.8 2.3 2.1 2.1 2.3 2.1
CT 1.9 2.2 1.9 2.4 2.2 2.2 2.0 2.2 1.9 2.0 1.9 2.4 2.2 2.2 2.4 2.2
GA 1.7 2.0 1.7 2.2 2.0 2.0 1.8 2.0 1.7 1.8 1.7 2.2 2.0 2.0 2.2 2.0
GC 1.5 1.8 1.5 2.0 1.8 1.8 1.6 1.8 1.5 1.6 1.5 2.0 1.8 1.8 2.0 1.8
GG 1.7 2.0 1.7 2.2 2.0 2.0 1.8 2.0 1.7 1.8 1.7 2.2 2.0 2.0 2.2 2.0
GT 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4
TA 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7
TC 1.9 2.2 1.9 2.4 2.2 2.2 2.0 2.2 1.9 2.0 1.9 2.4 2.2 2.2 2.4 2.2
TG 2.2 2.5 2.2 2.7 2.5 2.5 2.3 2.5 2.2 2.3 2.2 2.7 2.5 2.5 2.7 2.5
TT 1.7 2.0 1.7 2.2 2.0 2.0 1.8 2.0 1.7 1.8 1.7 2.2 2.0 2.0 2.2 2.0
# 5' ------> 3'
G X1 Y1 A
C X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.4 1.5 1.4 2.0 1.5 1.7 2.0 1.6 1.4 1.5 1.4 1.9 2.0 1.6 2.0 1.4
AC 1.7 1.8 1.7 2.3 1.8 2.0 2.3 1.9 1.7 1.8 1.7 2.2 2.3 1.9 2.3 1.7
AG 1.5 1.6 1.5 2.1 1.6 1.8 2.1 1.7 1.5 1.6 1.5 2.0 2.1 1.7 2.1 1.5
AT 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0
CA 1.7 1.8 1.7 2.3 1.8 2.0 2.3 1.9 1.7 1.8 1.7 2.2 2.3 1.9 2.3 1.7
CC 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9
CG 1.2 1.3 1.2 1.8 1.3 1.5 1.8 1.4 1.2 1.3 1.2 1.7 1.8 1.4 1.8 1.2
CT 1.8 1.9 1.8 2.4 1.9 2.1 2.4 2.0 1.8 1.9 1.8 2.3 2.4 2.0 2.4 1.8
GA 1.5 1.6 1.5 2.1 1.6 1.8 2.1 1.7 1.5 1.6 1.5 2.0 2.1 1.7 2.1 1.5
GC 1.7 1.8 1.7 2.3 1.8 2.0 2.3 1.9 1.7 1.8 1.7 2.2 2.3 1.9 2.3 1.7
GG 1.5 1.6 1.5 2.1 1.6 1.8 2.1 1.7 1.5 1.6 1.5 2.0 2.1 1.7 2.1 1.5
GT 2.2 2.3 2.2 2.8 2.3 2.5 2.8 2.4 2.2 2.3 2.2 2.7 2.8 2.4 2.8 2.2
TA 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1
TC 1.8 1.9 1.8 2.4 1.9 2.1 2.4 2.0 1.8 1.9 1.8 2.3 2.4 2.0 2.4 1.8
TG 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1
TT 1.6 1.7 1.6 2.2 1.7 1.9 2.2 1.8 1.6 1.7 1.6 2.1 2.2 1.8 2.2 1.6
# 5' ------> 3'
G X1 Y1 C
C X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 0.9 1.2 1.0 1.6 1.2 1.4 1.2 1.3 1.0 0.7 1.0 1.6 1.5 1.3 1.7 1.1
AC 1.2 1.5 1.3 1.9 1.5 1.7 1.5 1.6 1.3 1.0 1.3 1.9 1.8 1.6 2.0 1.4
AG 1.0 1.3 1.1 1.7 1.3 1.5 1.3 1.4 1.1 0.8 1.1 1.7 1.6 1.4 1.8 1.2
AT 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7
CA 1.2 1.5 1.3 1.9 1.5 1.7 1.5 1.6 1.3 1.0 1.3 1.9 1.8 1.6 2.0 1.4
CC 1.4 1.7 1.5 2.1 1.7 1.9 1.7 1.8 1.5 1.2 1.5 2.1 2.0 1.8 2.2 1.6
CG 0.7 1.0 0.8 1.4 1.0 1.2 1.0 1.1 0.8 0.5 0.8 1.4 1.3 1.1 1.5 0.9
CT 1.3 1.6 1.4 2.0 1.6 1.8 1.6 1.7 1.4 1.1 1.4 2.0 1.9 1.7 2.1 1.5
GA 1.0 1.3 1.1 1.7 1.3 1.5 1.3 1.4 1.1 0.8 1.1 1.7 1.6 1.4 1.8 1.2
GC 1.2 1.5 1.3 1.9 1.5 1.7 1.5 1.6 1.3 1.0 1.3 1.9 1.8 1.6 2.0 1.4
GG 1.0 1.3 1.1 1.7 1.3 1.5 1.3 1.4 1.1 0.8 1.1 1.7 1.6 1.4 1.8 1.2
GT 1.7 2.0 1.8 2.4 2.0 2.2 2.0 2.1 1.8 1.5 1.8 2.4 2.3 2.1 2.5 1.9
TA 1.6 1.9 1.7 2.3 1.9 2.1 1.9 2.0 1.7 1.4 1.7 2.3 2.2 2.0 2.4 1.8
TC 1.3 1.6 1.4 2.0 1.6 1.8 1.6 1.7 1.4 1.1 1.4 2.0 1.9 1.7 2.1 1.5
TG 1.6 1.9 1.7 2.3 1.9 2.1 1.9 2.0 1.7 1.4 1.7 2.3 2.2 2.0 2.4 1.8
TT 1.1 1.4 1.2 1.8 1.4 1.6 1.4 1.5 1.2 0.9 1.2 1.8 1.7 1.5 1.9 1.3
# 5' ------> 3'
G X1 Y1 G
C X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.0 1.3 1.1 1.8 1.3 1.5 0.9 1.3 1.1 1.2 1.1 1.6 1.6 1.3 1.5 1.1
AC 1.3 1.6 1.4 2.1 1.6 1.8 1.2 1.6 1.4 1.5 1.4 1.9 1.9 1.6 1.8 1.4
AG 1.1 1.4 1.2 1.9 1.4 1.6 1.0 1.4 1.2 1.3 1.2 1.7 1.7 1.4 1.6 1.2
AT 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7
CA 1.3 1.6 1.4 2.1 1.6 1.8 1.2 1.6 1.4 1.5 1.4 1.9 1.9 1.6 1.8 1.4
