Data tables for asymmetric interior loops of size 3 The Enthalpy at 37 degrees for RNA Data arrangement: Y ------------------ (X) A C G U ------------------ 5' --> 3' X A A U U YA 3' <-- 5' (A) . . . . (C) . . . . (G) . . . . (U) . . . . Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X A A A C A G A U A G A U U U U G U C U A U U U G YA YA YA YA YA YA 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 13.5 13.5 13.5 13.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 7.8 7.8 7.8 7.8 2.8 8.5 2.8 8.5 2.8 2.8 2.8 2.8 7.8 13.5 7.8 13.5 7.8 7.8 7.8 7.8 7.8 13.5 7.8 13.5 13.5 13.5 13.5 3.4 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X A A A C A G A U A G A U U U U G U C U A U U U G YC YC YC YC YC YC 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 13.5 13.5 13.5 13.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 7.8 13.5 7.8 13.5 2.8 8.5 2.8 8.5 2.8 8.5 2.8 8.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 13.5 13.5 13.5 3.4 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X A A A C A G A U A G A U U U U G U C U A U U U G YG YG YG YG YG YG 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 7.8 7.8 7.8 7.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 13.5 13.5 13.5 13.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 7.8 7.8 7.8 7.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 13.5 13.5 13.5 3.4 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X A A A C A G A U A G A U U U U G U C U A U U U G YU YU YU YU YU YU 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 13.5 13.5 13.5 13.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 7.8 13.5 7.8 13.5 2.8 8.5 2.8 8.5 2.8 8.5 2.8 8.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 3.4 3.4 3.4 3.4 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X C A C C C G C U C G C U G U G G G C G A G U G G YA YA YA YA YA YA 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 8.5 8.5 2.8 8.5 2.6 3.5 2.5 3.5 3.5 3.5 -2.3 3.5 8.5 8.5 2.8 8.5 8.5 8.5 2.8 8.5 8.5 8.5 2.8 8.5 8.5 8.5 8.5 8.5 1.6 3.5 3.5 3.5 3.5 3.5 3.5 3.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 2.8 2.8 2.8 2.8 -1.6 3.5 -4.1 3.5 -2.3 -2.3 -2.3 -2.3 2.8 8.5 2.8 8.5 2.8 2.8 2.8 2.8 2.8 8.5 2.8 8.5 8.5 8.5 8.5 -1.6 3.5 3.5 3.5 -6.7 3.5 3.5 3.5 -6.7 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X C A C C C G C U C G C U G U G G G C G A G U G G YC YC YC YC YC YC 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 8.5 8.5 2.8 8.5 3.5 -2.5 -2.3 3.5 3.5 3.5 -2.3 3.5 8.5 8.5 2.8 8.5 8.5 8.5 2.8 8.5 8.5 8.5 2.8 8.5 8.5 8.5 8.5 8.5 3.5 7.8 3.5 3.5 3.5 3.5 3.5 3.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 2.8 8.5 2.8 8.5 -2.3 3.5 -2.3 3.5 -2.3 3.5 -2.3 3.5 2.8 8.5 2.8 8.5 2.8 8.5 2.8 8.5 2.8 8.5 2.8 8.5 8.5 8.5 8.5 -1.6 3.5 5.8 3.5 -5.8 3.5 3.5 3.5 -6.7 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X C A C C C G C U C G C U G U G G G C G A G U G G YG YG YG YG YG YG 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 2.8 2.8 2.8 2.8 -2.3 -2.3 -2.3 -2.3 -2.3 -2.3 -2.3 -2.3 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 8.5 8.5 8.5 8.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 2.8 2.8 2.8 2.8 -3.1 -2.3 -2.3 -2.3 -2.3 -2.3 -2.3 -2.3 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 8.5 8.5 8.5 -1.6 3.5 3.5 3.5 -6.7 3.5 3.5 3.5 -6.7 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X C A C C C G C U C G C U G U G G G C G A G U G G YU YU YU YU YU YU 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 8.5 8.5 2.8 8.5 3.5 3.5 -2.3 3.5 3.5 3.5 -2.3 3.5 8.5 8.5 2.8 8.5 8.5 8.5 2.8 8.5 8.5 8.5 2.8 8.5 8.5 8.5 8.5 8.5 6.4 3.5 3.5 3.5 3.5 3.5 3.5 3.