## Terminal Mismatch ΔG° |
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5'––>3' |
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(X) Y–> | A | C | G | U |

(A) | –0.8 | –1.0 | –0.8 | –1.0 |

(C) | –0.6 | –0.7 | –0.6 | –0.7 |

(G) | –0.8 | –1.0 | –0.8 | –1.0 |

(U) | –0.6 | –0.8 | –0.6 | –0.8 |

5'––>3' CX GY 3'<––5' |
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(X) Y–> | A | C | G | U |

(A) | –1.5 | –1.5 | –1.4 | –1.5 |

(C) | –1.0 | –1.1 | –1.0 | –0.8 |

(G) | –1.4 | –1.5 | –1.6 | –1.5 |

(U) | –1.0 | –1.4 | –1.0 | –1.2 |

5'––>3' GX CY 3'<––5' |
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(X) Y–> | A | C | G | U |

(A) | –1.1 | –1.5 | –1.3 | –1.5 |

(C) | –1.1 | –0.7 | –1.1 | –0.5 |

(G) | –1.6 | –1.5 | –1.4 | –1.5 |

(U) | –1.1 | –1.0 | –1.1 | –0.7 |

5'––>3' GX UY 3'<––5' |
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(X) Y–> | A | C | G | U |

(A) | –0.3 | –1.0 | –0.8 | –1.0 |

(C) | –0.6 | –0.7 | –0.6 | –0.7 |

(G) | –0.6 | –1.0 | –0.8 | –1.0 |

(U) | –0.6 | –0.8 | –0.6 | –0.6 |

5'––>3' UX AY 3'<––5' |
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(X) Y–> | A | C | G | U |

(A) | –1.0 | –0.8 | –1.1 | –0.8 |

(C) | –0.7 | –0.6 | –0.7 | –0.5 |

(G) | –1.1 | –0.8 | –1.2 | –0.8 |

(U) | –0.7 | –0.6 | –0.7 | –0.5 |

5'––>3' UX GY 3'<––5' |
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(X) Y–> | A | C | G | U |

(A) | –1.0 | –0.8 | –1.1 | –0.8 |

(C) | –0.7 | –0.6 | –0.7 | –0.5 |

(G) | –0.5 | –0.8 | –0.8 | –0.8 |

(U) | –0.7 | –0.6 | –0.7 | –0.5 |