CC 1.5 1.8 1.6 2.3 1.8 2.0 1.4 1.8 1.6 1.7 1.6 2.1 2.1 1.8 2.0 1.6
CG 0.8 1.1 0.9 1.6 1.1 1.3 0.7 1.1 0.9 1.0 0.9 1.4 1.4 1.1 1.3 0.9
CT 1.4 1.7 1.5 2.2 1.7 1.9 1.3 1.7 1.5 1.6 1.5 2.0 2.0 1.7 1.9 1.5
GA 1.1 1.4 1.2 1.9 1.4 1.6 1.0 1.4 1.2 1.3 1.2 1.7 1.7 1.4 1.6 1.2
GC 1.3 1.6 1.4 2.1 1.6 1.8 1.2 1.6 1.4 1.5 1.4 1.9 1.9 1.6 1.8 1.4
GG 1.1 1.4 1.2 1.9 1.4 1.6 1.0 1.4 1.2 1.3 1.2 1.7 1.7 1.4 1.6 1.2
GT 1.8 2.1 1.9 2.6 2.1 2.3 1.7 2.1 1.9 2.0 1.9 2.4 2.4 2.1 2.3 1.9
TA 1.7 2.0 1.8 2.5 2.0 2.2 1.6 2.0 1.8 1.9 1.8 2.3 2.3 2.0 2.2 1.8
TC 1.4 1.7 1.5 2.2 1.7 1.9 1.3 1.7 1.5 1.6 1.5 2.0 2.0 1.7 1.9 1.5
TG 1.7 2.0 1.8 2.5 2.0 2.2 1.6 2.0 1.8 1.9 1.8 2.3 2.3 2.0 2.2 1.8
TT 1.2 1.5 1.3 2.0 1.5 1.7 1.1 1.5 1.3 1.4 1.3 1.8 1.8 1.5 1.7 1.3
# 5' ------> 3'
G X1 Y1 T
C X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.3 1.5 1.4 2.0 1.5 1.7 1.8 1.6 1.4 1.6 1.4 2.0 2.0 1.6 2.0 1.4
AC 1.6 1.8 1.7 2.3 1.8 2.0 2.1 1.9 1.7 1.9 1.7 2.3 2.3 1.9 2.3 1.7
AG 1.4 1.6 1.5 2.1 1.6 1.8 1.9 1.7 1.5 1.7 1.5 2.1 2.1 1.7 2.1 1.5
AT 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0
CA 1.6 1.8 1.7 2.3 1.8 2.0 2.1 1.9 1.7 1.9 1.7 2.3 2.3 1.9 2.3 1.7
CC 1.8 2.0 1.9 2.5 2.0 2.2 2.3 2.1 1.9 2.1 1.9 2.5 2.5 2.1 2.5 1.9
CG 1.1 1.3 1.2 1.8 1.3 1.5 1.6 1.4 1.2 1.4 1.2 1.8 1.8 1.4 1.8 1.2
CT 1.7 1.9 1.8 2.4 1.9 2.1 2.2 2.0 1.8 2.0 1.8 2.4 2.4 2.0 2.4 1.8
GA 1.4 1.6 1.5 2.1 1.6 1.8 1.9 1.7 1.5 1.7 1.5 2.1 2.1 1.7 2.1 1.5
GC 1.6 1.8 1.7 2.3 1.8 2.0 2.1 1.9 1.7 1.9 1.7 2.3 2.3 1.9 2.3 1.7
GG 1.4 1.6 1.5 2.1 1.6 1.8 1.9 1.7 1.5 1.7 1.5 2.1 2.1 1.7 2.1 1.5
GT 2.1 2.3 2.2 2.8 2.3 2.5 2.6 2.4 2.2 2.4 2.2 2.8 2.8 2.4 2.8 2.2
TA 2.0 2.2 2.1 2.7 2.2 2.4 2.5 2.3 2.1 2.3 2.1 2.7 2.7 2.3 2.7 2.1
TC 1.7 1.9 1.8 2.4 1.9 2.1 2.2 2.0 1.8 2.0 1.8 2.4 2.4 2.0 2.4 1.8
TG 2.0 2.2 2.1 2.7 2.2 2.4 2.5 2.3 2.1 2.3 2.1 2.7 2.7 2.3 2.7 2.1
TT 1.5 1.7 1.6 2.2 1.7 1.9 2.0 1.8 1.6 1.8 1.6 2.2 2.2 1.8 2.2 1.6
# 5' ------> 3'
G X1 Y1 G
C X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.5 1.8 1.5 2.0 1.8 1.8 1.5 1.8 1.5 1.7 1.5 2.0 2.0 1.8 2.0 1.8
AC 1.8 2.1 1.8 2.3 2.1 2.1 1.8 2.1 1.8 2.0 1.8 2.3 2.3 2.1 2.3 2.1
AG 1.6 1.9 1.6 2.1 1.9 1.9 1.6 1.9 1.6 1.8 1.6 2.1 2.1 1.9 2.1 1.9
AT 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4
CA 1.8 2.1 1.8 2.3 2.1 2.1 1.8 2.1 1.8 2.0 1.8 2.3 2.3 2.1 2.3 2.1
CC 2.0 2.3 2.0 2.5 2.3 2.3 2.0 2.3 2.0 2.2 2.0 2.5 2.5 2.3 2.5 2.3
CG 1.3 1.6 1.3 1.8 1.6 1.6 1.3 1.6 1.3 1.5 1.3 1.8 1.8 1.6 1.8 1.6
CT 1.9 2.2 1.9 2.4 2.2 2.2 1.9 2.2 1.9 2.1 1.9 2.4 2.4 2.2 2.4 2.2
GA 1.6 1.9 1.6 2.1 1.9 1.9 1.6 1.9 1.6 1.8 1.6 2.1 2.1 1.9 2.1 1.9
GC 1.8 2.1 1.8 2.3 2.1 2.1 1.8 2.1 1.8 2.0 1.8 2.3 2.3 2.1 2.3 2.1
GG 1.6 1.9 1.6 2.1 1.9 1.9 1.6 1.9 1.6 1.8 1.6 2.1 2.1 1.9 2.1 1.9
GT 2.3 2.6 2.3 2.8 2.6 2.6 2.3 2.6 2.3 2.5 2.3 2.8 2.8 2.6 2.8 2.6
TA 2.2 2.5 2.2 2.7 2.5 2.5 2.2 2.5 2.2 2.4 2.2 2.7 2.7 2.5 2.7 2.5
TC 1.9 2.2 1.9 2.4 2.2 2.2 1.9 2.2 1.9 2.1 1.9 2.4 2.4 2.2 2.4 2.2
TG 2.2 2.5 2.2 2.7 2.5 2.5 2.2 2.5 2.2 2.4 2.2 2.7 2.7 2.5 2.7 2.5
TT 1.7 2.0 1.7 2.2 2.0 2.0 1.7 2.0 1.7 1.9 1.7 2.2 2.2 2.0 2.2 2.0
# 5' ------> 3'
G X1 Y1 T
C X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.5 1.8 1.5 2.0 1.8 1.8 1.6 1.8 1.5 1.6 1.5 2.0 1.8 1.8 2.0 1.8
AC 1.8 2.1 1.8 2.3 2.1 2.1 1.9 2.1 1.8 1.9 1.8 2.3 2.1 2.1 2.3 2.1
