#Data table for symetric interior loops of size 2
#Free energies at 37 degrees for DNA
#Data Arrangement:
#For the 4x4 tables, each starting pair needs its own table.
#This is the AA table:
# 5' --> 3'
# X
# A A
# T T
# Y
# 3' <-- 5'
# Y->
# ----------------------------
# (X) A C G U
# | ----------------------------
# V
# (A) 1.3 2.2 0.9 1.0
# (C) 1.7 2.4 1.0 1.4
# (G) 0.4 1.0 0.3 2.0
# (U) 1.0 1.7 2.0 1.4
#An energy of "." is "infinity," i.e. not allowed.
# 5' --> 3'
X
A A
T T
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 1.3 2.2 0.9 1.0
C 1.7 2.4 1.0 1.4
G 0.4 1.0 0.3 2.0
U 1.0 1.7 2.0 1.4
# 5' --> 3'
X
A C
T G
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 0.8 1.4 -0.4 1.0
C 1.6 2.1 1.0 1.6
G -0.2 1.0 -1.2 2.0
U 1.0 1.4 2.0 1.1
# 5' --> 3'
X
A G
T C
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 1.0 1.7 0.3 1.0
C 1.5 2.0 1.0 1.0
G 0.1 1.0 -0.3 2.0
U 1.0 1.4 2.0 0.6
# 5' --> 3'
X
A T
T A
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 1.2 1.7 0.2 1.0
C 1.7 2.7 1.0 1.4
G 0.2 1.0 -0.3 2.0
U 1.0 1.4 2.0 1.4
# 5' --> 3'
X
A G
T T
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 2.0 2.7 1.3 1.0
C 2.5 3.0 1.0 2.0
G 1.1 1.0 0.7 2.0
U 1.0 2.4 2.0 1.6
# 5' --> 3'
X
A T
T G
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 1.8 2.4 0.6 1.0
C 2.6 3.1 1.0 2.6
G 0.8 1.0 -0.2 2.0
U 1.0 2.4 2.0 2.1
# 5' --> 3'
X
C A
G T
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 1.1 2.1 0.8 1.0
C 1.7 1.8 1.0 1.4
G 0.5 1.0 0.3 2.0
U 1.0 1.4 2.0 0.6
# 5' --> 3'
X
C C
G G
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 0.6 1.2 -0.5 1.0
C 1.6 1.5 1.0 1.6
G -0.1 1.0 -1.3 2.0
U 1.0 1.0 2.0 0.3
# 5' --> 3'
X
C G
G C
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 0.9 1.5 0.1 1.0
C 1.5 1.4 1.0 1.0
G 0.1 1.0 -0.3 2.0
U 1.0 1.0 2.0 -0.2
# 5' --> 3'
X
C T
G A
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 1.0 1.5 0.1 1.0
C 1.7 2.0 1.0 1.4
G 0.3 1.0 -0.3 2.0
U 1.0 1.0 2.0 0.6
# 5' --> 3'
X
C G
G T
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 1.9 2.5 1.1 1.0
C 2.5 2.4 1.0 2.0
G 1.1 1.0 0.7 2.0
U 1.0 2.0 2.0 0.8
# 5' --> 3'
X
C T
G G
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 1.6 2.2 0.5 1.0
C 2.6 2.5 1.0 2.6
G 0.9 1.0 -0.3 2.0
U 1.0 2.0 2.0 1.3
# 5' --> 3'
X
G A
C T
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 0.9 2.1 0.5 1.0
C 1.4 1.8 1.0 1.4
G -0.1 1.0 -0.7 2.0
U 1.0 2.0 2.0 1.1
# 5' --> 3'
X
G C
C G
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 0.3 1.3 -0.8 1.0
C 1.3 1.6 1.0 1.6
G -0.8 1.0 -2.2 2.0
U 1.0 1.6 2.0 0.9
# 5' --> 3'
X
G G
C C
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 0.6 1.6 -0.1 1.0
C 1.2 1.5 1.0 1.0
G -0.5 1.0 -1.3 2.0
U 1.0 1.6 2.0 0.3
# 5' --> 3'
X
G T
C A
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 0.8 1.6 -0.2 1.0
C 1.4 2.1 1.0 1.4
G -0.4 1.0 -1.2 2.0
U 1.0 1.6 2.0 1.1
# 5' --> 3'
X
G G
C T
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 1.6 2.6 0.9 1.0