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 2.8 8.5 2.8 8.5 -2.3 3.5 -2.3 3.5 -2.3 3.5 -2.3 3.5 2.8 8.5 2.8 8.5 2.8 8.5 2.8 8.5 2.8 8.5 2.8 8.5 -1.6 -1.6 -1.6 -1.6 -6.7 -6.9 -6.7 -7.0 -6.7 -6.7 -6.7 -6.7 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X G A G C G G G U G G G U C U C G C C C A C U C G YA YA YA YA YA YA 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 8.5 8.5 8.5 8.5 3.5 3.5 3.5 3.5 6.9 3.5 2.4 3.5 8.5 8.5 8.5 8.5 6.9 8.5 2.4 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 2.8 2.8 2.8 2.8 -2.3 3.5 -2.3 3.5 -2.3 -2.3 -2.3 -2.3 2.8 8.5 2.8 8.5 2.8 2.8 2.8 2.8 2.8 8.5 2.8 8.5 8.5 8.5 8.5 -1.6 3.5 3.5 3.5 -6.7 3.5 3.5 3.5 -6.7 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X G A G C G G G U G G G U C U C G C C C A C U C G YC YC YC YC YC YC 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 8.5 8.5 8.5 8.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 2.8 8.5 2.8 8.5 -2.3 3.5 -2.3 3.5 -2.3 3.5 -2.3 3.5 2.8 8.5 2.8 8.5 2.8 8.5 2.8 8.5 2.8 8.5 2.8 8.5 8.5 8.5 8.5 -1.6 3.5 3.5 3.5 -6.7 3.5 3.5 3.5 -6.7 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X G A G C G G G U G G G U C U C G C C C A C U C G YG YG YG YG YG YG 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 2.8 2.8 2.8 2.8 -2.3 -2.3 -2.3 -2.3 -5.0 -2.3 -2.3 -2.3 2.8 2.8 2.8 2.8 -5.0 2.8 2.8 2.8 2.8 2.8 2.8 2.8 8.5 8.5 8.5 8.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 2.8 2.8 2.8 2.8 -2.3 -2.3 -2.3 -2.3 -2.3 -2.3 -2.3 -2.3 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 8.5 8.5 8.5 -1.6 3.5 3.5 3.5 -6.7 3.5 3.5 3.5 -6.7 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X G A G C G G G U G G G U C U C G C C C A C U C G YU YU YU YU YU YU 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 8.5 8.5 8.5 8.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 3.5 3.5 3.5 3.5 3.5 1.3 3.5 3.5 8.5 8.5 8.5 8.5 8.5 1.3 8.5 8.5 8.5 8.5 8.5 8.5 2.8 8.5 2.8 8.5 -2.3 3.5 -2.3 3.5 -2.3 3.5 -2.3 3.5 2.8 8.5 2.8 8.5 2.8 8.5 2.8 8.5 2.8 8.5 2.8 8.5 -1.6 -1.6 -1.6 -1.6 -6.7 -6.7 -6.7 -6.7 -6.7 -6.7 -6.7 -6.7 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X U A U C U G U U U G U U A U A G A C A A A U A G YA YA YA YA YA YA 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 13.5 13.5 7.8 13.5 8.5 8.5 2.8 8.5 8.5 8.5 2.8 8.5 13.5 13.5 7.8 13.5 13.5 13.5 7.8 13.5 13.5 13.5 7.8 13.5 13.5 13.5 13.5 13.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 7.8 7.8 7.8 7.8 2.8 8.5 2.8 8.5 2.8 2.8 2.8 2.8 7.8 13.5 7.8 13.5 7.8 7.8 7.8 7.8 7.8 13.5 7.8 13.5 13.5 13.5 13.5 3.4 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X U A U C U G U U U G U U A U A G A C A A A U A G YC YC YC YC YC YC 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 13.5 13.5 7.8 13.5 8.5 8.5 2.8 8.5 8.5 8.5 2.8 8.5 13.5 13.5 7.8 13.5 13.5 13.5 7.8 13.5 13.5 13.5 7.8 13.5 13.5 13.5 13.5 13.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 7.8 13.5 7.8 13.5 2.8 8.5 2.8 8.5 2.8 8.5 2.8 8.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 13.5 13.5 13.5 3.4 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X U A U C U G U U U G U U A U A G A C A A A U A G YG YG YG YG YG YG 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 7.8 7.8 7.8 7.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 13.5 13.5 13.5 13.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 7.8 7.8 7.8 7.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 13.5 13.5 13.5 3.4 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X U A U C U G U U U G U U A U A G A C A A A U A G YU YU YU YU YU YU 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 13.5 13.5 7.8 13.5 8.5 8.5 2.8 8.5 8.5 8.5 2.8 8.5 13.5 13.5 7.8 13.5 13.5 13.5 7.8 13.5 13.5 13.5 7.8 13.5 13.5 13.5 13.5 13.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 7.8 13.5 7.8 13.5 2.8 8.5 2.8 8.5 2.8 8.5 2.8 8.