AG 1.6 1.9 1.6 2.1 1.9 1.9 1.7 1.9 1.6 1.7 1.6 2.1 1.9 1.9 2.1 1.9
AT 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4
CA 1.8 2.1 1.8 2.3 2.1 2.1 1.9 2.1 1.8 1.9 1.8 2.3 2.1 2.1 2.3 2.1
CC 2.0 2.3 2.0 2.5 2.3 2.3 2.1 2.3 2.0 2.1 2.0 2.5 2.3 2.3 2.5 2.3
CG 1.3 1.6 1.3 1.8 1.6 1.6 1.4 1.6 1.3 1.4 1.3 1.8 1.6 1.6 1.8 1.6
CT 1.9 2.2 1.9 2.4 2.2 2.2 2.0 2.2 1.9 2.0 1.9 2.4 2.2 2.2 2.4 2.2
GA 1.6 1.9 1.6 2.1 1.9 1.9 1.7 1.9 1.6 1.7 1.6 2.1 1.9 1.9 2.1 1.9
GC 1.8 2.1 1.8 2.3 2.1 2.1 1.9 2.1 1.8 1.9 1.8 2.3 2.1 2.1 2.3 2.1
GG 1.6 1.9 1.6 2.1 1.9 1.9 1.7 1.9 1.6 1.7 1.6 2.1 1.9 1.9 2.1 1.9
GT 2.3 2.6 2.3 2.8 2.6 2.6 2.4 2.6 2.3 2.4 2.3 2.8 2.6 2.6 2.8 2.6
TA 2.2 2.5 2.2 2.7 2.5 2.5 2.3 2.5 2.2 2.3 2.2 2.7 2.5 2.5 2.7 2.5
TC 1.9 2.2 1.9 2.4 2.2 2.2 2.0 2.2 1.9 2.0 1.9 2.4 2.2 2.2 2.4 2.2
TG 2.2 2.5 2.2 2.7 2.5 2.5 2.3 2.5 2.2 2.3 2.2 2.7 2.5 2.5 2.7 2.5
TT 1.7 2.0 1.7 2.2 2.0 2.0 1.8 2.0 1.7 1.8 1.7 2.2 2.0 2.0 2.2 2.0
# 5' ------> 3'
T X1 Y1 A
A X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9
AC 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0
AG 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9
AT 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5
CA 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0
CC 2.2 2.3 2.2 2.8 2.3 2.5 2.8 2.4 2.2 2.3 2.2 2.7 2.8 2.4 2.8 2.2
CG 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0
CT 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1
GA 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9
GC 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5
GG 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9
GT 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5
TA 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5
TC 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1
TG 2.4 2.5 2.4 3.0 2.5 2.7 3.0 2.6 2.4 2.5 2.4 2.9 3.0 2.6 3.0 2.4
TT 1.9 2.0 1.9 2.5 2.0 2.2 2.5 2.1 1.9 2.0 1.9 2.4 2.5 2.1 2.5 1.9
# 5' ------> 3'
T X1 Y1 C
A X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.4 1.7 1.5 2.1 1.7 1.9 1.7 1.8 1.5 1.2 1.5 2.1 2.0 1.8 2.2 1.6
AC 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7
AG 1.4 1.7 1.5 2.1 1.7 1.9 1.7 1.8 1.5 1.2 1.5 2.1 2.0 1.8 2.2 1.6
AT 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2
CA 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7
CC 1.7 2.0 1.8 2.4 2.0 2.2 2.0 2.1 1.8 1.5 1.8 2.4 2.3 2.1 2.5 1.9
CG 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7
CT 1.6 1.9 1.7 2.3 1.9 2.1 1.9 2.0 1.7 1.4 1.7 2.3 2.2 2.0 2.4 1.8
GA 1.4 1.7 1.5 2.1 1.7 1.9 1.7 1.8 1.5 1.2 1.5 2.1 2.0 1.8 2.2 1.6
GC 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2
GG 1.4 1.7 1.5 2.1 1.7 1.9 1.7 1.8 1.5 1.2 1.5 2.1 2.0 1.8 2.2 1.6
GT 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2
TA 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2
TC 1.6 1.9 1.7 2.3 1.9 2.1 1.9 2.0 1.7 1.4 1.7 2.3 2.2 2.0 2.4 1.8
TG 1.9 2.2 2.0 2.6 2.2 2.4 2.2 2.3 2.0 1.7 2.0 2.6 2.5 2.3 2.7 2.1
TT 1.4 1.7 1.5 2.1 1.7 1.9 1.7 1.8 1.5 1.2 1.5 2.1 2.0 1.8 2.2 1.6
# 5' ------> 3'
T X1 Y1 G
A X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.5 1.8 1.6 2.3 1.8 2.0 1.4 1.8 1.6 1.7 1.6 2.1 2.1 1.8 2.0 1.6
AC 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7
AG 1.5 1.8 1.6 2.3 1.8 2.0 1.4 1.8 1.6 1.7 1.6 2.1 2.1 1.8 2.0 1.6
