Internal loop enthalpies: initiation 4 -7.2 5 -6.8 6 -1.3 Asymmetry 3.2 AU/GU closure: 5.0 2x3 terminal mismatch: YR/AG -5.7 RY/GA -10.9 YR/GA -8.6 GG -9.0 UU -6.4 Other terminal mismatch: AG -3.4 GA -7.6 GG +2.8 UU -5.8