C 2.2 2.5 1.0 2.0
G 0.5 1.0 -0.3 2.0
U 1.0 2.6 2.0 1.3
# 5' --> 3'
X
G T
C G
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 1.3 2.3 0.2 1.0
C 2.3 2.6 1.0 2.6
G 0.2 1.0 -1.2 2.0
U 1.0 2.6 2.0 1.9
# 5' --> 3'
X
T A
A T
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 1.4 2.3 1.2 1.0
C 2.3 2.1 1.0 1.7
G 1.2 1.0 0.9 2.0
U 1.0 1.7 2.0 1.4
# 5' --> 3'
X
T C
A G
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 0.9 1.4 -0.1 1.0
C 2.1 1.8 1.0 2.0
G 0.5 1.0 -0.7 2.0
U 1.0 1.4 2.0 1.1
# 5' --> 3'
X
T G
A C
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 1.1 1.7 0.5 1.0
C 2.1 1.8 1.0 1.4
G 0.8 1.0 0.3 2.0
U 1.0 1.4 2.0 0.6
# 5' --> 3'
X
T T
A A
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 1.3 1.7 0.4 1.0
C 2.2 2.4 1.0 1.7
G 0.9 1.0 0.3 2.0
U 1.0 1.4 2.0 1.4
# 5' --> 3'
X
T G
A T
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 2.1 2.7 1.5 1.0
C 3.1 2.8 1.0 2.4
G 1.8 1.0 1.3 2.0
U 1.0 2.4 2.0 1.6
# 5' --> 3'
X
T T
A G
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 1.9 2.4 0.9 1.0
C 3.1 2.8 1.0 3.0
G 1.5 1.0 0.3 2.0
U 1.0 2.4 2.0 2.1
# 5' --> 3'
X
G A
T T
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 1.9 3.1 1.5 1.0
C 2.4 2.8 1.0 2.4
G 0.9 1.0 0.3 2.0
U 1.0 3.0 2.0 2.1
# 5' --> 3'
X
G C
T G
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 1.3 2.3 0.2 1.0
C 2.3 2.6 1.0 2.6
G 0.2 1.0 -1.2 2.0
U 1.0 2.6 2.0 1.9
# 5' --> 3'
X
G G
T C
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 1.6 2.6 0.9 1.0
C 2.2 2.5 1.0 2.0
G 0.5 1.0 -0.3 2.0
U 1.0 2.6 2.0 1.3
# 5' --> 3'
X
G T
T A
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 1.8 2.6 0.8 1.0
C 2.4 3.1 1.0 2.4
G 0.6 1.0 -0.2 2.0
U 1.0 2.6 2.0 2.1
# 5' --> 3'
X
G G
T T
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 3.0 3.0 3.0 3.0
C 3.0 3.0 3.0 3.0
G 3.0 3.0 3.0 3.0
U 3.0 3.0 3.0 3.0
# 5' --> 3'
X
G T
T G
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 3.0 3.0 3.0 3.0
C 3.0 3.0 3.0 3.0
G 3.0 3.0 3.0 3.0
U 3.0 3.0 3.0 3.0
# 5' --> 3'
X
T A
G T
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 2.1 3.1 1.8 1.0
C 2.7 2.8 1.0 2.4
G 1.5 1.0 1.3 2.0
U 1.0 2.4 2.0 1.6
# 5' --> 3'
X
T C
G G
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 1.6 2.2 0.5 1.0
C 2.6 2.5 1.0 2.6
G 0.9 1.0 -0.3 2.0
U 1.0 2.0 2.0 1.3
# 5' --> 3'
X
T G
G C
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 1.9 2.5 1.1 1.0
C 2.5 2.4 1.0 2.0
G 1.1 1.0 0.7 2.0
U 1.0 2.0 2.0 0.8
# 5' --> 3'
X
T T
G A
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 2.0 2.5 1.1 1.0
C 2.7 3.0 1.0 2.4
G 1.3 1.0 0.7 2.0
U 1.0 2.0 2.0 1.6
# 5' --> 3'
X
T G
G T
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 3.0 3.0 3.0 3.0
C 3.0 3.0 3.0 3.0
G 3.0 3.0 3.0 3.0
U 3.0 3.0 3.0 3.0
# 5' --> 3'
X
T T
G G
Y
# 3' <-- 5'
# Y
# ----------------------------
A C G U
# ----------------------------
A 3.0 3.0 3.0 3.0
C 3.0 3.0 3.0 3.0
G 3.0 3.0 3.0 3.0
U 3.0 3.0 3.0 3.0