AT 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2
CA 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7
CC 1.8 2.1 1.9 2.6 2.1 2.3 1.7 2.1 1.9 2.0 1.9 2.4 2.4 2.1 2.3 1.9
CG 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7
CT 1.7 2.0 1.8 2.5 2.0 2.2 1.6 2.0 1.8 1.9 1.8 2.3 2.3 2.0 2.2 1.8
GA 1.5 1.8 1.6 2.3 1.8 2.0 1.4 1.8 1.6 1.7 1.6 2.1 2.1 1.8 2.0 1.6
GC 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2
GG 1.5 1.8 1.6 2.3 1.8 2.0 1.4 1.8 1.6 1.7 1.6 2.1 2.1 1.8 2.0 1.6
GT 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2
TA 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2
TC 1.7 2.0 1.8 2.5 2.0 2.2 1.6 2.0 1.8 1.9 1.8 2.3 2.3 2.0 2.2 1.8
TG 2.0 2.3 2.1 2.8 2.3 2.5 1.9 2.3 2.1 2.2 2.1 2.6 2.6 2.3 2.5 2.1
TT 1.5 1.8 1.6 2.3 1.8 2.0 1.4 1.8 1.6 1.7 1.6 2.1 2.1 1.8 2.0 1.6
# 5' ------> 3'
T X1 Y1 T
A X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.8 2.0 1.9 2.5 2.0 2.2 2.3 2.1 1.9 2.1 1.9 2.5 2.5 2.1 2.5 1.9
AC 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0
AG 1.8 2.0 1.9 2.5 2.0 2.2 2.3 2.1 1.9 2.1 1.9 2.5 2.5 2.1 2.5 1.9
AT 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5
CA 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0
CC 2.1 2.3 2.2 2.8 2.3 2.5 2.6 2.4 2.2 2.4 2.2 2.8 2.8 2.4 2.8 2.2
CG 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0
CT 2.0 2.2 2.1 2.7 2.2 2.4 2.5 2.3 2.1 2.3 2.1 2.7 2.7 2.3 2.7 2.1
GA 1.8 2.0 1.9 2.5 2.0 2.2 2.3 2.1 1.9 2.1 1.9 2.5 2.5 2.1 2.5 1.9
GC 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5
GG 1.8 2.0 1.9 2.5 2.0 2.2 2.3 2.1 1.9 2.1 1.9 2.5 2.5 2.1 2.5 1.9
GT 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5
TA 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5
TC 2.0 2.2 2.1 2.7 2.2 2.4 2.5 2.3 2.1 2.3 2.1 2.7 2.7 2.3 2.7 2.1
TG 2.3 2.5 2.4 3.0 2.5 2.7 2.8 2.6 2.4 2.6 2.4 3.0 3.0 2.6 3.0 2.4
TT 1.8 2.0 1.9 2.5 2.0 2.2 2.3 2.1 1.9 2.1 1.9 2.5 2.5 2.1 2.5 1.9
# 5' ------> 3'
T X1 Y1 G
A X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.0 2.3 2.0 2.5 2.3 2.3 2.0 2.3 2.0 2.2 2.0 2.5 2.5 2.3 2.5 2.3
AC 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4
AG 2.0 2.3 2.0 2.5 2.3 2.3 2.0 2.3 2.0 2.2 2.0 2.5 2.5 2.3 2.5 2.3
AT 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9
CA 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4
CC 2.3 2.6 2.3 2.8 2.6 2.6 2.3 2.6 2.3 2.5 2.3 2.8 2.8 2.6 2.8 2.6
CG 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4
CT 2.2 2.5 2.2 2.7 2.5 2.5 2.2 2.5 2.2 2.4 2.2 2.7 2.7 2.5 2.7 2.5
GA 2.0 2.3 2.0 2.5 2.3 2.3 2.0 2.3 2.0 2.2 2.0 2.5 2.5 2.3 2.5 2.3
GC 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9
GG 2.0 2.3 2.0 2.5 2.3 2.3 2.0 2.3 2.0 2.2 2.0 2.5 2.5 2.3 2.5 2.3
GT 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9
TA 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9
TC 2.2 2.5 2.2 2.7 2.5 2.5 2.2 2.5 2.2 2.4 2.2 2.7 2.7 2.5 2.7 2.5
TG 2.5 2.8 2.5 3.0 2.8 2.8 2.5 2.8 2.5 2.7 2.5 3.0 3.0 2.8 3.0 2.8
TT 2.0 2.3 2.0 2.5 2.3 2.3 2.0 2.3 2.0 2.2 2.0 2.5 2.5 2.3 2.5 2.3
# 5' ------> 3'
T X1 Y1 T
A X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.0 2.3 2.0 2.5 2.3 2.3 2.1 2.3 2.0 2.1 2.0 2.5 2.3 2.3 2.5 2.3
AC 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4
