## Terminal Mismatch ΔH° (kcal/mol) |
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5'––>3' |
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(X) Y–> | A | C | G | U |

(A) | –3.9 | +2.0 | –3.5 | +2.0 |

(C) | –2.3 | +6.0 | –2.3 | –0.3 |

(G) | –3.1 | +2.0 | –3.5 | +2.0 |

(U) | –2.3 | +4.6 | –2.3 | –1.7 |

5'––>3' CX GY 3'<––5' |
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(X) Y–> | A | C | G | U |

(A) | –9.1 | –5.6 | –5.6 | –5.6 |

(C) | –5.7 | –3.4 | –5.7 | –2.7 |

(G) | –8.2 | –5.6 | –9.2 | –5.6 |

(U) | –5.7 | –5.3 | –5.7 | –8.6 |

5'––>3' GX CY 3'<––5' |
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(X) Y–> | A | C | G | U |

(A) | –5.2 | –4.0 | –5.6 | –4.0 |

(C) | –7.2 | +0.5 | –7.2 | –4.2 |

(G) | –7.1 | –4.0 | –6.2 | –4.0 |

(U) | –7.2 | –0.3 | –7.2 | –5.0 |

5'––>3' GX UY 3'<––5' |
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(X) Y–> | A | C | G | U |

(A) | –3.4 | +2.0 | –3.5 | +2.0 |

(C) | –2.3 | +6.0 | –2.3 | –0.3 |

(G) | –0.6 | +2.0 | –3.5 | +2.0 |

(U) | –2.3 | +4.6 | –2.3 | +1.6 |

5'––>3' UX AY 3'<––5' |
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(X) Y–> | A | C | G | U |

(A) | –4.0 | –6.3 | –8.9 | –6.3 |

(C) | –4.3 | –5.1 | –4.3 | –1.8 |

(G) | –3.8 | –6.3 | –8.9 | –6.3 |

(U) | –4.3 | –1.4 | –4.3 | +1.4 |

5'––>3' UX GY 3'<––5' |
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(X) Y–> | A | C | G | U |

(A) | –4.8 | –6.3 | –8.9 | –6.3 |

(C) | –4.3 | –5.1 | –4.3 | –1.8 |

(G) | +3.1 | –6.3 | –1.5 | –6.3 |

(U) | –4.3 | –1.4 | –4.3 | +1.4 |