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 3.4 3.4 3.4 3.4 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X G A G C G G G U G G G U U U U G U C U A U U U G YA YA YA YA YA YA 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 13.5 13.5 13.5 13.5 8.5 8.5 8.5 8.5 6.9 8.5 2.4 8.5 13.5 13.5 13.5 13.5 6.9 13.5 2.4 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 7.8 7.8 7.8 7.8 2.8 8.5 2.8 8.5 2.8 2.8 2.8 2.8 7.8 13.5 7.8 13.5 7.8 7.8 7.8 7.8 7.8 13.5 7.8 13.5 13.5 13.5 13.5 3.4 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X G A G C G G G U G G G U U U U G U C U A U U U G YC YC YC YC YC YC 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 13.5 13.5 13.5 13.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 7.8 13.5 7.8 13.5 2.8 8.5 2.8 8.5 2.8 8.5 2.8 8.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 13.5 13.5 13.5 3.4 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X G A G C G G G U G G G U U U U G U C U A U U U G YG YG YG YG YG YG 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 7.8 7.8 7.8 7.8 2.8 2.8 2.8 2.8 -5.0 2.8 2.8 2.8 7.8 7.8 7.8 7.8 -5.0 7.8 7.8 7.8 7.8 7.8 7.8 7.8 13.5 13.5 13.5 13.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 7.8 7.8 7.8 7.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 13.5 13.5 13.5 3.4 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X G A G C G G G U G G G U U U U G U C U A U U U G YU YU YU YU YU YU 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 13.5 13.5 13.5 13.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 8.5 8.5 8.5 8.5 8.5 1.3 8.5 8.5 13.5 13.5 13.5 13.5 13.5 1.3 13.5 13.5 13.5 13.5 13.5 13.5 7.8 13.5 7.8 13.5 2.8 8.5 2.8 8.5 2.8 8.5 2.8 8.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 3.4 3.4 3.4 3.4 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X U A U C U G U U U G U U G U G G G C G A G U G G YA YA YA YA YA YA 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 13.5 13.5 7.8 13.5 8.5 8.5 2.8 8.5 8.5 8.5 2.8 8.5 13.5 13.5 7.8 13.5 13.5 13.5 7.8 13.5 13.5 13.5 7.8 13.5 13.5 13.5 13.5 13.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 7.8 7.8 7.8 7.8 2.8 8.5 2.8 8.5 2.8 2.8 2.8 2.8 7.8 13.5 7.8 13.5 7.8 7.8 7.8 7.8 7.8 13.5 7.8 13.5 13.5 13.5 13.5 3.4 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X U A U C U G U U U G U U G U G G G C G A G U G G YC YC YC YC YC YC 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 13.5 13.5 7.8 13.5 8.5 8.5 2.8 8.5 8.5 8.5 2.8 8.5 13.5 13.5 7.8 13.5 13.5 13.5 7.8 13.5 13.5 13.5 7.8 13.5 13.5 13.5 13.5 13.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 7.8 13.5 7.8 13.5 2.8 8.5 2.8 8.5 2.8 8.5 2.8 8.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 13.5 13.5 13.5 3.4 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X U A U C U G U U U G U U G U G G G C G A G U G G YG YG YG YG YG YG 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 7.8 7.8 7.8 7.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 13.5 13.5 13.5 13.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 7.8 7.8 7.8 7.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 7.8 13.5 13.5 13.5 3.4 8.5 8.5 8.5 -1.6 8.5 8.5 8.5 -1.6 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 13.5 13.5 13.5 3.4 Y Y Y Y Y Y ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ A C G U A C G U A C G U A C G U A C G U A C G U ------------------ ------------------ ------------------ ------------------ ------------------ ------------------ 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' 5' --> 3' X X X X X X U A U C U G U U U G U U G U G G G C G A G U G G YU YU YU YU YU YU 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 3' <-- 5' 13.5 13.5 7.8 13.5 8.5 8.5 2.8 8.5 8.5 8.5 2.8 8.5 13.5 13.5 7.8 13.5 13.5 13.5 7.8 13.5 13.5 13.5 7.8 13.5 13.5 13.5 13.5 13.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 8.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 13.5 7.8 13.5 7.8 13.5 2.8 8.5 2.8 8.5 2.8 8.5 2.8 8.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 7.8 13.5 3.4 3.4 3.4 3.4 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 -1.6 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4