AG 2.0 2.3 2.0 2.5 2.3 2.3 2.1 2.3 2.0 2.1 2.0 2.5 2.3 2.3 2.5 2.3
AT 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9
CA 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4
CC 2.3 2.6 2.3 2.8 2.6 2.6 2.4 2.6 2.3 2.4 2.3 2.8 2.6 2.6 2.8 2.6
CG 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4
CT 2.2 2.5 2.2 2.7 2.5 2.5 2.3 2.5 2.2 2.3 2.2 2.7 2.5 2.5 2.7 2.5
GA 2.0 2.3 2.0 2.5 2.3 2.3 2.1 2.3 2.0 2.1 2.0 2.5 2.3 2.3 2.5 2.3
GC 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9
GG 2.0 2.3 2.0 2.5 2.3 2.3 2.1 2.3 2.0 2.1 2.0 2.5 2.3 2.3 2.5 2.3
GT 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9
TA 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9
TC 2.2 2.5 2.2 2.7 2.5 2.5 2.3 2.5 2.2 2.3 2.2 2.7 2.5 2.5 2.7 2.5
TG 2.5 2.8 2.5 3.0 2.8 2.8 2.6 2.8 2.5 2.6 2.5 3.0 2.8 2.8 3.0 2.8
TT 2.0 2.3 2.0 2.5 2.3 2.3 2.1 2.3 2.0 2.1 2.0 2.5 2.3 2.3 2.5 2.3
# 5' ------> 3'
G X1 Y1 A
T X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0
AC 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3
AG 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0
AT 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3
CA 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3
CC 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3
CG 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1
CT 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3
GA 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0
GC 2.1 2.2 2.1 2.7 2.2 2.4 2.7 2.3 2.1 2.2 2.1 2.6 2.7 2.3 2.7 2.1
GG 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0
GT 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5
TA 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5
TC 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3
TG 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5
TT 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3
# 5' ------> 3'
G X1 Y1 C
T X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7
AC 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0
AG 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7
AT 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0
CA 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0
CC 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0
CG 1.6 1.9 1.7 2.3 1.9 2.1 1.9 2.0 1.7 1.4 1.7 2.3 2.2 2.0 2.4 1.8
CT 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0
GA 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7
GC 1.6 1.9 1.7 2.3 1.9 2.1 1.9 2.0 1.7 1.4 1.7 2.3 2.2 2.0 2.4 1.8
GG 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7
GT 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2
TA 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2
TC 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0
TG 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2
TT 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0
# 5' ------> 3'
G X1 Y1 G
T X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7
AC 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0
AG 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7
AT 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0
CA 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0
CC 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0
CG 1.7 2.0 1.8 2.5 2.0 2.2 1.6 2.0 1.8 1.9 1.8 2.3 2.3 2.0 2.2 1.8
