Welcome to the Fold Web Server
The Fold server takes a sequence file of nucleic acids, either DNA or RNA, and folds it into its lowest free energy conformation.
A wide variety of constraints can be applied, including, but not limited to, pairing restraints, modifications, and addition of SHAPE data.
Note that this server does not just output the structure with a minimum free energy; it outputs those that fall within the required energy interval and maximum number.
If you plan to leave this page while waiting for calculations to complete, please make sure you have entered a valid email address below. Leaving this page without entering a valid email address will render results inaccessible.
If you need specific help using the Fold server, please click here.