CT 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0
GA 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7
GC 1.7 2.0 1.8 2.5 2.0 2.2 1.6 2.0 1.8 1.9 1.8 2.3 2.3 2.0 2.2 1.8
GG 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7
GT 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2
TA 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2
TC 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0
TG 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2
TT 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0
# 5' ------> 3'
G X1 Y1 T
T X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0
AC 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3
AG 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0
AT 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3
CA 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3
CC 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3
CG 2.0 2.2 2.1 2.7 2.2 2.4 2.5 2.3 2.1 2.3 2.1 2.7 2.7 2.3 2.7 2.1
CT 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3
GA 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0
GC 2.0 2.2 2.1 2.7 2.2 2.4 2.5 2.3 2.1 2.3 2.1 2.7 2.7 2.3 2.7 2.1
GG 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0
GT 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5
TA 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5
TC 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3
TG 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5
TT 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3
# 5' ------> 3'
G X1 Y1 G
T X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4
AC 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7
AG 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4
AT 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7
CA 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7
CC 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7
CG 2.2 2.5 2.2 2.7 2.5 2.5 2.2 2.5 2.2 2.4 2.2 2.7 2.7 2.5 2.7 2.5
CT 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7
GA 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4
GC 2.2 2.5 2.2 2.7 2.5 2.5 2.2 2.5 2.2 2.4 2.2 2.7 2.7 2.5 2.7 2.5
GG 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4
GT 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9
TA 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9
TC 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7
TG 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9
TT 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7
# 5' ------> 3'
G X1 Y1 T
T X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4
AC 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7
AG 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4
AT 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7
CA 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7
CC 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7
CG 2.2 2.5 2.2 2.7 2.5 2.5 2.3 2.5 2.2 2.3 2.2 2.7 2.5 2.5 2.7 2.5
CT 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7
GA 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4
GC 2.2 2.5 2.2 2.7 2.5 2.5 2.3 2.5 2.2 2.3 2.2 2.7 2.5 2.5 2.7 2.5
GG 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4
GT 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9
TA 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9
TC 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7
TG 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9
TT 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7
# 5' ------> 3'
T X1 Y1 A
G X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0
AC 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3
AG 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0
AT 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5
CA 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3
CC 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3
CG 2.2 2.3 2.2 2.8 2.3 2.5 2.8 2.4 2.2 2.3 2.2 2.7 2.8 2.4 2.8 2.2
CT 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3
GA 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0
GC 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0
GG 2.0 2.1 2.0 2.6 2.1 2.3 2.6 2.2 2.0 2.1 2.0 2.5 2.6 2.2 2.6 2.0
GT 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5
TA 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5
TC 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3
TG 2.5 2.6 2.5 3.1 2.6 2.8 3.1 2.7 2.5 2.6 2.5 3.0 3.1 2.7 3.1 2.5
TT 2.3 2.4 2.3 2.9 2.4 2.6 2.9 2.5 2.3 2.4 2.3 2.8 2.9 2.5 2.9 2.3
# 5' ------> 3'
T X1 Y1 C
G X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7
AC 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0
AG 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7
AT 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2
CA 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0
CC 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0
CG 1.7 2.0 1.8 2.4 2.0 2.2 2.0 2.1 1.8 1.5 1.8 2.4 2.3 2.1 2.5 1.9
CT 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0
GA 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7
GC 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7
GG 1.5 1.8 1.6 2.2 1.8 2.0 1.8 1.9 1.6 1.3 1.6 2.2 2.1 1.9 2.3 1.7
GT 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2
TA 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2
TC 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0
TG 2.0 2.3 2.1 2.7 2.3 2.5 2.3 2.4 2.1 1.8 2.1 2.7 2.6 2.4 2.8 2.2
TT 1.8 2.1 1.9 2.5 2.1 2.3 2.1 2.2 1.9 1.6 1.9 2.5 2.4 2.2 2.6 2.0
# 5' ------> 3'
T X1 Y1 G
G X2 Y2 C
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7
AC 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0
AG 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7
AT 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2
CA 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0
CC 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0
CG 1.8 2.1 1.9 2.6 2.1 2.3 1.7 2.1 1.9 2.0 1.9 2.4 2.4 2.1 2.3 1.9
CT 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0
GA 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7
GC 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7
GG 1.6 1.9 1.7 2.4 1.9 2.1 1.5 1.9 1.7 1.8 1.7 2.2 2.2 1.9 2.1 1.7
GT 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2
TA 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2
TC 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0
TG 2.1 2.4 2.2 2.9 2.4 2.6 2.0 2.4 2.2 2.3 2.2 2.7 2.7 2.4 2.6 2.2
TT 1.9 2.2 2.0 2.7 2.2 2.4 1.8 2.2 2.0 2.1 2.0 2.5 2.5 2.2 2.4 2.0
# 5' ------> 3'
T X1 Y1 T
G X2 Y2 A
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0
AC 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3
AG 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0
AT 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5
CA 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3
CC 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3
CG 2.1 2.3 2.2 2.8 2.3 2.5 2.6 2.4 2.2 2.4 2.2 2.8 2.8 2.4 2.8 2.2
CT 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3
GA 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0
GC 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0
GG 1.9 2.1 2.0 2.6 2.1 2.3 2.4 2.2 2.0 2.2 2.0 2.6 2.6 2.2 2.6 2.0
GT 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5
TA 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5
TC 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3
TG 2.4 2.6 2.5 3.1 2.6 2.8 2.9 2.7 2.5 2.7 2.5 3.1 3.1 2.7 3.1 2.5
TT 2.2 2.4 2.3 2.9 2.4 2.6 2.7 2.5 2.3 2.5 2.3 2.9 2.9 2.5 2.9 2.3
# 5' ------> 3'
T X1 Y1 G
G X2 Y2 T
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4
AC 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7
AG 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4
AT 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9
CA 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7
CC 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7
CG 2.3 2.6 2.3 2.8 2.6 2.6 2.3 2.6 2.3 2.5 2.3 2.8 2.8 2.6 2.8 2.6
CT 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7
GA 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4
GC 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4
GG 2.1 2.4 2.1 2.6 2.4 2.4 2.1 2.4 2.1 2.3 2.1 2.6 2.6 2.4 2.6 2.4
GT 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9
TA 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9
TC 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7
TG 2.6 2.9 2.6 3.1 2.9 2.9 2.6 2.9 2.6 2.8 2.6 3.1 3.1 2.9 3.1 2.9
TT 2.4 2.7 2.4 2.9 2.7 2.7 2.4 2.7 2.4 2.6 2.4 2.9 2.9 2.7 2.9 2.7
# 5' ------> 3'
T X1 Y1 T
G X2 Y2 G
# 3' <------ 5'
# Y
#----------------------------------------------------------------------------------------------------------------------------------
A A A A C C C C G G G G T T T T
A C G T A C G T A C G T A C G T
#----------------------------------------------------------------------------------------------------------------------------------
AA 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4
AC 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7
AG 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4
AT 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9
CA 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7
CC 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7
CG 2.3 2.6 2.3 2.8 2.6 2.6 2.4 2.6 2.3 2.4 2.3 2.8 2.6 2.6 2.8 2.6
CT 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7
GA 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4
GC 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4
GG 2.1 2.4 2.1 2.6 2.4 2.4 2.2 2.4 2.1 2.2 2.1 2.6 2.4 2.4 2.6 2.4
GT 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9
TA 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9
TC 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7
TG 2.6 2.9 2.6 3.1 2.9 2.9 2.7 2.9 2.6 2.7 2.6 3.1 2.9 2.9 3.1 2.9
TT 2.4 2.7 2.4 2.9 2.7 2.7 2.5 2.7 2.4 2.5 2.4 2.9 2.7 2.7 2.9 2.7